Transcriptional regulation of the inducible costimulator (ICOS) in t cells

... of TCR They are responsible for the initial tyrosine phosphorylation of the receptor, leading to the recruitment of the zeta-associated protein of 70 kD (ZAP-70) tyrosine kinase, as well as the ... controlled during the subsequent phase of Th cell differentiation forms the subject of the second part of the findings Although the role of ICOS in the overa...

Ngày tải lên: 13/09/2015, 19:52

... retinoic acid (RA) treatments on GnRH II promoter activity To investigate the in vivo effect of RARa and RXR on the transcriptional regulation of the hGnRH II gene, the expression vector of human ... on the promoter activity of the hGnRH II gene in TE671 and JEG-3 cells In vivo effect of RARa and RXRa with their ligands, ATRA and 9-...

Ngày tải lên: 16/03/2014, 10:20

... explaining the regulation of desA expression by binding of DmdR1 to the iron box The same overlapping was found in S pilosus DmdR1 binds to the promoter region of desABCD in both S coelicolor and ... regulation is mediated by binding of the regulatory protein DmdR1 to the iron box located in the promoter region of the...

Ngày tải lên: 16/03/2014, 11:20

... F99L kinase, suggests a mechanism of co-ordinated feedback regulation of the synthase and the kinase Arginine feedback inhibition of N-acetylglutamate kinase is altered in the absence of N-acetylglutamate ... expressing the kinase protein) allow growth of the argininedeficient mutant in the absence of arginine On the other hand, plasmids pYK...

Ngày tải lên: 23/03/2014, 21:20

... repeats in the DNA-binding domain including R3 MYB (MYB1 R) with one repeat, R2R3 MYB with two repeats, and R 1R2R3 MYB (MYB3 R) with three repeats [15,16] Among these MYB transcription factors, R2R3- MYBs ... dicots and monocots To ascertain if there is an identifiable protein motif specific for anthocyanin- promoting MYBs in the N-terminal R2R3 domain, the...

Ngày tải lên: 12/08/2014, 03:21

... Regulation of expression of the erm(C) gene Deletions in the regulatory region of erm(C) in staphylococci from animal and human origin were identified by sequencing PCR amplicons obtained using primers ... for reservoirs with different usage of tylosin This indicates that not only have the usage of tylosin selected for macrolide resistant staphylococci (...

Ngày tải lên: 12/08/2014, 15:21

... Pochareddy TRANSCRIPTIONAL REGULATION OF THE HUMAN ALCOHOL DEHYDROGENASES AND ALCOHOLISM Alcohol dehydrogenase (ADH) genes encode proteins that metabolize ethanol to acetaldehyde Humans have ... Accumulation of the ECM proteins alters the morphology of the liver, leading to the development of fibrotic liver 10 Alternative transcript isoforms and diseases On...

Ngày tải lên: 24/08/2014, 12:37

... seen in the putative T-box DNA-binding domain of t-bet, the STAT protein interaction domain, STAT protein all-alpha domain, STAT protein DNA-binding domain and SH2 domain of stat6, and the zinc-finger ... implicated in other protein–protein interactions, a STAT protein DNA-binding domain and an SH2 domain, which binds phosphorylated tyrosine residues in the context...

Ngày tải lên: 16/02/2014, 09:20

... overview of the regulation of pyruvate dehydrogenase complex activity in autotrophic plant cells Distinct regulatory mechanisms control the activity of mtPDC in the light and plPDC in the dark ... parallels that of fatty acid biosynthesis Thus, a unique mechanism for regulating activity of plPDC activity has evolved based Ó FEBS 2003 Regulation of PDC...

Ngày tải lên: 17/03/2014, 09:20

... LIP The increase in ferritin by the iron preparations showed a pattern of behavior similar to the increase of the LIP The more iron appeared in the LIP the faster the synthesis of ferritin took ... parenteral iron preparations enter HepG2- cells, add iron to the labile iron pool and that the cells adapt their iron metabolism accord...

Ngày tải lên: 31/03/2014, 07:20

... 76(10):4679-4687 Yuan B, Campbell S, Bacharach E, Rein A, Goff SP: Infectivity of Moloney murine leukemia virus defective in late assembly events is restored by late assembly domains of other retroviruses ... results indicated that intracellular budding of VLPs did occur in intracellular compartments of chronically infected cells Identification of the intrac...

Ngày tải lên: 13/08/2014, 09:21

... codes for the negative regulatory subunit of the PKAs, was specifically induced in committed cells (Figure 7b) To gain further insight into the regulation of the PKA pathway, we analyzed the expression ... activating the PKA pathway, but rather by inhibiting it through the induction of BCY1, the gene coding for the negative regulatory unit of the PKAs T...

Ngày tải lên: 14/08/2014, 16:21

... Accordingly, the great and urgent need presently is to investigate the role of each of the plenitude of genes and proteins important in the progression of cancer NUCLEAR RECEPTORS The nuclear receptors are ... Tan, Shazib Pervaiz, The NR4A orphan nuclear receptors are target genes of the novel drug C1 in cancer cells and...

Ngày tải lên: 14/09/2015, 14:04

... different mammalian cells including Cos-7, HEK293, PC12 and Neuro-2a and p10 fusion proteins were overexpressed in these cells The influences of p10 overexpression in these mammalian cells were subsequently ... p10 overexpression study Then, Chapter explores the influence of p10 overexpression on different mammalian kidney cells including Cos-7 and HEK293 Sub...

Ngày tải lên: 05/10/2015, 22:32

... different mammalian cells including Cos-7, HEK293, PC12 and Neuro-2a and p10 fusion proteins were overexpressed in these cells The influences of p10 overexpression in these mammalian cells were subsequently ... p10 overexpression study Then, Chapter explores the influence of p10 overexpression on different mammalian kidney cells including Cos-7 and HEK293 Sub...

Ngày tải lên: 06/10/2015, 20:35