1β in the lungs of infected caspase 1 deficient mice as compared to its wild type counterparts
The role of caspase 1 in a murine model of influenza pneumonitis, and studies on cell death inhibitors in vitro
... caspase- 9 and caspase- 10 , function upstream of the effector caspases in apoptosis and are known as initiator caspases A phylogenetically distinct group of 13 caspases (caspase- 1, caspase- 4, caspase- 5, ... present in the lungs caspase- 1- deficient mice at day postinfection 13 4 4.3.5 Lower expression of IL -1 in the lungs of infected caspase- 1- deficient mice as compared to its wild- type counterparts ... Biochemistry of caspase- 1 14 1. 8.2 Substrates of caspase- 1 14 1. 8.3 Synthetic caspase inhibitors 15 1. 9 Animal models in influenza pneumonia 16 1. 10 Caspase- 1 and...
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Báo cáo y học: " Abscopal effect of radiation on lung metastases of hepatocellular carcinoma: a case report" pptx
... http://www.jmedicalcasereports.com/content/5 /1/ 111 Page of 10 11 12 Figure CT scan showing the absence of both lung metastases, which regressed after radiation therapy 13 14 mediastinal resulted in tumor mass ... Journal of Medical Case Reports 2 011 , 5 :11 1 http://www.jmedicalcasereports.com/content/5 /1/ 111 capsule was not found A single lung metastasis and a single mediastinal lymph node metastasis were ... 2009, 15 (17 ):5379-5388 doi :10 .11 86 /17 52 -19 47-5 -11 1 Cite this article as: Okuma et al.: Abscopal effect of radiation on lung metastases of hepatocellular carcinoma: a case report Journal of Medical...
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Sculpture of the Exposition Palaces and Courts Descriptive Notes on the Art of the Statuary at the Panama-Pacific International Exposition San Francisco ppt
... these works among us Who is going to take the lead? The Contents Introduction The Fountain of Energy The Mother of Tomorrow The Nations of the Occident The Nations of the Orient The Alaskan The ... on held the place of chief assistant in the Saint-Gaudens studio He became instructor of the Art Students' League of New York in 19 06, holding the position until 19 11 He it was who made the new ... play of line that most satisfactorily charms the eye The Joy of Living Paul Manship, Sculptor With perfect abandon come these maidens into the Court of the Universe, carrying their festoons of wild...
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Effects of short term exposure to air pollution on hospital admissions of young children for acute lower respiratory infections in ho chi minh city
... per 10 ug/m3 Percent change per 10 ug/m3 15 C1: PM10 + O3 C2: PM10 + NO2 10 10 -5 -5 -10 -10 S C1 C2 C3 S C1 C2 C3 S C1 C2 C3 NO2 C1 C2 SO2 LAG LAG 0-5 50 LAG LAG 0-5 S: SO2 C1: SO2 + PM10 C2: ... mapping collaboration project of the Institute of Economic Research and the World Bank Poverty prevalence was defined as the million VND income poverty line of set by the People’s Committee of ... SEASON Lag0-5 Lag0 15 Percent change per 10 ug/m3 Percent change per 10 ug/m3 15 RAINY SEASON 10 10 -5 -5 -10 -10 Lag0 Lag0-5 Lag0 Lag0-5 Lag0 NO2 SO2 NO2 80 Lag0-5 SO2 RAINY SEASON DRY SEASON...
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Báo cáo y học: "Response of the mouse lung transcriptome to welding fume: effects of stainless and mild steel fumes on lung gene expression in A/J and C57BL/6J mice" pot
... activation in the A/J lung Further, MMP12 was recently shown to play a key role in welding fume-induced lung inflammation as well as in fibrotic diseases such as asbestosis [12 ,26,27] Nine genes in the ... disease Strain 5.92E-07 - 3.39E-02 11 (11 ,0) Diseases and disorders Inflammatory disease 5.92E-07 - 3 .11 E-02 11 (11 ,0) Skeletal and muscular disorders 5.92E-07 - 3.04 E-02 11 (11 ,0) Organismal injury ... sustained response to both GMA-MS and -SS welding fume in the A/J strain In contrast, increased MMP12 was evident only in response to GMA-SS welding fume at weeks in the B6 lung, but was the top...
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Báo cáo y học: "Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice" ppt
... immunostaining was less pronounced in lungs from IL-6/- mice than from IL-6+/+ mice (Figure 4b) Lung mRNA levels of the inflammatory biomarkers VCAM -1, ICAM -1, and MCP -1, as well as of endothelin -1 ... ICAM -1 and VCAM -1, and of the cytokine MCP -1, was markedly higher with hypoxia than normoxia in wild- type mice Surprisingly, similar increases were seen with hypoxia in the IL-6-/- mice, suggesting ... were measured using image-analysis software Percent wall thickness was then calculated as the diameter of the external elastic lamina minus the diameter of the internal lamina divided by the diameter...
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Báo cáo sinh học: " Development of a model for marburgvirus based on severe-combined immunodeficiency mice" doc
... blindly passed (200 µl IP) and used to infect new mice to evaluate lethality of the next virus passage Lethality was monitored in the remaining eight mice of each passage The supernatants of the ... determined using plaque assay and we found an upward trend in the viral titers amongst the liver homogenates with increasing passage in mice (Figure 1D–F) The increase in viral titer in the day ... Scid mice were infected with 10 00 pfu of the indicated 'scid-adapted' MARV (Ci67 P15, Musoke P10 or Ravn P10) (A) The weight of groups of 10 mice was assessed daily after infection with the 'scid-adapted'...
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báo cáo hóa học: " The effect of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial fibrillary acidic protein in the hippocampus of adult mice" pptx
... toxic insult to the CNS in many studies A single subcutaneous injection (50 μg/kg bw, 1/ 2 LD50) of the cholinesterase inhibitor Sarin was found to significantly increase GFAP levels in the cerebral ... 662.9 ± 15 6 640.6 ± 95 504.3* ± 11 6 CPF 0 .1 814 .7 ± 15 8 613 .8 ± 12 5 CPF 0 .1( s) 748.5* ± 18 5 564.5 ± 10 0 5 01* ± 11 9 CPF 0.2 768.7* ± 2 01 578.7* ± 10 3 483.3* ± 16 7 CPF 0.2(s) 746.6* ± 16 3 525.7* ... offspring in the CA1 sub-field of the hippocampus, and white matter and granular cell layer of the cerebellum [17 ,18 ] In the present study, GFAP expression was increased in the groups receiving...
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Báo cáo hóa học: " Development of a model for marburgvirus based on severe-combined immunodeficiency mice" docx
... blindly passed (200 µl IP) and used to infect new mice to evaluate lethality of the next virus passage Lethality was monitored in the remaining eight mice of each passage The supernatants of the ... determined using plaque assay and we found an upward trend in the viral titers amongst the liver homogenates with increasing passage in mice (Figure 1D–F) The increase in viral titer in the day ... Scid mice were infected with 10 00 pfu of the indicated 'scid-adapted' MARV (Ci67 P15, Musoke P10 or Ravn P10) (A) The weight of groups of 10 mice was assessed daily after infection with the 'scid-adapted'...
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Báo cáo khoa học: "Effects of Combination Dietary Conjugated Linoleic Acid with Vitamin A (Retinol) and Selenium on the Response of the Immunoglobulin Productivity in Mice" pdf
... purity of 76 .14 45%, the CLA (c9, t 11 isomer) was composed of c9, t 11, 27%; c12, t10, 26%; c18, t0, 5%; c18, t1, 27%; c18, t2, 0%; c16, t0, 13 % CLA at dose of 0.5% and 1. 5% was given at 13 3.5 mg/kg/day ... CVA1, CVA2, CS1 and CS2 were 1. 83 ±0 .16 , 1. 77±0.24, 1. 85±0. 31, 2.02 1. 72, 1. 90 1. 22, 1. 94 1. 26, and 1. 82 1. 35 ㎍/ml, respectively There was no significant difference among the groups MNL IgA The ... 26.73, 292.3 19 .56, 339.3 14 .6, 311 .6±62 .17 , 329.3 17 .7, and 311 ±38.3 ㎍/ml, respectively (Fig 5) In all of the treated groups, secretory IgA concentrations were increased compared to the control...
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Báo cáo khoa học: "Low dietary inorganic phosphate affects the lung growth of developing mice" pps
... performing 15 % SDS-PAGE The kinase activity of Akt was examined with using the Akt kinase assay kit (Cell Signaling Technology, USA) according to the manufacturer’s instructions Immunohistochemistry ... mTOR, 4E-PB1 and p-4E-BP1 protein in the lungs (B) The mTOR kinase activity and phosphorylation ratio for 4E-BP1 were measured in the lung homogenates (C) The bands -of- interests were further analyzed ... lung of developing mice 11 1 Fig Analysis of fibroblast growth factor (FGF-2) protein in the lungs of mice fed a low Pi diet (0 .1% Pi) or a normal (0.5% Pi) diet for weeks (A) The expression of...
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Báo cáo khoa học: "Early administration of IL-6RA does not prevent radiation-induced lung injury in mice" pot
... findings of our study, further intensive studies are needed into strategies for inhibition of cytokine signaling as a way to ameliorating lung toxicity from radiotherapy Competing interests The ... reduction of the radiation-induced increase in IL-6 proteins in plasma as compared with the control group 50 days (25 .1 ± 10 .5 versus 10 1.6 ± 31. 2 pg/ml, p < 0.05) and 10 0 days (48.5 ± 17 .2 versus ... Further, IL-6 plays an important role in the synergistic induction of the SAA gene and the anti-IL-6 receptor monoclonal antibody inhibits the synergistic induction of SAA [ 21] These findings indicate...
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Báo cáo y học: "Gender-specific effects of HIV protease inhibitors on body mass in mice" ppt
... the drinking water as previously described [16 ] At the end of weeks of treatment, the ani- Ritonavir increases food intake Mice were monitored during the six weeks of ritonavir treatment to assess ... ritonavir in the drinking water as compared to males [17 ] To begin to explore the mechanisms of this effect in more detail we addressed the effect of ritonavir treatment in male and female wild type ... following ovariectomy Ritonavir did not influence weight gain in the ovariectomized female mice, suggesting an interaction at the site of action of ritonavir and ovariectomy in the ability of the...
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Báo cáo y học: "Effect of smoking on lung function, respiratory symptoms and respiratory diseases amongst HIV-positive subjects: a cross-sectional study pptx
... function2, n (%) 96.2 (12 .5) 16 (17 ) 88.2 (16 .7) (32) 91. 4 (13 .7) (18 %) 94.6 (11 .7) (17 %) 97 .1 (14 .4) 12 (23%) 94.5 (13 .8)** 24 (20) Asthma history, n (%) (7) (29) (7) (13 ) (14 ) 13 (11 )** Asthmatic by ... variable was %FEV1 Pack-year of smoking was calculated by multiplying the number of packs of cigarette smoked per day and the number of years of smoking Restrictive lung function was defined as FEV1/FVC ... Thorax 19 91, 46 :11 2 -11 6 31 Miller A, Thornton J, Anderson H, Selikoff I: Clinical respiratory abnormalities in michigan prevalence by sex and smoking history in a representative sample of the adult...
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Báo cáo y học: " A QTL on mouse chromosome 12 for the genetic variance in free-running circadian period between inbred strains of mice" potx
... representing 14 of 15 known genes in the QTL, and 12 probe-sets representing of the 12 predicted genes In total, the chips had probe-sets for 85% of the genes in the AhR insert The only gene in the QTL ... AhR mice was CT 22 .1 ± 0.4 while that of the B6 mice was CT 21. 0 ± 0.2 The timing of the siesta under LD 12 :12 of the AhR and B6 strains differed by t-test (p < 0.05) Consequently, the AhR insert ... contain QTL for these traits Figure mice of the B6 and AhR strains Raster actograms of locomotor activity of representative Raster actograms of locomotor activity of representative mice of the B6 and...
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Báo cáo y học: "Early Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response" ppt
... poly(I:C) induced an markedly increased secretion of type- I collagenases MMP -1, MMP-8, MMP -13 as well as an increased release of the type- IV collagenase MMP-9 (Gelatinase B) and the stromelysin MMP -10 ... or in combination with IL -1 or TNF-α Similarly, the mRNA expression of TRIF was induced by the type -1 cytokine IFN-γ alone or in combination with IL -1 or TNF-α (Fig 9) In contrast to type -1 ... due to a biased release of pro-inflammatory mediators Since the lung epithelium is a major source of inflammatory molecules [1, 2 ,17 ], we aimed to analyze which cytokines and chemokines are released...
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Báo cáo khoa học: " A simple and rapid Hepatitis A Virus (HAV) titration assay based on antibiotic resistance of infected cells: evaluation of the HAV neutralization potency of human immune globulin preparations" potx
... representation of the genome of the HAV-Bsd The infectious cDNA of wild type HM -17 5 strain of HAV (wt HAV) containing a A 216 V amino acid substitution in the 2B protein was used as the background to construct ... based on the antibiotic resistance of HAV -infected cells conferred by the blasticidin deaminase gene inserted into the virus genome In the presence of blasticidin, HAV-Bsd -infected cells continue ... construct HAV-Bsd The blasticidin resistance (Bsd) gene coding for the blasticidin deaminase was inserted into the 2A-2B junction of the infectious cDNA of HAV [24] The Bsd gene was flanked by three...
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Báo cáo y học: " Therapeutic efficacy of alpha-1 antitrypsin augmentation therapy on the loss of lung tissue: an integrated analysis of 2 randomised clinical trials using computed " potx
... FEV1 (L), median 1. 63 ± 0.49 1. 63 1. 72 ± 0.53 1. 61 1.44 ± 0.60 1. 14 1. 35 ± 0.62 1. 14 1. 55 ± 0.56 1. 47 1. 48 ± 0.63 1. 38 0.553 FEV1% predicted, median 47.3 ± 11 .4 48.6 51. 2 ± 14 .5 49.0 46.3 ± 19 .6 ... (n = 59) p value 11 4 ± 14 .7 59.7 ± 16 .0 57.0 11 7 ± 16 .4 60 .1 ± 16 .3 65.0 94 ± 21. 8 50.7 ± 19 .5 47.6 98 ± 23.2 52.2 ± 15 .2 50 .1 103 .1 ± 21. 8 56.3 ± 17 .3 56 .1 104.7 ± 23.9 55.7 ± 15 .9 56.0 0.789 ... TLC-adjusted PD15† (g•L -1) 59.9 ± 11 .03 62.98 ± 13 .49 54.6 ± 17 .4 53.9 ± 16 .0 57 .1 ± 15 .2 58.2 ± 15 .7 0.6 91 Lung volume (L) 5. 71 ± 1. 27 5.52 ± 1. 34 7.46 ± 1. 60 7.27 ± 1. 78 6. 61 ± 1. 67 6.35 ± 1. 69 0.300...
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Báo cáo y học: " Protective role of vascular endothelial growth factor in endotoxin-induced acute lung injury in mice" potx
... staining and immunostaining of the pro-apoptotic proteins caspase- 3, Bax, AIF, and cytochrome C VEGF attenuated the increases in permeability of the HPAEC monolayer and the apoptosis of HPAECs induced ... streptavidin-HRP reagents, a substrate solution was added to the wells The intensity of the color measured was in proportion to the amount of active caspase- 3 bound in the initial step The sample ... VEGF inhibited the induction of Bax and activation of caspase- 3 in LPS-induced endothelial apoptosis, a finding that is comparable to our result [27] To the best of our knowledge, there has been...
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Báo cáo y học: " The role of endothelin-1 in hyperoxia-induced lung injury in mice" docx
... FR139 317 or PD 14 5065 Br J Pharmacol 19 94, 11 1(4) :10 09 -10 16 Henry PJ, Carr MJ, Goldie RG, Jeng AY: The role of endothelin in mediating virus-induced changes in endothelinB receptor density in ... In contrast with our findings that ET -1 induced primarily an increase in Raw, with a smaller increase in G and no change in H in the control mice, Nagase et al observed similar increases in the ... consequences [16 ] Besides being a major mediator regulating the vascular tone, ET -1 also plays a major role in the regulation of the airway caliber [6,7 ,11 -14 ] Accordingly, the use of ET -1 receptor blockers...
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