Construction of nerve growth factor loop 4 containing polypeptides for facilitated gene transfer to neurons

... Construction of Nerve Growth Factor Loop 4- Containing Polypeptides for Facilitated Gene Transfer to Neurons Jieming Zeng (MSc, MB) A THESIS SUMMITED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... success of gene therapy for neurological disorders In this study, chimeric polypeptides were constructed for targeted gene transfer to cells expressing...

Ngày tải lên: 16/09/2015, 17:13

... postoperative day to day Vessels were first noted on postoperative day As progressed, the Angiogenesis effects of nerve growth factor (NGF) on rat corneas 129 Fig Appearance of angiogenesis on day ... 1.0 ng of NGF group (Group 1.0), and the 5.0 ng of NGF group (Group 5.0) Data analysis The significant differences between groups were Angiogenesis effects o...

Ngày tải lên: 07/08/2014, 15:20

... Immunohistochemical Localization of Nerve Growth Factor, Glial Fibrillary Acidic Protein and Ciliary Neurotrophic Factor in Mesencephalon, Rhombencephalon, and Spinal Cord of Developing Mongolian Gerbil ... Immunohistochemical Localization of Nerve Growth Factor, Glial Fibrillary Acidic Protein and Ciliary Neurotrophic Factor in...

Ngày tải lên: 07/08/2014, 15:20

... demonstrated that VEGF1 65 induced transient activation of ERK1/2 and Akt after In contrast, NGF produced a stronger and persistent phosphorylation of ERK1/2 and Akt than VEGF1 65 much more pronounced ... Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells Comparison of the effects of...

Ngày tải lên: 11/08/2014, 08:20

... to in uence the in ammatory and proliferative cascades of PsA and RA Abbreviations ELISA, enzyme-linked immunosorbent assay; FLS, fibroblast-like synoviocyte; NGF, nerve growth factor; NGF-R, nerve ... expression in rheumatoid arthritis and spondyloarthritis Arthritis Res Ther 2009, 11:R82 Raychaudhuri SP, Raychaudhuri SK: The regulatory role of nerve growth factor...

Ngày tải lên: 12/08/2014, 14:21

... activation of the Smad pathway independently of the TGF-b ligand Fig PC12 cells express low levels of endogenous TbRII (A) C-terminal phosphorylation of Smad2 was investigated in either parental PC12 cells ... Smad activation occurs independently from phosphorylation at the C-terminal SSXS-motif Involvement of Smad4 in NGF-triggered activation of t...

Ngày tải lên: 16/03/2014, 16:20

... in the human brain after fatal head injury J Neurotrauma 2002, 19:279-84 Macdonald NJ, Taglialatela G: Tumor necrosis factor alpha and nerve growth factor synergistically induce iNOS in pheochromocytoma ... Cuzzocrea S: Inhibition of the nuclear factor- kappaB activation with pyrrolidine dithiocarbamate attenuating inflammation and oxidative stress after experimental spin...

Ngày tải lên: 19/06/2014, 22:20

... of PC-12 cells strongly induces MMP-10 gene expression We have previously identified the expression of the neurotrophin NGF and the pain-associated neuropeptide substance P in the human IVD and ... to increased nociception in painful IVD degeneration Page of (page number not for citation purposes) The aim of the current study was to examine the gene...

Ngày tải lên: 09/08/2014, 14:22

... there could be a link between EGF-induced reduction in Bid and tBid levels and the ubiquitin ligase activity of Itch In this study, we first examined the ability of Itch to interact with Bid and ... proteins Bim and Bak and the C-terminal fragment of Bid The ubiquitin ligases responsible for the ubiquitylation are in most cases not known [44] Her...

Ngày tải lên: 16/02/2014, 09:20

... system may be one of the mechanisms responsible for drug -induced apoptosis in a variety of JNK activation is critical for AG1478 -induced apoptosis cancer cells of different histotype [51] Chang ... RA & Davis RJ (2000) Requirement of JNK for stress -induced activation of the cytochrome c-mediated death pathway Science 288, 870–874 JNK activation is...

Ngày tải lên: 18/02/2014, 13:20

... remodeling has been investigated thoroughly in fibroblasts such as H-ras transformed NIH3T3 fibroblasts, mouse embryo fibroblasts and Swiss3T3 fibroblasts [145–148] In fibroblasts transformed by inducible expression ... review of < /b> the specific and integrated roles of < /b> small GTPases in the control < /b> and execution of < /b> the TGFb signaling pathway Interconnection between TGF...

Ngày tải lên: 07/03/2014, 01:20

... S, Sakiyama O, Takahashi K, Miyazaki H, Hashimoto S & Daikuhara Y (1988) Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure ... Hepsin activates pro -hepatocyte growth factor and is inhibited by hepatocyte growth factor Hepatocyte growth factor activator 19 20 21 22 23 24 25 26 27 28 29 30...

Ngày tải lên: 15/03/2014, 11:20

... signal after 120 of incubation The strong loss of function and loss of integrity observed after 60 of incubation agree with the almost complete inhibition of mitogenic activity of FGF (Fig 1B) ... parallels the functional impairment of FGF-2 in the presence of different time points of thrombin incubation Structural impairment is expressed as time-dependent decrease of...

Ngày tải lên: 16/03/2014, 01:20

... GEM To gain insight into the mechanisms involved in EGFr modulation by gangliosides (particularly GD3), we investigated the distribution of human EGFr in the plasma membrane of CHO-K1 cells that ... or intracellular domains of the receptor GD3 was mainly detected in the plasma membrane, showing a distribution in patches, while EGFr was observed both in plasma membra...

Ngày tải lên: 16/03/2014, 16:20

... (1993) Activation of the zymogen of hepatocyte growth factor activator by thrombin J Biol Chem 268, 22927–22932 11 Miyazawa K, Shimomura T & Kitamura N (1996) Activation of hepatocyte growth factor ... analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor J Biol Chem 268, 10024–10028 Lee SL, Dickson RB...

Ngày tải lên: 23/03/2014, 07:20