homeostatic regulation of glutamate neurotransmission in primary neuronal cultures
Tài liệu Báo cáo khoa học: Complex transcriptional and translational regulation of iPLA2c resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization docx
... Translational regulation of iPLA2c in myocardium Owing to the obvious complexity of the regulation of iPLA2c resulting from the combined presence of transcriptional and translational regulation, ... presence of multiple iPLA2c protein products in mitochondria resulting from usage of different translation initiation codons in rat myocardium Alternative splicing of iPLA2c in mammalian tissues In ... CdxA binding sites Oligonucleotide g177 shares homology with the Oct1 binding site, whereas oligonucleotide g230 did not contain a predicted site for binding of nuclear proteins Utilizing radiolabeled...
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Occupational therapy interventions and physical activity interventions to promote the mental wellbeing of older people in primary care and residential care pdf
... routines and activities that help to maintain or improve their health and wellbeing Sessions should: − involve older people as experts and partners in maintaining or improving their quality of ... have been trained in first aid and in creating suitable walking routes − incorporate a group meeting at the outset of a walking scheme that introduces the walk leader and participants − offer opportunities ... guidance, in their local context, in light of their duties to avoid unlawful discrimination and to have regard to promoting equality of opportunity Nothing in this guidance should be interpreted in...
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Báo cáo khoa học: Improvement of a monopartite ecdysone receptor gene switch and demonstration of its utility in regulation of transgene expression in plants pdf
... a DNAbinding domain (DBD) and a ligand-binding domain (LBD) The chimeric gene (transactivation domain– DBD–LBD) is expressed under the control of a constitutive promoter In the presence of a specific ... construction of a versatile system for the expression of foreign genes in plants Gene 61, 1–11 Tavva VS, Collins GB & Dinkins RD (2006) Targeted overexpression of the Escherichia coli MinC protein in higher ... flexible ligand binding pocket of ecdysone receptor: a single amino acid change leads to discrimination between two groups of nonsteroidal ecdysone agonists J Biol Chem 279, 27211–27218 Dinkins RD, Pflipsen...
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Báo cáo khoa học: Calcium-induced contraction of sarcomeres changes the regulation of mitochondrial respiration in permeabilized cardiac cells doc
... Kinetics of ADP production in dependence of [ATP] in conditions of the absence (continuous line) and presence (with 10 mM glutamate and mM malate, dashed line) of oxidative phosphorylation in ... Reversibility of the effects of calcium-induced contraction of cardiomyocytes on the kinetics of regulation of mitochondrial respiration by exogenous ADP The kinetics of respiratory regulation was ... creatine kinase reactions, including mitochondrial creatine kinase [3840] Increase of the free calcium concentration to lm resulted in some decrease of the Vmax, but its value stayed higher in...
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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx
... the increased rate of 13C label incorporation into the C6 position of glycogen in the ADM group is indicative of activated 6-phosphofructo-1-kinase, which can lead to increased 13C labeling at ... start of glucose infusion For the calculation of glycogen C6 changes, data acquired within h of the start of the glucose infusion was not included to avoid any in uence of transient changes in the ... up -regulation of glucokinase and a down -regulation of glucose-6-phosphatase gene expression, suggesting that this biofactor may also be involved in balancing the uptake and release of glucose from...
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Báo cáo sinh học: "Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets" doc
... biology, in view of proteomic experiments demonstrating that a single miRNA can directly repress the production of hundreds of proteins in mammalian cells, through both downregulation of mRNA ... Switzerland 2Department of Immunology, Page of National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan Laboratory of Experimental Hematology, Bordet Institute, University of Brussels (ULB) ... (group A) is in agreement with previous cloning studies in mouse CD8+ lymphocytes [15,18] showing that a few highly expressed microRNAs prevailed in frequency Interestingly, these microRNAs include...
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báo cáo hóa học: " On the potential role of glutamate transport in mental fatigue" ppt
... is indispensable for information intake and processing within the central nervous system Glutamate neurotransmission is crucial in information intake and information processing within the brain ... expression of glutamate transporters [47] thus creating a substrate for a fine-tuning of the glutamate neurotransmission Even the proinflammatory cytokine IL-1β could act as a regulator of glutamate ... brain capacity for information processing and, as a consequence, information intake One way to diminish information intake and processing at the cellular level would be to impair glutamate neurotransmission...
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báo cáo hóa học:" Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets" pptx
... biology, in view of proteomic experiments demonstrating that a single miRNA can directly repress the production of hundreds of proteins in mammalian cells, through both downregulation of mRNA ... Switzerland 2Department of Immunology, Page of National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan Laboratory of Experimental Hematology, Bordet Institute, University of Brussels (ULB) ... (group A) is in agreement with previous cloning studies in mouse CD8+ lymphocytes [15,18] showing that a few highly expressed microRNAs prevailed in frequency Interestingly, these microRNAs include...
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Báo cáo sinh học: "Multilevel regulation of growth rate in yeast revealed using systems biology" pptx
... 2-oxoglutarate and glutamine did not change, and there was a decrease in levels of glutamate Instead, there was a corresponding trend in the increase in the transcript and protein levels of the mitochondrial ... gain insights into the importance of mitochondrial energy and nitrogen metabolism in affecting growth rates These insights were possible only by integrating information from transcripts, protein ... abrupt changes in the levels of some yeast transcripts, with increases in expression of key genes involved in glucose transport and vesicle transport and repression of those involved in ethanol metabolism...
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Báo cáo y học: "Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross-sectional study" pps
... or definite osteophytes with moderate joint space narrowing; IV, severe with large osteophytes and definite joint space narrowing bScoring was as follows: +/-, minimum staining in one area of the ... tissue; +, patchy staining involving several areas; ++, moderate diffuse staining OST, osteotomy; SYV, synovectomy; TA, total joint arthroplasty Of the cytokines examined in our study, C-PTHrP ... independently of OA Further studies including the incidence of HTLV-I-modulated primary OA in seropositive patients, in addition to longitudinal studies, are required to enhance our understanding of the...
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Báo cáo khoa học: "Intraabdominal and retroperitoneal soft-tissue sarcomas - outcome of surgical treatment in primary and recurrent tumors" potx
... substantially in the planning of the study and the collection of data as well as in the interpretation of the data OSS contributed substantially in the analysis and interpretation of the data All ... within 30 days of surgery and serious complications were also very rare In primary sarcomas, resection of adjacent organs was necessary in 48%, which is in the same order of magnitude as in other ... advances in understanding of their biology Hum Pathol 1999, 30(10):1213-1220 Kindblom LG, Remotti HE, Aldenborg F, Meis-Kindblom JM: Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal...
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Báo cáo y học: "Increased levels of circulating microparticles in primary Sjögren''''s syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity" pdf
... layer of the bilayer membrane of MPs contains aminophospholipids, mainly anionic phosphatidylserine (PS), which is procoagulant and detectable by its binding to annexin V MPs also contain protein ... B, Martin T, Bischoff P, Lill H, Pasquali JL, Freyssinet JM: The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection J Clin Invest 1997, ... explain these discordant findings First, the decreased plasma level of MPs could be a result of consumption or confinement of MPs by adhesion in the tissue target of the AID such as the synovium in...
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Transcriptional regulation of protein complexes in yeast potx
... complexes in yeast: mining large scale protein-protein interaction screens Bioinformatics 2003, 19:1901-1908 Manke T, Bringas R, Vingron M: Correlating protein-DNA and protein-protein interaction ... Prediction of cis-acting regulatory elements in genes of multiprotein complexes comment Figure (see previous page) Detailed2view of the main clusters in the network linking annotated protein complexes ... 'core' of the binding site, and the number in brackets is the length of the spacer in terms of the number of intervening nucleotides The feature map shows that each upstream sequence contains at...
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báo cáo khoa học: " Salivary a-amylase exhibits antiproliferative effects in primary cell cultures of rat mammary epithelial cells and human breast cancer cells" docx
... between blind- and non-blind-performed investigations a-Amylase treatment in human mammary epithelial cells The effect of a-amylase in mammary cells of human origin was studied in primary HBCEC ... findings presented here indicate for the first time that a-amylase plays a role in the regulation of mammary cell proliferation However, the underlying mechanisms and the influencing factors of ... Dervan PA: Primary acinic cell carcinoma of the breast J Clin Pathol 2005, 55:545-547 Tanahashi C, Yasuki S, Akamine N, Yatabe Y, Ichihara S: Pure acinic cell carcinoma of the breast in an 80-year-old...
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báo cáo khoa học: "Transcriptome analysis by GeneTrail revealed regulation of functional categories in response to alterations of iron homeostasis in Arabidopsis thaliana" pdf
... successfully applied for data mining The main strength of GeneTrail was that it offered answers to individual biological questions with its feature of incorporation of individually defined categories (such ... strength of microarray interpretation lies in the possibility of extracting information beyond the single gene level to address questions on the co -regulation of genes, on the identification of gene ... category was found induced in comparisons of - Fe vs + Fe (in wild type and in nas4x1) and in nas4x-1 vs wild type at + Fe, indicating that biotic stress responses were generally induced by Fe deficiency...
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báo cáo khoa học:" The well-being and treatment satisfaction of diabetic patients in primary care" doc
... positive well-being However, this finding should not be generalized as the number of patients administering insulin therapy was very few in our study Patients with a diabetes period of less than ... Prize in Family Medicine" given by the Association of Education and Research in Family Medicine in 2009 Author Details Cukurova University Faculty of Medicine Department of Family Medicine, Adana, ... low number of patients using insulin It was interesting that hypoglycemia and hyperglycemia perceptions were not significantly related to the type of treatment Finally, there was an inverse correlation...
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Báo cáo y học: " Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium" doc
... proteincontaining supernatant was collected The protein concentrations were assessed using a bicinchoninic acid (BCA) protein concentration kit (Pierce, Rockford, IL) Equal concentration of protein ... subtracted using MetaMorph image analysis software (Universal Imaging, Downingtown, PA) MUC5AC Staining For MUC5AC staining in large airway and small airway epithelium, brush cells cytospin slides ... Ly6/neurotoxin (Lynx1), the founding member of a family of mammalian prototoxins, modulates nicotinic acetylcholine receptors in vitro by altering agonist sensitivity and desensitization kinetics...
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Báo cáo y học: " Differential regulation of neurotrophin expression in human bronchial smooth muscle cells" pptx
... h of culture (not shown) Effects of IL-1β on neurotrophin mRNA and protein expression We next investigated the ability of the proinflammatory cytokine IL-1β to induce neurotrophin expression in ... involvement of COX in the induction of BDNF but not of NGF To test this, we evaluated the effects of the COXinhibitors indomethacin and NS-398 (both 10 µM) on the secretion of these two neurotrophins ... mediators in BDNF induction Our finding that secretion of BDNF, but not NGF, was inhibited by the unselective COX inhibitor indomethacin and the COX-2 inhibitor NS-398 imply the prostaglandins as...
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Báo cáo y học: "Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cell" potx
... chemokines that bind to CCR7 The main aim of this study was to fully define the post-integration blocks to virus replication in this model of CCL19-induced HIV latency -2- Results High levels of integrated ... patients on cART, including a block in initiation and completion of HIV transcription as well as a block in translation of viral proteins by the expression of microRNAs (reviewed in [21]] In addition, ... Ki67 staining and dilution of carboxyfluorosceinsuccinate (CFSE) (data not shown) The exact mechanism of action of IL-7 in our CCL19-induced model of latency remains unclear TNFα resulted in quite...
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Báo cáo y học: "beta-estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL" pdf
... Zidovudine (AZT) synergistically inhibited HIV-1 replication in primary placental macrophages, possibly explaining why AZT can inhibit maternal fetal transmission in the absence of diminution of ... 33% of virus alone (VA, Table 1) In of the experiments summarized in Tables &2, virus levels in the presence of nM β-estradiol in combination with 50 nM D4T were higher than in the presence of ... HIV-1 replication in the presence of D4T to 74% (of VA, SE = 5.4), for a difference of 41% (of VA) To determine how the observed inhibition of drug efficacy translates into increased drug levels...
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