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6 Kulkarni V, Bora S S, Sirisha S, Saji M, Sundaran S (2013), A study on drug-drug interactions through prescription analysis in a South Indian teaching hospital, Ther Adv Drug Saf, 4(4), 141-6 Shetty V, Chowta M N, Chowta K N, Shenoy A, Kamath A,Kamath P (2018), Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care Hospital, J Aging Res, 2018, 5728957 Serbin M A, Guzauskas G F,Veenstra D L (2016), Clopidogrel-Proton Pump Inhibitor Drug-Drug Interaction and Risk of Adverse Clinical Outcomes Among PCI-Treated ACS Patients: A Meta-analysis, J Manag Care Spec Pharm, 22(8), 939-47 Serbin M A, Guzauskas G F, Veenstra D L (2016), Clopidogrel-Proton Pump Inhibitor Drug-Drug Interaction and Risk of Adverse Clinical Outcomes Among PCI-Treated ACS Patients: A Meta-analysis, J Manag Care Spec Pharm, 22(8), 939 947 10 Bundhun P K, Teeluck A R, Bhurtu A, Huang W Q (2017), Is the concomitant use of clopidogrel and Proton Pump Inhibitors still associated with increased adverse cardiovascular outcomes following coronary angioplasty?: a systematic review and metaanalysis of recently published studies (2012 - 2016), BMC Cardiovascular Disor, 17(1), 11 Wu J, Jia L T, Shao L M, et al (2013), Drug-drug interaction of rabeprazole and clopidogrel in healthy Chinese volunteers, Eur J Clin Pharmacol, 69(2):179 187 12 Funck-Brentano C, Szymezak J, Steichen O, et al (2013), Effects of rabeprazole on the antiplatelet effects and pharmacokinetics of clopidogrel in healthy volunteers, Arch Cardiovasc Dis, 106(12):661 671 13 Guérin A, Mody R, Carter V, Ayas C, Patel, H, Lasch K, Wu E (2016), Changes in Practice Patterns of Clopidogrel in Combination with Proton Pump Inhibitors after an FDA Safety Communication, PloS one, 11(1), e0145504 14 Farhat N, Haddad N, Crispo J, Birkett N, McNair D, Momoli F, Wen S W, Mattison D R, Krewski D (2019), Trends in concomitant clopidogrel and proton pump inhibitor treatment among ACS inpatients, 2000-2016, Eur J Clin Pharmacol, 75(2), 227-235 15 Chatsisvili A, Sapounidis I, Pavlidou G, et al (2010), Potential drug-drug interactions in prescriptions dispensed in community pharmacies in Greece, Pharm World Sci, 32, 187 193 (Ngày nh n bài: 02/3/2020 - Ngày 18/6/2020) CÁC V N THU NGO I TRÚ CHO TR EM T I THÀNH PH C C Lê Tr n Thanh Vy1, Nguy n Th ng2*, Nguy o1 i h c Thành ph H Chí Minh ih cC *Email: nthang@ctump.edu.vn TÓM T T tv : Các v n thu c (drug-related problems, DRPs) có th nh n an tồn hi u qu u tr c bi u tr cho tr em Tuy nhiên, nghiên c u h n ch M c tiêu nghiên c u: nh t l m i lo i DRPs y u t n DRPs c ngo i trú c a tr em ng nghiên c u: Nghiên c u c t ngang mô t c ngo i trú (t n 15/01/2020) t i m t khoa khám b nh nhi t i thành ph C c thu th p t ph n m nh 148 DRPs b ng cách so sánh s phù h p c thu c v i tài li u tham chi u: t ng d n s d ng c a thu c Gia Vi n thu c cho tr em) 2018ng d u tr c tra c u theo ph n m m Lexicomp Micromedex® K t qu : ng s nh 7.298, trung c 0% DRP ph bi n nh t n li u dùng (34.6%), ti p theo th m dùng thu c (26.6%), ch nh thu c (22.3%), t n su t dùng thu c (16 c (0 c c a nhóm b nh nhân t tu i tr xu ng x y DRP nhi i nhóm b nh nhân 15 tu i (OR=1.453, 95% CI: 1.209 1.746, p
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