MouseModels of Cell Cycle Regulators - New Paradigms

... Mouse Models of Cell Cycle Regulators: New Paradigms 291 3.5 Placental Defects and Endoreduplication Ablation of cell cycle genes in mice sometimes leads to extra-embryonic de- fects that compromise ... Models of Cell Cycle Regulators: New Paradigms 293 Collectively speaking, ablation of three different cell cycle genes DP-1, Rb or cyclin E (E1 and E2) result...

Ngày tải lên: 25/10/2013, 21:20

... proteins Lin-37, Lin-52, Lin-54 and chromatin- associated Lin-9 and Lin-53 ⁄ RBBP4 ⁄ RbAp48. Furthermore, A-Myb and B-Myb were present in immunoprecipitations for Lin-9, Lin-37 and Lin-54 [90,92]. ... compared with wild-type cells when assayed using in vivo footprinting. Loss of the two pocket proteins leads to deregulation of the B-Myb promoter during the cell cycle. Re-intro- duction...

Ngày tải lên: 16/02/2014, 09:20

... accompanied by a high cell turn- over as a result of p53-dependent apoptosis. Expression of the T 121 variant of T-antigeninaBax-, p53-orE2F-1 deficient background results in accelera- 198 J H.Dannenberg·H.P.J.teRiele tion ... critical regulator of most cell cycle responses. While each single pocket protein can mediate cell cycle arrest upon cell- cell contact, pRb is the cr...

Ngày tải lên: 25/10/2013, 21:20

... culture characteristics of the suspended cells of ginseng in shake flask, the effect of plant growth regulators (2,4-D or IBA or NAA combination with BA or kinetin) on cell growth, ginsenoside ... established cell suspension culture of ginseng cell and some attempts have been made to increase biomass and ginsenoside yield of ginseng cell culture. 2. Materials and m...

Ngày tải lên: 14/03/2014, 10:20

... the RP of the mammalian cell cycle using a yeast-like core model of the cyclin–Cdk interactions (emphasizing the deep similarities of the Cdk-regulatory systems of yeast and mammalian cells). ... 30 h is shown for six of the intermediates of the system. The G 1-, S/G 2- and M-phases for one cell cycle are indi- cated in the graph. The RP is also depicted in the G1-pha...

Ngày tải lên: 15/03/2014, 09:20

... G 2 -0 .4 -0 .2 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 P-3Ab P-7Ab P-19Ab P-32Ab P-54Ab P-110Ab A 450 P-Ser3 P-Thr7 P-Thr19 P-Ser54 P-Ser32 P-Thr110 phosphopeptides Fig. 2. Specificity of binding of phospho- MCM4 antibodies. The ... anti-MCM4 or an- tiphosphoMCM4 (P-3, -7 , -1 9, -3 2, -5 4, -8 8 and -1 10) sera as indicated. Arrows on the right-hand side of gel indicate...

Ngày tải lên: 16/03/2014, 13:20

... S-phase and G 2 -phase of the cell cycle but not in G 1 -phase have been reported for HeLa cells [26]. In some other mammalian cells, examples of cytoplasmic accumulation of H1, but not of core histones ... analysis of DNA synthetic activities in extracts of plasmodia revealed a cell cycle dependent inhibition and activation of DNA poly- merases. This could be explained...

Ngày tải lên: 16/03/2014, 18:20

... CH 3 CH 2 OH CH 2 N N H N CC H N HN CH 3 CH 2 trans-Zeatin 6-( 4-Hydroxy-3-methylbut-2-enylamino)purine cis-Zeatin N C C O C CC H H H H H C N C C C N N C N H H H 9 1 2 3 4 5 6 7 8 H Kinetin Amino purine Cytokinins: Regulators of Cell Division ... Disruption of ARR1, one of the type-B ARR genes, reduces the induction of the type-A ARR genes in response Cytokinins: Regulators...

Ngày tải lên: 16/03/2014, 22:20

... the synthesis of new Cdc6p. In contrast, the rapid S-phase-related elimination of Cdc6p that is characteristic for the yeast cell cycle does not occur i n mammalian cells, and levels of human Cdc6p (hCdc6p) ... transferred to n itro- cellulose membranes. Immunostaining showed that cells in all cell cycle phas es possess substantial amounts o f chroma- tin-bound hCdc6p although...

Ngày tải lên: 17/03/2014, 23:20