The role of adenosine, adenosine receptors and transporters in the modulation of cell death

... The number of amino acids comprising the extra- and intracellular loops and the extracellular N-terminal and intracellular C-terminal regions of the bovine A1 receptor are indicated in parentheses ... during the adenosine- induced apoptosis in 163 BHK cells Fig 3.70 Activation of caspase during the adenosine- induced apoptosis 165 in BHK cells Fig 3.71 Caspase-...

Ngày tải lên: 11/09/2015, 16:07

... kinases (ERKs), the cJun amino-terminal protein kinases (JNKs) and the p38 kinases MAPKs have been shown to be activated in animal models of reperfusion injury [3-7], suggesting that these kinases ... 3-ethyl5-benzyl-2-methyl-4-phenylethynykyl-6-phenyl-1,4-(±)-dihydropyridine-3,5 dicarboxylate (MRS1191; mg/kg intravenously) Assessment of injury and apoptosis For light micr...

Ngày tải lên: 12/08/2014, 23:23

... Cite this article as: Faria et al.: The NAC domain-containing protein, GmNAC6, is a downstream component of the ER stress- and osmotic stress-induced NRP-mediated cell-death signaling pathway BMC ... statistical analysis of the data and drafted the manuscript MTBR and PABR assisted directly the qRT-PCR assays and the caspase 3-like activit...

Ngày tải lên: 11/08/2014, 11:21

... purposes) Involvement of adenosine in PMN-dependent inflammatory responses has evoked growing interest in studying the role played by adenosine and AR in ALI Adenosine is constitutively released into ... proinflammatory properties of A2B activation in murine bleomycin-induced lung injury [56] These findings underline the complexity of adenosine signaling A2B - with its low a...

Ngày tải lên: 13/08/2014, 11:22

... ROLE OF P73 IN REGULATION OF CELL DEATH: SPECIFIC ROLE IN MITOTIC CELL DEATH AND POTENTIAL REGULATION OF CASPASE- 2s TOH WEN HONG NATIONAL UNIVERSITY OF SINGAPORE 2007 ACKNOWLEDGMENT ... Up -regulation of caspase- 2S in Saos2 p73 inducible cell line and Sh5y stably expressing DNp73β 146 Fig 4.10: ChIP of p73 on 22 bp p73 binding site...

Ngày tải lên: 13/09/2015, 21:21

... Takeno M, Saito N, Yokoe T, Kaneko A, Asai T, Sakane T: Modulation by proinflammatory cytokines of Fas/ Fas ligand- mediated apoptotic cell death of synovial cells in patients with rheumatoid arthritis ... to FasL -induced cell death, and TNF -α prevented these cells from undergoing FasL -induced cell death in a dose-dependent manner No such inhibitory ef...

Ngày tải lên: 09/08/2014, 01:23

... Forskolin up-regulates metastasis-related phenotypes and molecules via protein kinase < /b> B, but not PI-3K, in H7721 human hepato-carcinoma cell line Mol Cell Biochem (in press) 37 Giancotti, F.G & Mainiero, ... value in S-PKB and ASPKB transfected cells, respectively After insulin treatment, PKB activity was almost doubled in the mock and S-PKB/ H7721 cells...

Ngày tải lên: 21/02/2014, 00:20

... responses by death- associated protein kinase Proc Natl Acad Sci USA 106, 1457–1461 Michie AM, McCaig AM, Nakagawa R & Vukovic M (2009) Death- associated protein kinase (DAPK) and signal transduction: ... elegans during starvation Genes Dev 21, 2161–2171 Kang C & Avery L (2009) Death- associated protein kinase (DAPK) and signal transduction: fine-tuning...

Ngày tải lên: 29/03/2014, 08:20

... that loneliness and depression may act synergistically to diminish well being [36] Our study has also shown a moderately high correlation between loneliness and depression, and higher levels of loneliness ... once/month’ (Frequent) Depression was measured using the 21-point Beck Depression Inventory-version II (BDI), and loneliness using the UCLA-8 Loneliness scale (U...

Ngày tải lên: 11/08/2014, 16:22

... normal and cancer cells could be a valuable approach to target cancer cells for cell death One of the glaring differences between normal cells and cancer cells is their difference in telomerase ... overexpressing cells .…………………………………… 126 4.4 hTERT overexpression can protect cells from H2O2 induced cell death .130 4.5 hTERT overexpression can protect cell...

Ngày tải lên: 14/09/2015, 08:38

... difficult to assess in vivo, is involved in these pathways Since adenine is a substrate of ADPRT, the elevation of ATP in the absence of adenosine kinase shows that adenine must be released in the process ... Thus, there 5281 A theoretical study using elementary flux modes S Schuster and D Kenanov Table Elementary modes producing ATP from...

Ngày tải lên: 30/03/2014, 20:20

... Figure of intra-portal injection of (a) ATP and (b) adenosine on changes in hepatic arterial flow (∆ HAF) in vivo The effect The effect of intra-portal injection of (a) ATP and (b) adenosine on ... portal vein and the inferior vena cava of the in vivo rabbit model Figure Diagram of silastic H-shaped prosthesis inserted into the portal vein and...

Ngày tải lên: 13/08/2014, 13:20

... ADENOSINE A1 RECEPTORS IN NATIVE CORONARY ATHEROSCLEROSIS, IN- STENT STENOSIS, AND CORONARY BLOOD FLOW REGULATION IN METABOLIC SYNDROME AND EXERCISE Adenosine is widely thought to elicit coronary ... observed increased A1R in native CAD in MetS, which was reversed by exercise training, and upregulation of A1R expression and A1R-ERK1/2 act...

Ngày tải lên: 24/08/2014, 13:30

... in Role of helix and C-termini in bradykinin receptors receptor signaling because: (a) interruption of the amphipathic structure of B1wt helix in B1wt and B1KB2 through the presence of a serine ... TSIfiAAA N3 38* B1wt B1RB2 B1NB2 B1CB2 B1KB2 B1KB2 ⁄ SfiV B1KB2 ⁄ QGVfiKQ B1KB2 ⁄ VCfiCV B1YB2 B1V323S 10400 5020 52 98 383 2 625 127 511 1701 182 3 17 58 2142 1 786...

Ngày tải lên: 07/03/2014, 16:20

... the cytoplasmic signaling machinery [5] MyD88 was initially identified as part of the interleukin (IL) -1R and IL-18R signalling pathways and was subsequently implicated in signalling by almost ... signaling In addition to TLRs, a variety of other PRRs including the cytoplasmic NLRs and RLRs play important roles in the induction of lung inflammation For example, the cytopl...

Ngày tải lên: 11/08/2014, 03:20