fermentation and biochemical engineering handbook 2ed 1997 - vogel & todaro

[...]... medium For fed-batch processes, the usual fed-batch and the repeated fed-batch operations are listed in Table 2 A fed-batch operation is that operation in which one or more nutrients are added continuously or intermittently to the initial medium after the start of cultivation or from the halfway point through the batch process Details 4 Fermentation and Biochemical Engineering Handbook of fed-batch operation... i r Motor (a1Single-stage continuous culture system (bltevel controller Figure 1 Chemostat System V: Operation volume F: Feedrate ofmedium Sf: Concentration of limiting substrate Fermentation Pilot Plant m (a)Single-stage L r I m M I I I continuous operat ion 1 1 - 1 - _N_v 0 Figure 2 Homogeneous systems for continuous fermentation 7 8 Fermentation and Biochemical Engineering Handbook 1.3 Application... makes contamination cobonplace and reproducibility of data difficult to achieve Such problems quickly distort the relevant scale-up factors In this chapter, three research scientists from Kyowa Kogyo Co Ltd have addressed the problems of experimentation and pilot scale-up for I 2 Fermentation and Biochemical Engineering Handbook microorganisms, mammalian cells, plant cells, and tissue It is our sincere... insulin, and salmon growth hormone which now only exist in small amounts in plants and animals This section will discuss the general problems that arise in pilot plant, fermentation and scale-up The section will focus on three main topics: () i bioreactors and culture techniques, (ii) the application of computer and sensing technologies to fermentation, and (iii) the scale-up itself 1.2 Bioreactors and. .. base IO Fermentation and Biochemical Engineering Handbook Finally, the mainframe computer communicates with a company computer via a data highway This is used for decision-making, planning, and other managerial functions The lower level computer, shown as the first level in Fig 3, is directly interfaced to some highly-instrumented fermenters Figure 5 illustrates a brand new fermenter for fed-batch operation... NITROGEN AND SULFUR SOUR 5.0 THE SOURCE OF TRACE AND ESSENTIAL ELEMENTS 6.0 THE VITAMIN SOURCE AND OTHER GROWTH FACTORS 7.0 PHYSICAL AND IONIC REQUIREMENTS 8.0 MEDIA DEVELOPMEN 9.0 EFFECT OF NUTRIEN CENTRATION GROWTH RATE REFERENCES 4 Statistical Methods For Fermentation Optimization 149 159 161 Edwin 0 Geiger 1.O INTRODUCTION 2.0 TRADITIONAL ONE-VARIABLE-AT-A-TIME... Bubble column and air-loop reactors 1 Bubble column with fritted disc 2 Bubble column with a draft tube for gyration flow 3 Air lift reactor 4 Pressure cycle reactor 5 Sieve plate cascade system Table 2 Classification of Fermentation Processes 1 2 3 4 5 Batch process Fed-batch process (semi-batch process) Repeated fed-batch process (cyclic fed-batch process) Repeated fed-batch process (semi-continuous...Contents 1 Fermentation Pilot Plant 1 Yujiro Harada, Kuniaki Sakata, Seiji Sat0 and Shinsaku Takayama PROLOGUE (by Yujiro Harada) 1 1.O MICROBLAL FERMENTATION (by Kuniaki Sakato) 2 1.1 Fermentation Pilot Plant 3 1.2 Bioreactors and Culture Techniques 3 for Microbial Processes 1.3 Application of Computer Control and Sensing Technologies for Fermentation Process .8 1.4 Scale-up ... provide us with a great deal of information on fermentation This information can be used to design optimal and adaptive process controls In commercial plants, programmable logic controllers and process computers enable both process automation and labor-savings The present and likely future uses of computer applications to fermentation processes in pilot and industrial plants are summarized in Table... which maintains the pH value of the medium in the fermenter at a preset value Fermentation and Biochemical Engineering Handbook 6 Figure 1 is an example of chemostat equipment that we call a single-stage continuous culture Typical homogeneous continuous culture systems are shown in Fig 2 Table 4 Classification of continuous fermentation processes 1 Without feedback control a Chemostat 2 With feedback . index. 1. Biochemical engineering Handbooks, manuals, etc. ISBN 0-8 15 5-1 40 7-7 2. Fermentation Handbooks, manuals, etc. I. Vogel, Henry C. 11. Todaro, Celeste L. TP248.3.F74 1996 660'.28449. Cataloging-in-Publication Data Fermentation and biochemical engineering handbook. 2nd ed. / edited by Henry C. Vogel and Celeste L. Todaro. p. cm. Includes bibliographical references and. ofthe Fermentation andBiochemica1 Engineer- ing Handbook, like the previous edition, is intended to assist the develop- ment, design and production engineer who is engaged in the fermentation