1 down regulation of cx43 expression via snai1 in hscs
Regulation of gene expression by esrrb in embryonic stem cells
... resulted in loss of Oct4 expression both in vivo and in vitro (Gu et al., 2005), indicating the essential roles of LRH1 in maintaining Oct4 expression Its role in activation of Oct4 expression was ... phenotype induced by Esrrb depletion Thus, Nanog is a key downstream target of Esrrb in maintaining pluripotency In addition, Esrrb is involved in the regulation of genes encoding for chromatin modifiers, ... and function in maintaining or altering the physiological state of cells Generally, the receptors are modified by the binding of their ligands, which increases the receptor binding affinity for...
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Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx
... may in uence the expression of HO-1 The dominant expression of HO-2 protein, in comparison with the low expression of HO-1 protein, in H146 small cell lung cancer cells is of particular interest ... expression, expression of HO-2 mRNA and protein was not increased in several human cell lines examined [15,19,37] Such a mode of regulation of HO-2 expression may account for the severe phenotype of HO-1– ... determine the basal expression levels of HO-1 Effects of HO-1 or HO-2 short interfering RNA (siRNA) on the expression of HO-1 Fig Effects of SA and SnPP on cellular heme content in human cell lines...
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báo cáo hóa học:" Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a" pot
... changes in ET and PV PV and ET neutrophils were characterized by the down- regulation of miR-1 and miR-133a and changes in the expression of many genes involved in inflammation including those in the ... miR-133a down- regulation has been noted in squamous cell carcinoma of the tongue [40,41] In addition, the expression of miR-1 is also reduced in heptocellular carcinoma [42] and lung cancer [43] Down- regulation ... fluorescence intensity decreased (Table 7, Figure 7) In contrast, the number of neutrophils expressing CD177 and the mean fluorescence intensity of CD177 expression increased The expression of several...
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Báo cáo hóa học: " “Hypoxia-induced down-regulation of microRNA449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression” pptx
... be the inducer of SERPINE1 expression in a chronic remodeling process TGFb-1 can induce SERPINE1 expression but is inversely controlled by SERPINE1 via plasmin action [31] Expression of tumor ... transferred the finding of inverse expression of miRNA-449/SERPINE1 to an in vivo setting, i.e chronic allograft remodeling in kidney transplants We assumed that initial tissue damage and ongoing tissue ... in lieu of the primary antibody Results Hypoxia induced down- regulation of miRNA in primary fibroblasts MicroRNA profiling determined that only out of 377 miRNA subtypes were down- regulated in...
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Báo cáo sinh học: "Hypoxia-induced down-regulation of microRNA449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression" pptx
... Hypoxia-induced down- regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression Journal of Translational Medicine ... from independent experiments are shown for cell line F-18, but were likewise demonstrable in M15D expression by incorporating a dotted line The line was intended to highlight the additional increase ... Hussein K, Jacobi C, Kreipe H, Bock O: Hypoxiainduced downregulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression...
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Báo cáo hóa học: " Down-regulation of cell surface CXCR4 by HIV-1" pdf
... CD3 indicating that decreased expression of CXCR4 is not a non-specific consequence of HIV-1 infection (not shown) HIV-1 infection induces internalization of CXCR4 in RH9 cells Down- regulation of ... CXCR4 staining of noninduced Jurakt cells Panel E and G: CXCR4 staining of induced Jurkat cells The fluorescent cell in panel G is representative of a minor population of cells in the induced ... number of HIV-1 antigen expressing cells were measured by indirect immunofluorescence microscopy The decline in CXCR4 expression was accompanied by a rapid increase in HIV-1 protein expression in infected...
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báo cáo hóa học:" Hypoxia-induced down-regulation of microRNA449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression" pdf
... Hypoxia-induced down- regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression Journal of Translational Medicine ... from independent experiments are shown for cell line F-18, but were likewise demonstrable in M15D expression by incorporating a dotted line The line was intended to highlight the additional increase ... Hussein K, Jacobi C, Kreipe H, Bock O: Hypoxiainduced downregulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression...
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báo cáo khoa học: "Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties" pot
... The pathway involved in vivo is similar to that observed in Jurkat cells by involving a downregulation of UHRF1 with subsequent increase of p16INK4A gene expression The down- regulation of UHRF1 ... apoptosis involving p73 and UHRF1 deregulation in Jurkat cells and in an in vivo colorectal cancer model A Schematic representation of RWPs-induced apoptosis involving p73 and UHRF1 deregulation in ... Giordano A, Hughes AD, Schini-Kerth VB, Bronner C: The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression Oncogene 2008,...
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Báo cáo khoa học: "In vitro dynamics of HIV-1 BF intersubtype recombinants genomic regions involved in the regulation of gene expression" pdf
... observed in all of them but in NFκB and Sp1 sites The HIV-1 promoter contains Sp1 and NF-kB binding sites that regulate gene expression via the recruitment of both activating and repressing complexes ... recombination breakpoints distribution Considering this, sequence analysis was performed taking into account if the breakpoint was located in the Vpr or in the Tat coding region from a total of ... having site I an activating role and site II a repressing one Thus, mutations affecting these sites in different time points could function as a delicate mechanism of regulation of viral gene expression...
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Báo cáo khoa học: " In vitro dynamics of HIV-1 BF intersubtype recombinants genomic regions involved in the regulation of gene expression" docx
... observed in all of them but in NFκB and Sp1 sites The HIV-1 promoter contains Sp1 and NF-kB binding sites that regulate gene expression via the recruitment of both activating and repressing complexes ... recombination breakpoints distribution Considering this, sequence analysis was performed taking into account if the breakpoint was located in the Vpr or in the Tat coding region from a total of ... having site I an activating role and site II a repressing one Thus, mutations affecting these sites in different time points could function as a delicate mechanism of regulation of viral gene expression...
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Báo cáo y học: "Down-regulation of kallikrein-related peptidase 5 (KLK5) expression in breast cancer patients: a biomarker for the differential diagnosis of breast lesions" doc
... out in order to evaluate the clinical value of the KLK5 expression down- regulation for the prediction of breast cancer and its discrimination Table Descriptive statistics of KLK5 expression in ... significant down- regulation of KLK5 expression in malignant breast tissues has also been reported previously [28] Moreover, the down- regulation of the KLK5 expression was also confirmed in breast ... accumulation in colorectal cancer tissues [23] Finally, in testicular cancer, the down- regulation of KLK5 gene expression in tumor tissues is associated with later stage and more invasive tumors...
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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 1
... PPARγ-mediated down- regulation of NHE1 expression Figure 29: Re -expression of ERα blocks PPARγ-mediated downregulation of NHE1 expression in MDA-MB-231 cells Figure 20: Silencing ERα attenuates the inhibitory ... inhibiting PPARγ-mediated down- regulation of NHE1… 129 3B2.2 Transient silencing of ERα in ER positive MCF-7 cells abrogates the inhibitory effect of E2 on PPARγ-mediated down- regulation ... region is the DNAbinding domain consisting of two zinc fingers, and it is the most conserved region across all three PPAR isoforms (Berger and Moller, 2002) The D domain is involved in interaction...
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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 2
... analysis of NHE1 protein showed similar dose-dependent down- regulation of NHE1 protein level in both cell lines (Figure 2E) Interestingly, the levels of PPARγ protein in these three cell lines are ... endogenous ligands of PPARγ were capable of inducing down- regulation of PPARγ NHE1 and mRNA Among them, the inhibitory effect was the most pronounced in cell lines expressing higher level of PPARγ receptor ... PPARγ, the DNA binding domain of dominant-negative PPARγ contains mutations of C126A and E127A, rendering it unable to bind to DNA As a result, this form of PPARγ retains its ability to bind ligands...
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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 4
... reduction of NHE1 expression in regular FBS, we re-introduced 17β-estradiol to serumdeprived MCF-7 before addition of 15d-PGJ2 Interestingly, the down- regulation 126 of NHE1 protein expression ... presence of estrogen blocked the down- regulation of NHE1 expression induced by PPARγ lgiands, we next investigated the role of estrogen receptor in PPARγ-mediated inhibition of NHE1 3B2.1 Re -expression ... of ERα in ER negative MDA-MB-231 cells restores its response to E2 on inhibiting PPARγ-mediated down- regulation of NHE1 The status of ERα is a determining factor in the biological behaviors of...
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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 6
... binding sites was not observed, we showed that the DNA-binding domain of ERα is important in mediating its inhibitory effect on PPARγ-induced NHE1 down- regulation By what mechanism the DNA-binding ... NHE1 by forming a protein-protein complex and preventing the binding of activated PPARγ to its response element The data offer an explanation for the attenuated down- regulation of NHE1 expression ... upregulation of PPARγ target genes, it is also capable of inhibiting transcriptional repression of NHE1 gene 4.3.2 Unravelling the mechanism of how ERα inhibits PPARγ-mediated down- regulation of NHE1...
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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 3
... decrease in the number of colonies formed in MDA-MB231 cells, a 83% reduction in MCF-7 cells and only a 36% down- regulation in T47D cells (Figure 14D) Interesetingly, the extent of inhibition ... the colonies in both breast cancer cell lines (Figure 14C) It is noteworthy that 15d-PGJ2 resulted in different extent of inhibition in the colony-froming ability in all three cell lines Treatment ... equal number of cells were replated onto 100mm dish and maintained for 14 days After crystal violet staining, we observed a dose-dependent reduction in the number of colonies formed in both cells...
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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 5
... defective in DNA binding enhances the effect of PPARγ ligand on NHE1 down- regulation Having demonstrated that transcriptionally inactivating ERα in regular serum can facilitate the down- regulation of ... dominant-negative form of ERα in MCF-7 cells The DNA binding domain of dominant-negative ERα contains mutations that rendered it defective in binding to DNA As a result, this form of ERα competes with ... serum blocks PPARγ-mediated down- regulation of NHE1 expression 143 Figure 22: Re -expression of ERα blocks PPARγ-mediated down- regulation of NHE 1in MDA-MB-231 cells kept in regular serum condition...
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Tài liệu Báo cáo khoa học: Down-regulation of reduced folate carrier may result in folate malabsorption across intestinal brush border membrane during experimental alcoholism docx
... Haematoxylin–eosin staining Haematoxylin–eosin staining was carried out following the routine histological method described by Kayser and Bubenzer [38] The haematoxylin–eosin staining technique ... three times with 0.9% saline One end of the intestine was tied with a thread and filled with rinsing buffer containing mm d,l-dithiothreitol in normal saline The rinsing buffer was then replaced ... The investigation of the regulation of folate transport via RFC expression in absorptive epithelia may aid in the development of future therapeutic strategies targeting the regulatory protein In...
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Báo cáo khoa học: Improvement of a monopartite ecdysone receptor gene switch and demonstration of its utility in regulation of transgene expression in plants pdf
... construction of a versatile system for the expression of foreign genes in plants Gene 61, 1–11 Tavva VS, Collins GB & Dinkins RD (2006) Targeted overexpression of the Escherichia coli MinC protein in higher ... activity In the five T2 Arabidopsis lines containing a two-hybrid (GCfEVY:VCH9) gene switch, the level of luciferase reporter gene expression in the absence of methoxyfenozide was indistinguishable ... a DNAbinding domain (DBD) and a ligand-binding domain (LBD) The chimeric gene (transactivation domain– DBD–LBD) is expressed under the control of a constitutive promoter In the presence of a specific...
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Báo cáo khoa học: Regulation of the expression and subcellular localization of the taurine transporter TauT in mouse NIH3T3 fibroblasts doc
... taurine uptake in NIH3T3 mouse fibroblasts is linear within the initial 20 following the addition of 14C-labelled taurine Using taurine uptake within the initial 20 in NaCl medium containing extracellular ... serines, threonines and tyrosines in the intracellular domains of TauT are situated in motifs highly suitable as targets for protein kinases It is possible that a shift of TauT to a more tyrosine ... impairment of the NF-jB-mediated regulation of the transcription of TauT From Fig 6C it is seen that the taurine-induced downregulation of TauT is reversible and that TauT in NIH3T3 cells regain 50% of...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008