The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis

... containing the DNA binding motif but not the pRb-binding or transactivation domain or introduction of a competitor plasmid containing multiple E2F binding sites, preventing the binding of E2F and ... transformation, leading to Arf/p53-independent senescence. Genes Dev 16:2923–2934 The Retinoblastoma Gene Family 187 4 The Retinoblastoma Gene Family 4.1 Rb Gene Fa...

Ngày tải lên: 25/10/2013, 21:20

... site of the SCF core. The essentiality of dimerization in the function of other Cdc4/Fbw7 homologs remains to be determined. The second class of SCF cofactor F-box proteins involved in cell- cyclin ... ubiquitin and then effects the processive attachment of ubiqui- tin monomers first to lysines on the targeted protein and then to lysines of previously attached...

Ngày tải lên: 25/10/2013, 21:20

... evolution and function of the hormonal system. We first cloned the genes of the CYP11B family of the guinea pig. The 11b- hydroxylase of the guinea pig showed higher substrate specificity than the aldosterone ... 6) for the remaining introns. Finally, the 3¢ UTRs of the guinea pig CYP11B genes show only 42% similarity whereas the 3¢UTR of the guinea pig C...

Ngày tải lên: 22/02/2014, 07:20

... anchor the protein to the membrane, as mutation of these cysteine residues increases the release of the BACE-1 ectodomain into the medium [13]. The stability and turnover of BACE-1, like that of the ... cathepsins B and D, and that cathepsin inhibi- tors may be therapeutically useful in AD [47,48]. A recent study of the effect of glutaminyl cyclase inhi- bi...

Ngày tải lên: 07/03/2014, 00:20

... Masui and Markert 1971). The build up of cyclin B and its degra- dation at the end of the cell cycle is a hallmark of MPF activity guiding the initiation and termination of the cycle (Pines and ... understanding cell cycle regulation in mammalian germ cells has considerably lagged behind that of the mitotic cell cycle. Challenges to investigation...

Ngày tải lên: 25/10/2013, 21:20

... point of view of the biological role of the involved genes) character of the extracted mode. In order to obtain an idea of the amount of vari- ation at the single gene level explained by the above described ... some extracellular protein needed by the colony as a whole. An intriguing candidate is the lectin-like protein involved in flocculation, a cell wall...

Ngày tải lên: 30/03/2014, 08:20

... Role oftheRbGeneFamily 205 8Roleofp107 and p130 inHumanCancer 207 9 The Retinoblastoma Gene Family inDifferentiationandTumorigenesis 208 9.1 A Link between Pax, bHLH and Pocket Proteins inDifferentiationandTumorigenesis ... effect of the inhibitor in a system on the basic cell cycle machinery in the absence of func- tional checkpoints. Checkpoint pathways includi...

Ngày tải lên: 07/10/2012, 16:51

... indicating the direct suppression of Per1, 2 and 3 by these miRNAs (Fig. 3B–D). Together, these data indicate that the miR-192 ⁄ 194 cluster is a potent and direct regulator of the Per gene family. Endogenously ... interesting to determine the exact role of miR-192 ⁄ 194 in these tissues. Together, the identification of inhibitory miRNAs for the Per genes adds m...

Ngày tải lên: 18/02/2014, 06:20

... the intervillus epithe- lium. Cdt1 mRNA is mainly localized at the bases of the developing intestinal villi (the intervillus e pithelium), where the proliferating cells of the intestinal epithelium ... esulting in gross differences in relative amounts of Cdt1 and its i nhibitor in different cell lines. I t would b e interesting to investigate w hether geminin and/...

Ngày tải lên: 07/03/2014, 16:20