Involvement of nm23 m2 in dopaminergic neuronal differentiation and cell cycle arrest

... of the release of ATP demonstrates that the velocity of ATP release correlates well with that of the Ca2+ wave in astrocytes [5] All of these findings suggest that the extracellular molecule ATP ... followed by the spreading of Ca2+ transients in adjacent astrocytes to form intercellular Ca2+ waves by a mechanism of chemical coupling mediated by ATP In...

Ngày tải lên: 16/02/2014, 09:20

... (contained within the cyclic peptide CTRKKHDNAQC derived from jararhagin disintegrin) is essential for binding to the I domain of a2 integrins [24] Similarly, members of the lysine threonine–serine ... oxidase-hypoxanthine system (data not shown) These results suggested the involvement of lysine- containing sequences in the activation mechanism Involvement of lysine resid...

Ngày tải lên: 07/03/2014, 06:20

... direct involvement of Ech hydrogenase in energy conservation: (a) ATP synthesis was observed in the Ms mazei vesicular system that was dependent on the oxidation of Fdred (catalysed by Ech hydrogenase) ; ... clearly exclude the involvement of Na+ in energy conservation by Ech hydrogenase Instead, the data strongly support the model of proton translocation...

Ngày tải lên: 15/03/2014, 23:20

... oxidative stress in OA cartilage, as discussed above, we postulated that oxidative stress induces telomere instability and dysfunction in chondrocytes, subsequently resulting in cartilage ageing and ... pathogenesis of OA from the viewpoint of oxidative stress induced genomic instability, especially telomere erosion, and chondrocyte senescence Our f...

Ngày tải lên: 09/08/2014, 06:22

... was increased in hypoxic chondrocytes lacking HIF-1α, to twice R909 Our findings show the potential involvement of HIF-1α expression in the progression of articular cartilage degeneration In patients ... radicals) may induce the expression of HIF-1α in articular chondrocytes IL-1 has been shown both to inhibit chondrocyte anabolic activity, including the d...

Ngày tải lên: 09/08/2014, 06:23

Ngày tải lên: 09/08/2014, 07:20

... reflected by the presence of perforin, presumably secreted by CD3+ T cells It might therefore be of interest to conduct further studies of these naïve T cells and cytokines in sterile SF in order to ... difficult to obtain samples; it is only evaluated in intensively and chronically treated BD patients In contrast to most of the inflamed organs in BD, the joint...

Ngày tải lên: 09/08/2014, 14:20

... excitatory neuronal differentiation Whether the modulation of Pax6, Ngn2 and NeuroD by prenatal ethanol treatment is causally related to the regulation of excitatory neuronal differentiation and to hyperactive ... et al.: Prenatal exposure of ethanol induces increased glutamatergic neuronal differentiation of neural progenitor cells Journal of Biomedical...

Ngày tải lên: 10/08/2014, 05:21

... activation of mTOR (Figure 3A), cells were incubated with SPC in the presence or absence of rapamycin, a specific mTOR inhibitor Addition of rapamycin significantly abolished the inhibition of melanin ... containing 1% Triton X-100, and disrupted by freezing and thawing After quantifying the protein levels of the lysate and adjusting the protein concentrations with lysis buffe...

Ngày tải lên: 10/08/2014, 10:20

... determinant for Met and EGFR activation in A431 cells Adhesion-induced activation of Met and EGFR in A431 cells is independent of Src, ROS, or cytoskeleton Adhesion-induced activation of RTKs ... mM NaCl, 10% glycerol and mM Na3VO4) containing protease inhibitors (1 mM phenylmethylsulfonyl fluoride, 0.2 trypsin inhibitory units/ml aprotinin, and 20 µg/ml leupep...

Ngày tải lên: 10/08/2014, 10:20

... identified a number of strategies to facilitate the implementation of research findings by using these social influences One strategy generating considerable interest is the use of opinion leaders Opinion ... findings into practice is a slow and haphazard process For many years, the traditional approach to dissemination has been the publication of research...

Ngày tải lên: 11/08/2014, 05:21

... doi:10.1186/1471-2229-10-20 Cite this article as: Renault et al.: The Arabidopsis pop2-1 mutant reveals the involvement of GABA transaminase in salt stress tolerance BMC Plant Biology 2010 10:20 Submit your ... was partly due to induction of the gene in shoots GUS staining pattern of NaCl-treated roots seemed to be more complex GUS staining was indeed sharply...

Ngày tải lên: 12/08/2014, 03:21

... role in cardiac remodeling in hypertension- induced heart failure J Mol Cell Cardiol 2008, 45:779-86 15 Okayama Y, Ra C, Saito H: Role of mast cells in airway remodeling Current Opinion in Immunology ... distribution in chronically hypoxic animals J Appl Physiol 1977, 42:174-8 doi:10.1186/1465-9921-12-60 Cite this article as: Dahal et al.: Involvement of mast cells...

Ngày tải lên: 12/08/2014, 13:22

... gp120-independent HIV- 1 infection We previously reported that by employing a gp120-independent infection mechanism, HIV- 1 virus infected several CD4(-) cell lines, including oral cell lines Tu139 ... that the infection rate of LNCaP cells by HIV was similar to that of HeLa-CD4, suggesting that the infectivity of HIV- 1 for some types of CD4(-) cells is high Because 12...

Ngày tải lên: 13/08/2014, 09:21

... model 85 4.2 Temporal and spatial expression of nm23- M2 gene 85 4.3 The role of nm23- M2 in dopaminergic MN9D differentiation 87 4.4 The role of nm23- M2 in inducing cell cycle arrest 89 4.5 Further ... MN9D 64 cell differentiation 3.2 3.1.4 Spatial expression of nm23- M2 in MN9D and SH-SY5Y cells 66 3.1.5 Subcellular localization of nm23- M2...

Ngày tải lên: 08/11/2015, 17:09