genetics nongenetic factors and gene nutrient interaction in breast cancer

... form vitamin D3 The vitamin D3 formed in the skin is then swept out into the blood stream by the Vitamin D Binding protein (DBP), and -globulin that has a high affinity to vitamin D and its metabolites ... formation of previtamin D3 in the skin is influenced by several factors including UVB absorbing molecules like melanin, DNA, RNA, proteins, and 7-DHC skin content Previtamin D3 then undergoes ... are invited to consult the literature cited in these chapters Chapter Sunlight and skin cancer: recall of essential issues 3.1 The skin cancer burden Increasing incidence of skin cancer starting...

Ngày tải lên: 28/03/2014, 23:20

... India living in Ireland for nine years She was a lacto-vegetarian with no significant past medical history She complained of aches and pains in her pelvic region for the previous four years and ... prevalent in certain groups of the general population, such as in non-Caucasian immigrants living in Western Europe [3] In these patients studies have shown that reduced synthesis of 25-hydroxyvitamin ... features in vitamin D deficiency related myopathy are the proximal distribution, the waddling gait, and pain and discomfort due to muscular effort Both cases demonstrated these findings clinically The...

Ngày tải lên: 11/08/2014, 00:23

... [12-16], breast cancer [17], and testicular cancer [18] Both genes are involved in bone metabolism and development The VDR and the ESR1 genes are interesting because they encode proteins that ... supervised BK and CD, was instrumental in drafting and revising the manuscript, and give final approval for the publishing of this document All the authors have read and approved the final manuscript ... C, Crutchfield M, D'Agostino D, Jannausch M: Bone mineral density and its change in white women: estrogen and vitamin D receptor genes and their interaction J Bone Miner Res 1998, 13:695-705...

Ngày tải lên: 11/08/2014, 08:21

... was defined as participants not included in the low level or high level groups are dominating in fatty fish into the variable "marine fatty acids" AA exists in limited levels in liver, meat and ... be more important in inhibiting the development of several diseases, including cancer, inflammatory and heart diseases [45,46] We find no support for this in our results, since, the effect of ... questionnaires and were enrolled in the study In 2002/2003 a follow-up study was initiated, and women who had responded to the 1991/1992 questionnaire and who were alive and living in Sweden in October...

Ngày tải lên: 11/08/2014, 16:22

... cells, including those in myeloid leukemia, and breast, prostate, colon, skin and brain cancer [4– 8] Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was originally discovered in 1997 ... concentrations of vitamin D and HDAC inhibitors to minimize their toxicities, owing to their remarkable synergistic effects in activating target genes An interesting finding of this study is the ... and apoptosis was evaluated (D) *P < 0.05, **P < 0.01, (n = 3) participated in the VD3-induced apoptosis in gastric cancer cells indicated that vitamin D induced PTEN expression through binding...

Ngày tải lên: 22/03/2014, 21:20

... Powers L, Gerke A, Hunninghake GW: Vitamin D decreases respiratory syncytial virus induction of NF-kappaBlinked chemokines and cytokines in airway epithelium while maintaining the antiviral state ... http://respiratory-research.com/content/12/1/31 96 Leandro AC, Rocha MA, Cardoso CS, Bonecini-Almeida MG: Genetic polymorphisms in vitamin D receptor, vitamin D-binding protein, Tolllike receptor 2, nitric oxide synthase 2, and interferon-gamma ... authors contributed in writing and reviewing the paper All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests Received:...

Ngày tải lên: 12/08/2014, 13:22

... biến loại để trét Phô mai, chế biến thành lát mỏng Phô mai làm từ sữa gạn kem, 2% Bánh pút-đinh (pudding) sữa trứng Sữa chua (yogurt), nguyên chất Sữa chua, có trái đáy hủ Sữa chua đông lạnh, ... nấu chín Đậu tây (navy beans), nấu chín Đậu đen, nấu chín Đậu Ấn (pinto beans), nấu chín Đậu hồi (chick peas), nấu chín Tahini (bơ hạt mè) Hạt hạnh nhân, rang khô Bơ hạnh nhân Tim hạt mè, khô ... có tăng cường thêm chất canxi sinh tố D Sữa đậu nành thường Lá củ cải (turnip greens) Bắp cải Tàu/cải bok choy Đậu bắp Cải bẹ xanh Cải xoăn (kale) Cải bó xôi (Chinese broccoli)/cải (gai lan) Bông...

Ngày tải lên: 20/07/2015, 23:47

... Cancer and vitamin D deficiency (pages & 5) Why are cancer patients at risk for vitamin D deficiency? Why is sufficient vitamin D important for cancer patients? Identifying vitamin D levels Maintaining ... chemotherapy, or the cancer itself Vitamin D deficiency can also cause nonspecific aches and pains in the bones and muscles as well as feelings of weakness Identifying Vitamin D Levels Cancer patients ... between 1,000 and 2,000 IU of vitamin D ― During the spring, summer, and fall months (and year-round if a patient lives in the southern part of the U.S.) combining sensible sun exposure* and daily...

Ngày tải lên: 15/02/2014, 05:20

... vitamin D status including plasma levels of 25(OH)D and vitamin D binding protein (DBP) and their relationship to systemic LL-37 levels in a group of critically ill patients including those with and ... Plasma 25-hydroxyvitamin D, Vitamin D Binding Protein, and LL-37 Concentrations in Critically Ill Subjects With and Without Sepsis and Healthy Subjects Vitamin D status differed in the critically ... Figure jects sepsis, vitamin ill subjects without critically subjects with Plasma criticallyD binding protein insepsis andillhealthy subPlasma vitamin D binding protein in critically ill subjects...

Ngày tải lên: 18/06/2014, 15:20

... according to Declaration of Helsinki principles and Good Clinical Practice The study was a single centre, investigator blinded, within-subject randomised, active- and vehicle-controlled, repeated ... clinical score in a psoriasis plaque test as well as the effect on skin biomarkers, both in the clinical setting and the preclinical psoriasis model Materials and methods Patients and design Twenty-four ... deparaffinized and rehydrated and then incubated in hydrogen peroxide (3%) for to quench endogenous peroxidase (optimal immunohistochemical staining of CD4 required blocking of endogenous HRP after incubation...

Ngày tải lên: 18/06/2014, 15:20

... activity) and impairment of energy availability (with reduction in intracellular phosphate and mitochondrial oxygen consumption) and metabolism (including reduction in creatinine phosphokinase and ... neurons and glial cells [40-74] Experimentally, in animals, vitamin D is involved in neurophysiology and regulates the metabolism of neurotransmitters including dopamine, acetylcholine, serotonin and ... activating a second messenger in the cell - cyclic AMP and/ or diacylglycerol and/ or inositol triphosphate and/ or arachidonic acid - or by activating protein kinase C and the release of calcium into...

Ngày tải lên: 19/06/2014, 08:20

... polymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin D receptor gene J Bone Miner Res 2001; 16: 1256-1264 Sezer S, Tutal E, Bilgic A, et al Possible influence ... important role in increasing the risk of developing periodontitis Our findings suggest an important possibility when interpreting studies on the prevention of periodontitis for a parameter that generally ... smoking modulated gene expression of cytokines in the periodontium, such as interleukin (IL)-6 and IL-10 The association between the Abf haplotype and periodontal disease that we observed was independent...

Ngày tải lên: 08/08/2014, 16:23

... ceased in 1945 [19] and was started again in 1949 Merck AG also sold a combination of vitamin A and vitamin D (that was already on the market in the pre-war years) This combination, mimicking the ... precipitin and hemolysin was enhanced Both conditions intensified active and passive anaphylactic reactions In general, the changes were slightly more marked in hypervitaminosis than in deficiency." ... month with head sweating and craniotabes Rickets showed a seasonal incidence peak with most cases being born in fall Theories of the origin were manifold [10] ranging from genetics, over-nutrition,...

Ngày tải lên: 08/08/2014, 21:20

... same joint in both hands) were affected Our findings suggest that there may indeed be a relationship between the VDR ApaI and TaqI polymorphisms and the risk of symmetrical hand OA in Finnish ... residence as an inclusion criterion (Helsinki or its neighboring cities) for participation in a study concerning work-related factors and individual susceptibility in the etiology of hand OA Of those ... subset of hand OA in women [28,35-37], with three major determinants of the pattern of polyarticular involvement being symmetry, clustering by row, and clustering by ray (in descending order of...

Ngày tải lên: 09/08/2014, 07:20

... experimental process Moreover removing albumin protein would remove albumin-binding proteins in the same time and influence the reproducibility After the protein matching and statistics calculation with ... proteinases and inhibit fibrinolysis by reducing plasmin and kallikrein In inflammatory or injured liver, the increase of A2M inhibit catabolism of matrix proteins and thus cause liver fibrosis ... protein expressions by using western blotting for verifying the protein identification A2M was detected having higher protein expression in F1-F4 stage than in F0 stage (Fig 3A) Moreover, VDBP and...

Ngày tải lên: 10/08/2014, 05:21

... plots surrounding five genes involved in the vitamin D pathway in the SLSJ study Linkage Linkage disequilibrium (LD) plots surrounding five genes involved in the vitamin D pathway in the SLSJ study ... SNPs in the vitamin D pathway genes with asthma and atopy in the SLSJ study Genetic Genetic association of SNPs in the vitamin D pathway genes with asthma and atopy in the SLSJ study Only genes ... testing using the Bonferroni correction In stage two, a full two -gene interaction model, including the two main effects and the interaction term, was tested against the reduced model that includes...

Ngày tải lên: 12/08/2014, 14:20

... Bioinformatics 2004, 5:92 Wjst M: Genetic variants in the vitamin D receptor and childhood asthma BMC Genetics 2005, 6:2 Wjst M, Kruse S, Illig T, Deichmann K: Asthma and IL-4 receptor alpha gene ... genetics 2006: the long and winding road to gene discovery Genes Immun 2006 Ober C, Thompson EE: Rethinking genetic models of asthma: the role of environmental modifiers Curr Opin Immunol 2005, 17:670-678 ... being in HWE) SNPs indicated by ¶ were used to build haplotypes candidate genes was rather subjective, it turned out that some of the tested candidate genes are associated with both allergy and...

Ngày tải lên: 12/08/2014, 16:20

... PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice J Clin Invest 2008, 118:2771-2784 doi:10.1186/cc8894 Cite this article as: Krstić G: Th17 mediators and vitamin D ... response to influenza a virus infections PLoS One 2009, 4:4857 Bouwman JJ, Diepersloot RJ, Visseren FL: Intracellular infections enhance interleukin-6 and plasminogen activator inhibitor production by ... vitamin D in multiple sclerosis Brain 2009, 132:1146-1160 Rodríguez-Rodríguez E, Navia B, López-Sobaler AM, Ortega RM: Vitamin D in overweight/obese women and its relationship with dietetic and...

Ngày tải lên: 13/08/2014, 20:21

Ngày tải lên: 13/08/2014, 20:22