cell cycle regulated transcription
Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... Subunit 1 (Cks1) is Regulated During the Cell Cycle by a CDE ⁄ CHR TandemElement and is Downregulated by p53 but not by p63or p73. Cell Cycle 6, 853–862.37 Yoshida K (2005) Cell- cycle- dependent ... p53. Cell cycle arrest can be medi-ated by p53 downregulating the transcription of central cell cycle regulators such as cyclin B, Cks1, Cdc2 and Cdc25C.CDE ⁄ CHR-dependent cell cycle- gene transcription ... responsible for strong shifts in cell cycle distribu-tion. A large cell fraction is found in G2or appears tohave an 8n DNA content. Many cell cycle- regulated genes are downregulated upon Lin-9 knockdown...
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Báo cáo khoa học: 3 Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines potx
... upon cell cycle exit. To this effect, HFF cells weredeprived of serum f or 48 h to induce cell cycle exit. Serumwas th en r e-added a nd samples taken as cells progressedinto the cell cycle. ... proliferatingcellsin vivoThe experiments with cultured cells have suggested thatCdt1 and geminin mRNA and protein are down -regulated upon cell cycle exit and a re progressively up -regulated uponFig. ... ase,when licensing is legitimate [13]. When cells exit the cell cycle, licensing in lost, a nd is est ablished again a s cells prepare t oreenter the cell cycle. While a previous study did not detect...
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cell cycle regulation - Ebook USA ( biotechnology)
... restriction point of the cell cycle. Cell Cycle 1:103–110Buchkovich K, Duffy LA, Harlow E (1989) The retinoblastoma protein is phosphorylatedduring specific phases of the cell cycle. Cell 58:1097–1105Burdon ... starvation not only blocks cell cycle progression, but causes cells to exit the cycle and enter G0. However,if serum is removed after this point, cells continue through the cycle unhin-dered (Zetterberg ... ofcritical cell cycle machinery.2.3 Cell Cycle MachineryRecognition that specific protein catalysts are responsible for diverse cellu-lar processes such as fermentation (late 1800s) suggested that cell...
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Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"
... tangles contain the antigenic profile of many cell cycle markers, re-flecting a re-entry into the cell cycle by affected neurons. However, while such a cell cycle re-entry phenotype is an early and ... suppression of the cell cycle and cell survival instead of apoptosis and their presence may be a neuroprotective factor to prolong the life of the cell after re-entry into the cell cycle, pro-tecting ... dividing neuronal cells during development, and is present in smaller amounts in fully differentiated cells [13]. BRCA1 is known to regulate transcription, regulate cell cycle progression,...
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Báo cáo y học: "Cell Cycle Arrest by a Natural Product via G2/M Checkpoint"
... induction of cell cycle arrest and apoptosis. We have investigated its effects on cell cycle regulation using a gastric cancer cell line, AGS. The effects of CKBM on cell proliferation, cell cycle ... cell line. CKBM is found to inhibit cell proliferation through the induction of apoptosis and G2/M cell cycle arrest. To further elucidate the mechanism of CKBM on apoptosis and G2/M cell cycle ... AGS cells were seeded in a 6-well plate at a density of 1.2 x 106 cells/well. After 2, 4 or 6 hr of CKBM treatment at a concentration of 5, 10 or 15 % v/v, cells were trypsinized. Then cells...
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Cell Cycle Regulation in Mammalian Germ Cells
... female Cell Cycle Regulation in Mammalian Germ Cells 347Table 1 (continued)Gene Protein Name Effect on germ cell development Refs.B. Transcriptional and Translational FactorsAhch Dax1 A transcriptional ... Probl Cell Differ (42)P. Kaldis: Cell Cycle RegulationDOI 10.1007/003/Published online: 20 December 2005© Springer-Verlag Berlin Heidelberg 2005 Cell Cycle Regulation in Mammalian Germ CellsChanganamkandath ... stage of cell cycle, Ortega et al. 2003;kinase 2 while females lack follicular development Berthet et al. 2003due to breakdown at the pachytene stage.CyclinD2 Cell cycle Absence of germ cells...
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Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
... coordinate cell cycle exit with the induction of differentiationthat confers upon pRB its tumor suppressor function.230 L. Yamasaki2The Universality of the Cell Cycle The discovery of the cell cycle ... Nature 343:665–669Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor 231 cycle, and strongly suggested that deregulation of the mechanisms controlling cell cycle progression could ... PK (2004) Wagging the dogma; tissue-specific cell cycle control in themouse embryo. Cell 118:535–538Palmero I, Peters G (1996) Perturbation of cell cycle regulators in human cancer. CancerSurv...
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MouseModels of Cell Cycle Regulators - New Paradigms
... principal cell cycle inhibitor in β cells, as it accumu-latesinthenucleusofβ cells from obese mice, inhibiting compensatory β cell expansion (Uchida et al. 2005).Mouse Models of Cell Cycle Regulators: ... one round of cell division, every cell in metazoans hasto decide whether it will re-enter the cell cycle, exit the cell cycle and en-ter a quiescence state, and every quiescent cell has to similarly ... re-enter the cycle. Allthese crucial decisions are made by a set of information processors (cell cycle machinery) that integrate extracellular and intracellular signals to coordinate cell cycle events.In...
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Senescence and Cell Cycle Control
... RA (1995) The role of Rb in cell cycle control. Prog Cell Cycle Res 1:9–19Senescence and Cell Cycle Control 259eliminates telomere-mediated signaling, allowing cells to undergo transform-ation ... ofretinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424:223–228Serrano M, Hannon GJ, Beach D (1993) A new regulatory motif in cell- cycle controlcausing specific inhibition of ... and cell mortality. Cell 85:27–37Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokespremature cell senescence associated with accumulation of p53 and p16INK4a .Cell 88:593–602Sharpless...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
... critical regulator of most cell cycle responses. While each single pocket protein can mediate cell cycle arrest upon cell- cell contact, pRb is the critical mediator of cell cycle arrestupon growth ... roles in controlling cell cycle exit upon growth-inhibiting signals. Only ablation of all pocket proteins fullyalleviated a cell cycle arrest upon serum withdrawal, cell- cell contact inhi-bition, ... Estes S, Starz M, Vernon JP, Lees JA (1997) E2F activity is regulated by cell cycle- dependent changes in subcellular localization. Mol Cell Biol 17:7268–7282Vooijs M, Berns A (1999) Developmental...
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The ubiquitin-proteasome pathway in cell cycle control
... from studies on the early embryonic cell cycles ofTable 1 Cell cycle targets of the anaphase promoting complexSubstrate Organism Specificity factor Cell cycle functionSecurin S. cerevisiae ... Probl Cell Differ (42)P. Kaldis: Cell Cycle RegulationDOI 10.1007/b136681/Published online: 6 July 2005© Springer-Verlag Berlin Heidelberg 2005The ubiquitin-proteasome pathway in cell cycle ... linking cell cycle regulation to internal and external signaling pathways via regulated protein kinaseactivities.1IntroductionThe importance of ubiquitin-mediated proteolysis for cell cycle...
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Tài liệu Báo cáo khoa học: Protein kinase CK2 activates the atypical Rio1p kinase and promotes its cell-cycle phase-dependent degradation in yeast pdf
... phase of the cell- division cycle. Therefore, we tested,using light microscopy and after DAPI staining, whetherthe slow growth yields a cell- cycle phenotype. Cells ofthe logarithmically ... asynchronouscells. To test whether phosphorylated Rio1p is, in fact,degraded at a certain stage of the cell- division cycle, whereas the unphosphorylated form is not, we per-formed cell- cycle arrest ... for cell life, CK2 activity by itself isapparently unregulated [4,5], although some fluctua-tion in activity in correlation with cell- cycle progres-sion has been seen in cultured mammalian cells...
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Báo cáo khoa học: A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis doc
... staining cells. Scale bars = 200 lm. (F) Quantification of binucle-ated cells in control and Grx3-KD cells. Total 600 cells counted for control cells and 360 cells counted for Grx3-KD cells. The ... finish cell cycle back to G1phase. Cells were harvested at 2-h intervals.Half of cells were stained with propidium iodide, and analyzed by FACS. Another half of cells were prepared for cell ... Given the complexity of cell cycle regulation and the numerous intracellular compo-nents responding to oxidative stress, it is not surprisingthat Grx3-mediated cell cycle control may be depen-dent...
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Báo cáo khoa học: Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex doc
... (a) cellspulse treated (1 h) with cycloheximide early in the cell cycle (before RP) immediately suffer a long delay inthe cell division cycle; (b) cells treated late in the divi-sion cycle ... asthe emergent RP in the mammalian cell cycle) in termsof the multitude of reaction steps and interactionsbetween the cell s molecular parts (e.g. cell cycle pro-teins) [18]. Numerous studies ... restrictionpoint of the cell cycle. Cell Cycle 1, 103–110.4 Yao G & Lee TJ, Mori S, Nevins JR & You L (2008)A bistable Rb-E2F switch underlies the restrictionpoint. Nat Cell Biol 10, 476–482.5...
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Báo cáo khoa học: Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells pot
... HeLa cellswere incubated with nocodazole. Cellsdetached from the bottle by shaking werecollected and named mitotic (M) cells.Residual cells were collected and named G2cells. These cells ... treatments; i.e. theDNA content of G2, M cells are almost double that of G1cells and the DNA content of S cells ranges between thatof G1cells and G2or M cells (data not shown). BrdU wasdetected ... fluorescence and the reactivity to anti-BrdU sera, the cell- cycle stage was determined in each cell. Y. Komamura-Kohno et al. MCM4 phosphorylation in mammalian cellsFEBS Journal 273 (2006) 1224–1239 ª 2006...
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