summary conclusions involvement of 5 ht in brain reward
Báo cáo y học: "Enhanced glutamate, IP3 and cAMP activity in the cerebral cortex of Unilateral 6-hydroxydopamine induced Parkinson’s rats: Effect of 5-HT, GABA and bone marrow cell supplementation" ppsx
... mGluR5 NMDA2B Control 23. 25 ± 3 .50 26 ± 3.1 6-OHDA 83.12 ± 3.23a 60 ± 6.1a 6-OHDA + 5HT 6-OHDA +GABA b,f 50 ± 5. 9b,f b,f 52 ± 5. 7b,f a 67.12 ± 2 .50 68.23 ± 3. 05 6-OHDA +BMC 79.33 ± 7 .55 59 ± 5. 1a ... 367: 95- 122 Glowinski J, Iversen LL: Regional studies of catecholamines in the rat brain: The disposition of [3H] norepinephrine, [3H] dopamine and [3H] dopa in various regions of the brain J ... Specific [ H] MK-801 binding was obtained by subtracting nonspecific binding in the presence of 100 μM unlabeled MK-801 from the total binding Protein Determination Figure Apomorphine induced rotational...
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Tài liệu Báo cáo khoa học: Synchronization of Ca2+ oscillations: involvement of ATP release in astrocytes pdf
... transients are accentuated in pathological conditions, suggesting the involvement of astrocytic Ca2+ transients in brain disorders, including epileptic seizures Interestingly, astrocytes also show ... Nedergaard M (1998) Connexins regulate calcium signaling by controlling ATP release Proc Natl Acad Sci USA 95, 157 35 157 40 10 Volterra A & Meldolesi J (20 05) Astrocytes, from brain glue to communication ... Imaging cellular network dynamics in three dimensions using fast 3D laser scanning Nat Methods 4, 73–79 28 Wetherington J, Serrano G & Dingledine R (2008) Astrocytes in the epileptic brain Neuron...
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Báo cáo khoa học: Involvement of lysine 1047 in type I collagen-mediated activation of polymorphonuclear neutrophils doc
... derived from jararhagin disintegrin) is essential for binding to the I domain of a2 integrins [24] Similarly, members of the ‘lysine–threonine–serine (KTS)–disintegrin’ family contain the consensus ... than RGD, in their integrin- binding loop [ 25, 26] In addition, glycation of collagen lysine side chains is responsible for an impaired interaction of type I collagen with b1 integrins [27,28] ... a-amino group of the tissue inhibitor of metalloproteinases-2 NH2-terminal cysteine has been used to demonstrate the key role of this amino group in the inhibitory effect of tissue inhibitor of metalloproteinases-2...
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Báo cáo khoa học: Involvement of Ech hydrogenase in energy conservation of Methanosarcina mazei pptx
... Function of Ech in energy conservation C Welte et al ATP (nmol·mg protein–1) 20 15 10 0 10 15 20 Time (min) Fig Fd-dependent ATP synthesis Test vials contained 5% CO ⁄ 95% N2 in the headspace, 50 0–700 ... resazurin, pH 7.0), 5% CO ⁄ 95% N2 in the 1 .5 mL headspace, 50 0–700 lg washed inverted membrane vesicles, 33 .5 lg Fd, 150 nmol AMP and 300 nmol ADP Before starting the reaction by the addition of ... curve Determination of H2 To determine H2 production rates, rubber stoppered glass vials were filled with 50 0 lL buffer A, 5% CO ⁄ 95% N2 in the 1 .5 mL headspace, 50 0–700 lg washed inverted membrane...
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báo cáo hóa học: " Recovery of visual fields in brain-lesioned patients by reaction perimetry treatment" potx
... VF size of – 7° Reading training had a similar effect: In 34% of hemianopic patients who participated in reading training, an average VF enlargement of 5. 4° was obtained after 15 24 training sessions, ... performance in manipulating things, visually orienting, walking around, driving or reading In only two studies so far the effects of visual treatment on daily living have been investigated Within the ... +6.2% ± 16.4 increase of detection rate and 8.9° ± 11.9 increase of VF size in the occluded and a +6.6% ± 12 .5 increase in detection rate as well as a 7.8° ± 6.8 increase of VF size in the open...
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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
... Conclusion This study provides insight into the involvement of oxidative stress in the pathogenesis of OA from the viewpoint of oxidative stress induced genomic instability, especially telomere ... Roles of chondrocytes in the pathogenesis of osteoarthritis Curr Opin Rheumatol 2002, 14 :57 8 -58 4 Martin JA, Ellerbroek SM, Buckwalter JA: Age-related decline in chondrocyte response to insulin-like ... number of cells in the dish was determined, and the cells (1 × 1 05 cells/dish) were placed in a new dish The number of cells that had attached hours after seeding was determined The increase in cumulative...
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Báo cáo y học: "Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis" ppt
... light-emitting oxidation of luciferin by luciferase in the presence of extremely low levels of ATP After collecting the chondrocytes by scraping, cells were centrifuged for 10 at 50 0 × g in the ... conditions, IL-1β-induced apoptosis was increased in hypoxic chondrocytes lacking HIF-1α, to twice R909 Our findings show the potential involvement of HIF-1α expression in the progression of articular ... degeneration In patients with OA, stronger expression of HIF-1α mRNA in chondrocytes was observed in degenerating regions than in intact regions from the same articular cartilage samples Our findings in...
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Báo cáo y học: "Do synovial biopsies help to support evidence for involvement of innate immunity in the immunopathology of Behçet’s disease" pot
... stimulating an immune response in BD Most tissue studies of the pathophysiology of BD are conducted in skin One of the unique and diseasespecific features of BD is the occurrence of a positive skin ... elevated levels of IFN-γ, IL-12-p40 and IL- 15; MIP3-α (macrophage inflammatory protein-3α); IP-10 (IFN-inducible protein-10); Mig (monokine induced by IFN-γ); iTac (interferon-inducible T cell ... markers such as E-selectin, P-selectin, and endoglin are linked to SPR [9] Infiltrating cells are mainly of the HLA-DR+/CD3+/CD4+/CD45RO+ type [10] Other observations include mature dendritic cells;...
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Báo cáo y học: " Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects" pps
... activation of the serine/threonine mTOR protein kinase is involved in the inhibition of melanin synthesis in B16 melanoma cells [30] Because SPC triggers the activation of Akt, we Jeong et al Journal of ... quantities of melanin [22] Mel-Ab cells were maintained in DMEM supplemented with 10% FBS, 100 nM TPA, nM CT, 50 μg/mL streptomycin, and 50 U/mL penicillin at 37°C in 5% CO B16/F10 murine melanoma ... quantifying the protein levels of the lysate and adjusting the protein concentrations with lysis buffer, 90 μL of each lysate containing the same amount of protein was placed in each well of a 96-well...
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Báo cáo y học: "Involvement of lipid rafts in adhesion-induced activation of Met and EGF" pdf
... Involvement of lipid rafts in adhesion-induced activation of Met and EGFR Ying-Che Lu1 and Hong-Chen Chen1,2,3,4* Graduate Institute of Biomedical Sciences, National Chung Hsing University, ... determinant for integrin-dependent membrane rafts trafficking and regulation of growth signalling [13] In this study, we set out to examine the mechanism for adhesion-induced activation of Met ... were maintained in Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% fetal bovine serum and cultured at 37°C in a humidified atmosphere of 5% CO2 and 95% air To examine adhesion-induced...
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báo cáo khoa học: "Is the involvement of opinion leaders in the implementation of research findings a feasible strategy?" doc
... (43.2%) N/A 53 (43.1%) 356 202 80 638 230 (64.6%) 151 (74.6%) 58 (72 .5% ) 439 (68.8%) 130 (56 .5% ) 98 (64.9%) 35 (60.3%) 263 (59 .9%) 111 (48.3%) 85 (56 .3%) N/A 196 (51 .4%) 41 33 41 78 193 21 (51 .2%) ... DGH2 11 57 .8% 15. 6% 26.3% TH 33.3% 33.3% 10.2% Simple network, within ward nominations Simple network, mainly within ward nominations Simple network, within ward nominations 87 .5% 0% 50 % 87 .5% 0% ... 23–29 29 25 37 100 20.97 (4 .56 ) 19.68 (4.22) 18.81 (4 .57 ) 16. 45 (6.04) 12–28 9–28 7–27 5 30 7 18 26.71 (1. 25) 25. 40 (2.70) 25. 71 (1.11) 25. 28 (2.11) 25 28 21–28 24–27 23–30 31 21.16 (5. 54) 12–29...
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báo cáo khoa học: " The Arabidopsis pop2-1 mutant reveals the involvement of GABA transaminase in salt stress tolerance" pps
... metabolite profiling during cold acclimation of Arabidopsis reveals Renault et al BMC Plant Biology 2010, 10:20 http://www.biomedcentral.com/1471-2229/10/20 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 ... according to the following gradient: initial, 99.9% A; 0 .54 min, 99.9% A; 6 .50 min, 90.9% A, curve 7; 8 .50 min, 78.8% A, curve 6; 8.90 min, 40.4% A, curve 6; 9 .50 min, 40.4% A, curve 6; 9.60 min, ... (Control), with 150 mM NaCl before GUS staining (A) GUS staining pattern in shoots of plantlets (B-C) GUS staining pattern in roots of plantlets shown in A (D-E) Focus on root apices visible in B and...
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Báo cáo y học: " Involvement of mast cells in monocrotalineinduced pulmonary hypertension in rats" pot
... population of interest, was prevalent in MCT-rats (p < 0. 05 versus healthy rats) Interestingly, there was about 9-fold increase in the number of MCs around the intra-acinar vessels (20 -50 μm in diameter), ... healthy; †p < 0. 05 versus MCT-placebo group B 250 0 2000 † 150 0 600 450 300 150 † † Healthy Placebo PLX Cromolyn Imatinib MCT Index of Granulation (%) Mast cells/10mm2 A 1 25 † 100 † 75 † 50 25 Healthy ... self-perpetuating owing to the involvement of a host of redundant factors Such factors include various growth factors, proteases and inflammatory mediators that have been incriminated in the pathogenesis of...
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Báo cáo y học: " The clinical significance of 5% change in vital capacity in patients with idiopathic pulmonary fibrosis: extended analysis of the pirfenidone trial" potx
... times by definition of disease progression as death or ≥ 5% relative decline in absolute VC were obtained (In our previous paper, we used ≥ 10% instead of ≥ 5% decline in VC to define PFS times ... group might remain in the state at year However, the Table Outcome after month 12; Mortality ratio and incidence of acute exacerbation in patients with ≥ 5% and < 5% decline in VC 5% decline in VC ... manner using a 5% change in VC as indices, evaluated the coincidence of the ratings based on 5% change in VC between months and 12, and examined the usefulness and significance of the 5% change...
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Báo cáo y học: " Involvement of claudin-7 in HIV infection of CD4(-) cells" pdf
... 11(1 .5 ng), 24 ± 5. 6 (0 .5 ng), 8 .5 ± 0.7 (0. 15 ng), 2 .5 ± 0.7 (50 pg); and 2) HeLa-CD4: 1114 ± 1 15 (5 ng), 638 ± 47 (1 .5 ng), 80 ± 10 (0 .5 ng), 14 .5 ± 2.1 (0. 15 ng), 3 .5 ± 0.71 (50 pg), ± ( 15 pg) ... [13- 15] or chemokine receptors, including CXCR4 and CCR5, on the surface of CD4(-) cells [ 15- 19], and that this binding initiates HIV entry into CD4(-) cells Therefore, gp120 would be a key protein ... the binding of gp120 to CD4 mole- cules on the cell surface of HeLa-CD4 cells, we would expect that infection of LNCaP by HIV Env(-) virus would occur through binding of unknown proteins of the...
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Báo cáo y học: "A prospective trial of elective extubation in brain injured patients meeting extubation criteria for ventilatory support: a feasibility study" pot
... trial of early extubation in brain injured patients [11] We assessed the feasibility of performing this study by designing a pilot study of mechanically ventilated patients with brain injury intubated ... decreasing the rate of nosocomial pneumonia [7,8] Thus, identifying the optimal timing of extubation in a population of brain injured patients should improve outcome and shorten length of stay in ... of extubation delay in brain injured patients meeting standard weaning criteria Am J Respir Crit Care Med 2000, 161: 153 0- 153 6 Altman DG, Dore CJ: Randomization and baseline comparisons in clinical...
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The involvement of cellular components in west nile virus replication cycle
... Pretreatment of Coverslips for Cultivation of Cells 2.1 .5 52 53 Storage of Cells 53 INFECTION OF CELLS 2.2.1 Viruses 54 2.2.2 Infection of Cell Monolayers 54 2.2.3 56 Preparation of Virus Pool ... common integrin molecular binding motif arginine-glycine-asparate (RGD) is incorporated in domain III (Rey et al., 19 95) However, several recent studies have shown that this integrin binding motif ... its isoforms 184 Figure 53 Inhibition of WNV infectivity in cells transfected with antibodies against PKC and its isoforms Figure 54 186 Acridine orange staining of lysomotrophic and VATPase inihibitor...
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Involvement of nm23 m2 in dopaminergic neuronal differentiation and cell cycle arrest
... al 1998), have all resulted in patterning defects in the midbrain-hindbrain region, arguing for a role of these genes in the establishment of midbrain and hindbrain identities 1.6.2 Extracellular ... with cerebrospinal fluid within the brain In this region, only about one in three hundred cells is a stem cell (Cassidy and Frisen, 2001) 1.4 .5 Deep brain stimulation therapy Deep brain stimulation ... most prominent dopaminergic cell group resides in the ventral part of mesencephalon, which contains approximately 90% of the total number of brain dopaminergic cells The mesencephalic dopaminergic...
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A study to investigate the involvement of nadph oxidase 5 (NOX5) in resveratrol (RSV) induced reactive oxygen species (ROS) production in u937 cells
... to investigate the involvement of RSV-induced ROS production in regulating NOX5 expression in the U937 lymphoma cells The initial part of the study involved analyzing the expression of NOX5 following ... level in U937 50 3.4: Resveratrol produces ROS in U937 55 3 .5: Scavenging of ROS produced by RSV abrogates the increase in NOX5 expression 57 ROS regulation of NOX5 expression 3.6: ... calmodulin (CaM), a calcium binding protein also regulates the activity of NOX5 CaM binding domains were found on the C-terminus rather than the EF domains which are known to function as Ca2+ binding...
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