Development of novel drug delivery system lipid microemulsion of tributyrin

... Of course, targeted colloidal carriers will be much more effective if they are also sterically stabilized 1.2.2 Samples of Drug Delivery Systems As far as the physical form of drug delivery systems ... characterize the lipid submicroemulsion of tributyrin (tributyrin emulsion) Lipid submicro-emulsion prepared with 1.2% PC-60 (emulsifier) had a particle size of about 2...

Ngày tải lên: 16/09/2015, 08:30

... concentration on the surface of the film and finally ks is the desorption rate constant Substituting known values and by fitting the experimental data with the mathematical model of Eq 1, the h value ... bulk, C10 is the concentration inside the gel, S and V1 are, respectively, the surface and the volume of film, V2 is the volume of the bulk, h is the mas...

Ngày tải lên: 22/06/2014, 00:20

... physician and founder of chemotherapy, developed an organic arsenical, Salvarsan (Arsphenamine), which was effective in treating tuberculosis and syphilis Arsphenamine was the standard therapy for ... (ROS) and depletion of glutathione [Park MJ et al., 2005] Induction of apoptosis through depolarization of mitochondrial membrane, activation of caspase-9, caspase-3 and PARP [...

Ngày tải lên: 11/09/2015, 16:03

... = 100 μm intranasal drug delivery helps in improving the efficacy of drug by assisting in its lung delivery and biodistribution The PLGA- PEGPS341 provides controlled and targeted drug delivery ... drug- delivery therapeutics for CF and other airway diseases like COPD and asthma The nanodrug delivery system here provides controlled and sustained PS-34...

Ngày tải lên: 11/08/2014, 00:22

... 70 2. 2 .2. 3.1.3 Coomassie Blue staining 71 2. 2 .2. 3.1.4 Electroblotting 71 2. 2 .2. 3.1.5 Immunoblotting 71 2. 2 .2. 3 .2 Flow cytometry 72 2 .2. 2.4 Animal work 73 2. 2 .2. 4.1 Mouse strains 73 2. 2 .2. 4 .2 Intranasal ... Bacterial strains 67 2. 2 .2. 1 .2 Culture conditions 68 2. 2 .2. 2 Bacterial transformation 69 2. 2 .2. 2.1 Preparation of electrocompetent cells 6...

Ngày tải lên: 09/09/2015, 08:18

... for transdermal delivery of schizandrol A More specifically, the aims are: Establishing a detailed preformulation and solubility profile of schizandrol A Physicochemical properties of schizandrol ... shengmaisan in rat after oral administration and pharmacokinetic results demonstrated that schizandrol A was rapidly absorbed in blood, rapidly eliminated after h a...

Ngày tải lên: 10/09/2015, 09:03

... Schematic of multifunctional drug delivery system The specific aims of this research include: (1) Development a carrier system for hydrophobic drug delivery for enhanced delivery of anticancer drugs ... DEVELOPMENT OF MULTI- FUNCTIONALIZED CARRIERS FOR DELIVERY OF ANTICANCER DRUG COMBINATIONS DUONG HOANG HANH PHUOC (B Eng., HOCHIMINH UNIVERSITY OF...

Ngày tải lên: 10/09/2015, 09:06

... tolerance of a variety of manufacturing methods Polymeric drug delivery systems under wide investigations are classified according to the mechanism controlling the release of the drug Some of the basic ... give benefits to drug companies by creating new forms of established drugs and offering improved versions of drugs It has been shown that companies developing new dru...

Ngày tải lên: 13/09/2015, 19:46

... development of a non- aqueous gel system intended for topical delivery of moisture-sensitive drugs Both the non- aqueous hydrophilic and lipophilic gel systems were formulated The hydrophilic gels ... Model drug 38 I-D3 Formulation of non- aqueous MH gel 40 I-D3.1 Solvents and gelling agents 42 iii Table of Contents I-D3.1.1 Non- aqueous hydrophilic gel s...

Ngày tải lên: 15/09/2015, 17:10

... overview of the progress made by using different types of promoters and vectors for gene delivery to the CNS 1.1 Current progress in gene therapy Gene therapy, which usually refers to somatic gene therapy, ... by the selection of promoters The gene delivery vector that carries and transfers the gene into the nuclei of target cell is another...

Ngày tải lên: 16/09/2015, 08:30

... chimera genes Our novel adaptation of the Mz separated the activating segment of the RNA from the cleaved segment, such that the activating RNA and cleaved RNA became separate RNA species (i .e. , ... clearance of malaria parasites [Mens et al, 2007], poor sensitivities at low but clinically relevant levels of parasitaemia, and the false negatives of certain strains that epito...

Ngày tải lên: 04/10/2015, 15:52

... for Simulation of Drug Delivery from Microgels 73 5.1 Formulation of mathematical model 73 5.2 Model implementations 77 5.3 Numerical simulations and discussions 79 5.3.1 Identification of physical ... dissertation for simulation of the swelling equilibrium of temperature -sensitive hydrogels with fixed charges 1.2.2 Microgel- based drug delivery system In d...

Ngày tải lên: 26/11/2015, 12:31

... determining the SOFC system performance The detailed designs of each of these components in the INER SOFC system are described in the following subsections 3.1 Flow distributor In general, an SOFC ... 44%) Design of SOFC BOP components The BOP components of a SOFC system account for between 50% and 70% of the total system cost Due to the high operating temper...

Ngày tải lên: 05/09/2013, 16:10

... develop a controller for temperature control inside a room within a desired band of temperatures for comfort The details of the geometry of the room and the HVAC system based on displacement ventilation ... disadvantages of the DMC controller First, the DMC controller is a local controller which can only guarantee the stability of the...

Ngày tải lên: 05/09/2013, 16:11

... of tax proceeds; to create a credit history for the further development of SMEs through the bank sector; to barrier SMEs for their transition to the shady sector of economics Why not a bank? ... adopted Under these rules incidence of taxation was reduced either on non-bank MFIs or on clients using given them loans  Nowadays: Microfinance activity has become more mature The models...

Ngày tải lên: 24/10/2013, 03:15