cell cycle and transcription
Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
... mechanisms for controlling cell cycle progression (Morgan 1997; Zachariae and Nasmyth 1999). These studies and others demonstrated the universality of the cell Modeling Cell Cycle Control and Cancer with ... Nature 343:665–669 Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor 231 cycle, and strongly suggested that deregulation of the mechanisms controlling cell cycle progression could ... Orc1 and Mcm2–7) and DNA replication (e.g. Dhfr, Rnr, TK, TS and Polα). Many E2F target genes encode products in- volved in cell cycle progression (e.g. cyclins A and E, pRB, p107, E2F1–3) and apoptosis...
Ngày tải lên: 25/10/2013, 21:20
Senescence and Cell Cycle Control
... RA (1995) The role of Rb in cell cycle control. Prog Cell Cycle Res 1:9–19 Senescence and Cell Cycle Control 259 eliminates telomere-mediated signaling, allowing cells to undergo transform- ation ... loss of G1 control and immortalization. Genes Dev 14:3037–3050 Senescence and Cell Cycle Control 267 Campisi J (2001) Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol 11:S27–S31 Carnero ... mouse cells. p19 ARF is predominantly upregulated during senescence by oncogene activation and/ or oxidative stress Senescence and Cell Cycle Control 263 induction by controlling p16 INK4a (and...
Ngày tải lên: 25/10/2013, 21:20
The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
... most cell cycle responses. While each single pocket protein can mediate cell cycle arrest upon cell- cell contact, pRb is the critical mediator of cell cycle arrest upon growth factor deprivation and ... roles in controlling cell cycle exit upon growth-inhibiting signals. Only ablation of all pocket proteins fully alleviated a cell cycle arrest upon serum withdrawal, cell- cell contact inhi- bition, ... suppression and cell mortality. Cell 85:27–37 Serrano M, Lin AW, Mila EM, Beach D, Lowe SW (1997) Oncogenic ras provokes prema- ture cell senescence associated with accumulation of p53 and p16 Ink4a . Cell...
Ngày tải lên: 25/10/2013, 21:20
Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... Regulated During the Cell Cycle by a CDE ⁄ CHR Tandem Element and is Downregulated by p53 but not by p63 or p73. Cell Cycle 6, 853–862. 37 Yoshida K (2005) Cell- cycle- dependent regulation of the human and mouse ... p53. Cell cycle arrest can be medi- ated by p53 downregulating the transcription of central cell cycle regulators such as cyclin B, Cks1, Cdc2 and Cdc25C. CDE ⁄ CHR-dependent cell cycle- gene transcription ... encoded by cyclin B1 and cyclin B2 genes is Keywords cell cycle; cell cycle genes homology region (CHR); cell cycle- dependent element (CDE); DREAM complex; E2F Correspondence K. Engeland, Molecular...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Protein kinase CK2 activates the atypical Rio1p kinase and promotes its cell-cycle phase-dependent degradation in yeast pdf
... phase of the cell- division cycle. Therefore, we tested, using light microscopy and after DAPI staining, whether the slow growth yields a cell- cycle phenotype. Cells of the logarithmically ... which is stable throughout the cell cycle and highly resistant to proteolytic degradation [40]. Miscellaneous procedures Yeast were grown on standard media [41] and transformed as described by ... distribution of G 2 ⁄ M cells: the number of metaphase cells with a single DNA mass at the bud neck and the number of anaphase cells were increased slightly in the mutant (metaphase cells: 30.2% in the...
Ngày tải lên: 18/02/2014, 16:20
Báo cáo khoa học: 3 Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines potx
... during the cell cycle [13], upon exit and entry to the cell cycle both genes are controlled, at least in part, transcriptionally. Cdt1 and geminin are highly expressed in proliferating cells in ... upon cell cycle exit. To this effect, HFF cells were deprived of serum f or 48 h to induce cell cycle exit. Serum was th en r e-added a nd samples taken as cells progressed into the cell cycle. ... in G0 cells and induced upon cell cycle re-entry [23] and to be under the transcriptional c ontrol of E2F [24– 26]. We show here that, similar to Cdc6, Cdt1 mRNA levels are r educed in G0 and r...
Ngày tải lên: 07/03/2014, 16:20
Báo cáo Y học: Synthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle potx
Ngày tải lên: 17/03/2014, 23:20
Báo cáo khoa học: Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle ppt
Ngày tải lên: 23/03/2014, 06:20
Báo cáo khoa học: The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest pdf
Ngày tải lên: 31/03/2014, 01:20
cell cycle control mechanisms and protocols methods in molecular biology - tim humphrey, gavin brooks
Ngày tải lên: 08/04/2014, 12:50
cell cycle regulation - Ebook USA ( biotechnology)
... completion of the cell division cycle is significantly extended compared with continually fed cells. Thus, starvation not only blocks cell cycle progression, but causes cells to exit the cycle and enter ... 3) cell cycle machinery is highly regulated, and 4) cell cycle components are an obvious target in proliferative diseases like cancer (Murray and Hunt 1993). 3 G1 Progression in Cultured Cells If ... restriction point of the cell cycle. Cell Cycle 1:103–110 Buchkovich K, Duffy LA, Harlow E (1989) The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58:1097–1105 Burdon...
Ngày tải lên: 07/10/2012, 16:51
Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"
... suppression of the cell cycle and cell survival instead of apoptosis and their presence may be a neuroprotective factor to prolong the life of the cell after re-entry into the cell cycle, pro- tecting ... neuronal cells during development, and is present in smaller amounts in fully differentiated cells [13]. BRCA1 is known to regulate transcription, regulate cell cycle progression, and may ... the cell cycle by affected neurons. However, while such a cell cycle re-entry phenotype is an early and consistent feature of Alzheimer disease, the mechanisms responsible for neuronal cell cycle...
Ngày tải lên: 26/10/2012, 10:04
Báo cáo y học: "Cell Cycle Arrest by a Natural Product via G2/M Checkpoint"
... induction of cell cycle arrest and apoptosis. We have investigated its effects on cell cycle regulation using a gastric cancer cell line, AGS. The effects of CKBM on cell proliferation, cell cycle ... cell line. CKBM is found to inhibit cell proliferation through the induction of apoptosis and G2/M cell cycle arrest. To further elucidate the mechanism of CKBM on apoptosis and G2/M cell cycle ... Y, Xie LP, Yu XY, Zhang RQ. Effects of genistein and daidzein on the cell growth, cell cycle, and differentiation of human and murine melanoma cells. J Nutr Biochem 2002; 13:421-426. 2. Chen...
Ngày tải lên: 02/11/2012, 11:12
Cell Cycle Regulation in Mammalian Germ Cells
... based upon the cell cycle process affected: initiation and maintenance of meiosis, transcriptional and translational fac- tors, cellular signaling, cytoplasmic and apoptotic factors and prophase ... pregnancy loss and birth defects, it is critical to dissect out mei- otic cell cycle checkpoints and proper chromosome segregation (Hassold and Hunt 2001). However, understanding cell cycle regulation ... Masui and Markert 1971). The build up of cyclin B and its degra- dation at the end of the cell cycle is a hallmark of MPF activity guiding the initiation and termination of the cycle (Pines and...
Ngày tải lên: 25/10/2013, 21:20