1 hypoxia and the hif family of transcription factors
Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
... transcription factor of the Ets -family is involved in the regulation The members of the Ets -family of transcription factors bind to specific purine-rich sequences with a core motif of GGAA/T and ... plasmid The assays were carried out in triplicate, and the error bars indicate the standard deviation Fig Nucleotide sequence of the 5¢-flanking region of the mouse a3 integrin gene Major and minor transcription ... analysis of the 5¢-flanking region and determination of transcription start sites of mouse integrin a3 subunit gene The nucleotide sequence of the 0.5 kb SalI/SacI fragment and a part of exon is...
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Báo cáo y học: "The AP-2 family of transcription factors." potx
... http://genomebiology.com/2005/6/13/246 The lethal phenotypes of the AP-2 mutants generated so far have precluded an analysis of the roles of AP-2 transcription factors in adult tissues We and others are currently exploiting the ... following the expansion of the family during vertebrate evolution, redundant and non-redundant functions of the individual AP-2 family members evolved Although the single AP-2 protein in the cephalochordate ... in the primitive ectoderm of both invertebrates and vertebrates, suggesting an evolutionarily conserved role for the family in the formation of this tissue In mice, three of the five AP-2 family...
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Báo cáo khoa học: Structure of FocB – a member of a family of transcription factors regulating fimbrial adhesin expression in uropathogenic Escherichia coli pdf
... member of the PapB family of fimbrial transcriptional factors The members of the PapB family identified so far exist in both the E coli and Salmonella species and are all involved in the regulation of ... to the left and overlays of Ca-traces of the structurally similar proteins (light blue) and FocB (dark red) are shown to the right DNA strands are shown in yellow and orange, and the RNA strand ... steps in the DNA is the main cause of the extreme DNA-bending ability of these proteins [48] Also, LacI [49,50] and PurR [51], members of the LacI family, bend their operator DNA Both LacI and PurR...
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Báo cáo Y học: Properties of group I allergens from grass pollen and their relation to cathepsin B, a member of the C1 family of cysteine proteinases pdf
... parasites of the genus Giardia are one of the earliest lineages of eukaryotic cells, and the Giardia protease is the earliest known branch of the cathepsin B family [23] Its phylogeny confirms that the ... Isoelectric focusing of rPhl p N and rPhl p Q, as detected by mAb IG12 The pH values of the respective fractions and the size of the protein markers used are indicated (A) The full-length allergen ... concentrating the allergen according to the isoelectric point (pI) of the molecule A pH gradient from to 11 was established for the characterization of Phl p After completion of the run, the individual...
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Báo cáo khoa học: The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs pdf
... above the relevant lanes, and the absence of any added protein is indicated by ()) The position of the free RNA and of the loading slots is indicated to the right of each gel A B abolished by the ... series of GFP fusions with the various motifs of Roquin, and by selectively deleting domains from the full-length protein, we determined that the ROQ domain in the N-terminus of the protein is the ... indicate this On the left side of the gel, bands in the Icos mRNA probe ladder are aligned to the Icos target RNA (B) Nucleotide sequence of Icos-specific RNA used in the REMSA (Fig 6) and RNase footprinting...
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Báo cáo khoa học: The yeast stress response Role of the Yap family of b-ZIP transcription factors The PABMB Lecture delivered on 30 June 2004 at the 29th FEBS Congress in Warsaw potx
... the formation of an intermolecular bond occurs between the Orp1 Cys36 and the Cys598 of Yap1 leading to its activation The subsequent formation of the Yap1 Cys303-Cys598 disulfide bond masks the ... absence of oxygen and in this case binds directly to the c-CRD Cys598, Cys620 and Cys629 in a manner independent of the Orp1 pathway [23] Metalloid and metal stress The widespread distribution of the ... with activation of FRM2 transcription, but also with growth in increasing concentrations of cadmium but not of H2O2 Because of the high degree of homology to Yap1, the role of the Yap2 cysteine...
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Báo cáo hóa học: " Caveolin-1 interacts with the Gag precursor of murine leukaemia virus and modulates virus production" docx
... precursor of MLV Gag-Cav-1 co-localization, the presence of the putative CBD in MA of MLV and the high degree of conservation among γ-retroviruses motivated us to investigate whether the two proteins ... 10,11] The identified L-domains differ in their sequence within the retrovirus family and each retroviral L-domain binds specific factors to redirect Gag into the MVB pathway, thereby directing the ... 622–633 of gp41 [41] The CBD in gp41 is highly conserved within HIV-isolates and SIV lentivirus However, the binding region was mapped to the lentiviral ectodomain of the transmembrane protein and the...
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Báo cáo toán học: "Maximising the permanent of (0,1)-matrices and the number of extensions of Latin rectangles" docx
... consequence of the work of Heilmann and Lieb [8], while the second is due to Joni and Rota [9] Theorem For any R ∈ L(k, n) where k ≥ 2, the roots of ρ G(R), x are real and lie in the open interval ... two paths they correspond to, one is a maximal proper subpath of the other The root of T (R, v) is the vertex corresponding to the empty path Let ηv,r be the number of closed walks of length ... number of perfect matchings in an (n − k)-regular subgraph of Kn,n The other incarnation of the problem is in (0, 1)-matrices Let Λk denote the set of n (0, 1)-matrices of order n in which the...
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Báo cáo y học: "Sequence similarity between the erythrocyte binding domain 1 of the Plasmodium vivax Duffy binding protein and the V3 loop of HIV-1 strain MN reveals binding residues for the Duffy Antigen Receptor for Chemokines" ppsx
... pHKGDR22 encode for the region II (amino acids 198-522) of the P vivax DBP and region II of the P knowlesi a, b and g genes, respectively, in the context of the HSV gD protein These plasmids have ... conserved regions of the env gene of HIV and amplify the region between nucleotides 6884 and 7783, which includes the V3 loop This PCR product then served as template in a nested PCR of the HIV-1 MN ... surface of COS-7 cells was confirmed by immunofluorescence staining, and the number of COS-7 cells stained was 5-10% of the population The same number of COS-7 cells transfected with the parental...
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báo cáo khoa học: " Analysis of a c0t-1 library enables the targeted identification of minisatellite and satellite families in Beta vulgaris" ppt
... Identity values between 35% and 100% of the monomers within the inverted arrangement of the two arrays are similar to the values of head to tail monomers The tandem arrays of the head to head junction ... DH and BW performed the sequencing of the c0t-1 clones, provided the BAC end sequence database and helped to draft the manuscript TS participated in the design and coordination of the project and ... contributions FZ and TW wrote the paper, participated in the bioinformatic analyses of the c0t-1 library, carried out the alignments of the tandemly repeated c0t-1 sequences and performed the molecular...
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báo cáo khoa học: " The Puf family of RNA-binding proteins in plants: phylogeny, structural modeling, activity and subcellular localization" potx
... Page of 19 Figure Models of the plant PUM-HD bound to RNA (A, B) Ribbon (left) and stick (right) models of the PUM-HDs of AtPUM2 (A) and Os01g62650 (B) bound to the RNA bases of Box of the NRE ... determine the binding affinity of the AtPum2 PUM-HD to the wildtype and mutant NRE1 The AtPum2 PUM-HD Figure Models of the AtPum13 PUM-HD bound to RNA Ribbon (A) and stick (B) models of the PUM-HD of ... one region of chromosome 2, and other tandemly located genes are also evident (i.e., AtPum and 10, AtPum 13 and 14, and AtPum 18 and 19) Greater than half of the Arabidopsis (15/26) and rice (13/19)...
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Báo cáo y học: "Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL40 in Danish patients with rheumatoid arthritis and in healthy subjects" ppsx
... influence of the remaining seven SNPs on serum concentrations of YKL-40 none of the other SNPs contributed significantly to the association supporting the isolated highly significant effect of the ... seen with any of the haplotypes (data not shown) LD analysis of the eight genotyped SNPs revealed that both the proximal promoter and the distal part of the gene contained blocks of high or moderate ... inclusion in the study population The study was approved by the local ethics committee Table summarizes the demographic data for the patients with RA and the controls Table Characteristics of the study...
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Báo cáo y học: " Live cell visualization of the interactions between HIV-1 Gag and the cellular RNA-binding protein Staufen1" pot
... subsequently fixed, and immunofluorescence was performed to obtain snapshots of the distributions of Gag and of the raft marker protein, Caveolin-1 (Figure 4B) Indeed, both Caveolin-1 and Gag staining ... complementation of both VN and VC fragments the simultaneous expression of three plasmids is required In the first case the VN is expressed as a fusion MS2-VN protein and can tether to the RNA reporter ... concomitantly, via the same protein domain (NC), reveals a rather multifaceted property of Gag and further strengthens the implication of Staufen1 in HIV-1 assembly [21] Furthermore, time-lapse...
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Báo cáo y học: "HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form" pdf
... construct a recombinant map of CRF49_cpx representing a consensus of breakpoints across the three full genomes Results and Discussion Description of the Cohort The majority of the subjects was female ... of 800 bp of sequence whereas many of the LAHDB subtype designations are provided for sequences of less than 300 bp) Furthermore, of subtype designations, there can be multiple listings for the ... barrier and documentation of new CRFs and accurate representation of global sequence diversity is essential for these strategies While the majority prevalence of subtype A and CRF02_AG in the new...
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Báo cáo y học: "Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis" pps
... through changes in the activity of the immune system In this regard, the effect of sepsis and the influence of nutrition on tissue protein metabolism and on the functioning of the growth hormone ... changes at the level of the mucosa of the gastrointestinal tract In mice, the presence or absence of nutrients within the gut lumen has a major influence on the size and function of the gut mucosal ... differentially influence circulating cytokine profiles and the expression of mRNA of SOCS proteins, of the GHR and of IGF-I The present study demonstrates that the choice of nutrition route in sepsis may influence...
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Báo cáo y học: "The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer" pptx
... and 19 can activate one or more of these ligands [37] The shed form of these ligands binds to one or more of the EGFR/HER family of receptors Four members of this family exist, i.e., HER1 (c-erbB1), ... epiregulin ADAM10, on the other hand, appears to be the major sheddase for the release of EGF and betacellulin [35,36] In certain situations however, other ADAMs including ADAM8, 9, 12, 17 and 19 can activate ... ADAM17, release of EGFR ligands and EGFR/ERK signalling This cascade of events ultimately resulted in enhanced migration While shedding of the extracellular domain of the HER ligands results in...
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EXPRESSION AND FUNCTION OF THE PRL FAMILY OF PROTEIN TYROSINE PHOSPHATASE
... factor function The combined results of these studies have expanded our current understanding of the expression and function of the PRL family of enzymes as well as of the role these important ... 2G) Equivalent levels of expression were noted in the villous epithelium, crypt epithelium, and muscularis mucosae of the duodenum and jejunum and in the Brunner’s glands of the duodenum PRL-2 was ... closer to the base of the gastric glands PRL-2 was heavily expressed in all regions of the stomach As with PRL-1, the strongest expression of PRL-2 occurred toward the base of the gastric glands (Figure...
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Distinct histone deacetylases repress expression of LH and FSH beta genes in the immature gonadotrope alphat3 1 cells and the repression is reversed by GNRH
... synthesized in and released from the hypothalamus, binds to GnRH receptors on the surface of the gonadotrope This leads to the synthesis and secretion of LH and FSH, which stimulate the production of steroid ... activation of transcription factors and rapid induction of early genes This figure illustrates the distributed and interconnected movement of information from the receptor to the genome (Ruf and Sealfon ... EXPRESSION OF LH AND FSH β GENES IN THE IMMATURE GONADOTROPE αT3-1 CELLS AND THE REPRESSION IS REVERSED BY GNRH YANG MENG A THESIS SUBMITTED FOR THE DEGREE OF MASTERS OF SCIENCE DEPARTMENT OF BIOLOGICAL...
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the positive and the negative sides of globalization
... words instead of the advised 250-265) It has a sound structure, your position is clearly expressed, the information is well-organized, and structure-wise the sentences are fine The vocabulary ... outweigh the disadvantages Overall, I am convinced that we should further promote globalization and meanwhile the local government should take measures to combat culture assimilation and sweat ... sentences are fine The vocabulary is impressive and there were only a few grammatical errors (see comments underlined in blue) Overall, this seems to be a band 7.5 + essay ...
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