by quinones antioxidant responsive element target genes role of pi3 kinase in acti
Tài liệu Báo cáo khoa học: Role of ceramide kinase in peroxisome proliferatoractivated receptor beta-induced cell survival of mouse keratinocytes ppt
... resulting from activation of PPARb 3818 Activation of PPARb by LD induces CERK mRNA expression and increases CerK activity in SP1 cells To investigate the role of CerK and its regulation of Cer ... keratinocytes [14] 3816 In this study, we examined the interaction between CerK and PPARb, and its role in regulating keratinocyte survival We report that in a mouse keratinocyte cell line upregulation ... 3821 Role of CerK in PPARb-induced keratinocyte survival K Tsuji et al Fig Schematic model illustrating the role of CerK in cell survival mediated by PPARb in mouse keratinocytes Under injury...
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Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx
... Tuberculin Skin Testing and Interpretation of Results After BCG Vaccination Postvaccination BCG-induced tuberculin reactivity ranges from no induration to an induration of 19 mm at the skin-test site ... preventing pulmonary TB in adolescents and adults These studies also were not useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered ... rates of local reactions may result from using subcutaneous injection in comparison with reactions from intradermal injection In the United States, a recent study of the effects of BCG in adults...
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Tài liệu Báo cáo khoa học: DNA strand exchange activity of rice recombinase OsDmc1 monitored by fluorescence resonance energy transfer and the role of ATP hydrolysis pptx
... the latter Interestingly, it appears that protein binding to ssDNA in the absence of any nucleotide cofactor results in attenuation of spontaneous annealing (compare line 1, Fig with line 2, Fig ... absence of ATP; (2) with 1.25 lM of OsDmc1 in presence of 2.0 mM of AMP-PNP; (3) with 1.25 lM of OsDmc1 in presence of 2.0 mM ATP-c-S; (4) with 1.25 lM of OsDmc1 in presence of 2.0 mM of ATP absence ... exchange activity of OsDmc1 by FRET C Rajanikant et al ficant changes either in ATPase or in DNA binding domains of OsDmc1 [22] The only discernible change in OsDmc1 is an insertion of seven amino...
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Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... stimulation of 2-oxoglutarate conversion was observed in the presence of penicillin G for the R160Q, R162Q and R162A mutants (Table 2, entries 10–12), consistent with loss of penicillin binding Arginines ... the increased specific activity for the R306L mutant may reflect a decreased rate of inactivation for this mutant binding to the enzyme (arginines 160, 162 and 266), as demonstrated by the lack of ... third type of mutant, represented by arginines 306 and 307, are located in the C-terminus They appear to modulate the activity of the C-terminus, which encloses the DAOCS active site during catalysis...
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Báo cáo khoa học: "The role of ectomycorrhizal fungi in calcareous soil tolerance by "symbiocalcicole" woody plants" doc
... iron-complexing molecules could interact with iron in the soil as well as in the plant organs, counteracting any inactivation CONCLUSION A characteristic difficulty in understanding the behaviour of calcifuge ... dehydrogenase, its activity can be expressed or repressed in ectomycorrhizas depending on the host plant porting Fungus-calcareous soil interface Irrespective of the direct action of the funon the ... response of Helianthemum chamaecistus Mill to mycorrhizal infection in two different types of soil Plant Soil 50, 719-722 Kinzel H (1983) Influence of limestone, silicates and soil pH on vegetation In: ...
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The role of leadership theory in raising the profile of women in management
... superiority in utilising effective leadership styles of interaction with their subordinates and organisational outcomes, actually translates into a dramatic increase in the numbers of women being appointed ... solving’’ (Klenke, 1993, p 330) which is more typical of male behaviours Of interest is the inclusion of ‘‘control’’ as a significant feature of the transactional style, common in definition of ... viewed as limited in raising the profile of women in management However, during this period of research, there was an emerging recognition of the importance of a concern for people in the behavioural...
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Globalization: the Role of Institution Building in the Financial Sector _ The Case Study of China
... The role of FDI in institution building Over the past 20 years, foreign financial institutions, mainly foreign banks have played an important role in the opening up of Chinese financial industry ... technology, in exploring on-line banking business as well as in promoting non-bank financial institutions Efforts should be made in upgrading financial operations and financial services, and in conducting ... China Statistics Yearbook, China Financial Yearbook and People’s Bank of China Statistics Quarterly bulletin B Development of direct financing and indirect financing markets providing financing...
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Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
... shown that interactions between KCs and endotoxin comprise the initiating event leading to hepatotoxicity in liver injury, including endotoxemia and ischemia ⁄ reperfusion injury [14] In our studies, ... [22] ROS indirectly reduced the activity of selected isoforms of CYP by inducing phosphorylation of the isoforms [23] Activated KCs cause oxidative stress on the surrounding tissue, releasing large ... CLP CYP1A1 β-actin CYP1A2 β-actin CYP2B1 β-actin CYP2E1 β-actin Fig Effects of KCs on hepatic CYP1A1, 1A2, 2B1 and 2E1 protein expression levels 24 h after CLP Rats were pretreated intravenously...
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Tài liệu Rethinking the Role of the State in Finance doc
... Rethinking the Role of the State in Finance Global Financial Development Report 2013 Rethinking the Role of the State in Finance Washington, D.C © 2012 International Bank for ... play an active role in financial systems Second, there are practical reasons to be wary of the state playing too active a role in financial systems The tensions inherent in these two building blocks ... important role, especially in providing supervision, ensuring healthy competition, and strengthening financial infrastructure Incentives are crucial in the financial sector The main challenge of financial...
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Tài liệu The Role of Community Banks in the U.S. Economy pdf
... them to maintain higher net interest margins Indeed, during most of the 1990s, the net interest margin of small banks held steady at over 4.5 percent, while the net interest margin of large banks ... key role serving certain types of communities and providing certain types of banking services ECONOMIC REVIEW • SECOND QUARTER 2003 17 Definition of a community bank There is no single definition ... Banking Industry,” Journal of Banking and Finance, August Sullivan, Richard J 2000 “How Has the Adoption of Internet Banking Affected Performance and Risk in Banks? A Look at Internet Banking in...
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Tài liệu SICK WATER? THE CENTRAL ROLE OF WASTEWATER MANAGEMENT IN SUSTAINABLE DEVELOPMENT pdf
... Depending on the type of ore deposit being mined, tailings can also contain heavy metals like copper, lead, zinc, mercury and arsenic The contaminants in mine waste may be Cooling waters used in industrial ... Figure 19 in the timing and intensity of rainfall, or the period of time without rain, as well as affecting the quality of water in rivers and lakes through changes in the timing and volume of peak ... can contain a wide range of contaminants and originate from a myriad of sources Some of the biggest generators of toxic industrial waste include mining, pulp mills, tanneries, sugar refineries,...
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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt
... or without hematoxylin staining In hypoxia experiments, 3T3-L1 cells were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati, OH, USA) constantly maintained at 1% O2 Culture ... initiated at 48 h post-transfection by maintaining the cells in culture medium containing 2% horse serum Cells were fixed on day of differentiation and stained with hematoxylin and eosin One of ... DMEM containing 10% fetal bovine serum OP9 cells were grown in aMEM containing 20% fetal bovine serum C2C12 cells were maintained in DMEM containing 10% fetal bovine serum Adipogenic differentiation...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx
... transport of cholesterol to post-lysosomal destinations Cells from NPC subjects show a decrease in acid sphingomyelinase activity, leading to the accumulation of sphingomyelin [27] Because one of the ... phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase Biochemistry 46, 10170– ... should have a key role in our understanding of the mechanisms of the disease We propose that pathology data will, in most cases, be more insightful than clinical data in defining the disease This...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... CYP1A1 targeted efficiently to the ER, suggesting that an open N-terminal signal domain is critical for protein targeting to the ER (Fig 2D) In contrast to the targeting of CYP1A1 requiring N-terminal ... determine the role of PKA in mitochondrial targeting of CYP2E1 In mutants lacking PKA, CYP2E1 was exclusively localized to the microsomal fraction, indicating that PKA is required for CYP2E1 targeting ... extraction In (A), increasing concentrations of trypsin (0–100 lgÆmL)1) were used, and in (B), (D) and (E), a fixed concentration (50 lgÆmg)1) of trypsin were used Fifty micrograms of protein in...
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Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
... Electrostatic interactions and antitumor RNases the dimer interface of the models or in the surroundings of the hinge loop residues Likewise, the models of nonexchanging and exchanging HHP-RNase ... trafficking, specifically associate to negatively charged membranes As all these data are suggestive of a role of membranes, in particular of negatively charged membranes, in the mechanism of action of ... features and structural element( s) for destabilizing and eventually permeating membranes, and that intracellular membranes play a decisive role in defining the antitumor action of an RNase Experimental...
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Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... that N-linked oligosaccharide side-chains are important for the GABA transport activity 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the ... substrate binding process This provides strong evidence that N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT1 ... that of DDN, showing a value of only 5.5 h In contrast, the stability of NNN containing only mannosidic N-glycans after treatment with dMM 1629 Role of N-glycosylation and N-glycan trimming of...
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Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx
... Because of the parallel activation of a l l meanings of each recognized word in HOPE, the determination of the phonetic representation of a recognized word determines the breadth of active competition ... the basis of the discussion I t is the in interaction of the results of these asynchronous processes that the process of comprehension is defined 4.1 The processes are independent of the knowledge ... often generic and mark masculine, feminine, or plural (Gross, 1977; Goffic and McBride, 1975) And furthermore, these same articles often are not translated into meaning preserving sentences in...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
... mode of actions of TS, we examined the effect of TS on LPS/IFNinduced NO production in VSMC We found that TS activated LPS/IFN-induced NO production in VSMC through enhancement of iNOS protein ... Activation of extracellular signal-regulated kinase and c-Jun NH2-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-a-tocopheryl succinate-induced apoptosis of human ... sonicated in a bath-type sonicator for 5min The amount of protein of the solubilized cells was determined with a bicinchoninic acid protein assay kit (PIERCE, Rockford, IL, USA) using bovine serum...
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The Role of the Media in Promoting and Reducing Tobacco Use doc
... questioning the accuracy of tobacco industry communications, and the declining social acceptability of smoking Other forms of smoking-relevant advertising include advertisements for commercial smoking ... Bioethics Institute The Johns Hopkins University Washington, DC Monograph 19 The Role of the Media Pamela Ling, M.D, M.P.H Assistant Professor in Residence Department of Medicine, General Internal ... use,12,13 underscoring the urgency of examining the media’s role in global tobacco marketing At the same time, the media have an equally powerful role in influencing individuals and policymakers and...
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