2 prognostic factors in relapsed and refractory hodgkin lymphoma
báo cáo khoa học: "Lenalidomide induced good clinical response in a patient with multiple relapsed and refractory Hodgkin''''s lymphoma" pptx
... 10.1186/1756-8722-3-20 Cite this article as: Mandac and Kolonic, Lenalidomide induced good clinical response in a patient with multiple relapsed and refractory Hodgkin' s lymphoma Journal of Hematology & Oncology ... patient was based on the standard dose used in multiple myeloma, nonHodgkin's lymphoma, and classic Hodgkin' s lymphoma (25 mg daily for 21 days of every 28-day cycle) [1-4] In this patient, no significant ... D, Takeshita K, Ervin-Haynes A, Zeldis JB, Vose JM: Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non -Hodgkin' s lymphoma J Clin Oncol 2009, 27:5404-5409...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... proline-rich and glutamine-rich N-terminus, which is important for transactivation, is shown in yellow, and contains the PY-motif (green) The helix–span–helix domain at the C-terminus shown in ... AP-2e in chondrogenesis Overview of the differentiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of an embryonic cartilaginous ... transcription factors Essential transcription factors in chondrocyte differentiation are Sox9 and Runx2 Sox9 plays a key role in chondrogenesis, as an inactivating mutation in the gene encoding Sox9...
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báo cáo khoa học: "Gastrointestinal stromal tumors: correlation between symptoms at presentation, tumor location and prognostic factors in 47 consecutive patients" pot
... considered as indications for adjuvant therapy Histological processing was obtained with formalin fixation followed by paraffin inclusion, μm sectioning, and staining with hematoxylin and eosin Morphologic ... 50-70% in the stomach, 25-30% in the small intestine, 5-10% in the colon-rectum, < 5% in the esophagus, the remaining may arise within the omentum or within the peritonel layers (Extra-Gastro-intestinal ... common clinical presentation of these tumors is gastrointestinal bleeding, otherwise they may cause intestinal obstruction, abdominal pain, a palpable mass, or can be incidentally detected during...
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Báo cáo khoa học: "Evaluation of clinical, laboratory and morphologic prognostic factors in colon cancer" ppsx
... in distinguishing T1 and T2 lesions The cancer was found in the ileocecal junction of 11 patients (11.9%), in ascending colon of 14 patients (15.2%), in transverse colon of subjects (8.7%), in ... follows: pT1, tumor invading submucosal layer; pT2, tumor invading muscularis propria or subserosa; pT3, tumor penetrating serosa and perivisceral fat; and pT4, tumor invading adjacent organs ... Takahashi I: Increase in both CEA and CA19.9 in sera is an independent prognostic indicator in colorectal carcinoma J Surg Oncol 2006, 94:132-137 Blomqvist L, Torkzad MR: Whole-body imaging with...
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Báo cáo khoa học: "Outcome and prognostic factors in critically ill patients with systemic lupus erythematosus: a retrospective study" pdf
... to the ICU Gastrointestinal bleeding, intracranial haemorrhage and septic shock during the ICU stay were associated with a greater risk of death, indicating that clinical course and medical care ... morbidity and acute physiological condition – play key roles in influencing the prognosis of SLE patients in the ICU 0.01 Concurrent septic shock in the ICU The incidence of gastrointestinal haemorrhage ... intracranial haemorrhage, including brainstem haemorrhage, subarachnoid haemorrhage and frontal lobe haemorrhage, to be a factor that increases the risk of dying Acute stroke (infarction or intracranial...
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Tài liệu LESSON 2: BASIC COMMANDS IN LINUX AND WINDOWS docx
... ISECOM LESSON – BASIC COMMANDS IN LINUX AND WINDOWS 2.1 Introduction and Objectives This lesson introduces commands and basic tools for both Windows and Linux operating systems so that you can ... following table with parallelisms between Windows and Linux For example: the Linux command “command -help” is equivalent to the Windows 13 LESSON – BASIC COMMANDS IN LINUX AND WINDOWS command “command ... command equivalences for Windows/Linux This is a table showing the basic command equivalences between Linux and Windows Commands are executed from a shell (in Linux) or from a MS-DOS window (in...
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Tài liệu Báo cáo khoa học: Roles of heat shock factors in gametogenesis and development pptx
... coronal section and scheme of the coronal section at E14.5 in (F) (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline Surprisingly, the ... before and after birth in mouse brains [122,124] No HSF4 DNA-binding activity was reported in the developing mouse brain so far However, Hsf4b is expressed in the adult mouse brain, including cerebellum, ... seems to be intimately correlated with neurogenesis and neuronal migration in different parts of the mouse brain HSF1 and HSF2 might interact in the developing mouse brain in a stage- and tissue-specific...
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báo cáo khoa học: "Prognostic factors in patients with node-negative gastric cancer: an Indian experience" pdf
... according to the UICC TNM guidelines [15] and were included in the analysis Patients with carcinoma -in- situ were excluded from the study, since the risk of nodal metastasis is very low in these ... various prognostic factors influencing the disease-free survival (DFS) was performed using log-rank test Factors identified to be significant in univariate analysis were included in the multivariate ... nodes and recurrence rates By cutpoint analysis, these authors reported better survival in pT1-2 patients in whom ≥15 nodes were dissected, in pT3-4 patients in whom ≥20 nodes were dissected and in...
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Báo cáo khoa học: "Prognostic factors in primary adenocarcinoma of the small intestine: 13-year single institution experience" ppt
... mainly adenocarcinomas followed in decreasing order by carcinoid tumors, non -Hodgkin lymphomas, gastrointestinal stromal tumors, melanomas, and other rare entities In the United States, the incidence ... was located in the duodenum in 48% of the patients while 22% had a lesion in the jejunum and 30% had a lesion in the ileum Elective surgery was performed in 89% and emergency surgery in 11% of ... decade in an effort to determine the factors influencing the long-term survival The median follow up of patients was 7.9 years ranging from 0.6 to 13 years Patients and Methods This study includes...
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Báo cáo y học: " Interactions between genes and environmental factors in asthma and atopy: new developments" pps
... polymorphisms in candidate genes for asthma/atopy have been identified Linkage and candidate gene studies in asthma and atopy Linkage studies Results from linkage studies (genome-wide searches and candidate ... of inconsistent findings, it is intriguing that chromosomal regions linked to asthma have also shown evidence for linkage to other inflammatory and autoimmune diseases (such as psoriasis, inflammatory ... other genes involved in the allergic inflammation (e.g IL-4Rα [21], β2AR [24]) We can therefore speculate that inconsistent findings in the genetic studies of asthma and atopy summarized in this...
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Báo cáo y học: "Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology" ppsx
... stages in the proposed pathway are indicated Genistein is an inhibitor of tyrosine protein kinase and competitive inhibitor of ATP in other protein kinase reactions; NaF is a nonspecific kinase inhibitor; ... pull NF-κB off DNA, and export NF-κB back to its resting state in the cytoplasm Thick lines indicate the activating pathway; thin lines indicate the inactivating pathway IκB-independent pathways, ... significance of maintaining reducing conditions in cells and the fight against the damaging effect of ROS intermediates [17,22,35,37–39] Oxidants, for instance, can cause carcinogenesis, sclerosis,...
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Báo cáo y học: "Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity" pptx
... this idea, and it is possible that increased Ang-2 release is one of the mechanisms underlying this finding Clinical studies investigating the endothelium in sepsis commonly use circulating markers ... Weissfeld LA, Yealy DM, Pinsky MR, Fine J, Krichevsky A, Delude RL, Angus DC: Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers ... Reduced citrulline production in sepsis is related to diminished de novo arginine and nitric oxide production Am J Clin Nutr 2009, 89:142-152 20 Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus...
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Báo cáo y học: "Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma" docx
... which included 17 genes with p53 binding sites in cluster A and 26 genes with NF-κB binding sites in cluster B In cluster A genes with p53 binding sites, putative models containing three and four ... transcription factors associated with NF-κB were ETSF (human and murine ETS1 factors; 8/14) and ZBPF (zinc binding protein factors; 8/14) In most cases the locations of NF-κB binding sites were ... NM_003528 h IGFBP2 Insulin-like growth factor binding protein (36 kDa) NM_000597 hmr (hr) LGALS3BP Lectin, galactoside-binding, soluble, binding protein NM_005567 hmr MATN2 Matrilin NM_002380 h (hmr)...
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Báo cáo y học: "The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease" docx
... be mediated by two distinct domains In VEGF-A, these correspond to the basic heparin-binding domain encoded by exon and the NRP1/heparin-binding domain encoded by exons and [10] The nuclear magnetic ... the heparin-binding domain; N, encodes the NRP1/heparin-binding domain; NP, encodes the amino-terminal propeptide domain; SP, signal peptide; VHD, encodes the VEGF/PDGF homology domain Information ... mammals; VEGF-A121 lacks exons and 7, and VEGF-A165 lacks exon (Table 2) Exon encodes a heparinbinding domain, while exons and encode a NRP1/heparin-binding domain; with the exception of VEGF-A121,...
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Báo cáo khoa học: " Chemotherapy followed by low dose radiotherapy in childhood Hodgkin''''s disease: retrospective analysis of results and prognostic factors" ppt
... advanced Hodgkin' s lymphoma reducing relapses in initially involved sites and improving survival Conclusion This data demonstrating the importance of RT consolidation with low dose and reduced ... localized intermediate- and high-grade non -Hodgkin' s lymphoma N Engl J Med 1998, 339:21-6 Hunger SP, Link MP, Donaldson SS: ABVD/MOPP and low dose involved-field radiotherapy in pediatric Hodgkin' s ... with relapsed and refractory Hodgkin' s disease Ann Oncol 2002, 13:1628-1635 Colwill R, Crump M, Couture F: Mini-BEAM as salvage therapy for relapsed refractory Hodgkin' s disease before intensive...
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báo cáo hóa học:" Factors associated with psychological and behavioral functioning in people with type 2 diabetes living in France" pptx
... disease was defined in this study as myocardial infarction or angina, or heart arteries surgery, and no distinction could be performed between myocardial infarction and angina Moreover, no information ... mean that factors were not included in the final multivariable model Underlining indicates the most important association with the DHP scores a Presence of myocardial infarction, angina or heart ... observed in our sample were close to scores observed in people treated by insulin, OHAs or diet in previous studies [17,19] As in our study, insulin therapy was associated with a marked decrease in...
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Báo cáo khoa học: "Marjolin''''s ulcers: theories, prognostic factors and their peculiarities in spina bifida patients" ppsx
... multifactorial theory, a combination of any of Figure Marjolin’s ulcer with sinuses extending into the thigh and labia majora One sinus was found in the anus, and another in the vagina Note benign appearance ... prognostic factors, with a view to applying these to spina bifida patients This understanding would aid the healthcare worker in developing programs suited to a growing population of spina bifida ... http://www.wjso.com/content/8/1/108 Figure Marjolin’s ulcer with sinuses included within surgical excision margins Note deep ulcer and benign appearance of ulcer edges fully These postulates include the toxin, the chronic irritation,...
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Báo cáo khoa học: " Neoadjuvant radiochemotherapy in the treatment of fixed and semi-fixed rectal tumors. Analysis of results and prognostic factors" pptx
... J, Grandjean JP, Partensky C, Souquet JC, Adeleine P, Gerard JP: Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing ... an issue being addressed in the ongoing randomized EORTC trial 22921 Its preliminary results showed a greater incidence of grade diarrhea in the CT group (34.3% Vs 17.3%; p < 0.005) and two patients ... ultrasound in predicting staging and outcome in patients with rectal adenocarcinoma Dis Colon Rectum 2004, 47:1323-1330 Chan AKP, Wong A, Jenken D, Heine J, Buie D, Johnson D: Posttreatment TNM staging...
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Báo cáo khoa học: " Whole brain radiation therapy in management of brain metastasis: results and prognostic factors" ppsx
... 48% in the SRS alone arm, and 82% in the SRS and WBRT arm (P = 0.003) Actuarial year brain tumor control rate for the lesions treated with SRS was 70% in the SRS alone arm and 86% in the SRS and ... Discussion Brain metastases are the most common form intra cranial tumor accounting significantly more than one- half of brain tumors in adults Because of advanced in the diagnoses and management ... Oncology 2006, 1:20 Background Brain metastases represent an important cause of morbidity and mortality, and are the most common intracranial tumors in adults, occurring in approximately 10% to 30%...
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báo cáo khoa học: "Temozolomide and cisplatin in relapsed/refractory acute leukemia" potx
... elevated creatinine (one patient level 2, three patients level 3) None of the patients treated at level developed an increased creatinine, indicating that patient factors other than cisplatin dose ... administered as a single agent in our previous study Toxitcities were as expected and included myelosuppression, nausea, vomiting and (mild) renal and electrolyte abnormalities We chose not to increase ... in vitro data showing that some leukemia cell lines are sensitive to cisplatin [18] Complete remissions have also been reported in relapsed and refractory AML patients treated with carboplatin[19]...
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