1 aggrecan and type ii collagen no silencing by dna methylation
Báo cáo y học: " Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial"
... rate, and pulse rate), and liver (bilirubin, GGT, and ALP) and kidney (BUN and creatinine) functions were not affected by UC -II treatment, suggesting that UC -II is well toler- 320 ated and does not ... in UC -II induced pharmacological anti-arthritic effects in humans, dogs or horses is not clearly established Type II collagen is the primary form of collagen contained in cartilage Type II collagen ... human OA (7) An emerging novel nutraceutical ingredient known as UC -II has received considerable attention in the treatment of OA UC -II is a novel undenatured type II collagen derived from chicken...
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Báo cáo y học: "Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading" ppt
... femoral heads: normal versus mild and severe osteoarthritis Osteoarthritis Cartilage 2003, 11:217-227 Pfander D, Rahmanzadeh R, Scheller EE: Presence and distribution of collagen II, collagen I, ... of collagen type II C-telopeptide fragments in patients with osteoarthritis Pathobiology 2004, 71:70-76 31 Garnero P, Conrozier T, Christgau S, Mathieu P, Delmas PD, Vignon E: Urinary type II collagen ... OA progression by means of early and late disease markers is quite an attractive prospect According to our data, col II and YKL40 are good candidates for use as robust, early and sensitive markers...
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Báo cáo y học: "Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice" docx
... and macropinocytosis Available online http://arthritis-research.com/content/8/4/R93 Figure type II collagen (CII) Confocal micrographs of dendritic cells and macrophages pulsed with type II collagen ... intracellular CII dropped, probably due to terminal lysosomal transport and degradation II collagen (CII) by macrophages The effect of inhibitors of uptake on the intracellular processing of type II collagen ... derived type II collagen for autoreactive T cells Int Immunol 2004, 16:717-726 Manoury-Schwartz B, Chiocchia G, Lotteau V, Fournier C: Selective increased presentation of type II collagen by leupeptin...
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Báo cáo y học: "Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen" pot
... Materials and methods Purification of type II collagen Bovine collagen was purified from articular cartilage, and mouse and chicken collagens were purified from non-articular (sternal) cartilage All collagens ... Larsson P, Andersson M, Holmdahl R: Association of pepsin with type II collagen (CII) breaks control of CII autoimmunity and triggers development of arthritis in rats Scand J Immunol 1993, 37:337-342 ... 2-mercaptoethanol (20 μM), L-glutamine (1% wt/vol), penicillin (100 U/ mL), and streptomycin (100 μg/mL) in the presence or absence of type II collagen or the synthetic collagen fragment CII256-270...
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Báo cáo y học: "Arthrogenicity of type II collagen monoclonal antibodies associated with complement activation and antigen affinity" pps
... CII-6 and CM-5), clones (C2B14, CII-6 and CM-5), clones (CII-3, CII-6 and CM-5), clones (CII-3, C2B-14 and CM-5), and clones (CII-3, C2B-14 and CII-6) on day followed by LPS Each value is the mean ... arthritis and the ability of mAbs to activate complement and bind mouse CII has not fully been examined We have previously developed IgG2a (CII-6) and IgG2b (CII-3) subtypes of anti-CII mAbs from ... circulating and cartilage-bound antibodies produced by outbred and inbred rats using cyanogen bromide-derived peptides purified from heterologous and homologous type II collagens J Immunol 1992,...
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Báo cáo y học: "Arthrogenicity of type II collagen monoclonal antibodies associated with complement activation and antigen affini" doc
... CII-6 and CM-5), clones (C2B14, CII-6 and CM-5), clones (CII-3, CII-6 and CM-5), clones (CII-3, C2B-14 and CM-5), and clones (CII-3, C2B-14 and CII-6) on day followed by LPS Each value is the mean ... arthritis and the ability of mAbs to activate complement and bind mouse CII has not fully been examined We have previously developed IgG2a (CII-6) and IgG2b (CII-3) subtypes of anti-CII mAbs from ... circulating and cartilage-bound antibodies produced by outbred and inbred rats using cyanogen bromide-derived peptides purified from heterologous and homologous type II collagens J Immunol 1992,...
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Báo cáo khoa học: A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major pot
... two types The rst type, exemplied by Trypanosoma cruzi GPXII, apparently shows specic, but low activity with glutathione and none at all with tryparedoxin [22] This enzyme is specic for linoleic ... were separated by SDS PAGE and stained with Coomassie Brilliant Blue: lanes and 2, TDPX1 wild -type; lanes and 4, TDPX1 Cys35Ala; lanes and 6, TDPX1 Cys83Ala; lanes and 8, TryP1 wild -type Odd numbered ... for linoleic hydroperoxide and shows no activity towards hydrogen peroxide or short-chain hydroperoxides The second type, exemplied by T cruzi GPXI [23] and T brucei Px III [24], are actually tryparedoxin-dependent...
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Báo cáo khoa học: Signalling and regulation of collagen I synthesis by ET-1 and TGF-b1 doc
... [46], and neomycin [47–49] and N-butanol [50–52] as specific inhibitors of PLD The inhibition of PC-PLC by D609 (Fig 5B) and inhibition of PLD by neomycin (Fig 5C) as well as by N-butanol (not shown) ... persistent increase in steady state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts Biochem J 247, 597–604 42 Ignotz RA & Massague J (1986) Transforming ... stimulated by 180 pm TGF-b1 [41,42] were included in all subsequent analyses Induction of collagen I by TGF-b1 and by ET-1 was perceptible by coomassie staining as well as by immunoblotting (Fig...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
... with 20 ng/ ml TNF, 15 ng/ml IFN, ng/ml E2, and 500 U/ml IFN or null, and were co-stimulated with TNF and IFN, with IFN and IFN, or with E2 and IFN PBMCs were cultured at a final concentration ... mononuclear cells by TNF stimulation for SLE patients and healthy individuals Seven downregulated genes (CD40, CD1C, CD14, chemokine (C-C motif) receptor 7, IL12B, IL-4 receptor, and prostaglandin ... as IFIT1, IFIT3, OAS1, ISG15 and IRF7, and IL8RA were upregulated in vivo, but IFIT1, IFIT3, OAS1 and IL8RA were downregulated, while ISG15 and IRF7 showed almost no response to TNF in vitro These...
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Báo cáo y học: " Induction of IL-10-producing CD4+CD25+ T cells in animal model of collagen-induced arthritis by oral administration of type II collagen" pptx
... AS, Kang AH: Incidence and specificity of antibodies to type I, II, III, IV, and V collagen in rheumatoid arthritis and other rheumatic disease as measured by 125I-radioimmunoassay Arthritis Rheum ... normal DBA/1, and tolerized and nontolerized collagen- induced arthritis (CIA) mice at weeks after primary immunization with type II collagen (CII) for induction of CIA Mononuclear cells were isolated ... IL-10 and (b) transforming growth factor (TGF)-β production by mononuclear lymphocytes from lymphoid organs of tolerized and nontolerized mice Organs were extracted from normal DBA/1, and tolerized...
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Báo cáo y học: "Antibodies against the CB10 fragment of type II collagen in rheumatoid arthritis" pdf
... Abs to human CII human CII Correlation of antibodies against bovine type II collagen (CII) and human CII Scatter plot of the levels of IgG antibodies against human CII and bovine CII in sera of ... Hasty DL, Townes AS: Physicochemical and immunological studies of the renatured alpha 1 (II) chains and isolated cyanogen bromide peptides of type II collagen Collagen Relat Res 1985, 5:469-480 ... Ayad S, Phinn SD, Holt PJ: Incidence of antibodies to native and denatured cartilage collagens (types II, IX, and XI) and to type I collagen in rheumatoid arthritis Ann Rheum Dis 1987, 46:902-907...
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Báo cáo y học: "Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro" pps
... acid decarboxylase [24] CIIC1, CIIF4 and GAD6 are IgG2a, and M2139 is IgG2b The mAbs CIIC1, M2139 and CIIF4 were derived from hybridomas derived from CII immunized mice and GAD6 was obtained from ... studies with type II collagen antibody in B10.D2/old and new line and C57Bl/6 normal and beige (Chediak-Higashi) strains: evidence of important roles for C5 and multiple inflammatory cell types in ... collagen J Immunol 1992, 148:2103-2108 Nandakumar KS, Andren M, Martinsson P, Bajtner E, Hellstrom S, Holmdahl R, Kleinau S: Induction of arthritis by single monoclonal IgG anti -collagen type II antibodies...
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Báo cáo y học: "Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen" ppt
... whereas type II collagen (CII) was coated at 10 µg/ml CIIC1, M2139 and UL1 are mouse monoclonal antibodies and were all tested at a concentration of µg/ml; 122.9 is a rat monoclonal antibody and ... Origin of the autoreactive anti -type II collagen response II Specificities, antibody isotypes and usage of V gene families of anti -type II collagen B cells J Immunol 1989, 142:1881-1886 Schulte ... of arthritis by single monoclonal IgG anti -collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory Fcγ RIIB Eur J Immunol 2003, 33:2269-2277 Hietala MA, Nandakumar KS,...
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Báo cáo y học: "Modulation of granulocyte-endothelium interactions by antileukoproteinase: inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium" ppt
... the incidence and severity of anti -collagen type II (CII) antibody-induced arthritis (CAIA) In addition to clinical amelioration, decreased leukocytic infiltration of synovial tissue and protective ... purified to homogeneity by a multistep purification protocol by ion-exchange, metalchelate and size-exclusion chromatography as originally described by Heinzel-Wieland and colleagues [16] Analytical ... Holmdahl R: Epitope-specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen- induced arthritis in the mouse...
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Báo cáo y học: "Analog peptides of type II collagen can suppress arthritis in HLA-DR4" docx
... with type II collagen (CII) and analog peptides Immunizing antigen Core of co-immunogen Incidence of arthritis CII antibodies CII alone 11/18 (61%) 61 ± 11 CII + A13 (1:480) N A - 0/10a ± 2b CII ... shown for DR1 and suggest that positions 263 and 266 in CII are critical for T-cell Figure type II collagen Proliferation of DR4-(DRB1*0401)-restricted T cells in response to type II collagen A ... transgenic mice were immunized with CII, CII plus A12, CII plus A13, or CII plus the control peptide 266D, and were observed for the development of arthritis When CII and either A12 or A13 were used...
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Báo cáo y học: " Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" pptx
... with 20 ng/ ml TNF, 15 ng/ml IFN, ng/ml E2, and 500 U/ml IFN or null, and were co-stimulated with TNF and IFN, with IFN and IFN, or with E2 and IFN PBMCs were cultured at a final concentration ... mononuclear cells by TNF stimulation for SLE patients and healthy individuals Seven downregulated genes (CD40, CD1C, CD14, chemokine (C-C motif) receptor 7, IL12B, IL-4 receptor, and prostaglandin ... as IFIT1, IFIT3, OAS1, ISG15 and IRF7, and IL8RA were upregulated in vivo, but IFIT1, IFIT3, OAS1 and IL8RA were downregulated, while ISG15 and IRF7 showed almost no response to TNF in vitro These...
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Báo cáo y học: " Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis" pptx
... IL-6 in arthritis, by examining the effects of anti-IL-6 mAb treatment in a murine model of type II collagen induced arthritis (CIA) Methods Induction and Assessment of Type II Collagen- induced ... surfaces Loss of joint landmarks Complete fibrosis and collagen bridging Overall score Classical normal joint appearance Minor changes; consistent with remission; may be clinically normal Moderate inflammatory ... the SAA ELISA and real time RT-PCR assays XS and PW conceived of the study, and participated in its design and coordination DS reviewed and edited the manuscript All authors read and approved...
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Báo cáo y học: "A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis" ppsx
... administration of type II collagen suppresses pro-inflammatory mediator production by synoviocytes in rats with adjuvant arthritis Clin Exp Immunol 2003, 132:416-423 Trentham DE: Evidence that type II collagen ... (ESR) and C-reactive protein decreased, but changes in the two variables in the chicken type II collagen (CCII) group were not significant Rheumatoid factor was not significantly affected by either ... laboratory found that collagen- induced arthritis (CIA) could be established in Wistar rats, Kunming mice, and DBA/1 mice with chicken type II collagen (CCII) [15,16] Feeding CCII to rats by oral administration...
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Báo cáo y học: "Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development" ppsx
... 1999, 52: 332-340 28 Andersson M, Holmdahl R: Analysis of type II collagen reactive T cells in the mouse I Different regulation of autoreactive versus nonautoreactive anti -type II collagen T cells ... Immunol Rev 1995, 144: 109-135 Stuart JM, Tomoda K, Yoo TJ, Townes AS, Kang AH: Serum transfer of collagen- induced arthritis II Identification and localization of autoantibody to type II collagen ... well-defined animal model Collagen induced arthritis (CIA) has been extensively used as an animal model for human RA, and is induced by immunization with type II collagen (CII) Development of CIA...
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Dynamic studies of type i and type II cadherins EC domains
... EC domains not affect the adhesive strength of Type I and Type II cadherins, the EC domains explored in the present study should be enough for the comparison between Type I and Type II cadherins ... them, classical Type I and Type II cadherins are the best understood families in both structure and physiological function so far The sequence characteristics of Type I and Type II cadherins result ... (12, 13) However, Type I and II cadherins show no heterophilic adhesion between each other (14) The distinct adhesive strength and binding specificity between Type I and Type II cadherins are...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25