Jagged notch signaling in zebrafish pronephros development

... process, since it interacts with Jagged2 a and facilitates Jagged2 a internalization In summary, our findings indicate a new function of Notch signaling in cell differentiation within a zebrafish ... and the inner ear, and that of Delta -Notch signaling in neural tissue, the inner ear and the intestine In all these cases, the blockage of Notch signaling leads to a failu...

Ngày tải lên: 14/09/2015, 10:29

... Wnt/ β-catenin Signaling in Zebrafish Fin Regeneration Wnt/ β-catenin Signaling in Mammalian Bone Formation and Fracture Repair Wnt/ β-catenin Pathway as a Therapeutic Target ... et al 2002) Wnt signaling can be divided into two general pathways, the canonical Wnt/ β-catenin signaling pathway and the non-canonical β-catenin independent Wnt signaling pathway The can...

Ngày tải lên: 24/08/2014, 11:36

... Furthermore, we investigated the roles of Wnt ligand genes wnt1 , wnt5 b and wnt1 1 in the early development of the zebrafish swimbladder and revealed the synergetic roles of wnt5 b and wnt1 1 for the ... Expression of Wnt pathway members in the swimbladder during early development 4.2.1 Screening of Wnt signaling genes expressed in...

Ngày tải lên: 11/09/2015, 09:07

... THE ROLE OF CYCLOPS/ NODAL SIGNALING IN ZEBRAFISH EARLY EMBRYOGENESIS TIAN JING (M.Sc.) Wuhan Institute of Virology Chinese Academy of Science A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF ... representation of the TGFβ signaling from cell membrane β to the nucleus The TGFβ ligand initiates signaling by binding to and bringing together type I and type...

Ngày tải lên: 15/09/2015, 17:09

... the hindbrain and its deficiency in morphants is in line with expression of these genes in this part of brain ctrl/brain A gli2b MO/brain B ctrl/trunk D gli2 MO/brain C gli2b MO/trunk E gli2 ... that in Gli2b morphant (data now shown) These results indicated a minor role of both gli2 and gli2b in regulating expression of nkx2.2 in the ventral hindbrain Due to d...

Ngày tải lên: 15/09/2015, 17:10

... containing gli2 genes 101 Results 3 .2 Expression analysis of gli2b in zebrafish 3 .2. 1 Temporal expression of gli2b in zebrafish embryos Temporal expression of gli2b was first compared with that of ... hpf gli2b dorsal smu-/-/48 hpf B gli2b dorsal syu-/-/48 hpf C gli2b dorsal cyclopamine/48 hpf E gli2b WT/48 hpf D gli2b dorsal shh mRNA/48 hpf F Fig 3-10 gli2b expression...

Ngày tải lên: 15/09/2015, 17:10

... affected in mib-/- embryos 11 1 Fig 3 -12 gli2b and Fgf3/8 11 3 Fig 3 -13 Validation of gli2b MO for blocking translation of zebrafish 11 6 gli2b Fig 3 -14 gli2b MO blocks zebrafish gli2b mRNA splicing 11 7 ... Concluding remarks 13 1 13 4 13 6 13 6 13 9 14 3 14 6 14 8 15 7 15 9 16 1 16 3 16 5 16 6 16 7 17 0 Chapter V Conclusion 17 3 Chapter VI References 17 5...

Ngày tải lên: 15/09/2015, 17:10

... Amino acid sequence alignment of Zebrafish, Human, Mouse and Chick ColIXα2 88 Phylogenetic tree of FACIT family comprising of chains of collagen IX, collagen XII, collagen XIV and collagen XIX ... chains of zebrafish type IX collagen and type II collagen alpha in the tail bud during segmentation and post-segmentation period 106 Translation inhibition of col...

Ngày tải lên: 15/09/2015, 22:06

... 28 2. 1 Fish Spawning and Maintenance 28 2. 2 Molecular Biology Techniques 28 2. 2.1 RT-PCR Molecular Cloning 28 2. 2 .2 Polymerase Chain Reaction (PCR) 29 2. 2.3 Agarose Gel Electrophoresis 29 2. 2.4 ... prior finding of possibly interacting proteins of BNIP- 2 led to the formation of research questions: Does the physical interaction of BNIP- 2 with these prote...

Ngày tải lên: 05/10/2015, 19:05

... al.: Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins Journal of Translational Medicine 2011 9:2 Submit your next ... to tumor induced by E6/E7 oncoproteins and human SCLC In particular, the Aryl Hydrocarbon receptor signaling is the predominant pathway dere...

Ngày tải lên: 18/06/2014, 16:20

... Phosphoinositide Pathway 1. 10 Aim of Thesis 6 7 9 10 11 12 13 14 16 16 19 19 19 21 21 26 26 28 28 30 31 32 ii Chapter Materials and Methods 2 .1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 2 .10 2 .11 2 .12 2 .13 ... Hedgehog 1. 3.4 Regulation of Smoothened Activity 1. 4 Activation of Hedgehog protein 1. 5 Comparing Hedgehog Orthologs 1. 5 .1 Patched 1. 5.2 Smoothened...

Ngày tải lên: 10/09/2015, 15:49

... kinesin-like protein of 1363 amino acids was assembled Like Drosophila Cos2 and other members of the kinesin heavy chain (KHC) superfamily of proteins, the N-terminal and C-terminal regions of ... about the mechanism of the pathway The aim of this study focuses on two proteins, Cos2 /Kif7 and Iguana /Dzip1 Drosophila Cos2 plays an important role in Hh signal...

Ngày tải lên: 10/09/2015, 15:49

... def (digestive- organ expansion factor) IS A CRUCIAL GENE FOR THE DEVELOPMENT OF ENDODERM- DERIVED ORGANS IN ZEBRAFISH (Danio rerio) RUAN HUA (M.Sc., Wuhan University, P.R.China) A THESIS SUBMITTED ... before reviewing zebrafish intestine, liver and pancreas organogenesis 1.3.1 Endoderm formation in zebrafish 1.3.1.1 Endoderm formation and...

Ngày tải lên: 11/09/2015, 16:06

... paracrine signaling in liver development The coexpression of hgfa and c- met in pectoral fin, hgfb and c- met in proneprhic duct also indicate their paracrine signaling in the development of these ... Characterizing HGF and its receptor c- met s role in zebrafish development (Manuscript in preparation) v LIST OF FIGURES Fig.1.1 Schematic represent...

Ngày tải lên: 12/09/2015, 08:18

... proteins of RhoA have been discovered, including protein kinases (protein kinase N/protein kinase C-related kinase (PKN/ PRK1), PRK2, citron kinase), non-kinases (Rhophilin, Rhotekin, Kinectin), ... profilin, an actin monomer-binding protein, through their FH domain [Sohn et al 1994] This interaction allows them to bind to the barbed ends of actin filaments, which antagonizes the binding...

Ngày tải lên: 12/09/2015, 08:19