Telomere chromosome integrity in breast cancer 2

... (TPP1, TIN2 and hRap1) include those that bind to the telomeric DNA through interaction with the directly interacting proteins TIN2 binds to TRF1 and TRF2 hRap1 binds to TRF2 (Blasco, 20 07) 1.1 .2: ... through its role in maintaining genome integrity, instead of directly inhibiting cell proliferation (Deng, 20 01b; Deng, 20 01a; Deng and Scott, 20 00b; Venkitaraman, 20 02) The role o...

Ngày tải lên: 12/09/2015, 08:16

... All telomeres (mean + SE) Lþ/2 p 532 /2 cLLp 532 /2 LLp 532 /2 cLLp 532 /2 cLþ/2 p 532 /2 cLLp 532 /2 37 .0 + 0.6 22.4 + 0.5 36 .6 + 0.4 33 .8 + 0.4 38 .1 + 0.5 32 .2 + 0 .3 56 .3 + 0.8 34 .3 + 0.6 45 .3 + 0.5 39 .8 ... 42.9 + 0 .3 33. 8 + 0.2 44.5 + 0.5 39 .1 + 0.5 41.6 + 0.6 33 .2 + 0.4 35 .6 + 0.5 32 .3 + 0.4 56.9 + 0.8 38 .4 + 0.5 51.7 + 0.7 44.4 + 0.7 39 .1 + 0.6 37 ....

Ngày tải lên: 12/09/2015, 08:16

... of telomere dysfunction in breast cancer progression 73 3.2.1: Telomere shortening in breast cancer tissues with greater shortening in the higher grades of tumours 73 3.2.2: Telomere shortening ... observed in breast cancer cell lines compared to normal cell lines 76 3.2.3: Telomere shortening associated with increased chromosomal instability 77 3.2.4: Increased ch...

Ngày tải lên: 12/09/2015, 08:16

... DJ: Assessment of methods for tissue-based detection of the HER-2/ neu alteration in human breast cancer: a direct comparison of fluorescence in situ hybridization and immunohistochemistry J Clin ... Hospital and Traditional Chinese Medicine Hospital which are the two main hospitals for the treatment of breast cancer in Guilin city of China The specimens...

Ngày tải lên: 09/08/2014, 04:21

... Cite this article as: Cosar et al.: Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy? Radiation ... DMe Alive DM Death DM Death DM Death DM Death DM Alive Out-come a Lateral, bMedial, cInvasive ductal carcinoma, dInvasive Paget’s disease, eDistance...

Ngày tải lên: 09/08/2014, 09:20

... programmed cell death The induction of apoptosis by PER was confirmed by a significant increase in PARP [poly(ADPribose)polymerase] cleavage, an indicator of activated caspases [33] Finally, Western ... expressed in normal human mammary epithelium and at a reduced level in breast cancer cells leading to an alteration in the cell cycle, cell growth, and cell survival Materials an...

Ngày tải lên: 10/08/2014, 09:20

... 44 2. 1 2. 1.1 2. 1 .2 2.1.3 2. 1.4 Materials Ligand and inhibitors Antibodies Cell-lines Fresh frozen clinical specimens 44 44 44 45 45 2. 2 2. 2.1 2. 2 .2 2 .2. 3 2. 2.4 2. 2.5 2. 2.6 2. 2.7 2. 2.8 2. 2.9 2. 2.10 ... REGULATION OF PP2A BY HER- 2/ neu 77 4.1 77 Overview 4 .2 4 .2. 1 4 .2. 2 4 .2. 3 4 .2. 4 Results 80 Inhibition of HER- 2/ neu signalling using AG...

Ngày tải lên: 11/09/2015, 10:06

... damaging and telomeretelomerase effects and hence the mechanism of action of TQ in breast cancer cells In addition, it is of interest to investigate the effects of TQ in normal breast epithelial cells ... Black cumin seeds (left) and chemical structure of thymoquinone (right) 23 Figure 10 Growth inhibitory effects of TQ on breast cancer cells 39...

Ngày tải lên: 30/09/2015, 13:41

... responsible for their operation should take this guidance into account when planning, commissioning and organising services for cancer patients The recommendations in the guidance concentrate on ... organisations is permitted without the express written permission of the Institute Guidance on Cancer Services Improving Outcomes in Breast Cancer Manual Update Conte...

Ngày tải lên: 14/02/2014, 22:20

... Surprisingly, however, the protein synthesis inhibitor cycloheximide did not abolish the induction, which suggested that GPR30 is directly regulated by progestins We were not able to locate any progestin ... expressed in MCF-7 cells relatively late, although in a progestindependent manner, we decided to investigate whether MAPK activation is responsible for GPR30 mRNA regulation by p...

Ngày tải lên: 24/03/2014, 00:21

... www-dep.iarc.fr/globocan/globocan.html] Jarvandi S, Montazeri A, Harirchi I and Kazemnejad A: Beliefs and behaviours of Iranian teachers toward early detection of breast cancer and breast self-examination ... behaviors and contribute to subsequent delayed presentation of breast cancer in Iranian women [22] The study did not demonstrate any association between age and pat...

Ngày tải lên: 28/03/2014, 14:20

... support the hypothesis that BRCA1 enhances TRAIL s ability to mediate apoptosis in breast cancer cell lines Discussion There is increasing interest in the association between hypoxia and BRCA1 ... induce apoptosis in breast cancer cells Therefore, we assessed the requirement for functional BRCA1 in TRAIL- stimulated apoptosis HCC1937 cells have...

Ngày tải lên: 30/03/2014, 03:20