05 kaposi s sarcoma associated virus governs gene expression profiles toward b cell transformation
Báo cáo y học: " Kaposi''''s sarcoma associated herpes virus-encoded viral FLICE inhibitory protein activates transcription from HIV-1 Long Terminal Repeat via the classical NF-κB pathway and functionally cooperates with Tat" pptx
... Moore PS: Transcription mapping of the Kaposi'< /b> s < /b> sarcoma-< /b> associated < /b> herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1) J Virol 1998, 72:1 005-< /b> 12 Tibbetts MD, ... NF- B pathway by TNF family receptors is critically dependent on NIK and IKK1 [9,10] Kaposi'< /b> s < /b> sarcoma < /b> associated < /b> herpes virus < /b> (KSHV), also known as Human herpes virus < /b> (HHV8), is a γ-2 herpes virus < /b> ... pandemic and can be classified into several distinct subtypes [37] Subtype B is predominant in North America and Europe, subtype E in Southeast Asia and subtype C in subSaharan Africa, respectively...
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Báo cáo sinh học: " Kaposi''''s sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular endothelial ce" pptx
... Herndier B, Ganem D: Restricted expression < /b> of Kaposi < /b> sarcoma-< /b> associated < /b> herpesvirus (human herpesvirus 8) genes in Kaposi < /b> sarcoma < /b> Proc Natl Acad Sci U S < /b> A 1996, 93(13):6641-6646 Staskus KA, Zhong ... features of carcinogenesis including mutagenesis, mitogenesis, angiogenesis, metastasis, inhibition of apoptosis and immunosuppression [29] KS lesions are characterized by increased levels of PGE2 and ... 71(1):715-719 Bais C, Santomasso B, Coso O, Arvanitakis L, Raaka EG, Gutkind JS, Asch AS, Cesarman E, Gershengorn MC, Mesri EA: G-protein-coupled receptor of Kaposi'< /b> s < /b> sarcoma-< /b> associated < /b> herpesvirus is a...
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Báo cáo hóa học: " Kaposi''''s sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular endothelial cells" ppt
... Herndier B, Ganem D: Restricted expression < /b> of Kaposi < /b> sarcoma-< /b> associated < /b> herpesvirus (human herpesvirus 8) genes in Kaposi < /b> sarcoma < /b> Proc Natl Acad Sci U S < /b> A 1996, 93(13):6641-6646 Staskus KA, Zhong ... features of carcinogenesis including mutagenesis, mitogenesis, angiogenesis, metastasis, inhibition of apoptosis and immunosuppression [29] KS lesions are characterized by increased levels of PGE2 and ... 71(1):715-719 Bais C, Santomasso B, Coso O, Arvanitakis L, Raaka EG, Gutkind JS, Asch AS, Cesarman E, Gershengorn MC, Mesri EA: G-protein-coupled receptor of Kaposi'< /b> s < /b> sarcoma-< /b> associated < /b> herpesvirus is a...
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Báo cáo y học: " Seroprevalence and risk factors of Kaposi''''s sarcoma-associated herpesvirus infection among the general Uygur population from south and north region of Xinjiang, China" docx
... pathogenesis of Kaposi'< /b> s < /b> sarcoma-< /b> associated < /b> herpesvirus Phil Trans R Soc Lon Biol Sci 2001, 356: 517-534 18 Fu B, Sun F, Li B, et al: Seroprevalence of Kaposi< /b> s < /b> Sarcoma-< /b> associated < /b> Herpesvirus and Risk ... compare antibody titers between KSHV -infected individuals and KS patients List of abbreviations KS Kaposi < /b> sarcoma < /b> KSHV Kaposi< /b> s < /b> sarcoma-< /b> associated < /b> herpesvirus HHV-8：Human herpesvirus AIDS： acquired ... progression of KSHV infection to KS development in the local minority groups Key words: Kaposi< /b> s < /b> sarcoma-< /b> associated < /b> herpesvirus (KSHV); Kaposi< /b> s < /b> sarcoma < /b> (KS); seroprevalence; Uygur people; risk...
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báo cáo hóa học:" AIDS-associated Kaposi’s sarcoma is linked to advanced disease and high mortality in a primary care HIV programme in South Africa" pdf
... time, months Disseminated Cutaneous Lesions IRIS Table Associations with mortality in AIDS-KS patients Mortality 112 (59) Unadjusted 34(29-41) 82 (31-174) HR Site of Kaposi< /b> s < /b> sarcoma < /b> Lesions Oral ... References Franceschi S,< /b> Maso LD, Rickenbach M, Polesel J, Hirschel B, Cavassini M, Bordoni A, Elzi L, Ess S,< /b> Jundt G, Mueller N, Clifford GM: Kaposi < /b> sarcoma < /b> incidence in the Swiss HIV Cohort Study before ... patients with AIDS-KS are needed Baseline CD4 count of less than 100 cells/mm3 was associated < /b> with mortality on univariate analysis, but not on multivariate analysis This is likely because the...
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Báo cáo y học: " Kaposi''''s sarcoma of the hand mimicking squamous cell carcinoma in a woman with no evidence of HIV infection: a case report" pptx
... M, Bendsoe N: Human herpesvirus (Kaposi'< /b> s < /b> sarcoma-< /b> associated < /b> herpesvirus) DNA in Kaposi'< /b> s < /b> sarcoma < /b> lesions, AIDS Kaposi'< /b> s < /b> sarcoma < /b> cell lines, endothelial Kaposi'< /b> s < /b> sarcoma < /b> simulators, and the skin ... A) Kaposi'< /b> sabundant spindle-shaped cells HE × vascular A) Kaposi'< /b> s < /b> sarcoma < /b> consisting of angiomatoid vascular spaces and abundant spindle-shaped cells HE × 40 B) – Tumor cells are strongly positive ... making clinical suspicion essential and histological evaluation necessary to establish the diagnosis Abbreviations HHV8: human herpes virus < /b> type 8; KS: Kaposi'< /b> s < /b> sarcoma;< /b> PCR: polymerase chain reaction...
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Báo cáo y học: "Uncovering the complexities of Kaposi’s sarcoma through genomewide expression analysis" pdf
... Kaposi< /b> s < /b> sarcoma-< /b> associated < /b> herpesvirus is a viral oncogene and angiogenesis activator Nature 1998, 391:86-89 Smit MJ, Verzijl D, Casarosa P, Navis M, Timmerman H, Leurs R: Kaposi< /b> s < /b> sarcoma-< /b> associated < /b> ... transmission of Kaposi< /b> s < /b> sarcoma-< /b> associated < /b> herpesvirus in cultured endothelial cells J Virol 2002, 76:2440-2448 Glaunsinger B, Ganem D: Lytic KSHV infection inhibits host gene < /b> expression < /b> by accelerating ... findings ArrayExpress [29] Accession number: E-MEXP-66 Expression < /b> profile of KS lesions closely resembles that of endothelial cells; infection of BECs and LECs results in an intermediate gene-< /b> expression...
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Báo cáo khoa học: A functional polymorphism at the transcriptional initiation site in b2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of b2-glycoprotein I docx
... and expression < /b> study did not link these mutations to an altered b2 GPI gene < /b> expression < /b> [32] Although, in vitro mutagenesis and expression < /b> study not rule out the possibility that these mutations ... probe membranes (Bio-Rad Laboratories, Hercules, CA, USA) Blots were hybridized with 32P-labeled cDNA probes for b2 GPI as described elsewhere [6] or GAPDH using the manufacturer s < /b> protocol (Ambion, ... consensus sequence at the b2 GPI transcriptional initiation site, which is disrupted by the )1CfiA mutation that would ultimately affect the b2 GPI gene < /b> expression < /b> Discussion Human b2 GPI, also known...
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Báo cáo khoa học: Wild-type p53 enhances annexin IV gene expression in ovarian clear cell adenocarcinoma docx
... functional status is critical in governing the ANX4 up-regulation in EOC cells Several previous studies have suggested a close relationship between wild-type p53 and ANX4 expression < /b> ANX4 expression < /b> is ... findings of these previous studies and our own reveal an association between p53 and ANX4 expression < /b> that suggests that tumor cells carrying wild-type p53, such as CCA, may exhibit chemoresistance ... is known to serve as a key player in responding to cellular stresses such as DNA damage, oncogenic activation and microtubule disruption [24,25] When p53 is activated by such cellular stress,...
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Báo cáo y học: "Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis" docx
... arthritis, or autoimmune diseases, such as systemic lupus erythematosus, multiple sclerosis, allergic rhinitis and asthma (Table 3) Analysis of expression < /b> profiles < /b> of specific transcripts In order ... arthritis; PDB, Paget 's < /b> disease of bone; PIA, pristane-induced arthritis; RA, rheumatoid arthritis; SD, spondylocostal dysostosis; SLE, systemic lupus erythematosus R109 Arthritis Research & ... transporter gene < /b> SLC22A4 by RUNX1 is associated < /b> with susceptibility to RA [44] Other transporter genes (SLC12A8 and SLC9A3R1) have also been linked to susceptibility to other autoimmune diseases...
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Báo cáo y học: "Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted biopsy specime" pot
... reports about gene-< /b> expression < /b> profiles < /b> in rheumatoid synovitis The analysis by Zanders and colleagues [16] showed an overall increased expression < /b> of inflammationrelated genes in synovial tissues ... progression stage [40-42] Rheumatoid synovial tissues and synovial fibroblasts exhibit some features of transformation, including autonomous invasion into cartilage, expression < /b> of oncogenes, loss ... germinal centers (score 1) Many plasma cells were involved in these lesions (score 3) (Fig 2) Partial fibrinoid necrosis was also present (score 1) Gene-< /b> expression < /b> profiles < /b> and clustering As shown in...
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Báo cáo y học: "Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles" ppt
... SpA = axial spondyloarthropathy probes [7] After normalization, differential gene < /b> expression < /b> between groups was assessed by Significance Analysis of Microarrays (SAM) [8] Differential expression < /b> ... predisposition to SpA Discussion There are few published studies of gene < /b> expression < /b> in SpA Our study reveals a number of genes that are differentially expressed in peripheral blood of patients with ... in Tables and based on likelihood calculations Pathway analysis of gene < /b> expression < /b> results Each gene < /b> was studied using a network analysis module within MetaCore™ bioinformatics software (GeneGo...
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Báo cáo y học: " DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines" ppt
... Gudjonsson SA, Sverrisson S,< /b> Stacey SN, Sigurgeirsson B, Benediktsdottir KR, Sigurdsson H, Jonsson T, Benediktsson R, Olafsson JH, Johannsson OT, Hreidarsson AB, Sigurdsson G, DIAGRAM Consortium, ... expressed genes (right), looking across 12,670 autosomal genes (b) Methylation levels with respect to the TSS in sets of genes categorized by gene < /b> expression < /b> levels, from highest (red) to lowest ... ten cases where genetic variants associated < /b> with both methylation and expression,< /b> but they only examined gene < /b> expression < /b> data for fewer than 100 genes in these comparisons in a subset of the sample,...
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Báo cáo y học: "Gene expression profiles in BCL11B-siRNA treated malignant T cells" ppt
... dots represent genes absent from both samples; blue dots represent genes present in one sample but absent from the other sample; and red dots represent genes present in both samples Dots outside ... 2.9 software Results and discussion Global gene < /b> expression < /b> profile in BCL1 1B- siRNA935 treated Molt-4 cells To determine the molecular mechanisms of BCL1 1B siRNA-mediated cell apoptosis, global gene < /b> ... Molt-4 cells, suggesting that the SPP1 gene < /b> may be a BCL1 1B gene < /b> target CREBBP overexpression has been detected in Jurkat cells [21] However, previous studies have not reported a change in CREBBP expression...
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Báo cáo y học: "High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma" doc
... patients had stage III-IV diseases and 50 patients were diagnosed with the non-GCB subtype STAT3 expression < /b> Among the 74 patients, 66 cases (89.19%) had the STAT3 expression,< /b> including 19 cases (25.7%) ... difference of OS OS was defined as the time from diagnosis to death or the last follow-up The Cox regression model was used to evaluate the prognostic value The statistical software SPSS16.0 was used for ... frequency of STAT3 in DLBCL tumors, the difference of STAT3 expression < /b> in different DLBCL subtypes, and its prognostic value in DLBCL patients Materials and methods Patients Seventy-four consented...
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Báo cáo y học: "Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects" docx
... exerts robust gene < /b> expression < /b> changes in the liver of schizophrenia patients In order to address individual AP drug effects on gene < /b> expression,< /b> we subclassified the schizophrenia subjects into ... drugs (FDR adjusted p < 0 .05)< /b> Among the four AP drugs compared, the phenothiazines affected most of the genes, and a subset of those genes (n = 26) were associated < /b> with stress responses (adjusted ... transporters ABC proteins transport various molecules across extra- and intra-cellular membranes and are expressed in liver tissue Polymorphisms in the ABC gene < /b> are associated < /b> with treatment resistance...
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báo cáo khoa học: " Comparative gene expression profiles between heterotic and non-heterotic hybrids of tetraploid Medicago sativa" pps
... datasets, assessments, and assessment statistics used in different studies In this study, more differentially expressed genes between parental pairs were identified by RMA than by MAS, but smaller ... expression < /b> observed in these studies could be due to biological, technical, and/or statistical analysis differences, so generalizations about nonadditive gene < /b> expression < /b> in hybrids across studies ... levels between parents, n1 is the total number of probe sets whose expression < /b> was significantly different between parents, m2 is the number of probe sets with nonadditive expression < /b> whose expression...
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Báo cáo y học: "Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer" ppt
... specific gene < /b> expression < /b> signatures in breast cancer using gene < /b> expression < /b> data from fibroblastic tumors as in vivo models of homogenous populations of malignant mesenchymal cells Based on stromal -cell ... donor blocks Immunohistochemistry images were acquired with the BLISS Microscope System (Bacus Laboratories, Lombard, IL, USA) Staining results were assessed using a three-point scoring system, where ... co-cultures of breast cancer cell lines and normal breast epithelial cells with fibroblasts Overview of gene < /b> expression < /b> Overview of gene < /b> expression < /b> changes over multiple co-cultures of breast cancer cell...
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Báo cáo sinh học: "Association between plasma metabolites and gene expression profiles in five porcine endocrine tissues" docx
... roles in maintaining homeostasis of metabolites in blood Here, we report an association analysis between gene < /b> expression < /b> profiles < /b> in five endocrine tissues and plasma metabolites in pigs The associations ... found in backfat tissue than in other tissues, although NEFA is mainly secreted by adipose tissue To assess the tissue specificity of associations between transcripts and metabolites and to which ... probesets in external tissues, here index l indicates all the Not probesets in tissues other than the tissue to which probeset i corresponds The strength of connection between a pair of tissues...
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