Item 6.1.3 - Science_PharmaceuticalChemstreamProposal_CPRC_approved

University of Ontario Institute of Technology Organization and Program Information 1.1 Submission Title Page Full Legal Name of Organization: University of Ontario Institute of Technology Operating Name of Organization: University of Ontario Institute of Technology Common acronym of Organization: UOIT URL for Organization Homepage: www.uoit.ca Degree Level and Type to be awarded for program or part of program: Bachelor of Science (Honours) in Chemistry Proposed Degree Titles: Bachelor of Science (Honours) in Chemistry - specialization in Pharmaceutical Chemistry Proposed Degree Nomenclature: B.Sc (Hons.) in Chemistry - Specialization in Pharmaceutical Chemistry Date of Submission: Location where program to be delivered: University of Ontario Institute of Technology 2000 Simcoe St N Oshawa, ON L1H 7K4 Contact Information: Persons responsible for this submission: Dr William Smith Dean, School of Science University of Ontario Institute of Technology 2000 Simcoe Street North Oshawa, Ontario, L1H 7K4 Tel: 905-721- 3235 Fax: 905-721- 3304 Email: william.smith@uoit.ca Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −1− University of Ontario Institute of Technology EXECUTIVE SUMMARY Proposed Program Title: Bachelor of Science (Honours) in Chemistry - specialization in Pharmaceutical Chemistry Proposed Credential Nomenclature: B.Sc (Honours) in Chemistry Disciplines/Fields of Study: Pharmaceutical Chemistry Is a work experience/work placement term required for degree completion? Work experience is not required for degree completion, but work placements will be facilitated for interested students through the University's Career and Employment Services Office Anticipated Program Start Date: First-year entry in September 2006 Given sufficient demand and background preparation, students may enter the second year of the program in September 2006 Description of the Proposed Program and Program Strengths The Faculty of Science proposes the addition of a Pharmaceutical Chemistry specialization within the Chemistry (Honours) B.Sc program The program map for the proposed specialization is provided The program is based on courses in the existing Chemistry (Honours) program, and consists of an integrated and focused combination of existing Chemistry and Biology (Pharmaceutical Biotechnology specialization) courses, with the addition of new courses in the organic/medicinal chemistry area (Structure Determination of Organic Molecules: CHEM3220U; Pharmaceutical Discovery: CHEM 4510U; and Advanced Topics in Pharmaceutical Chemistry: CHEM4520U), and the courses Introductory Physiology: BIOL2010U; Principles of Phamacology and Toxicology: BIOL3020U; and Advanced Topics in Pharmaceutical Biotechnology: BIOL4050U The proposed specialization in the B.Sc (Honours) Chemistry program provides an integrated basic grounding in science fundamental to the pharmaceutical research and industry, providing an attractive program for students wishing to proceed into industry, or into post-degree studies in chemistry, biology, pharmacy, dentistry, or medicine Like all the existing specializations in Science (Biology, Chemistry, Physics), it has a common first year core of courses in calculus, biology, chemistry, and physics, providing a sound and broad foundation in basic areas of science The specified second-year courses are the same as the core courses in the Chemistry (Honours) program, with the addition of a specified physiology course in the proposed specialization The specified third-year courses are the same as the core courses in the Chemistry (Honours) program, with the addition of a specified pharmacology course This common core provides flexibility for students in deciding upon their ultimate specialization Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −2− University of Ontario Institute of Technology Admission, promotion and graduation requirements are exactly the same as those in place for the Chemistry (Honours) program Rationale for introduction of new specialization The pharmaceutical industry plays a key role in the economy of the Greater Toronto Area, and its success requires heavily on access to local, highly qualified personnel UOIT is a market-orientated university, and as the pharmaceutical industry is rooted in chemistry, it is a natural focus for specialization The study of the basic and applied aspects of chemistry, under the umbrella of the science of the pharmaceutical industry, will provide students with the training necessary to support this important industry, or with the skills necessary for further success in the chemical and medical sciences Program Learning Outcomes and Curriculum Design All the attributes of the original Chemistry (Honours) program are retained, including program learning outcomes, course content, sequencing and the maintenance of appropriate degree level standards In order to cover the breadth of biology/pharmacology courses required for a specialization in Pharmaceutical Chemistry, the following 4000-level Chemistry (Honours) courses were replaced by biological and specialist chemistry courses: CHEM 4010U Industrial Chemistry, CHEM 4060U Molecular Spectroscopy, and CHEM 4050U Environmental Chemistry, but remain available as science electives Additional program learning outcome specific to this specialization include: • • • • Understanding the major physiological process involved in animal growth; Understanding the action and toxicity of drugs; Understanding the research and application of pharmaceutical biotechnology in selected areas including psychopharmacology, cardiovascular pharmacology, neuropharmacology, endocrine pharmacology, quantitative pharmaceutical analysis, drug discovery and design, safety and quality assurance, and protein engineering; Understand the chemical techniques used by the pharmaceutical industry to the development of novel therapeutics Only three of the courses in the proposed program are new (Structure Determination of Organic Molecules (shared with the proposed Biological Chemistry specialization) and Pharmaceutical Discovery and Advanced Topics in Pharmaceutical Chemistry); draft outlines for these new courses are provided in this submission Capacity to Deliver - Resource Requirements (Human and Physical) None of the new courses required for the specialization involve laboratory components In view of its modest resource requirements, the proposed specialization is expected to be a very cost-effective addition to the UOIT Science program Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −3− University of Ontario Institute of Technology Projected Enrolment and Faculty Growth Projected steady-state enrolment is 20 students per year entering the program Since there are only new courses required for the program, the faculty resource requirements are minimal These new courses entail the addition of the equivalent of approximately 0.75 faculty member, beginning in July, 2007 Employment Opportunities There are many opportunities for graduates holding an undergraduate degree in Pharmaceutical Chemistry, whether the student wants to continue on to higher education, especially Medical School, or go directly into the workplace Some of the options available to UOIT Pharmaceutical Chemistry graduates include: - Pharmaceutical industry Research laboratories Professional school (Medicine, Dentistry, Pharmacy, Business, Law) Graduate School (Chemistry or related fields) Program Support/Recognition from Profession The Faculty of Science is seeking letters of support on the quality of the proposed specialization from Provincial, Canadian, and International Pharmaceutical Companies Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −4− University of Ontario Institute of Technology Program Map - BSc in Chemistry - Specialization in Pharmaceutical Chemistry Shading indicates a new course All other courses have been previously approved by PEQAB in conjunction with the Chemistry, Biological Science or other UOIT programs YearSem Subject Subject Subject Subject Subject 1-1 Chemistry I CHEM1010U Biology I BIOL1010U Physics I PHY1010U Calculus I MATH 1010U Scientific Computing Tools CSCI1000U 1-2 Chemistry II CHEM1020U Biology II BIOL1020U Physics II PHY1020U Calculus II MATH1020U Elective* 2-1 Structure and Bonding CHEM2010U Introduction to Organic Chemistry CHEM2020U Analytical Chemistry CHEM 2030U Introductory Physiology BIOL2010U Statistics and Probability for Physical Science STAT2010U Thermodynamics Organic Chemistry and kinetics CHEM2120U CHEM2040U Biochemistry BIOL2040U Elective* Elective* Inorganic Chemistry I CHEM3510U Principles of Pharmacology and Toxicology BIOL3020U Elective* Inorganic Chemistry II CHEM3520U Fundamentals of Physical Chemistry CHEM3040U Elective* Thesis CHEM4400U Elective* 2-2 Advanced Organic Chemistry CHEM3120U Instrumental Analysis I CHEM3530U 3-2 Structure Determination of Organic Molecules CHEM3220U Instrumental Analysis II CHEM3540U 4-1 Physical Chemistry CHEM4040U Pharmaceutical Discovery CHEM4510U 3-1 4-2 BIOL 4050UAdvanced Topics Advanced Topics in Pharmaceutical in Pharmaceutical Chemistry Biotechnology CHEM4520U Elective* Elective* Elective* Elective* *Students are required to take science electives and liberal studies electives (which must include BUSI 1600U: Management of the Enterprise, and BUSI 2000U: Collaborative Leadership *Recommended science electives: CSCI 1020U – Fundamentals of Programming BIOL 2030U – Cell Biology Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −5− University of Ontario Institute of Technology CHEM 4010U – Industrial Chemistry CHEM 4110U – Bio-Organic Chemistry PROGRAM ADMISSIONS REQUIREMENTS Program Admission Requirements Academic Grade 12U English Grade 12U Advanced Functions and Introductory Calculus Grade 12U credits from: Biology, Chemistry, Physics, or Geometry & Discrete Mathematics additional 12U or 12U/C credits Applicants will be required to have a minimum 70% overall average A combined minimum average of 70% is also required in the mathematics and science courses Language Proficiency All applicants are required to give evidence of their oral and Test written proficiency in English This requirement can be satisfied with one of the following criteria: - Their mother tongue or first language is English OR - They have studied full time for at least three years (or equivalent in part-time studies) in an educational institution where the language of instruction and examination was English OR - They have achieved the required proficiency on one of the tests in English language acceptable to UOIT English Second Language Test Requirements – Recommended UOIT Scores TOEFL Paper – 560 TOEFL CBT – 220 IELTS – MELAB – 85 PROMOTION AND GRADUATION REQUIREMENTS COURSE TYPE Courses in Disciplines Outside the Main Field(s) of Study Courses in Disciplines Within the Main Field(s) of Study Overall PROMOTION GRADUATION GPA of 2.0 (60-66%) GPA of 2.0 (60-66%) GPA of 2.0 (60-66%) GPA of 2.0 (60-66%) GPA of 2.0 (60-66%) GPA of 2.0 (60-66%) Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −6− University of Ontario Institute of Technology Program Comparison Statement The applicant has on file and available upon request the research undertaken to complete Appendix 6.3 The applicant found that there are not more than similar or related existing programs offered at Ontario universities and that there are no similar or related existing programs offered at universities in other Canadian jurisdictions that could have been included in appendix 6.3 Institution: York University Program Name and Credential: B.Sc in Chemistry with Pharmaceutical and Biological Chemistry (Honours) stream Program Description: This is a program of study designed for students interested in Biochemistry, Bio-organic and/or Bio-Inorganic Chemistry (enzyme mechanisms, biomimetics) and/or Bioanalytical Chemistry, Pharmaceutical Chemistry or other aspects of biologically related chemistry The program provides a solid grounding in Chemistry plus a specialized exploration of the chemistry of biologically and pharmaceutically relevant substances and processes Thus, it provides a broader, more chemical focus than is available in other degree programs dealing with these subjects (Spec Hon BSc in Biochemistry, Hon Double Major in CHEM and BIOL, or Hon Major/Minor in CHEM and BIOL) http://www.chem.yorku.ca/ugrad/P&BC.html Similarities and Differences: UOIT's proposed curriculum is similar to York's four-year specialized program, in that it emphasizes core chemistry subjects However, the proposed UOIT program is more industry focused and contains and the designated UOIT breadth courses Collaborative Leadership, and Management of the Enterprise, which are particularly relevant in the pharmaceutical industry As well, the UOIT program specializes on the chemical, physiological, pharmacological and toxicological aspects of drugs, and not on the biological sciences, as does York’s program Institution: University of Guelph Program Name and Credential: B.Sc (Tech) in Applied Pharmaceutical Chemistry Program Description: The B.Sc (Tech) program was designed for students who not intend to pursue postgraduate studies and are strongly focused on securing industrial employment that makes use of the knowledge acquired in their bachelors degree This program provides students with the knowledge and skills deemed to be essential by employers and exemplifies the positive benefits of cooperation between colleges and universities The program combines rigorous theory with practical applications http://www.uoguelph.ca/undergrad_calendar/c10/c10bsc_tech-appc-c.shtml Similarities and Differences: The proposed UOIT specialization focuses on the practical aspects of chemistry, and the theoretical aspects of chemistry, physiology, pharmacology, and toxicology in drug design, at a level required for students to continue on with post-graduate studies Importantly, by maintaining a clear emphasis on the core aspects of chemistry, the UOIT program gives students more versatility to adapt to market demands outside of the pharmaceutical industry While the Guelph program contains a college management Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −7− University of Ontario Institute of Technology course, it lacks a course equivalent to the UOIT breadth course Collaborative Leadership which is particularly relevant for future research group leaders of the pharmaceutical industry, which the UOIT program aims to produce Institution: Laurentian University Program Name and Credential: Certificate in Medicinal Chemistry Program Description: Graduates of the 4-year B.Sc in Chemistry or those students enrolled in a 4-year B.Sc in Chemistry program are eligible for admission to the certificate programs, a valueadded feature of the 4-year specialized program in Chemistry The program (30 credits) provides the student with a solid background in chemistry and a unique insight into the important issues and concepts used in the development of drugs in the pharmaceutical industry http://laurentian.ca/chem/index.html Similarities and Differences: The Laurentian Certificate adds a significant amount (30 credits) of chemistry courses to an existing B.Sc degree and thus offers a broader range of chemistry courses than the UOIT specialization However, the Certificate is focused primarily on the chemical aspects of the pharmaceutical industry and does not address the interaction of chemistry with physiological and pharmacological processes Nor does it offer the designated UOIT breadth courses Collaborative Leadership, and Management of the Enterprise, which are particularly relevant to the pharmaceutical industry Institution: University of Toronto Program Name and Credential: B.Sc in Pharmaceutical Chemistry Program Description: Collaborative Program of the Faculty of Arts & Science and the Leslie Dan Faculty of Pharmacy Pharmaceutical Chemistry combines knowledge of the biological, medical, and physical sciences in the study of the scientific aspect of drug therapy The emphasis is on the chemical nature of the reactions and interactions involved in drug therapy The students will receive a solid background in the aspects of chemistry the most relevant to drugs: physical, organic, and analytical chemistry They will also learn the fundamental aspects of the synthesis, manufacture, use, and mode of action of drugs http://www.artsandscience.utoronto.ca/ofr/calendar/prg_phc.htm Similarities and Differences: The University of Toronto offers a Pharmaceutical Chemistry program with very similar course content to the proposed UOIT Pharmaceutical Chemistry specialization U of T’s program offers a broader choice of elective courses, reflecting its base in a medical school, but the set of core courses in both programs is very similar U of T’s program lacks the designated UOIT breadth courses Collaborative Leadership and Management of the Enterprise, which are particularly relevant to the pharmaceutical industry PROGRAM LEVEL LEARNING OUTCOMES Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −8− University of Ontario Institute of Technology The shading indicates new UOIT courses associated with the proposed specialization The remaining courses have all been previously approved by PEQAB as part of the Chemistry, Biological Science or other UOIT programs Program Level Learning Outcomes Apply knowledge and understanding of the basic concepts, theories, and principles of chemistry and the related physical and biological sciences to theoretical and practical problems in these areas Program requirement(s), or segments of requirements, that contribute to this outcome Chemistry I and II, Physics I and II, Calculus I and II, Biology I and II, Structure and Bonding, Thermodynamics and Kinetics, Introduction to Organic Chemistry, Organic Chemistry, Biochemistry, Analytical Chemistry, Introductory Physiology, Principles of Pharmacology and Toxicology explore the current state of knowledge in chemistry and investigate innovative solutions to significant related scientific problems Advanced Organic Chemistry, Structure Elucidation of Organic Molecules, Fundamentals of Physical Chemistry, Inorganic Chemistry I and II, Instrumental Analytical Chemistry I and II, Pharmaceutical Discovery, Advanced Topics in Pharmaceutical Chemistry, Thesis Project, Advanced Topics in Pharmaceutical Biotechnology utilize knowledge to analyze, evaluate, and Any course with laboratory exercises apply the scientific concepts, techniques or and reports meets these requirements processes needed in the study and Chemistry I, Chemistry II, Introduction application of chemistry to Organic Chemistry, Analytical Chemistry, Instrumental Analytical Chemistry I, Instrumental Analytical Chemistry II, Organic Chemistry, Fundamentals of Physical Chemistry, Inorganic Chemistry I, Inorganic Chemistry II, Advanced Organic Chemistry, Structure Elucidation of Organic Molecules, Physical Chemistry, Pharmaceutical Discovery, Advanced Topics in Pharmaceutical Chemistry, Thesis Project communicate effectively in written, spoken Collaborative Leadership and visual format with both technical experts and members of the general public All courses with lab reports, discussion on science issues components, cooperative learning activities, and oral presentations will contribute to this learning outcome Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −9− University of Ontario Institute of Technology Written analyses, essays, lab reports, and tests will require students to use written communication skills regularly This is applicable to all required science and non-science electives understand and utilize contemporary Physics I and II, Chemistry I and II, laboratory and measurement techniques, Biology I and II, Analytical Chemistry, procedures, safety protocols and Introduction to Organic Chemistry, equipment necessary for conduct of work in Thermodynamics and Kinetics, chemistry and related sciences Advanced Organic Chemistry, Instrumental Analysis II and II, Inorganic Chemistry I and II, Fundamentals of Physical Chemistry, Thesis Project, Introductory Physiology Program Level Learning Outcomes Program requirement(s), or segments of requirements, that contribute to this outcome plan and implement experiments and investigations, critically examine the results Advanced Organic Chemistry, Structure and draw valid conclusions Elucidation of Organic Molecules, Instrumental Analysis II and II, Inorganic Chemistry I and II, Physical Chemistry, Thesis Project, apply to scientific study, an appreciation for the level of uncertainty in experimental Most laboratory experiments will give results and theoretical predictions; students experience with variability in data and present an opportunity to evaluate and explain the variation Statistics and Probability for Physical Science apply relevant numerical skills including statistical analysis as necessary for Statistics and Probability for Physical chemical sciences Science use current Information Technology to access, store and retrieve information, to acquire and process data, and to analyze and solve problems All students in UOIT will be supplied with a laptop computer and will access, store and retrieve information on a daily basis in every course Scientific Computing Tools Collaborative Learning contribute as effective participant in multidisciplinary and multi-cultural teams, in both membership and leadership roles The population of the geographic region from which the students of UOIT will come is very culturally diverse Thus the student population of UOIT will be diverse Daily experience in labs, Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −10− University of Ontario Institute of Technology PHY 1020U Physics II Introduction to electromagnetism and optics Electric charge and Coulomb’s law; electric field, electric flux, Gauss' law; electrostatic potential, capacitance; Kirchoff’s laws in DC circuits Magnetic forces and magnetic field; BiotSavart law; Ampere’s law; magnetic flux, Faraday's law, inductance; AC circuits Electromagnetic waves; wave propagation; waves in matter Geometrical and wave optics cr, lec, lab (biweekly), oth (biweekly) Prerequisite: PHY 1010U Credit restrictions: PHY 1040U, PHY 1810U MATH 1020U Calculus II A continuation of Calculus I that addresses techniques of integration, applications of integration to volumes, arc length and surface area, parametric equations, polar coordinates, functions of two or more variables, partial derivatives, differentials, Taylor and MacLauren series, double and triple integrals, and other topics as time permits Applications to science and engineering will be incorporated Lect: 3hrs, Other: 2hrs Prerequisites: MATH 1010U CHEM 1020U Chemistry II Introduction to the fundamental principles governing chemical transformations Thermochemistry and thermodynamics (energy, heat, enthalpy, entropy and free energy); the rates of reaction, the law of radioactive decay and reaction mechanisms; redox reactions and electrochemistry Lect: 3hrs, Lab: 3hrs Bi-Weekly, Other: 2hrs Bi-Weekly Prerequisites: CHEM 1010U Credit may be obtained for only one of CHEM 1020U and CHEM 1800U BIOL 1020U Biology II Biology explores some of the basic challenges that organisms face in order to develop, survive and reproduce The second half of the course will address the fundamental principles of ecology and give a basic understanding of individual populations and communities Lect: 3hrs, Lab: 3hrs Bi-Weekly, Other: 2hrs Bi-Weekly Prerequisites: BIOL 1010U Elective Students may select science or liberal studies electives from a variety of courses offered by other schools in UOIT or through Trent University at Durham Pre-requisite(s): As required for selected subject YEAR 2, SEMESTER CHEM 2010U Structure and Bonding An introduction to modern inorganic chemistry which provides a systematic overview of bonding theories designed to explain molecular arrangements, with emphasis on structure and reactivity An introduction to transition group elements, as well as the use of modern structural methods to determine composition, structure and bonding cr, lec, oth Prerequisite: CHEM 1020U CHEM 2020U Introduction to Organic Chemistry An introduction to the principles and techniques of organic chemistry, including a study of the correlation of reactions and physical properties of organic compounds with structure and energetic concepts; structure, bonding, properties, reactions and synthesis of mono-functional aliphatic and aromatic compounds; stereochemistry and reaction mechanism theory; study of infrared, nuclear magnetic resonance and mass spectroscopy Lect: 3hrs, Lab: 3hrs Bi-Weekly, Other: 2hrs, Bi-Weekly Prerequisites: CHEM 1020U Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −16− University of Ontario Institute of Technology CHEM 2030U Analytical Chemistry A study of the principles of analytical chemistry through demonstrations of applications in chemistry, biology, medicine and the study of the environment Includes: standard analytical chemistry techniques based on chemical equilibrium, volumetric analysis, analytical electrochemistry; use of buffers for pHcontrol; statistical treatment of analytical data cr, lec, lab (biweekly), oth (biweekly) Prerequisite: CHEM 1020U STAT 2010U Statistics and Probability for Physical Science This course introduces the concepts and techniques of statistics and probability to collect, present, analyze and interpret data, and make decisions in the presence of variability Students study a selection of topics relevant to biological science, selected from: basic concepts of probability theory: events, sample spaces, probability; basic concepts of discrete mathematics: set theory, propositional logic, combinatorics; probability: marginal probability, conditional probability, independence, discrete and continuous random variables; probability distributions: binomial, Poisson, uniform, normal, etc.; mean and variance; the central limit theorem; statistical inference: estimation, significance tests, confidence intervals; introduction to experimental design; applications to quality control Lect: 3hrs, Other: 1hr Prerequisites: MATH 1020U Credit may be obtained for only one of the following: STAT 2010U, STAT 2020U, STAT 2800U, STAT 3800U, BUSI 1450U, JSTS 2810U BIOL 2010U Introductory Physiology Overview of the major physiological processes involved in plant and animal growth and development including the mechanism of action of growth regulators and hormones Emphasis is placed on the use of genetic, biochemical, and physiological approaches to understand the regulation of different systems in plants and animals Lect: 3hrs, Lab: 3hrs Bi-Weekly, Other: 2hrs BiWeekly Prerequisites: BIOL 1020U YEAR 2, SEMESTER BIOL 2040U Biochemistry Focuses on enzyme mechanisms and stereochemistry, carbohydrate metabolism, glycolysis, glycogen breakdown and synthesis, transport across membranes, the citric acid cycle, electron transport and oxidative phosphorylation, the pentose phosphate pathway and the glycoxylate pathway, lipid metabolism, synthesis and role of ketone bodies, amino acid metabolism, and an overview of the urea cycle Lect: 3hrs, Other: 2hrs Bi-Weekly Prerequisites: BIOL 1020U, CHEM 2020U Credit Restrictions: BIOL1810U CHEM 2120U Organic Chemistry Mechanistic analysis of chemical reactivity of common functional groups with a focus on nucleophilic substitutions at carbonyl centers, functional group transformations in organic synthesis; aromatic chemistry, alkanes, alkyl halides, alkynes, alkenes, and alcohols; carbohydrates, amino acids, proteins, heterocycles; applications of spectroscopic techniques Lect: hrs, Lab: 3hrs Prerequisites: CHEM 2020U CHEM 2040U Thermodynamics and Kinetics Classical thermodynamics: first and second laws, Gibbs and Helmholtz functions, chemical potential; phase diagrams, applications to phase equilibrium in one, two, and many component systems, Gibbs phase rule; phase diagrams for steels and other alloys; behaviour of real gases; steam tables Chemical kinetics: gas phase kinetics; Arrhenius rates; enzyme kinetics cr, Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −17− University of Ontario Institute of Technology lec, lab (biweekly) Prerequisites: CHEM 1020U, MATH 1020U Credit restriction: PHY 2050U Electives Students may select science or liberal studies electives from a variety of courses offered by other schools in UOIT or through Trent University at Durham Pre-requisite(s): As required for selected subject YEAR 3, SEMESTER CHEM 3120U Advanced Organic Chemistry Application of advanced synthetic methodologies used in modern organic synthesis Emphasis will be placed on the use of retrosynthetic analysis, stereochemical control, and protection/ deprotection schemes cr lec lab Prerequisite: CHEM 2120U CHEM 3530U Instrumental Analytical Chemistry I Instrumental methods of trace chemical analysis This course deals with the scope and use of instruments in chemical analysis, and the theory and applications of ultraviolet/visible, infrared and atomic absorption spectroscopy A range of other analytical techniques is examined cr, lec, oth Prerequisite: CHEM 2030U Credit restriction: CHEM 3830U Note: Students are expected to take CHEM 3540U in the following semester CHEM 3510U Inorganic Chemistry I Detailed treatments of inorganic and organometallic coordination chemistry of the transition and main group elements; the emphasis is on structure, bonding, and reactivity; solid state chemistry; acid-base chemistry; inorganic chemistry in non-aqueous media The lab portion of this course will emphasize the use of modern structural methods to determine composition, structure and bonding cr, lec, lab Pre-requisite: CHEM 2010U Note: Students are expected to take CHEM 3520U in the following semester BIOL 3020U Principles of Pharmacology and Toxicology An overview of the action and toxicity of drugs that affect the autonomic nervous system, the central nervous system, and cardiovascular function in both normal and pathological conditions Toxicological effects of food, food additives, household and industrial products and wastes will also be examined cr, lec, oth Prerequisites: BIOL 2010U, BIOL 2040U Credit restriction: BIOL 2810U Elective Students may select science or liberal studies electives from a variety of courses offered by other schools in UOIT or through Trent University at Durham Pre-requisite(s): As required for selected subject YEAR 3, SEMESTER CHEM 3220U Structure Determination of Organic Molecules This course explores the theory and the application of mass spectrometry, and NMR, ultraviolet/visible, and IR spectroscopy to the structure determination of organic molecules cr lec Prerequisites: CHEM 2120U Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −18− University of Ontario Institute of Technology CHEM 3540U Instrumental Analysis II A continuation of the topics of Instrumental Analytical Chemistry I Arc, spark and inductively-coupled plasma, emission spectroscopy and ICP mass spectroscopy; X-ray fluorescence; gas chromatography; surface characterization, vacuum ultraviolet and X-ray photoelectron spectroscopy; auger and SIMS; neutron activation analysis; electrochemical techniques; HPLC cr, lec, oth Prerequisite: CHEM 3530U Credit restriction: CHEM 3830U Note: Students are expected to take this course immediately after CHEM 3530U CHEM 3520U Inorganic Chemistry II A continuation of the lecture and laboratory topics of Inorganic Chemistry I Spectroscopy of metal complexes, reaction mechanisms of d-block complexes, d-block organometallic complexes, catalysis; introduction to bioinorganic chemistry cr, lec, lab Prerequisite: CHEM 3510U Note: Students are expected to take this course immediately after CHEM 3510U CHEM 3040U Fundamentals of Physical Chemistry Thermodynamics concepts including solution thermodynamics, phase equilibria, and electrochemistry; transport phenomena, the random walk problem and diffusion; introduction to statistical mechanics including probability distributions and entropy, fluctuations, the Boltzmann distribution, and partition functions and their relation to thermodynamic functions cr, lec, lab Prerequisite: CHEM 2040U Elective Students may select science or liberal studies electives from a variety of courses offered by other schools in UOIT or through Trent University at Durham Pre-requisite(s): As required for selected subject YEAR 4, SEMESTER CHEM4400U Thesis The thesis project provides students with the opportunity to integrate and synthesize knowledge gained throughout their program of study, to satisfy specific objectives and requirements The project may comprise an individual or group project, or an individual research project Each student must write an individual thesis independently cr Prerequisite: Completion of three years of chemistry specialization Note: Students will carry out independent or group work under the guidance of individual Chemistry professors CHEM 4040U Physical Chemistry An introduction to phenomena at surfaces and interfaces: colloids, adsorption, thermodynamic treatments and examples of technological applications The course describes modern methods to characterize surfaces in materials science and chemical dynamics at electrode interfaces cr, lec, lab Prerequisite: CHEM 3040U CHEM4510U Pharmaceutical Discovery This course explores topics in the drug discovery process from the discovery of lead molecular candidates to their optimization as drug candidates Topics include natural products drug discovery; combinatorial chemistry; medicinal synthetic organic chemistry cr lec Prerequisites: CHEM 3120U Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −19− University of Ontario Institute of Technology Electives Students may select science or liberal studies electives from a variety of courses offered by other schools in UOIT or through Trent University at Durham Pre-requisite(s): As required for selected subject YEAR 4, SEMESTER Electives Students may select science or liberal studies electives from a variety of courses offered by other schools in UOIT or through Trent University at Durham Pre-requisite(s): As required for selected subject BIOL 4050U Advanced Topics in Pharmaceutical Biotechnology Highlights the fundamental research and industrial applications of pharmaceutical biotechnology in selected areas including psychopharmacology, cardiovascular pharmacology, neuropharmacology, endocrine pharmacology, quantitative pharmaceutical analysis, drug discovery and design, safety and quality assurance, and protein engineering cr, lec Prerequisite: BIOL 3020U Note: An independent term project will be part of this course CHEM4520U Advanced Topics in Pharmaceutical Chemistry This course covers current research topics in pharmaceutical chemistry with a focus on techniques that facilitate a drug candidate’s entry into the marketplace Topics include molecular modeling, pharmacokinetics, and pharmaceutics cr lec Prerequisites: CHEM 4510U Recommended Science Electives CSCI 1020U Fundamentals of Programming (Formerly CSCI 1600U) This course provides a basic introduction to computer programming using the C programming language Topics include basic computer hardware and software concepts, problem analysis, design of algorithms and programs, the basic principles of object-oriented languages cr, lec, oth Prerequisite: CSCI 1000U Credit Restrictions: BUSI 1830U, ENGR 1200U, CSCI 1600U BIOL 2030U Cell Biology Provides a basic knowledge of the structural and functional properties of cells Emphasizes the mechanisms by which signalling molecules and the process of signal transduction integrate and coordinate the functions of many individual cells in a multi-cellular organism Explores factors regulating the cell cycle and growth cr, lec, lab (biweekly), oth (biweekly) Prerequisite: BIOL 1020U Credit restriction: BIOL 2840U CHEM 4010U Industrial Chemistry This course introduces the principles and practice of industrial chemistry with a survey of the chemical industry, pollution control, plant design, corrosion and similar topics Selected industrial processes will be discussed in detail, such as production of primary petrochemicals; plastics and synthetic fibres; pharmaceutical agents; insecticides, herbicides and insect pheromones, dyes, detergents, perfumes and flavours Tours of chemical plants and industrial laboratories Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −20− University of Ontario Institute of Technology are included to show the student the practical side of production cr lec Prerequisite: CHEM 3520U CHEM 4110U Bio-Organic Chemistry This course will explore the structure and function of biological molecules including proteins, nucleic acids, carbohydrates, lipids, and alkaloids Pharmaceutical implications will also be discussed Prerequisites: CHEM 2120U (course from the proposed Biological Chemistry specialization) 9.1 Program Design and Credential Recognition Research was conducted to compare the breadth and rigour of the elements of the Pharmaceutical Chemistry program to similar programs in Canada and elsewhere Upon graduation, students in the proposed program will have achieved the Degree Level Standard for a B.Sc degree in Chemistry (Honours) 9.2 Consultation The Chemistry (Honours) degree with a specialization in Pharmaceutical Chemistry has been carefully designed to provide a pathway to graduate study for students who wish to pursue advanced academic study in their science discipline or industry employment It is understood that other institutions will review the academic credentials and related experiences of UOIT graduates on a case-by-case basis Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −21− University of Ontario Institute of Technology COURSE OUTLINES Provided on the pages that follow are the three courses specific to the Pharmaceutical Chemistry specialization and new to the B.Sc in Chemistry (Honours) program Course Title: Spectroscopy in Organic Chemistry CHEM 3220U Pre-Requisites: Organic Chemistry CHEM 2120U Year and Semester: Year 3, Semester • Course Description and Content Outline(by topic): This course explores the theory and the application of mass spectrometry, and NMR, IR, Ultraviolet/Visible and chiroptical spectroscopy to the structure determination of organic molecules The course covers the following topics: Mass spectrometry: This section describes ionization techniques, mass analyzers, high resolution MS, and the analysis of mass spectral fragmentation patterns Nuclear magnetic resonance spectroscopy: This section deals with the theory of NMR and spin ½ nuclei, chemical shifts, and scalar coupling; as well as, the analysis of 1D NMR spectra, the nuclear Overhauser effect, and an introduction to 2D NMR spectra Infrared spectroscopy: This section explains the theory of infrared spectroscopy and the analysis of IR spectra Ultraviolet/Visible spectroscopy: This section reviews the theory of UV/Visible spectroscopy and the analysis of UV/Visible spectra Chiroptical spectroscopy: This section describes plane- and circularly polarized light and explains the background and application of optical rotary dispersion and circular dichroism spectroscopies Applications of techniques to chemical and biochemical problems: This section provides examples for the use of spectroscopic techniques in investigating biosynthesis and enzyme mechanisms, reaction mechanisms, and protein structure characterization • Methods of Delivery: hours of lecture per week Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −22− University of Ontario Institute of Technology Spectroscopy in Organic Chemistry CHEM 3220U continued… • Student Evaluation: This course will involve extensive problem solving using complex spectra; therefore, students will be evaluated with multiple problem sets, two midterms and a comprehensive final exam • Resources to be purchased/provided by students: Textbook, reference sources and internet access (see Textbook requirements below) • Textbook requirements: representative texts are: Lambert, J.B.; Shruvell, H.F.; Lightner, D.A.; Cooks, R.G 1998 Organic Structural Spectroscopy, Prentice-Hall, Inc Pavia, D.L.; Lampman, G.M.; Kriz, G.S 2000 Introduction to Spectroscopy, 3rd Edition, Brooks-Cole, Inc Crews, P.; Jaspars, M.; Rodriguez, J.; Rodriguez, J 1998 Organic Structure Analysis Oxford University Press Field, L.D.; Sternhell, S.; Kalman, J.R 2002 Organic Structures from Spectra 3rd Edition John Wiley & Sons • Learning Outcomes Students who successfully complete the course have reliably demonstrated the ability to: Outcome 1: Describe currently available types of mass spectral analyses with regards to ionization source and mass analyzers, and select the appropriate method of analysis for a specific organic analyte Outcome 2: Interpret the mass spectra of organic molecules Outcome 3: Describe the theory of 1D NMR spectroscopy Outcome 4: Interpret 1D NMR spectra of organic molecules Outcome 5: Describe the theory of IR spectroscopy Outcome 6: Interpret IR spectra of organic molecules Outcome 7: Describe the theory of UV/Visible spectroscopy Outcome 8: Interpret UV//Visible spectra of organic molecules Outcome 9: Describe the theory and application of chiroptical spectroscopic methods Outcome 10: Describe the use of spectroscopic techniques in chemistry and biochemistry Information about Course Designer/ Developer: Course designed by T Barsby, Ph.D; K Paal, Ph.D; W Smith, Ph.D List faculty eligible to teach the course T Barsby, Ph.D; K Paal, Ph.D Are there any plans to teach all or portions of this course on-line? A course website will play an integral role in the delivery of resources for this course: syllabus, schedule, assignments, solutions to assignments, handouts, supplementary notes, etc This course may take advantage of the UOIT laptop hybrid environment by using a combination of face-to-face lecture hours and online course activities Over time, there may be an evolution of the course's mode of delivery to increase the amount of online structured contact time and decrease the amount of conventional face-to-face lecture time As a hybrid course, a core component of face-to-face contact will always be preserved Laboratory experiences will continue to be delivered in face-to-face sessions Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −23− University of Ontario Institute of Technology Spectroscopy in Organic Chemistry CHEM 3220U continued… Please see the general statement on mode of delivery in the preface to the course outlines for a discussion of these possibilities Faculty Qualifications to teach/supervise the course: Postgraduate degree with expertise in organic chemistry Classroom requirements: technology-enhanced classroom with laptop connections, data projector, internet access Equipment requirements: None Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −24− University of Ontario Institute of Technology Course Title: Pharmaceutical Discovery CHEM 4510U Pre-Requisites: Advanced Organic Chemistry CHEM 3120U Year and Semester: Year 4, Semester • Course Description and Content Outline(by topic): This course explores topics involved in the drug discovery process from the discovery of lead molecular candidates to their optimization as drugs Topics include high-throughput screening, natural products drug discovery; combinatorial chemistry/diversity-orientated synthesis; and medicinal synthetic organic chemistry The course covers the following topics: Natural products drug discovery: This section describes the history of the use of drugs from nature, the main classes of secondary metabolites, the process of discovery (bioassay-guided fractionation and structure elucidation), and new approaches to natural products drug discovery (biosynthetic engineering) High-throughput screening: This section reviews the processes of robotics, assay development, assay optimization, and experimental design, and their effect of the drug discovery paradigm and its shift from natural products to synthetics Diversity-orientated synthesis: This section deals with the theory and practice of combinatorial chemistry, and diversity-orientated synthesis, in the production of libraries of drug candidates Specific chemical reactions will be profiled Medicinal synthetic organic chemistry: This section explains the process of the bioassay-guided optimization of an identified drug candidate to a lead compound using synthetic organic chemistry Specific chemical reactions will be profiled and the difference between medicinal and process chemistry will be highlighted The role of metabolic studies will be introduced • Methods of Delivery: hours of lecture per week • Student Evaluation: Multiple assignments will cover each of the four units, a term oral presentation is required alongside a comprehensive final exam • Resources to be purchased/provided by students: Textbook, reference sources and internet access (see Textbook requirements below) Textbook requirements: No specific textbook for the course is required Weekly readings will be selected from articles of peer-reviewed electronic journals (Science, Nature, Proceedings of the National Academy of Science, USA, Journal of the American Chemical Society, Angewandte Chemie International Edition, Journal of Medicinal Chemistry, Journal of Natural Products, Bioorganic & Medicinal Chemistry, etc.) Some representative texts that will be made available are: Thomas, G 2000 Medicinal Chemistry, An Introduction, John Wiley and Sons Ltd Dewick, P.M 1997 Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −25− University of Ontario Institute of Technology Pharmaceutical Discovery CHEM 4510U continued… • Medicinal Natural Products, A Biosynthetic Approach John Wiley and Sons Ltd Delgado, J.N.; Gisvold, O.; Remers, W.A 1998 Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry 10th edition Lippincott Williams, & Wilkins Silverman, R.B 2004 The Organic Chemistry of Drug Design and Drug Action 2nd Edition Academic Press • Learning Outcomes Students who successfully complete the course have reliably demonstrated the ability to: Outcome 1: Discuss the drug discovery process from the use of natural products to synthetic chemical libraries Outcome 2: Identify the chemical features of families of secondary metabolites, and their roles in current therapies Outcome 3: Identify the impact of high-throughput screening on the discovery process, and the principles that govern the successful implementation of a highthroughput protocol Outcome 4: Discuss the theory of combinatorial/diversity-orientated synthesis and the features of adaptable synthetic methodology Outcome 5: Apply knowledge of appropriate synthetic transformations to the design of a combinatorial/diversity-orientated strategy Outcome 6: Discuss the protocols of medicinal chemistry, and how they differ from process chemistry Outcome 7: Apply knowledge of synthetic organic chemistry to the synthesis of a target molecule Information about Course Designer/ Developer: Course designed by T Barsby, Ph.D; K Paal, Ph.D; F Naumkin, Ph.D; W Smith, Ph.D List faculty eligible to teach the course T Barsby, Ph.D; K Paal, Ph.D Are there any plans to teach all or portions of this course on-line? A course website will play an integral role in the delivery of resources for this course: syllabus, schedule, assignments, solutions to assignments, handouts, supplementary notes, etc This course may take advantage of the UOIT laptop hybrid environment by using a combination of face-to-face lecture hours and online course activities Over time, there may be an evolution of the course's mode of delivery to increase the amount of online structured contact time and decrease the amount of conventional face-to-face lecture time As a hybrid course, a core component of face-to-face contact will always be preserved Laboratory experiences will continue to be delivered in face-to-face sessions Please see the general statement on mode of delivery in the preface to the course outlines for a discussion of these possibilities Faculty Qualifications to teach/supervise the course: Postgraduate degree with expertise in organic chemistry, or industrial experience Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −26− University of Ontario Institute of Technology Pharmaceutical Discovery CHEM 4510U continued… Classroom requirements: technology-enhanced classroom with laptop connections, data projector, internet access Equipment requirements: None Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −27− University of Ontario Institute of Technology Course Title: Advanced Topics in Pharmaceutical Chemistry CHEM 4520U Pre-Requisites: Pharmaceutical Discovery CHEM 4510U Year and Semester: Year 4, Semester • Course Description and Content Outline(by topic): This course covers current research topics in pharmaceutical chemistry with a focus on techniques that facilitate a drug candidate’s entry into the marketplace The course covers the following topics: Molecular Modeling: This section deals with the computational chemistry, computeraided drug design, virtual screening, virtual combinatorial libraries, protein structure predictions, and pharmacophore development Pharmacokinetics: This section describes the pharmacological response to drugs, the concept of bioavailability, kinetics, metabolism, clearance, and dosing The role of synthetic functional groups at improving bioavailability will also be discussed Pharmaceutics: This section explains the physicochemical features of dosage forms, the design of dosage regimes, and advanced formulations • Methods of Delivery: hours of lecture per week • Student Evaluation: Multiple assignments will be used for each section, a term oral presentation, and a comprehensive final exam • Resources to be purchased/provided by students: Textbook, reference sources and internet access (see Textbook requirements below) Textbook requirements: No specific textbook for the course is required Weekly readings will be selected from articles of peer-reviewed electronic journals (Science, Nature, Proceedings of the National Academy of Science, USA, Journal of the American Chemical Society, Angewandte Chemie International Edition, Journal of Medicinal Chemistry, Journal of Natural Products, Bioorganic & Medicinal Chemistry, etc.) Some representative texts that will be made available are: Delgado, J.N.; Gisvold, O.; Remers, W.A 1998 Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry 10th edition Lippincott Williams, & Wilkins Silverman, R.B 2004 The Organic Chemistry of Drug Design and Drug Action 2nd Edition Academic Press Kwon, Y 2001 Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists 1rst Edition Kluwer Academic Press Aulton, M.E 2001 Pharmaceutics: The Science of Dosage Form Design 2nd Edition Churchill Livingston Cohen, N.C 1996 Guidebook on Molecular Modeling in Drug Design Academic Press Ahuja, S and Scypinski, S 2001 Handbook of Modern Pharmaceutical Analysis Academic Press Leach, A 2001 Molecular Modelling: Principles and Applications 2nd Edition Prentice Hall Schlick, T Molecular Modeling and Simulation, 2002 Springer-Verlag, Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −28− University of Ontario Institute of Technology Advanced Topics in Pharmaceutical Chemistry CHEM 4520U continued… • Learning Outcomes Students who successfully complete the course have reliably demonstrated the ability to: Outcome 1: Discuss the impact of computer simulations on the design of drugs Outcome 2: Use computer software to model pharmacophores and protein-ligand interactions Outcome 3: Identify sites of metabolism of lead compounds Outcome 4: Discuss techniques used to identify metabolic compounds, and the role of metabolism studies in the design of drug candidates Outcome 5: Discuss the chemical principles involved in drug formulation Outcome 6: Discuss the impact of chemistry on novel research in drug formulation Information about Course Designer/ Developer: Course designed by T Barsby, Ph.D; K Paal, Ph.D; F Naumkin, Ph.D; W Smith, Ph.D List faculty eligible to teach the course T Barsby, Ph.D; K Paal, Ph.D Are there any plans to teach all or portions of this course on-line? A course website will play an integral role in the delivery of resources for this course: syllabus, schedule, assignments, solutions to assignments, handouts, supplementary notes, etc This course may take advantage of the UOIT laptop hybrid environment by using a combination of face-to-face lecture hours and online course activities Over time, there may be an evolution of the course's mode of delivery to increase the amount of online structured contact time and decrease the amount of conventional face-to-face lecture time As a hybrid course, a core component of face-to-face contact will always be preserved Laboratory experiences will continue to be delivered in face-to-face sessions Please see the general statement on mode of delivery in the preface to the course outlines for a discussion of these possibilities Faculty Qualifications to teach/supervise the course: Postgraduate degree with expertise in organic chemistry, or industrial experience Classroom requirements: technology-enhanced classroom with laptop connections, data projector, internet access Equipment requirements: None Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −29− University of Ontario Institute of Technology Pharmaceutical Chemistry Business Plan The Business Plan is based on the following assumptions: - Annual intake of 20 students - Attrition factors of 0.8, 0.7, and 0.65 in years 2, 3, and 4, relative to first year - Operating Grant per FFTE = $2736 per first year student, and $7,858 for subsequent years (government instructions) - One student = FFTE - Tuition for Forensic Science = $4184 - No inflation factor is used - Average salary for FT faculty member is $90,000 plus 18.5% benefits - TA cost per hour = $35 - New lecture sections are required only for the new courses in this program - Existing Science courses are taken in existing sections; faculty costs are shared according to enrolment (e.g if 25 students in a program are part of a lecture section of 150, then 25/150 of the cost of the faculty member is attributed to the program - All marginal lab and tutorial costs are calculated on the same basis as for other Science programs The hours for existing courses are specified in the Calendar, while hours for new courses are specified in the course descriptions - Electives and required courses from other Faculties are estimated at $11,000 per section of maximum 50 students; costs include faculty and TA’s Using the above assumptions, the following revenues and expenses are estimated as the program rolls out (intake of 20 students each year): 2006/07 2007/08 2008/09 2009/10 Revenue: $138,400 $331,072 $499,660 $656,206 Expenditures: $38,130 $93,365 $183,923 $322,648 Expenditures/Revenue: 27.6% 28.2% 36.8% 49.2% Bachelor of Science in Chemistry – Pharmaceutical Chemistry Specialization −30− ... Study Overall PROMOTION GRADUATION GPA of 2.0 (6 0-6 6%) GPA of 2.0 (6 0-6 6%) GPA of 2.0 (6 0-6 6%) GPA of 2.0 (6 0-6 6%) GPA of 2.0 (6 0-6 6%) GPA of 2.0 (6 0-6 6%) Bachelor of Science in Chemistry – Pharmaceutical... conventional face-to-face lecture time As a hybrid course, a core component of face-to-face contact will always be preserved Laboratory experiences will continue to be delivered in face-to-face sessions... conventional face-to-face lecture time As a hybrid course, a core component of face-to-face contact will always be preserved Laboratory experiences will continue to be delivered in face-to-face sessions