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BỘ GIÁO DỤC VÀ ĐÀO TẠO BỘ Y TẾ TRƯỜNG ĐẠI HỌC DƯỢC HÀ NỘI HỒNG VĂN ĐỨC CÁC CƠNG TRÌNH ĐÃ CƠNG BỐ LIÊN QUAN ĐẾN LUẬN ÁN TIẾN SĨ DƯỢC HỌC Nghiên cứu bào chế viên nén felodipin giải phóng kéo dài CHUN NGÀNH: CƠNG NGHỆ DƯỢC PHẨM VÀ BÀO CHẾ THUỐC MÃ SỐ 62720402 Người hướng dẫn khoa học: PGS TS Nguyễn Thị Thanh Duyên GS TS Võ Xuân Minh HÀ NỘI, NĂM 2020 DANH MỤC CÁC CƠNG TRÌNH ĐÃ CƠNG BỐ LIÊN QUAN ĐẾN LUẬN ÁN TIẾN SĨ DƯỢC HỌC TT Số Tạp chí thời điểm phát hành Tên báo Tên tạp chí Preparation of felodipin solid dispersion Vietnam Journal of system (SDS) by using the solvent Medicine & Pharmacy Vol (3)/ 2015 Tạp chí Dược học 480 /2016 wetting method Nghiên cứu xây dựng công thức bào chế viên nén felodipin giải phóng kéo dài hệ cốt thân nước Sử dụng quy hoạch thực nghiệm Tạp chí Khoa học nghiên cứu bào chế viên nén felodipin Công nghệ Việt Nam giải phóng kéo dài hệ cốt thân nước Nghiên cứu bào chế hệ phân tán rắn Tập - Số /2015 Felodipin phương pháp phun sấy Tạp chí Kiểm nghiệm thuốc (số đặc biệt) Nghiên cứu bào chế đánh giá độ ổn định hệ phân tán rắn felodipin Tạp chí Dược học 463/ 2014 3A.2014 Yêu cầu quy cách photocopy báo trong cơng trình liên quan đến luận án: Trang bìa Trang mục lục Toàn văn báo VIETNAM JOURNAL OF MEDICINE & PHARMACY VIETNAM JOURNAL OF MEDICINE & PHARMACY Volume N HA NOI - 12/2015 VJMP 9(3) - 2015 VIETNAM JOURNAL OF MEDICINE & PHARMACY N03 - 2015 VIETNAM JOURNAL OF MEDICINE & PHARMACY EDITOR IN CHIEF ASSOCIATE EDITORS Nguyen Thi Kim Tien Clinical Medicine Le Quang Cuong Pham Nhat An DEPUTY EDITORS Nguyen Lan Viet Truong Manh Dung Nguyen Viet Tien Pham Minh Thong Pham Manh Hung Nguyen Cong Khan Ngo Quy Chau Bui Dieu Nguyen Duc Hinh Nguyen Anh Tri Nguyen Kim Thu Nguyen Dang Hoa Tran Hau Khang Luong Ngoc Khue Pham Trong Van Tran Thi Giang Huong COORDINATING EDITOR Ha Huy Tai Truong Thanh Huong Ngo Van Toan Le Ngoc Thanh Hoang Anh Tien Tran Hieu Hoc Hoang Bui Hai DEPUTY COORDINATING EDITORS Nguyen Thi Viet Ha Vo Truong Nhu Ngoc Nguyen Thi Bich Thu Pharmacy Vo Xuan Minh Tran Thi Oanh ASSISTANT EDITORS Nguyen Thuong Dong Nguyen Ngoc Chien Tran Xuan Bach Nguyen Ngoc Vinh Vu Dang Hoang Le Hieu Nguyen Thanh Binh Phuong Thien Thuong Bui Van Nhon Nguyen Hai Nam Nguyen Hoang Anh Basic Medicine Public Health Nguyen Vu Trung Nguyen Ngo Quang OFFICE Dang Van Duong Le Van Hoi Room 611, 6th floor, A1 Building, Tran Thi Ngoc Ha Nguyen Thi Thuy Hanh Hoang Yen ISSN: 0866 - 7942 Hanoi Medical University, No.1, Ton That Tung Street, Dong Da District, Hanoi, Vietnam Tel: +84-466829252 Email: info@vjmp.vn Website: http://vjmp.vn License N 2477/GP-Ministry of Information & Communication of the Socialist Republic of VN dated 19/12/2012 Printed: 1,000, *Printed by Hanoi Printing Joint Stock Company, * Tel: +84 (4) 3943 7063 Legal deposit in December, 2015 VJMP 9(3) - 2015 VIETNAM JOURNAL OF MEDICINE & PHARMACY VIETNAM JOURNAL OF MEDICINE AND PHARMACY Instruction Vietnam Journal of Medicine and Pharmacy (VJMP) which is belonging Ministry of Health publishes original research articles and reviews in Medicine - Pharmacy fields The Journal will focus on clinical, pharmacy and biomedical technologies A Original Research: Instructions for manuscript: Follows the guidelines for manuscripts submitted to Biomedical Journals of the International Committee for Medical Journal Editors (http://www.icmje.org/, ICMJE), and ensure that the manuscripts have not been published or submitted for any scientific journal, or republished if the journals have published before allowed Format for Manuscripts: Submit all articles in 1.5 spaced 12 point Arial font in a Microsoft® Office Word file or a compatible file in English Each article must not exceed 3000 words, included tables/ graphs/ diagrams/ illustrations and references Abbreviations must be annotated Process and presentation of the items in the article: 2.1 Title: The title should be short and informative, less than 40 words, and should not include non-standard acronyms or abbreviations 2.2 Title page: The title page should contain the full names of all authors and the addresses of the institutions at which the work was carried out together The full postal and email address, plus facsimile and telephone numbers (if any) of corresponding author 2.3 Authors: Those who have contributed significantly to the article should be listed as authors Write in full name with Vietnamese authors, without marks followings sequences: name, surname and middle name The sequences of author’s name should be arranged and followed the contribution to the article 2.4 Abstracts: Structured article with an abstract of ≤250 words, short background, objectives, methods, results, and conclusions Keywords: show the main meanings of the research, maximum of words or phrases 2.5 Contents: Background: Show clearly the reasons why research, introduce the research objectives, and show concise overview of the research fields in the World and in Vietnam Methods: Should be concise, enough information which the readers can know the research process The new processes and technologies implemented first time should be described in details and cited from original sources Present the selection criteria of subjects, research designs, samples and sampling, short present the process of data analysis and ethical issues Results: Present the main results The images, diagrams, tables and graphs should be presented clearly with short annotations It is recommended that results should be presented in figures and tables along with a suitable description in the text Discussion: The discussion should be concise and focus on the interpretation of the obtained results, compare with the previous research results domestic and abroad Conclusions: Should be short and not listed again the results Acknowledgements: Contributors who not fulfil the requirements to be an author may be acknowledged Permission from all Contributors in the acknowledgement section should be given VJMP 9(3) - 2015 VIETNAM JOURNAL OF MEDICINE & PHARMACY References: Reference the most recent and relevant publications Use Vancouver style referencing, cite by number Do not use the name of authors and the year of publication The references should be collected and sorted in sequence cited in the article Limited use of the thesis, dissertations and textbooks Do not use the websites which disseminating knowledge as references Vietnamese references should be translated into English A reference should be presented as follows: name, family name and middle name of authors are written in full name by Vietnamese without marks Family name is written in full, middle name and name written in abbreviation (with foreign name) Articles with many authors, write the name of the first authors and et al For examples: Halpern SD, Ubel PA and Caplan AL Solid-organ transplantation in HIV-infected patients N Engl J Med 2002; 347(4): 284-287 Ngoc Ngo Diem, Hau Bui Duc, Liem Nguyen Thanh et al Screening of the RET gene of Vietnamese Hirschsprung patients identifies novel missense mutations J Pediatr Surg 2012; 47: 1859-1864 Conflicts of interest: The manuscript will be accepted when submitted with a commitment have no conflicts of interest with full signature of author’s institution Conflicts of interest may be financial, institutional, research or personal B Reviews: The reviews should be in accordance with the format and requirements of scientific articles The reviews should have full references and data sources The authors of the reviews need to write positions, degrees, specialist agencies, workplaces C Article submission and peer review process: Article submission: Submit articles to the Editor at the address: Vietnam Journal of Medicine and Pharmacy Department, room 611, 6th floor, A1 Building, Hanoi Medical University, No Ton That Tung street, Dong Da District, Hanoi, Vietnam; and submit a Microsoft® Office Word file of the article through the Email address: submission@vjmp.vn or the website: www.vjmp.vn Requirements when submitting the article: - A cover letter describing the article and why it should be published - The commitments have no conflicts of interest between the authors and author’s institution as well as sponsors Peer review process: every article will be reviewed firstly by the editorial team to ensure the article is within the scope of Vietnam Journal of Medicine and Pharmacy and the quality is sufficient for undergoing peer review All articles will undergo external peer review by two reviewers This will be a blinded peer review process After satisfactory revision (approximate 02 months), accepted manuscripts will be edited and sent to the authors for final approval before publication D.Corrections: if authors of a published article become aware of any errors with the article they should contact to the Editor to correct Corrections will be published online on the website: www.vjmp.vn Author of the article must be responsible to the Editorial Board, the public opinions and the rules relating to the Press Law, copyright and intellectual property rights VJMP 9(3) - 2015 VIETNAM JOURNAL OF MEDICINE & PHARMACY CONTENTS Serology of Rubella and surveillance of congenital Rubella syndrome in Hanoi where an outbreak has occurred Bang Nguyen Van, Anh Nguyen Thi Van, Van Vu Thi Tuong, Thai Trieu Thi Hong Thuong Nguyen Van, Gulam Khandaker and Elizabeth Elliott Relationship between bode index and the classification of chronic obstructive 10 pulmonary disease patients according to Gold Guideline 2014 in Respiratory Center of Bach Mai hospital Giap Vu Van, Hang Doan Thi Influence of swim - up time on the embryo quality and pregnancy rate 17 Hoang Le, Huong Nguyen Thi Lien Tidal volume, vital capacity and force vital capacity changing in adult women and some 23 related factors after months practice the fountain of youth-five tibetan exercises Binh Nguyen Thi Characteristics of obstructive sleep apnea syndrome in patients with chronic 29 obstructive pulmonary disease Thuy Phan Thanh, Giap Vu Van Associations between plasma uric acid levels and some cardiovascular risk facrors in 36 females patients with early rheumatoid arthritis Hanh Dao Hung, Nhan Vu Van The results of concurrent radiochemotherapy regimen for unresectable stage of 43 hypopharyngeal and laryngeal cacinoma at Vietnam National Cancer hospital Tung Ngo Thanh Assessment of periodontal disease in students at Hanoi Medical University 52 Dung Bui Trung, Thanh Tran Ngoc Saponins derived from the roots of Platycodon grandiflorum suppress cytotoxicity of 60 cadmium Tuan Dao Trong, Hien Tran Thi 10 Preparation of felodipine solid dispersion system (SDS) by using the solvent wetting 66 method Duyen Nguyen Thi Thanh, Minh Vo Xuan, Duc Hoang Van 11 Nutritional status and dietary intake in cancer patients receiving chemotherapy in Hanoi 75 Medical University hospital 2015 Huong Tran Thi Giang, Linh Nguyen Thuy, Nhung Nguyen Thi 12 Status and affected factors of outpatient service use among older people 82 Hoi Le Van 13 Changes in the use of health services among children in a rural district in Vietnam from 88 2003 to 2007: Effects of the introduction of a child health insurance Hoan Le Thi, Peter Allebeck VJMP 9(3) - 2015 VIETNAM JOURNAL OF MEDICINE & PHARMACY 14 Total technical curative health services patterns towards basic health service package 96 in Vietnam: Do affordability and capacity matter? Tuan Pham Le, Osmat Azzam, Raja Chowdhry and Dung Tham Chi 15 The nutrtional status of pre-operative patient’s gastrointestinal and the relation with 105 post operative complications of patients in Hanoi Medical University hospital 2015 Linh Nguyen Thuy, Huong Tran Thi Giang, Hang Nguyen Thuy 16 Effectiveness of working environment improvement at metal recycling facilities in Van 112 Mon commune, Yen Phong district, Bac Ninh province Duong Nguyen Thi Thuy, Thien Tran Van Huong Nguyen Thi Lien, Huong Tran Van 17 The clinical characteristics and treatment results of odontoma at the National Hospital 119 of Odonto - Stomatology Tuyen Le Ngoc 18 Knowledge of health workers on medical waste segregation at health facilities in a 126 flooded area Huong Nguyen Thi Lien VJMP 9(3) - 2015 VIETNAM JOURNAL OF MEDICINE & PHARMACY VJMP 9(3) - 2015 VIETNAM JOURNAL OF MEDICINE & PHARMACY PREPARATION OF FELODIPINE SOLID DISPERSION SYSTEM (SDS) BY USING THE SOLVENT WETTING METHOD Duyen Nguyen Thi Thanh1, Minh Vo Xuan1, Duc Hoang Van2 Hanoi University of Pharmacy, Hanoi, Vietnam Drug Administration of VietNam, Hanoi, Vietnam ABSTRACT In this research, we study on preparation of felodipine solid dispersion system (SDS) by using the solvent wetting method with ingredient PVP K30, PEG 4000, PEG 6000 and poloxamer Objectives Preparation of felodipine solid dispersion system by using the solvent wetting method is used to improve solubility and dissolution rate of felodipine (FDP) Methods Preparation of solid dispersion system (SDS) by solvent wetting method is applied Felodipine and surface active agent were dissolved in a minimum amount of absolute ethanol to obtain a solution Spread carrier powder on porcelain miller, pour gradually small amount of solution into the powder, and mix well Drying to evaporate most of the solvent to obtain SDS of FDP Results We have succeeded in preparing solid dispersion system of felodipine which improve the solubility and dissolution rate of felodipine Influence of the hydrophilic carriers including PVP K30, PEG 4,000, PEG 6,000 on the solubility & dissolution rate of felodipine solid dispersion system (SDS) was studied In addition, Poloxamer was used as surfactant in felodipine SDS and the impacts of Poloxamer on the improvement of solubility & dissolution of FDP was also assessed Finally, the formular of FDP SDS including FDP: PVP K30: PLX (1: 9: 1.5) was chosen The solubility of FDP from SDS was at 3.52 times higher than that of the felodipine material Conclusion The major problem of felodipine is its very low solubility in biological fluids The results revealed that it is possible to enhance the solubility and dissolution rate of felodipine by preparation of solid dispersion system SDS was prepared by the formular FDP: PVP K30: PLX (1: 9: 1.5) which obtained the best results Keywords Solid dispersion system, felodipine, solvent wetting method 66 VJMP 9(3) - 2015