Kh¸ng thÓ kh¸ng nh©n vµ c¸c bÖnh tù miÔn PGS. TS. TrÇn HËu Khang PGS. TS. TrÇn HËu Khang ViÖn Da liÔu ViÖt Nam ViÖn Da liÔu ViÖt Nam Kh¸ng thÓ kh¸ng nh©n (Anti Nuclear Antibody: Kh¸ng thÓ kh¸ng nh©n (Anti Nuclear Antibody: ANA) ANA) d ¬ng tÝnh trong c¸c bÖnh: - Tù miÔn. - Mét sè bÖnh nhiÔm trïng kinh diÔn. - NhiÔm virus. - Do thuèc. Kh¸ng thÓ kh¸ng c¸c thµnh phÇn cña nh©n (ANA Kh¸ng thÓ kh¸ng c¸c thµnh phÇn cña nh©n (ANA patterns, ANA subunits) patterns, ANA subunits) bao gåm: Anti Smith antibody Anti centromere antibody (Anti Kineto chore) Anti-double stranded DNA antibody (dsDNA) Anti-single stranded DNA antibody (ssDNA) Anti-Ribosomel P antibody Anti-Ribonucleoprotein antibody (anti-RNP) Anti-Ro (anti SSA) Anti-La (anti SSB) Anti-Ku antibody Anti-Mi-2 antibody ANA Subunit vµ c¸c bÖnh tù miÔn ANA Subunit vµ c¸c bÖnh tù miÔn 1. SLE (Systemic Lupus Erythematosus) - Anti-dsDNA: Nh¹y 60% - Anti- Smith: Nh¹y 30% RÊt ®Æc hiÖu Anti-ssDNA: Nh¹y 30-70% RÊt ®Æc hiÖu, ®Æc biÖt Lupus Nephritis. - Anti-Somal P: Nh¹y 20-30% Liªn quan tíi Lupus t©m thÇn. - Anti Ro(SSA): Lupus Psychosis Nh¹y 40% - Anti-RNP: Nh¹y 30-40% Liªn quan tíi thêi kú v îng bÖnh vµ mixed cennective tisue disease. - Anti-RNP: Nh¹y 30-40% 2. Héi chøng CREST vµ x¬ cøng b× (Calcinosis Raynaud Esophageal disfunction sclerodactylis Telangectasias) - Anti-centromere: §Æc hiÖu cao. - Anti-RNP: 30% 3. Viªm b× c¬ vµ viªm ®a c¬: - Anti-Jo1: Nh¹y 30% Hay gÆp trong hiÖn t îng Raynaud vµ x¬ phæi. - Anti-Ku - Anti-Mi -2 4. Héi chøng Sjogrene: - Anti-SSA (anti-Ro): 75% - Anti-SSB (anti-la): 40% 5. BÖnh tù miÔn phèi hîp (Mixed connective tissue diseases) - Anti-RNP: 95% RÊt ®Æc hiÖu 6. LE do thuèc (Drug-induced LE) - Anti-hostone: Nh¹y 90%