cell cycle regulation transcription factors

... TransductionofDNADamageSignals 74 4 Regulation of Downstream Cellular Processes . . . . . . . . 76 4.1 RegulationoftheCellCycle 77 4.2 RegulationofDNAReplicationForks 78 4.3 RegulationofDNARepair 79 4.4 RegulationofTelomeres ... restriction point of the cell cycle. Cell Cycle 1:103–110 Buchkovich K, Duffy LA, Harlow E (1989) The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58:1097–1105 Burdon ... Division of the cell cycle into temporally ordered, discrete steps implied different proteins regu- late specific cell cycle transitions (Hartwell 1974). If so, then factors advancing cell cycle progression...

Ngày tải lên: 07/10/2012, 16:51

... female Cell Cycle Regulation in Mammalian Germ Cells 347 Table 1 (continued) Gene Protein Name Effect on germ cell development Refs. B. Transcriptional and Translational Factors Ahch Dax1 A transcriptional ... Probl Cell Differ (42) P. Kaldis: Cell Cycle Regulation DOI 10.1007/003/Published online: 20 December 2005 © Springer-Verlag Berlin Heidelberg 2005 Cell Cycle Regulation in Mammalian Germ Cells Changanamkandath ... mediating cell cycle regulators, growth factors and intracellular communication pathways for germ cell development. 5 Cytoplasmic and Apoptotic Factors During gametogenesis, apoptosis of germ cells...

Ngày tải lên: 25/10/2013, 21:20

... critical regulator of most cell cycle responses. While each single pocket protein can mediate cell cycle arrest upon cell- cell contact, pRb is the critical mediator of cell cycle arrest upon growth ... roles in controlling cell cycle exit upon growth-inhibiting signals. Only ablation of all pocket proteins fully alleviated a cell cycle arrest upon serum withdrawal, cell- cell contact inhi- bition, ... pro- teins at these specific stages of the cell cycle. 4.4 pRb Family Mediated Regulation of E2F by Cellular Localization Another level of control of the E2F transcriptional activity is added by the...

Ngày tải lên: 25/10/2013, 21:20

... p53. Cell cycle arrest can be medi- ated by p53 downregulating the transcription of central cell cycle regulators such as cyclin B, Cks1, Cdc2 and Cdc25C. CDE ⁄ CHR-dependent cell cycle- gene transcription ... Regulated During the Cell Cycle by a CDE ⁄ CHR Tandem Element and is Downregulated by p53 but not by p63 or p73. Cell Cycle 6, 853–862. 37 Yoshida K (2005) Cell- cycle- dependent regulation of the ... found to play only a limited role in cell cycle- dependent transcription [4]. Later, this finding on the CDE was confirmed and the major cell cycle- depen- dent regulation was attributed to a novel...

Ngày tải lên: 16/02/2014, 09:20

... and human T-cells, B-cells, myeloid cells, monocytic cells and fibroblasts, but not neuronal cells or embryonic stem cells, express STAT6, indicating that this gene is expressed in haematopoietic cells ... effector cell populations exist, Th1, Th2 and Th17, characterized by their cytokine repertoire and how they regulate B -cell and T -cell Keywords adaptive immunity; fish immunology; T-cells; transcription ... relationship between the expression of these transcription factors and the cytokine genes known to be produced by dif- ferent T -cell subtypes in mammals. These transcription factors, together with many of...

Ngày tải lên: 16/02/2014, 09:20

... and several molecular factors are known to influence the events of this enchondral ossification, especially transcription factors. Members of the AP-2 family of transcription factors play important ... M, Schorle H & Buettner R (2000) Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell- cycle con- trol. Gene 260, 1–12. 46 Pfisterer P, Ehlermann J, Hegen ... binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2. Mol Cell Biol 22, 7877–7888. 44 McPherson LA, Loktev AV & Weigel...

Ngày tải lên: 16/02/2014, 09:20

Ngày tải lên: 08/03/2014, 08:20

Ngày tải lên: 23/03/2014, 07:20

Ngày tải lên: 30/03/2014, 04:20

... tangles contain the antigenic profile of many cell cycle markers, re- flecting a re-entry into the cell cycle by affected neurons. However, while such a cell cycle re-entry phenotype is an early and ... suppression of the cell cycle and cell survival instead of apoptosis and their presence may be a neuroprotective factor to prolong the life of the cell after re-entry into the cell cycle, pro- tecting ... dividing neuronal cells during development, and is present in smaller amounts in fully differentiated cells [13]. BRCA1 is known to regulate transcription, regulate cell cycle progression,...

Ngày tải lên: 26/10/2012, 10:04

... of cell cycle arrest and apoptosis. We have investigated its effects on cell cycle regulation using a gastric cancer cell line, AGS. The effects of CKBM on cell proliferation, cell cycle regulation ... cell line. CKBM is found to inhibit cell proliferation through the induction of apoptosis and G2/M cell cycle arrest. To further elucidate the mechanism of CKBM on apoptosis and G2/M cell cycle ... AGS cells were seeded in a 6-well plate at a density of 1.2 x 10 6 cells/well. After 2, 4 or 6 hr of CKBM treatment at a concentration of 5, 10 or 15 % v/v, cells were trypsinized. Then cells...

Ngày tải lên: 02/11/2012, 11:12

... Nature 343:665–669 Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor 231 cycle, and strongly suggested that deregulation of the mechanisms controlling cell cycle progression could ... coordinate cell cycle exit with the induction of differentiation that confers upon pRB its tumor suppressor function. 230 L. Yamasaki 2 The Universality of the Cell Cycle The discovery of the cell cycle ... progression. Results Probl Cell Differ (42) P. Kaldis: Cell Cycle Regulation DOI 10.1007/b136682/Published online: 1 September 2005 © Springer-Verlag Berlin Heidelberg 2005 Modeling Cell Cycle Control and...

Ngày tải lên: 25/10/2013, 21:20

... mammals within certain cell types such as trophoblast giant cells of the placenta and megakaryocytes, but it can also be observed in cells due to a defect in the cell cycle regulation of these cells. For ... principal cell cycle inhibitor in β cells, as it accumu- latesinthenucleusofβ cells from obese mice, inhibiting compensatory β cell expansion (Uchida et al. 2005). Mouse Models of Cell Cycle Regulators: ... one round of cell division, every cell in metazoans has to decide whether it will re-enter the cell cycle, exit the cell cycle and en- ter a quiescence state, and every quiescent cell has to similarly...

Ngày tải lên: 25/10/2013, 21:20

... RA (1995) The role of Rb in cell cycle control. Prog Cell Cycle Res 1:9–19 Senescence and Cell Cycle Control 259 eliminates telomere-mediated signaling, allowing cells to undergo transform- ation ... of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424:223–228 Serrano M, Hannon GJ, Beach D (1993) A new regulatory motif in cell- cycle control causing specific inhibition of ... and cell mortality. Cell 85:27–37 Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16 INK4a .Cell 88:593–602 Sharpless...

Ngày tải lên: 25/10/2013, 21:20

... a transcription factor that is activated in response to variety of cellular stresses, evokes a number of responses ranging from cell cycle arrest to programmed cell death, depending on the cell ... Probl Cell Differ (42) P. Kaldis: Cell Cycle Regulation DOI 10.1007/b136681/Published online: 6 July 2005 © Springer-Verlag Berlin Heidelberg 2005 The ubiquitin-proteasome pathway in cell cycle ... from studies on the early embryonic cell cycles of Table 1 Cell cycle targets of the anaphase promoting complex Substrate Organism Specificity factor Cell cycle function Securin S. cerevisiae...

Ngày tải lên: 25/10/2013, 21:20

... phase of the cell- division cycle. Therefore, we tested, using light microscopy and after DAPI staining, whether the slow growth yields a cell- cycle phenotype. Cells of the logarithmically ... asynchronous cells. To test whether phosphorylated Rio1p is, in fact, degraded at a certain stage of the cell- division cycle, whereas the unphosphorylated form is not, we per- formed cell- cycle arrest ... observed a cell- cycle phenotype with this mutant. Cytological approaches investigating cell- cycle stages reveal that this mutant yeast strain accumulates G 1 cells, whereas the number of S phase cells...

Ngày tải lên: 18/02/2014, 16:20

... pathological roles in RA. Other transcription factors Other transcription factors implicated in the patho- genesis of RA are the signal transducer and activator of transcription (STAT) family of ... remarks Transcription factors play critical roles in the function of immune effector cells, including cytokine ⁄ chemokine expression and also in the control of synovial cell apop- tosis. These cells ... SAA in RA joints binds to RAGE on synovial cells and acti- vates the NF-jB signaling pathway in these cells. H. Okamoto et al. Role of transcription factors FEBS Journal 275 (2008) 4463–4470 ª...

Ngày tải lên: 18/02/2014, 18:20

... integrin gene in these cells is regulated by the Ets-family of transcription factors. Keywords: integrin; gene promoter; luciferase assay; Ets -transcription factor; gastric carcinoma cell. The a3b1integrin(VLA-3) ... receptor that mediates both cell- extracellular matrix and cell cell interactions. It has been suggested that this integrin is a promiscuous receptor for a variety of extracellular matrix proteins ... recently reported that these transcription factors regulated the expression of the aV integrin in mouse melanoma cells [54] and the a5 integrin in human glioma cells [55]. These factors have also been...

Ngày tải lên: 21/02/2014, 03:20

Ngày tải lên: 07/03/2014, 00:20