... dihydrotestosterone inthe gland The periurethral portion ofthe gland increases in size during puberty and after the age of 55 due to the growth of nonmalignant cells inthe transition zone ofthe prostate ... (SRD5A2) gene have also been implicated inthe variations in incidence The incidence of autopsy-detected cancers is similar around the world, while the incidence of clinical disease varies Thus, environmental ... survival in prospective randomized trials The paradox of management is that although the disease remains the second leading cause of cancer deaths in men, only man in with prostate cancer will die of...
... based on the tempo ofthe illness as it unfolds inthe individual, relative to the riskto-benefit ratio ofthe therapy being considered No Cancer Diagnosis Prevention Several agents are under investigation ... control, in which the tempo ofthe illness is altered and symptoms controlled until the patient dies of other causes These can be equivalent therapeutically from a patient standpoint if the patient ... detected inthe finasteride group were high-grade [37% (280 of 757 cancers) vs 22% (237 of 1068 cancers) for the placebo group] have been shown to be an artifact ofthe reduced volume ofthe malignant...
... Each core ofthe biopsy is examined for the presence of cancer, and the amount of cancer is quantified based on the length ofthe tumor within the core and the percentage ofthe core involved ... changed the clinical spectrum ofthe disease Now, 95–99% of newly diagnosed cancers are clinically localized, 40% are not palpable, and of these, 70% are pathologically organ-confined The downside of ... ongoing Until the results of these studies are available, men are advised to make an informed decision about whether to undergo testing A diagnostic algorithm based on the DRE and PSA findings...
... to the extent ofthe disease within the gland, the presence or absence of capsular invasion, involvement of seminal vesicles, and extension of disease to lymph nodes Because ofthe inadequacy of ... staging, the staging system was modified to include the results of imaging studies Unfortunately, no single test has proven to indicate accurately the stage or the presence of organ-confined ... histologic grade) often determines biologic behavior The presence or absence of perineural invasion and extracapsular spread are also recorded Prostate Cancer Staging The TNM staging system includes categories...
... undetectable inthe blood within weeks, based on the PSA half-life inthe blood of days If PSA remains detectable, the patient is considered to have persistent disease After radiation therapy, in contrast, ... to assess The more advanced the disease, the lower the probability of local control and the higher the probability of systemic relapse More important is that within the categories of T1, T2, ... rates range from 25 to 89% Part ofthe variability relates to how the complication is defined and whether the patient or physician is reporting the event The time ofthe assessment is also important...
... further shaping ofthe dose, allowing the delivery of still higher doses to the prostate and a further reduction in normal tissue exposure These advances have enabled the safe administration of doses ... with intensity-modulated radiation therapy (IMRT) to maximize the dose to the prostate and to minimize the exposure ofthe surrounding normal structures The addition of IMRT has permitted further ... disruption ofthe vascular supply and not the nerve fibers Neoadjuvant hormone therapy has also been studied in combination with radiation therapy The aim is to decrease the size ofthe prostate...
... waiting, or deferred therapy, is a policy of monitoring the illness at fixed intervals with DREs, PSA measurements, and repeat biopsies ofthe prostate as indicated, but with no therapeutic intervention(s) ... disease on scan For these patients the central issue is whether the rise in PSA results from persistent disease inthe primary site, systemic disease, or both In theory, disease inthe primary site ... estimated that 10–15% of patients had "insignificant" cancers Given the multifocality ofthe disease, a concern is the limited ability to predict pathologic findings on the basis of a needle biopsy,...
... potency The initial rise in testosterone may result in a clinical flare ofthe disease These agents are therefore contraindicated in men with significant obstructive symptoms, cancer-related pain, ... disease at the same time intervals was 23, 32, and 53%, vs 47, 69, and 79% if the doubling time was short (
... first 2–4 weeks of treatment to protect against the flare Intermittent Hormone Therapy Another way to reduce the side effects of androgen depletion is to administer hormones on an intermittent basis ... differentiation pathway In this way, the surviving cells that are allowed to proliferate inthe presence of androgen will retain sensitivity to subsequent androgen depletion Applied inthe clinic, androgen ... normal in 60–70% of patients, and measurable disease regression occurs in 50%; improvements in bone scan occur in 25% of cases, but the majority remains stable Duration of survival is inversely...
... act by relaxing the smooth muscle ofthe bladder neck and increasing peak urinary flow rates No data show that these agents influence the progression ofthe disease Surgical approaches include TURP, ... Always the time after you finished urinating? Over the 5 how often past month, have you had to urinate again less than h after you finished urinating? Over the past month, how often have you found ... regardless ofthe size ofthe gland, while those with an inability to urinate, gross hematuria, recurrent infection, or bladder stones may require surgery In patients with symptoms, uroflowmetry...
... 23 of them have been found in humans [21-23] The members ofthe MMP family have many similarities in their structure All MMPs have a zinc-binding motif inthe catalytic domain In addition, they ... metalloproteinase inhibitors (MMPIs) in cancer therapy Inhibition of MMP activity inthe ECM has been involved in invasion ofmalignant cells Shah et al reported functional degradation of ECM and therapeutic ... an Nterminal domain called predomain, followed by the propeptide domain The majority of MMPs also have additional domains, e.g., Hemopexin domain These additional domains are important in substrate...
... different organs ofthe human body with an unusual predilection for the gastrointestinal tract Gastrointestinal invasion is a rare condition and is often associated with the invasion of other visceral ... Concerning the anatomical site ofthe gastric metastases, the majority of them are reported to occur inthe body and the fundus, most often at the greater curvature with lesser curvature lesions being ... an intraabdominal location The mean survival time of these patients is consistently less than one year The exact clinical incidence of gastrointestinal melanoma cannot be determined from any...
... CLT and teaching speaking and group work in teaching speaking are reviewed Chapter Three describes the methodology used inthe research study The findings ofthe procedures in organizing group work, ... main stages: setting up (organizing the pairs and group/ giving instructions), monitoring (listening to the pairs/ groups during the activity and guiding / giving support/ making notes) and winding ... experience, the ten interviews were conducted in Vietnamese At the beginning of each interview, the students were explained clearly, explicitly and unambiguously about the nature ofthe study During the...
... guide for other customers inthe Vietnamese market 1.5 Organization ofthe study Chapter I provides an introduction including the rationale ofthe study, indentification ofthe problem, objectives, ... understanding ofthe store by evaluating the store in terms ofthe factors comprising the choice criteria Based on the evaluation, the consumer 18 forms a degree of preference for the store If ... 20.10% Here there is again opposing behavior in prior intention of going supermarkets between the two groups, describing in table 4.9 The option “plan before going” appeared much more often in heavy-users...
... Non- linguistic contexts include : the type of communicative event; the topic; the purpose ofthe event, the setting including location, time of day, season of year and physical aspects ofthe ... with the help of interjections (2; p.67) Scholar I.P Krylova thinks that the main means of expressing modality is the mood ofthe verb Thus in English we find the Indicative Mood representing ... up the main points in Recapitulation and Limitations ofthe Study and makes Suggestions for the Futher Studies The part REFERENCES consists of all ofthe materials that the author has used in the...
... based on the conserved amino acid sequences ofthe catalytic domain of members ofthe GH18 family resulted inthe amplification of an expected 147 bp sequence Cloning and sequencing of this fragment ... composed ofthe sole Glyco_18 domain, the C-terminal tail of C gigas CLPs may not noticeably contribute to the structure and the function of these proteins Interestingly, Cg-Clp1 and Cg-Clp2 C-terminal ... from the oyster Crassostrea gigas [5] Interestingly, this protein, named C gigas chitinase-like protein (CgClp1) was found to be involved inthe control of growth and remodelling processes in a...
... histidine (Fig 4A,C,D) However, in all C-domains of catalase– peroxidases, there is a conserved arginine (Arg622 in HalomarCPc) inthe corresponding position, indicating that these domains lost their ... and thus the role ofthe corresponding part ofthe gene is also unknown These gene fusions together with single-copy genes of APXs and CCPs are ideal for investigating the evolution of a widespread ... only in some minor nodes is refining ofthe particular species within groups moderate Inthe case of PUZZLE, the likelihood mapping analysis also revealed strong support of all main nodes Hence, the...