Transcriptional regulation of the inducible costimulator (ICOS) in t cells

... of TCR They are responsible for the initial tyrosine phosphorylation of the receptor, leading to the recruitment of the zeta-associated protein of 70 kD (ZAP-70) tyrosine kinase, as well as the ... controlled during the subsequent phase of Th cell differentiation forms the subject of the second part of the findings Although the role of ICOS in the overall differentiation program of Th cells ... respectively The binding dynamics of these transcription factors coincided with the chromatin accessibility of these regulatory regions in the different Th cells as assessed by histone trimethylation...

Báo cáo khoa học: Involvement of NF-jB subunit p65 and retinoic acid receptors, RARa and RXRa, in transcriptional regulation of the human GnRH II gene pot

... retinoic acid (RA) treatments on GnRH II promoter activity To investigate the in vivo effect of RARa and RXR on the transcriptional regulation of the hGnRH II gene, the expression vector of human ... on the promoter activity of the hGnRH II gene in TE671 and JEG-3 cells In vivo effect of RARa and RXRa with their ligands, ATRA and 9-cisRA, on the promoter activity of the hGnRH II gene in TE671 ... on the GnRH II gene, has also been reported [6] The present study aimed to deﬁne the cis-acting element and investigate the protein factors involved in regulation of the hGnRH II gene in TE61 and...

Báo cáo khoa học: Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene doc

... explaining the regulation of desA expression by binding of DmdR1 to the iron box The same overlapping was found in S pilosus DmdR1 binds to the promoter region of desABCD in both S coelicolor and ... regulation is mediated by binding of the regulatory protein DmdR1 to the iron box located in the promoter region of the desABCD cluster Electrophoretic mobility-shift assays of the desA promoters of ... that iron control of the Regulation of the desferrioxamine gene cluster expression of the des cluster is mediated by the DmdR1 regulator Results Deletion of the desA gene of S coelicolor blocks desferrioxamine...

Báo cáo khoa học: The N-acetylglutamate synthase/N-acetylglutamate kinase metabolon of Saccharomyces cerevisiae allows co-ordinated feedback regulation of the ﬁrst two steps in arginine biosynthesis potx

... F99L kinase, suggests a mechanism of co-ordinated feedback regulation of the synthase and the kinase Arginine feedback inhibition of N-acetylglutamate kinase is altered in the absence of N-acetylglutamate ... expressing the kinase protein) allow growth of the argininedeﬁcient mutant in the absence of arginine On the other hand, plasmids pYK7 and the empty vector pTrc99a (both lacking the yeast kinase ... kinase activity in cell extracts was assayed in the presence of increasing arginine concentrations Figure 5A compares the arginine inhibition curves of the wild-type and F99L mutant kinases The...

báo cáo khoa học: " An R2R3 MYB transcription factor associated with regulation of the anthocyanin biosynthetic pathway in Rosaceae" pptx

... repeats in the DNA-binding domain including R3 MYB (MYB1 R) with one repeat, R2R3 MYB with two repeats, and R 1R2R3 MYB (MYB3 R) with three repeats [15,16] Among these MYB transcription factors, R2R3- MYBs ... dicots and monocots To ascertain if there is an identifiable protein motif specific for anthocyanin- promoting MYBs in the N-terminal R2R3 domain, the isolated rosaceous MYBs and other anthocyanin- promoting ... Figure Analysis of R2R3 DNA binding domains of anthocyanin- promoting MYBs Alignment (A) of three consensus amino-acid sequences from 22 rosaceous MYB1 0s, 38 dicot anthocyanin- promoting MYBs, and the...

Báo cáo khoa học: "Regulation of the erm(C) Gene in Staphylococci from Reservoir with Different Usage of Macrolides" docx

... Regulation of expression of the erm(C) gene Deletions in the regulatory region of erm(C) in staphylococci from animal and human origin were identiﬁed by sequencing PCR amplicons obtained using primers ... for reservoirs with different usage of tylosin This indicates that not only have the usage of tylosin selected for macrolide resistant staphylococci (2) but regulation of expression of the erm(C) ... in a reservoir with no usage of tylosin regulated erm(C) genes was most prevalent (81% in human isolates) When comparing porcine erm(C) positive S hyicus isolates from 1995-98 with isolates from...

TRANSCRIPTIONAL REGULATION OF THE HUMAN ALCOHOL DEHYDROGENASES AND ALCOHOLISM

... Pochareddy TRANSCRIPTIONAL REGULATION OF THE HUMAN ALCOHOL DEHYDROGENASES AND ALCOHOLISM Alcohol dehydrogenase (ADH) genes encode proteins that metabolize ethanol to acetaldehyde Humans have ... Accumulation of the ECM proteins alters the morphology of the liver, leading to the development of fibrotic liver 10 Alternative transcript isoforms and diseases One of the post -transcriptional ... et al., 1987), α- and β-fibrinogen (Courtois et al., 1987), and others (Schrem et al., 2002) Alcohol and the liver In addition to understanding the genetic risk factors of alcoholism, it is also...

Tài liệu Báo cáo khoa học: Identiﬁcation and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebraﬁsh, Danio rerio docx

... seen in the putative T-box DNA-binding domain of t-bet, the STAT protein interaction domain, STAT protein all-alpha domain, STAT protein DNA-binding domain and SH2 domain of stat6, and the zinc-ﬁnger ... implicated in other protein–protein interactions, a STAT protein DNA-binding domain and an SH2 domain, which binds phosphorylated tyrosine residues in the context of a longer peptide motif within a ... expression of these genes within humans and mice, of T-bet within Ginbuna crucian carp [27] and STAT6 in mandarin ﬁsh [28] have shown similar widespread expression In the case of STAT6, highest...

Báo cáo khoa học: Regulation of pyruvate dehydrogenase complex activity in plant cells ppt

... overview of the regulation of pyruvate dehydrogenase complex activity in autotrophic plant cells Distinct regulatory mechanisms control the activity of mtPDC in the light and plPDC in the dark ... parallels that of fatty acid biosynthesis Thus, a unique mechanism for regulating activity of plPDC activity has evolved based Ó FEBS 2003 Regulation of PDC activity in plant cells (Eur J Biochem ... plants, and preliminary promoter analyses have been conducted only for the E3 genes from A thaliana [19] Thus, the increase in our understanding of regulation of PDC activity in plant cells over the...

Báo cáo khoa học: Transient increase of the labile iron pool in HepG2 cells by intravenous iron preparations Brigitte Sturm, Hans Goldenberg and Barbara Scheiber-Mojdehkar doc

... LIP The increase in ferritin by the iron preparations showed a pattern of behavior similar to the increase of the LIP The more iron appeared in the LIP the faster the synthesis of ferritin took ... parenteral iron preparations enter HepG2- cells, add iron to the labile iron pool and that the cells adapt their iron metabolism according to the size of incoming iron by highly increasing ferritin biosynthesis ... initiation of translation of ferritin by an increase in the labile iron pool (LIP) and the subsequent incorporation of labile iron into newly synthesized ferritin, followed by a decrease in the LIP...

Báo cáo y học: " Intracellular assembly and budding of the Murine Leukemia Virus in infected cells" pps

... 76(10):4679-4687 Yuan B, Campbell S, Bacharach E, Rein A, Goff SP: Infectivity of Moloney murine leukemia virus defective in late assembly events is restored by late assembly domains of other retroviruses ... results indicated that intracellular budding of VLPs did occur in intracellular compartments of chronically infected cells Identification of the intracellular VLPs by EM immunolabeling To further ... ways in MLV -infected NIH3T3 cells: the classical budding at the plasma membrane, and the budding into MVB These budding events were both detected in cells expressing only Gag, suggesting the recruitment...

Báo cáo y học: "Modulation of the transcription regulatory program in yeast cells committed to sporulation" ppt

... codes for the negative regulatory subunit of the PKAs, was specifically induced in committed cells (Figure 7b) To gain further insight into the regulation of the PKA pathway, we analyzed the expression ... activating the PKA pathway, but rather by inhibiting it through the induction of BCY1, the gene coding for the negative regulatory unit of the PKAs This inhibition is probably required in order to ... non-fermenting yeast culture results in a rapid increase in the cellular level of cyclic AMP (cAMP, red circle), which binds to the regulatory subunit of PKA, thereby releasing and activating the catalytic...

The NR4A orphan nuclear receptors are target genes of the novel drug c1 in cancer cells and potential mediators of drug induced apoptosis

... Accordingly, the great and urgent need presently is to investigate the role of each of the plenitude of genes and proteins important in the progression of cancer NUCLEAR RECEPTORS The nuclear receptors are ... Tan, Shazib Pervaiz, The NR4A orphan nuclear receptors are target genes of the novel drug C1 in cancer cells and potential mediators of drug induced apoptosis (manuscript under preparation) CONFERENCE ... family of receptors This study characterizes the role of nuclear receptors NR4A1 and NR4A3 in drug C1 mediated apoptosis and has identified the functional relevance of the increase in the transcript...

Expression studies of the proteolytic p10 fragment of the neuronal cdk5 activator in mammalian cells

... different mammalian cells including Cos-7, HEK293, PC12 and Neuro-2a and p10 fusion proteins were overexpressed in these cells The influences of p10 overexpression in these mammalian cells were subsequently ... p10 overexpression study Then, Chapter explores the influence of p10 overexpression on different mammalian kidney cells including Cos-7 and HEK293 Subsequently, Chapter further examines the influence ... implicated in the cytotoxicity in AD brains On the other hand, the expression of p39 is similar to p35 in 18 adult brains Moreover, the proteolytic pathway and cleavage of p39 is also similar to that of...

Expression studies of the proteolytic p10 fragment of the neuronal cdk5 activator in mammalian cells

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