1 70 the normal stress in the members of the truss shown in figure p1 70 is to be limited to 160 mpa in tension or compression
Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... transforming growth factor, CD40 ligand, interleukin 1, or interleukin [10 ] Oxidative stress also promotes angiogenesis [13 ] The link between oxidative stress and angiogenesis is emphasised in SSc ... by impaired in this disease without implication of the sVEGFR -1 Endothelium injury is critical in SSc and is suspected to occur early in the disease process Circulating sVCAM -1 is a recognised ... protein) 0.34 (0 .15 –0.64) 0.83 (0.37 1. 48) P < 0.00 01 AOPP (µmol/l of chloramine-T equivalents) 75.5 ( 21 91) 10 9 .1 (50–2 81) P < 0.00 01 VEGF (pg/ml) 2 21 (19 –499) 573.5 (26 19 15) P = 0.00 01 sVEGFR-1...
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Báo cáo khoa học: Post-ischemic brain damage: targeting PARP-1 within the ischemic neurovascular units as a realistic avenue to stroke treatment pptx
... PARP -1 Neuron Inflammatory mediators AIF PARP -1 M ina am ll asa P M PARP -1 B HM G B1 M P M HM GB M P M X Endothelium X PM TR Ca2+ Inflammatory mediators X AIF Inflammatory mediators PARP -1 Mic ... This, of course, would reduce the risk of side effects The latter might be further reduced by the forthcoming development of PARP isoform-specific inhibitors [84] In conclusion, preclinical and clinical ... of proinflammatory mediators [17 ] It is now widely accepted that the latter are responsible for disruption of the 40 capillary basal lamina, opening of the BBB and in ltration of blood-borne leukocytes...
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Salt stress in the plant 1 pot
... treephys.oxfordjournals.org at East China Normal University on October 28, 2 010 HA1 HA1 sense1 HA1 antisense1 HA1 sense2 HA1 antisense2 VHA-c1 VHA-c1 sense VHA-c1 antisense SOS1 SOS1 sense1 SOS1 antisense1 SOS1 sense2 ... synthesis inhibitors and PM H+-ATPase and Na+/H+ antiporter inhibitors on Na+ flux kinetics were examined in the salt glands of A marina Before the SNP or inhibitor addition, steady Na+ flux was recorded ... for at least 10 Then an SNP or inhibitor was added to the measuring solution, with the transient Na+ flux in the salt gland monitored for an additional 16 –20 The data for the first 2–3 were discarded...
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Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
... sniffing, paw licking, rearing and wet dog shakes that persist for 10 15 min), clonic movements of forelimbs, head bobbing and tremors [ 21, 22] These behavioral changes progress to motor limbic seizures ... compensatory increase in catalase activity, which may be a long-term compensatory mechanism including activity modulation of enzymes [ 31] In addition, in the normal physiological state, changes in ... on at 07:00 h) The experiments were performed according to the Guide for the Care and Use of Laboratory Animals of the US Department of Health and Human Services, Washington, DC (19 85) Control...
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Tài liệu Báo cáo khoa học: Fra-1 targets the AP-1 site/2G single nucleotide polymorphism (ETS site) in the MMP-1 promoter docx
... required for MMP -1 expression and may explain the decrease in protein binding to the AP -1/ 2G site Therefore, to determine which factors in the AP -1 or Ets family might be downregulated, we compared ... Fra -1 protein binds to the proximal AP -1 site at )73 bp in the MMP -1 promoter [39] Thus, the increase in expression from the 1G promoter in the presence of increasing amounts of Fra1 may be due to ... identical [15 ], thereby suggesting that the ERK inhibitor and Fra -1 antisense may be working in a similar manner We next examined the effect of mutating the AP -1 site at )73 bp in the MMP -1 promoter...
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Báo cáo khoa học: The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPases pdf
... panel of known Vps4p interactors indicating that the N-terminal domain is correctly folded in each of the mutant proteins and that the b domain is correctly folded in the Vps4p proteins harbouring ... alignments of some of the proteins listed in the PFAM database that contain the Vps4 C-terminal oligomerization domain (PF09336) The sequence of the SRH of each protein is also shown The sequence of the ... plasmids expressing wild-type Vps4p (WT) or a Vps4p mutant protein or carrying empty vector (YCplac 111 ) were assayed for MVB sorting of Fth1p– GFP–Ub (A), CPY missorting into the medium (B),...
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Báo cáo khoa học: Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells pptx
... factor-2 (Nrf2), a member of the cap’n’collar family of basic leucine transcription factors and a well-established regulator of HO -1 [ 31] In view of the beneficial effects of upregulation of HO -1 ... administered to establish the role of protein synthesis in insulin-induced HO -1 expression (Fig 2B,C) CHX abrogated HO -1 protein induction following insulin treatment but, in agreement with other ... p38MAPK inhibitor SB20 219 0, or the mitogen-activated kinase kinase (MEK1) inhibitor PD98059, and treated with insulin Adequate inhibition of p38-MAPK was demonstrated by probing for phosphorylated...
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Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx
... al The ATP-binding domain of HSP70 is important for the interaction of HSP70 with apoptosis signalregulating kinase (ASK1) and the inhibition of ASK1-induced apoptosis in vitro [28] Furthermore, ... Q2 Q1 Q2 Q1 Q2 Q4 Q3 Q4 Q3 Q4 10 2 10 3 10 4 10 0 10 1 45 40 35 30 25 20 15 10 10 2 10 3 Annexin V-FITC 10 4 10 0 10 1 10 2 10 3 10 4 * # O H + 2 O 70 SP H 70 SP H -2 + -1 NA D pc H O + SP H 70 -1 H SP 70 ... GAPDH Ratio of HSP70 to GAPDH 14 # 12 # 10 * The role of the ATP-binding domain of HSP70 in the prevention of the release of Smac and apoptosis after exposure to H2O2 pcDNA3 .1 HSP70 -1 HSP70-2 HS...
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Báo cáo khoa học: Retention of the duplicated cellular retinoic acid-binding protein 1 genes (crabp1a and crabp1b) in the zebrafish genome by subfunctionalization of tissue-specific expression doc
... prominent in the posterior hindbrain and, to a lesser extent, in the spinal cord and ventral part of anterior myotomes (Fig 5H,J,L) Tissue-specific distribution of crabp1a and crabp1b mRNA in adult ... detection of cellular retinoic acid binding proteins I and 3 570 R.-Z Liu et al 15 16 17 18 19 20 21 22 23 24 25 26 27 28 II with new antibodies J Histochem Cytochem 46, 11 03 11 11 Zetterstrom RH, Lindqvist ... corresponding to the cDNA for crabp1a and crabp1b A RT-PCR product corresponding to the constitutively expressed rack1 mRNA coding for receptor for activated C kinase was generated from RNA in...
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The role of sentence stress in enhancing english speaking competence of HPU english majors
... 34 8 .1 Final intonation 36 8 .1. 1 Rising-falling intonation 36 8 .1. 2 Rising intonation 37 8.2 Non-final intonation 39 8.2 .1 Rising-falling intonation ... degree of force or emphasis that words or parts of words have when they are used in connected speech, that is, in combination with other words forming phrase and sentences Before finding out information ... partners, they listen for stressed words, because stressed words provide important information It is often difficult to understand the meaning of the sentence in which even one content word is missing...
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Báo cáo khoa học: New members of the brachyurins family in lobster include a trypsin-like enzyme with amino acid substitutions in the substrate-binding pocket potx
... chymotrypsin numbering) is involved in the formation of a salt bridge with the N-terminal Ile of the mature enzyme for completing the formation of Fig Distribution of charged amino acids in Panulirus ... in lobster Fig Distinctive features of Loop2 in PaTry4 in relation to all other Panulirus argus trypsins The Cys1 91 Cys220 (chymotrypsin numbering) disulfide bond is important in determining the ... 5¢-TACTTGCGTTCAGGGGGAGC-3¢ 96 11 5 11 5 13 2 15 9 17 6 220–238 Forward Forward Forward Reverse Reverse Forward Forward Reverse Forward Reverse 5 51 569 532–5 51 620–639 5 71 5 91 642–6 61 a In cases of the same primer for several...
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Báo cáo Y học: Two 1 : 1 binding modes for distamycin in the minor groove of d(GGCCAATTGG) docx
... binding of distamycin on the DNA conformation One of the most important effects of drug binding on the DNA conformation is the widening of the minor groove as illustrated in Fig The width of the ... structures describe the interaction of distamycin in the minor groove of the central CAATTG sequence in a : binding mode The present tight crystal packing due to the triplet formation is not compatible ... and C13, the puckering modes are closer to those for A-DNA, which is a consequence of triplet formation DNA–distamycin interactions Distamycin binds in the minor groove of the central octamer The...
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Báo cáo khoa học: The C-terminal region of the proprotein convertase 1⁄ 3 (PC1⁄ 3) exerts a bimodal regulation of the enzyme activity in vitro pdf
... shown in Fig 1, release of the product by PC1 ⁄ is increased upon the addition of nm amount of CT-peptide, a behavior compatible with the CT-peptide being an activator Following incubations of ... cleavage of the proregion at Arg 51- Ser-Arg-Arg54 leads to disruption of this complex and to release of the 87 kDa form of PC1 ⁄ encompassing positions 84–726 [6] This latter form was shown to be active ... stimulating conversion of the 87 kDa form into the more active 66 kDa form via activation Hence, after the synthesis of proPC1 ⁄ 3, the propeptide is cleaved off in the early secretory compartments but...
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Báo cáo khoa học: Oxidative stress and apoptotic events during thermal stress in the symbiotic sea anemone, Anemonia viridis potx
... activity (%) A 0 .1 100 80 60 40 20 0 .1 10 10 0 10 00 10 000 10 0000 Inhibitor concentration (nM) 10 10 0 10 00 10 000 10 0000 Inhibitor concentration (nM) 10 10 0 10 00 10 000 10 0000 Inhibitor concentration ... emerging therapeutic target in cancer Semin Cancer Biol 14 , 2 31 243 48 Beere HM (2004) The stress of dying’: the role of heat shock proteins in the regulation of apoptosis J Cell Sci 11 7, 26 41 26 51 ... [7,52,57] Nevertheless, independently of the resulting effect of the thermal stress, all mechanisms point to the involvement of oxidative stress in the early stages of symbiosis breakdown In fact,...
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Báo cáo khoa học: "A Logical Basis for the D Combinator and Normal Form in CCG" pptx
... what ( 21) This shows another instance of the schema in (1) , which is undefined for any of the combinators in (3): The preceding data motivates adding D rules (we return to the distribution of the ... CCG parsing (Eisner, 19 96), by providing both combinatory and logical bases for D This additionally allows Eisner’s normal form constraints to be derived as grammar internal theorems Eisner uses ... all the binary rules in CCG (including the D-rules) can be reduced to (iterated) instantiations of the unary combinators ˆ ˆ B, S, or T plus function application This provides a basis for CCG in...
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Báo cáo Y học: Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo potx
... D (19 94) In vitro interactions between nuclear proteins and uncoupling protein gene Ó FEBS 2002 10 11 12 13 14 15 16 17 18 19 20 21 promoter reveal several putative transactivating factors including ... control mice The results of the morphometric analysis indicated induction of mitochondrial biogenesis by ectopic UCP1 in the unilocular adipocytes The stimulatory effect of UCP1 on mitochondrial ... cells, could induce mitochondrial biogenesis and upregulate its co-ordinating factor, the nuclear respiratory factor -1 (NRF -1) In animals treated with b3-adrenoreceptor agonists [43], the metabolic...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... 10 1 10 2 10 3 10 4 10 5 10 6 10 7 10 8 10 9 11 0 11 1 11 2 11 3 11 4 11 5 11 6 11 7 11 8 cell line by cisplatin Biochem Biophys Res Commun 19 97, 233:788-7 91 Xie Z, Wei M, Morgan TE, Fabrizio P, Han D, Finch CE, ... precursor protein (APP) [12 -14 ] These data support the potential utility of anti-inflammatory drug therapies in the treatment of AD Microglia are the principle immune effector cells in the brain ... Rac1 Biochemistry 20 01, 40 :14 557 -14 566 Nisimoto Y, Freeman JL, Motalebi SA, Hirshberg M, Lambeth JD: Rac binding to p67(phox) Structural basis for interactions of the Rac1 effector region and insert...
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báo cáo hóa học: " The effect of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial fibrillary acidic protein in the hippocampus of adult mice" pptx
... gyrus, which then projects to the CA3 area The CA3 neurons then send projections to CA1 Dendrites of CA1 neurons project to the subiculum and then back to the entorhinal cortex CA3 being an early ... proportional to the amount of corticosteronetracer bound to the well The amount of free corticosterone present in the well was inversely proportional to the amount of emission The purification of serum ... 710 .5 ± 14 6 640.7 ± 75 Control(s) 902 .1 ± 12 4 662.9 ± 15 6 640.6 ± 95 504.3* ± 11 6 CPF 0 .1 814 .7 ± 15 8 613 .8 ± 12 5 CPF 0 .1( s) 748.5* ± 18 5 564.5 ± 10 0 5 01* ± 11 9 CPF 0.2 768.7* ± 2 01 578.7* ± 10 3...
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Báo cáo hóa học: " Members of the Hyposoter didymator Ichnovirus repeat element gene family are differentially expressed in Spodoptera frugiperda" docx
... have been carried out by Northern blot analysis [12 ,14 ] or by RT-PCR [11 ] and have indicated that members of this gene family may be transcribed in both wasp and caterpillar hosts [11 ,14 ] and in ... similarity between the rep6 and rep 11 coding sequences, the rep6 probe (rep6 &11 ) should allow detection of both genes SH-J, containing rep5 and rep 11 genes, and SH-H, containing the rep6 gene, are indicated ... Whether this is due to promoter activity or virus penetration in this tissue remains to be determined Pattern of transcription in different tissues of HdIVinfected S frugiperda larvae In order to...
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Salt stress in the plant 2 pdf
... opening is not being inhibited[27] Because of enhancing the transfer resistance to CO2 and decreasing the efficiency for RUBISCO, stoma opening is not affected According to the feedback of other ... Net photosynthesis rate of Rs increased appreciably in the beginning (< 20) and decreased subsequently (> 20), but the changes tended to be minor Stomata conductance of Rs increased to 10 , the highest ... of the stoma affects the photosynthesis rate depends on the partial pressure of CO2 in the lamina However a study reported that under salt stress, photosynthesis decreases because stoma opening...
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