2 therapy of advanced cervical cancer
báo cáo hóa học:" Substitutions in the Reverse Transcriptase and Protease Genes of HIV-1 Subtype B in Untreated Individuals and Patients Treated With Antiretroviral Drugs" potx
... of APOBEC3G is inhibited by the Vif protein.[5,7,8] In the absence of Vif, the synthesis of the negative strand of DNA can result in the insertion of a uracil as a result of the deamination of ... error of the mean) Page of (page number not for citation purposes) Journal of the International AIDS Society 2005, 7:69 AG transition Another high-prevalence mutation was T215Y (33.3% of patients), ... standard error of the mean.) Page of (page number not for citation purposes) Journal of the International AIDS Society 2005, 7:69 http://www.jiasociety.org/content/7/1/69 Table 1: Prevalence of Patients...
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báo cáo hóa học:" Trends in the clinical characteristics of HIVinfected patients initiating antiretroviral therapy in Kenya, Uganda and Tanzania between 2002 and 2009" pdf
... acquisition of data, and critical revisions of the manuscript PO contributed to acquisition of data, interpretation of data, and critical revisions of the manuscript DRB contributed to acquisition of ... interpretation of data, and critical revisions of the manuscript MBB contributed to acquisition of data, interpretation of data, and critical revisions of the manuscript CRC contributed to acquisition of ... design of the study, acquisition of data, data analysis, interpretation of data, drafting the manuscript, and critical revisions of the manuscript PWH contributed to conception and design of the...
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Báo cáo y học: "Infliximab therapy in rheumatoid arthritis and ankylosing spondylitis-induced specific antinuclear and antiphospholipid autoantibodies without autoimmune clinical manifestations: a two-year prospective study" potx
... during infliximab treatment of RA patients, of AS patients and in the control RA population were of IgM isotype (11 of 13 [85%], of [100%] and of [100%] respectively) One of the sera from infliximab-treated ... treatment of RA with infliximab were of IgM isotype Furthermore, we showed that most of the detected aPL autoantibodies were also of IgM isotype The role of these IgM in the development of autoimmune ... end of the study, including in eight of nine patients who discontinued the treatment One RA became negative months after the end of the treatment Furthermore, in six of the nine R538 sera of infliximab-treated...
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Báo cáo y học: "Is there an association between anti-TNF monoclonal antibody therapy in rheumatoid arthritis and risk of malignancy and serious infection" ppt
... Silman overall increase of twofold (OR 2.0, 95% CI 1.3-3.1) but with a much less marked influence of dose Therefore, these data overall raise concerns about the safety of anti-TNF monoclonal antibody ... incidence of around 8/1000 per year, which is at least eight times that seen in the comparison arm patients and is of the same order of magnitude as that seen in the anti-TNF arms of the trials ... investigator (with Professor Deborah Symmons) of the British Society for Rheumatology Biologics Register (BSRBR) The goals of the BSRBR are primarily related to examining the long-term safety of biologic...
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Báo cáo y học: "HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form" pdf
... nM dNTP mix, 0.3 μM of primers MO186 and MO187, 0.75 μl of the Expand Long Template enzyme mix and μl of cDNA template PCR conditions were as follows: 94°C for min, 10 cycles of 94°C (10 sec), ... construct a recombinant map of CRF49_cpx representing a consensus of breakpoints across the three full genomes Results and Discussion Description of the Cohort The majority of the subjects was female ... major grouping of sequences Five of the new Gambian sequences cluster with the Senegalese A3 variant sequences with a bootstrap support of 81 (∞) Branch lengths represent the number of substitutions...
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Báo cáo y học: " Distinct expression profiles of TGF-β1 signaling mediators in pathogenic SIVmac and non-pathogenic SIVagm infections" pot
... determinants, i.e the level of Nef-mediated downregulation of CD3 [39] or the levels of Siglec expression [40], for the levels of T cell activation and thus for the outcome of HIV/ SIV infections ... lack of induction of Th1-associated transcription factor in AGMs The expression of T-bet is known to be suppressed by TGFβ1 [15] The latter plays indeed a major role in the negative regulation of ... highlighted the important role of TGF-β1 responsiveness not only for the induction and stabilization of regulatory activity of CD4+CD25+ Treg but also for the capacity of other cells to respond to...
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Báo cáo y học: "Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock - does the dose matter" pps
... properties of antimicrobials (Figure 2) Given that similar antibiotics may have very different diffusion profiles, knowledge of antibiotic concentration at the site of infection is of paramount ... days of therapy, appropriate LDs of teicoplanin (400 mg every 12 hours at least three times) were administered to only onethird of patients (78 out of 202) Interestingly, the percentage of patients ... Pharmacodynamics of a time-dependent antimicrobial Shown is a comparison of the simulated drug concentration profile of a timedependent anitmicrobial with an elimination half-life of hour administered...
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Báo cáo y học: "Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1" doc
... towards retardation of joint damage [11] Assessment of outcome variables The aim of this study was to assess the effects of HRT on serum levels of the osteoclast-stimulating cytokines, tumor necrosis ... Nineteen (22%) of the patients were given corticosteroids at a mean dosage of 4.6 mg of prednisolone and 68 (77%) were given nonsteroidal anti-inflammatory drugs The proportions of patients given ... associated with any of the other factors Increase in serum levels of E2 correlated strongly with improvement of BMD in the hip and lumbar spine and to a lower degree with reduction of sIL-6R The alteration...
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Báo cáo y học: " Effectiveness of antiretroviral therapy and development of drug resistance in HIV-1 infected patients in Mombasa, Kenya" doc
... and accompanying resistance are of concern with regard to the risk of disease progression and potential transmission of drug resistant virus to partners The aim of this study was to assess, in ... Accumulation of mutations against drugs from different drug classes and/or the presence of broad cross-resistance mutations will jeopardize the effectiveness of the NRTI backbone of second-line ... danger of the absence of viral monitoring, with regard to the accumulation of resistance mutations Besides high quality adherence counselling, efforts are needed to guarantee a robust supply of drugs...
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Báo cáo y học: " Pre-treatment mortality and loss-to-follow-up in HIV-1, HIV-2 and HIV-1/HIV-2 dually infected patients eligible for antiretroviral therapy in The Gambia, West Africa" doc
... patients offered ART counselling as a part of routine clinic care The MRC HIV clinic eventually became the largest provider of ART in the country with responsibility for care and follow-up of approximately ... visit of patients who are considered lost to follow-up is done as part of routine clinic practice to ascertain survival status or change of address Table shows the finding at field visits of the ... many of these patients who could not be traced or relocated outside of The Gambia may have died The median CD4 T cell count of the ART-eligible individuals is 150 cells/μL indicating that many of...
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báo cáo khoa học: "The efficacy of computer reminders on external quality assessment for point-of-care testing in Danish general practice: rationale and methodology for two randomized trials" pot
... the start of the study period This information includes gender, age, year of graduation from university, working address, type of practice, and list size Outcomes Outcomes are measures of split ... each four-month followup round The contents of the reminder are presented in Figure Page of Power calculation We used an estimate of a mean number of 1.5 INR split tests based on laboratory data ... laboratory data from 2007 in order to ascertain the power of the study Given a standard deviation of 1, a power of 90%, and an effect of 0.5, we estimated that 172 practices are to be included...
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báo cáo khoa học: "Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy" ppt
... prevention of carcinogenesis, in non-cancerous animal- and cell-based studies [22-24] These studies support the potential utility of LA as an anticancer agent and the importance of the elucidation of ... novel role of cyto- Page of (page number not for citation purposes) Journal of Hematology & Oncology 2008, 1:4 http://www.jhoonline.org/content/1/1/4 Figure Proposed mechanism of action of LA Proposed ... The actin-adjusted level of bax and bcl-2 and changes in the ratio of bax to bcl-2 in HL-60 cells treated for 48 h with increasing dose of LA (E) Subcellular distribution of immunoreactive AIF and...
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Báo cáo y học: " Co-receptor usage and prediction of v3 genotyping algorithms in hiv-1 subtype b’ from paid blood donors experienced anti-retroviral therapy in chinese central province" pps
... http://www.virologyj.com/content/7/1/280 Page of Table Association of HIV-1 co-receptor usage with the net charge of V3 loop Characteristic a Distribution b and frequency c of net charge of V3 loop Groups tropism ... Note: a: the number of cases; b:it is the net charge of V3 loop according to the formula (V3 net charge=(R+K)-(D+E)); c:it is the frequency of b in the a bold: No of net charge of V3 for R5-tropic ... X4-tropic viruses which the number of net charge of V3 is below in ART group, suggesting the number of net charge of V3 is not available for co-receptor prediction of HIV-1 B’ subtype exposed to...
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Báo cáo y học: "Endogenous TGF-β activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells" docx
... transplantation, cancer and HIV infection [1-5] Human CD4+CD25+ Tregs possess most of the basic features of their counterparts in mice [6,7], including specific expression of Foxp3 and immunosuppression of ... cells (see C) B Profile of DHE fluorescence (ROS+) on FL-2 vs FSC of R1 and R2 cells The values are shown as the MFI of R1 and R2 cells (R1/R2) Data not shown here are the MFI of unlabeled cells ... cells, consequently enhancing the frequency of the minor population of CD25-Foxp3+ T cells In support of a critical role of TGF-β signaling in the induction of Foxp3, we have observed that CD4+CD25-...
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Báo cáo sinh học: "A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma" ppsx
... quantification of the cytotoxic effect of HSV-TK by BLI Correlation of enzymatic activities Fusion of two enzymes is the only way to guarantee stoichiometric, and thus correlated expression of both ... models of cancer In addition, high costs, the need for a radiopharmacy and considerable technical experience currently preclude widespread application of PET in experimental gene therapy of cancer ... histopathological analyses of gene therapy-treated brain tumors Cancer Gene Ther 1997, 4:118-128 Gambhir SS: Molecular imaging of cancer with positron emission tomography Nat Rev Cancer 2002, 2:683-693...
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Báo cáo y học: "HIV DNA and Dementia in Treatment-Naïve HIV-1-Infected Individuals in Bangkok, Thailand"
... importance of HIV DNA in the pathogenesis of HAD Other limitations of the current study include the assumption that the CD14- subsets were composed mainly of CD4 lymphocytes The calculations of HIV ... reservoir of virus in the majority of subjects who had been on HAART for longer than years [24] Calcaterra et al found higher levels of HIV DNA in monocytes than in CD4+ lymphocytes in a subset of non-viremic ... (P S.) established a diagnosis of HAD using standard -of- care approaches for Thailand In general, the evaluation included participant and proxy informant reports of symptoms and function, the HIV...
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Báo cáo y học: "Antiviral therapy of HCV in the cirrhotic and transplant candidate"
... respectively [7] Results of two ongoing prospective studies are awaited to answer an important question that remains; is there any benefit of prolonged treatment of patients with advanced fibrosis or ... absence of SVR? The National Institutes of Health sponsored HALT-C trial (Hepatitis C Antiviral Long Term Treatment against Cirrhosis), is a multicenter study of the potential benefit of prolonged ... there are major obstacles toward treatment of this group of patients Since the advent of MELD-based allocation, with the associated lessened importance of waiting time, those awaiting liver transplant...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf
... C-terminal domain-tail of the largest subunit of RNA polymerase II at serine and 5; phos- phorylation of DSIF (converts DSIF into an activator); and phosphorylation of components of the NELF complex, ... activation of this complex results in short transcripts of 50 nucleotides All further steps require the presence of P-TEFb kinase (CDK9 ⁄ CCNT1) and TFIIH (CDK7 ⁄ CCNH): phosphorylation of the ... data) The presence of the AF4–MLL fusion protein seems to enhance transcription via activation of P-TEFb kinase In line with this, after days of induction, ectopic expression of AF4–MLL resulted...
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Tài liệu IMPLANT AND REGENERATIVE THERAPY IN DENTISTRY A GUIDE TO DECISION MAKING docx
... removal of approximately mm of bone at the area of the entrance to the mesial furcation of the first molar Such therapy would compromise the prognosis of the first molar Removal of mm of bone from ... the elimination of soft tissue concavities, in the area of the interproximal col and elsewhere, soft tissue clefts, and marked gingival margin discrepancies The establishment of the most plaqueresistant ... because of the vast extent of the intercellular spaces and the sparseness of desmosomes” (28) Numerous studies have demonstrated the permeability of the junctional epithelium to a variety of substances...
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Tài liệu ACCOUNTING FOR HETEROGENEITY, DIVERSITY AND GENERAL EQUILIBRIUM IN EVALUATING SOCIAL PROGRAMS pptx
... integrals of the empirical CDFs of the control and treatment group earnings distributions for various values of o Table displays the re- sults of tests of the null hypothesis of equality of the ... generalization of his proof is given in Theorem A-2 of Appendix A of Heckman and Smith, 1998 28 is not as informative about the economic aspects of program evaluation as one might hope The Problem of Recovering ... corresponds to the case of perfect negative dependence, where q1 = 100— q The first and last rows of Table display estimates of quantiles of the impact distribution and other features of the impact distribution...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25