regulation of transforming growth factorβ1driven lung fibrosis by galectin3
Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
... an in vitro measure of the in vivo efficiency of TGF-β1 activationTo examine the ability of SLE patients and control individualsto activate TGF-β1, a ratio of levels of TGF-β1 in freshly ... development of earlyatherosclerosis.Introduction Transforming growth factor (TGF)-β1 is the most potent natu-rally occurring immunosuppressant [1]; it is produced by allcells of the immune ... proliferation and the fate of cells through apoptosis.In TGF-β1 knockout mice [2] lack of TGF-β1 initiates indiscrim-inate loss of self-tolerant T cells. Consequential dysregulation of B cell activity...
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Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot
... go to only one of thetwo daughter cells, leaving the other relatively clear of such signaling byproducts. A deeper understanding of the role of microtubules in the regulation of Smadtrafficking ... localization of transforming growth factor-beta in idiopathic pulmonary fibrosis. Am J Respir CellMol Biol 5, 155–162.153 Broekelmann TJ, Limper AH, Colby TV & McDonaldJA (1991) Transforming growth ... characterized by thedissolution of epithelial cell–cell junctions and reorga-nization of the actin cytoskeleton with the formation of focal adhesions and stress fibers, acquisition of aspindle-shaped...
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Báo cáo khoa học: Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases docx
... concentration of 1 mm, and this was followed by theaddition of 100 ng of each KLK. The final volume of eachmixture was 150 lL. The enzymatic activity was monitored by the release of p-nitroaniline ... Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Japan2 Department of Urology, Faculty of Medicine, University of Miyazaki, ... surface of various epithelial cells andFig. 4. Analysis of cleavage sites of pro-HGFA by KLKs. (A) Time-dependent cleavage patterns of pro-HGFA (52 nM) were analyzed by usingthree kinds of antibody...
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báo cáo hóa học:" Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?" pot
... activation of mesenchymal HSCs. Thisinterpretation is strengthened by the findings of a negativecorrelation of serum TGF-β1 with fibrosis score, feature of stable collagen deposition, and by a good ... biopsy-proven diagnosis.Measurements: Serum concentrations of transforming growth factor-beta1 and ferritin.Results: High concentrations of transforming growth factor-beta1 were noticed in patients suffering ... Medical School of Naples, Department of Biochemistry and Medical Biotechnology, Naples, Italy and 4Federico II University Medical School of Naples, Department of Neurosciences, Section of Clinical...
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Báo cáo y học: "Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees" potx
... Robbins11Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA2Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, ... clinicalapplications of transforming growth factor-beta (TGF-beta). Growth Factors 1993, 8:1-9.3. Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB: Transforming growth factor-beta in ... sequence analysis of simian transforming growth factor-beta cDNA. DNA 1987, 6:239-244.5. Miller DA, Pelton RW, Derynck R, Moses HL: Transforming growth factor-beta. A family of growth regulatory peptides.Ann...
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Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf
... lg of pcDL-SRa296JNK2(VPF) or pcMKP-1 and 1.5 lg of pBabePuro by using the Lipofectamine reagent, and the transfected cellswere selected by exposure to 2.5 mg of puromycin (Sigma)per mL of ... Department of Genome Biology, Kinki University School of Medicine, Osaka, JapanEpidermal growth factor receptor (EGFR), a member of the ErbB family, is important in the regulation of growth, differentiation ... level of MKP-2 was not affected by AG1478 treatment,indicating that the expression of MKP-1, but not that of MKP-2, is controlled by signals via EGFRs.Brondello et al. reported that activation of...
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Báo cáo khoa học: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1⁄TSC2 in C2C12 myotubes pptx
... of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USAKeywordsmTOR; rapamycin; TSC1; TSC2; wortmanninCorrespondenceK. A. Esser, Department of Physiology,College of ... influences mTOR signaling by regulation of the protein complex of tuberous sclerosiscomplex (TSC)1 ⁄ TSC2 [9–12]. The TSC1 ⁄ TSC2 pro-tein complex is a heterodimer composed of the TSC1and TSC2 ... it is clear that growth factor-induced activation of Akt blocks TSC1 ⁄ TSC2 inhibi-tion of mTOR signaling [9–11], the molecular mecha-nism by which Akt inhibits the function of TSC1 ⁄ TSC2 protein...
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Báo cáo khoa học: Fragile X-related protein FXR1 controls posttranscriptional suppression of lipopolysaccharide-induced tumour necrosis factor-a production by transforming growth factor-b1 doc
... anti-inflammatorycytokine transforming growth factor-b1 (TGF-b1) of the proinflammatory cytokine TNF-a via the induction of FXR1 is the focus of this article.TGF-b1, a member of the large transforming growth factor-b ... expression of several other proinflammatoryproteins was also affected by FXR1 deficiency, but thecytokines involved in the induction of FXR1 remain un-characterized. The regulation by the anti-inflammatorycytokine ... also dem-onstrate that this process is regulated by TGF-b1.Induction of FXR1 expression by TGF-b1 leads topost-transcriptional downregulation of TNF-aproteinMany RNA-binding proteins, such...
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Báo cáo y học: Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor-b ppt
... its down -regulation by TGF-b1.DISCUSSIONThe inhibition by TGF-b1 of SeP expression is to date theonly known regulation of this protein by a factor other thanthe availability of selenium. ... Cell-specific regulation of human arylhydrocarbonreceptor expression by transforming growth factor-b1. Mol.Pharmacol. 59, 716 724.22. Doăhr, O. & Abel, J. (1997) Transforming growth factor-beta ... point-mutation of putative SBEs led to a loss of promoter sensitivity towardsTGF-b1treatment. Hence, we demonstrated an involvement of Smad 3 and 4 in transcriptional regulation of SeP by TGF-b1and...
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Báo cáo hóa học: " The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs)" pdf
... key role in the growth and development of nor-mal tissue. However, aberrations of this molecular path-way such as overexpression of IGF1R, elevated plasmalevels of IGF1, loss of IGF2 imprinting, ... suchas receptor upregulation or overexpression of l igandsdriven by multiple mechanisms like fusion genes(PAX3-FKHR; EWS-WT1; EWS-FLI1), loss of imprint-ing (LOI) of IGF2, or loss of tumor suppressor ... al. Journal of Translational Medicine 2010, 8:117http://www.translational-medicine.com/content/8/1/117Page 2 of 6 COMM E N T ARY Open AccessThe emerging role of insulin-like growth factor1...
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báo cáo hóa học: " Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised" potx
... obstruction of CSF clearance by meningeal fibrosis [34,35]. Other examples exist of hydrocephalus caused by growth factor-induced fibrosis [36]. The site and mechanism of action of pioglitazone ... degradation of Aβ42. Alsoibuprofen has been shown to reduce plaque-associatedand soluble Aβ42 in mice over-expressing the Swedishmutation of human APP [15,16]. The lack of effect of ibu-profen in ... resolution of injuries by inhib-iting local inflammation, and by stimulating the synthesisand deposition of matrix components leading to thereconstitution of the basal membrane in the final stages of angiogenesis....
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Báo cáo y học: "Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1" doc
... increase of IGF-1 in this trial iscaused by estrogen-mediated reduction of the IL-6/sIL-6Rpathway or by effects on the GH/IGF-1 axis or by a combi-nation of these mechanisms.Administration of IL-1Ra ... to these direct effects on bone cells,the major action of estrogens in vivo is believed to bemostly by indirect actions, regulation of growth factors andcytokines in osteoblasts, which in turn ... one of the key mediators of increased bone loss inpostmenopausal women. Production of this cytokine by mononuclear blood cells increases with age andmenopause [21] and is inhibited in vitro by...
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Báo cáo y học: "Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes" ppt
... act independently of theinhibition of IGF-1-binding to IGFBPs. However, anFigure 5Comparative activity of NBI-31772, a small-molecule inhibitor of the binding of insulin-like growth factor (IGF)-1 ... mutant of IGF-1 with strongly decreased affin-ity for IGFBPs was able to stimulate the synthesis of Figure 4Effect of NBI-31772, a small-molecule inhibitor of the binding of insulin-like growth ... severity of the disease [26]. The molarconcentration of IGFBP-3 in the synovial fluid of OApatients was higher than that of IGF-1, leading to a molarratio of free to bound IGF-1 of less than...
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Báo cáo y học: "Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity" ppsx
... RT, Heydemann A, Izumi T, Reddi AH: Regulation of theexpression of the type-II collagen gene in periosteum-derivedcells by three members of the transforming growth factor-betasuperfamily. J ... tibia.Figure 3Percentage of cells expressing transforming growth factor (TGF)-beta in medial and lateral tibial cartilagePercentage of cells expressing transforming growth factor (TGF)-beta in ... postulate that the lack of responsiveness to TGF-betacounteraction of IL-1 in old mice is due to an overall lack of responsiveness to TGF-beta caused by a down regulation of receptors and/or Smad...
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Báo cáo y học: "Constitutive upregulation of the transforming growth factor-β pathway in rheumatoid arthritis synovial fibroblasts" doc
... levels of activeTGF-β1 have recently been reported in RA synovial fluid inFigure 2mRNA-expression of the transforming growth factor (TGF)-β related genesmRNA-expression of the transforming growth ... downregulated.Upregulation of TGF-β1 and THBS1 mRNA (both positivelycorrelated with clinical markers of disease activity/severity) anddownregulation of TGF-β2 mRNA in RA SFBs were confirmed by qPCR. ... Analy-sis of the oligonucleotide microarray dataCentral components of the transforming growth factor (TGF)-β pathway are shown with their scores, as determined by Gene Set Enrichment Analy-sis of the...
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