Regulation of antigen presentation in dendritic cells

... also involved in the antigen presentation pathway by modifying cystatin and caspase activities However, direct evidence of NO regulating antigen presentation in DCs is still lacking Addressing ... antigen to CD4+ T cells In turn, the CD4+ T cells stimulate the B cells to grow into plasma B cells that produce antibodies In fact, the antigen presentation by B ce...

Ngày tải lên: 11/09/2015, 16:05

... macrophages therefore play an important role in protecting the host against invading pathogens as the pro-inflammatory cytokines produced would result in the killing and elimination of the invading pathogens ... effective interplay of the both arms in the immune system 1.2 Innate Immunity 1.2.1 Overview of Innate Immunity The innate immunity is known as the fro...

Ngày tải lên: 16/10/2015, 11:59

... disruption of the STAT1 gene in mice revealed a role for STAT1 in the JAK-STAT signaling pathway [40] The JAK-STAT signaling pathway is involved in mediating biologic responses induced by many cytokines ... Post Infection Figure Replication of HSV-1 in macrophages Replication of HSV-1 in macrophages Analyses of virus replication, viral gB mRNA, and...

Ngày tải lên: 12/08/2014, 04:21

... disruption of the STAT1 gene in mice revealed a role for STAT1 in the JAK-STAT signaling pathway [40] The JAK-STAT signaling pathway is involved in mediating biologic responses induced by many cytokines ... Post Infection Figure Replication of HSV-1 in macrophages Replication of HSV-1 in macrophages Analyses of virus replication, viral gB mRNA, and...

Ngày tải lên: 12/08/2014, 04:21

... arrangement of mitochondria in the cells, in the changes in the kinetics of regulation of mitochondrial respiration by exogenous ADP and ATP, and in the direct channelling of endogenous ADP and ATP ... the observed decrease in the apparent Km for exogenous adenine nucleotides in the regulation of respiration of permeabilized bers with intac...

Ngày tải lên: 16/03/2014, 22:20

... KG-1.B27.H114D.D11 6Y Thus in KG-1 dendritic cell-like cells HLA-B*2705 interacts relatively weakly with TAP Induction of HLA-B27 heavy chain- homodimers after dendritic cell stimulation We then determined the ... Conclusion In summary, our data indicate that detectable HLA-B27 heavychain dimer formation may be induced in important cell types such as dendritic cells...

Ngày tải lên: 09/08/2014, 13:21

... before hypoxia to further confirm the mechanism of BSO modulating the Page of expression of HIF-1a by the changes of micro-environment redox status in the cells Intracellular GSH assay After the ... considered the mechanism, the redox status influencing the expression of HIF1a, as following: (i) The biosynthesis of GSH impose a reducing micro-en...

Ngày tải lên: 10/08/2014, 10:21

... Differential induction of inflammatory cytokines by dendritic cells treated with novel TLRagonist and cytokine based cocktails: targeting dendritic cells in autoimmunity Journal of Inflammation ... TIMP1 and DC cocktail screening and validation Potent IL-12p70 and TNFa stimulating cocktails were designed by series of combinations of pro -infla...

Ngày tải lên: 11/08/2014, 06:22

... Cathepsin L Cathepsin J Cathepsin H Cathepsin D/E Cathepsin C Chymotrypsin BLT Esterase Cathepsin A Chymotrypsin BLT Esterase Cathepsin L Cathepsin J Cathepsin H Cathepsin D/E Cathepsin C 20 ... Journal of Immune Based Therapies and Vaccines 2004, 2:8 DCI E-64 100 80 40 20 Cathepsin D/E Cathepsin C Cathepsin A Chymotrypsin BLT Esterase Cathepsin L Cathepsin J Cathepsin H 0 Cathepsin A Cathe...

Ngày tải lên: 11/08/2014, 10:23

... BMDCs, bone marrow-derived dendritic cells; BMCs, bone marrow cells; FLDCs, dendritic cells induced by FL; mDCs, myeloid dendritic cells; FL, FMS-like tyrosine kinase ligand; GM-CSF, granulocyte ... CD3- bone marrow cells; FLDC, dendritic cells induced by FL; FL, FMS-like tyrosine kinase ligand; GMCSF, granulocyte macrophage-colony-stimulating factor; IL-4, interleukin...

Ngày tải lên: 12/08/2014, 12:20

... distribution of CFTR expression in non-epithelial cells and cells of the immune system implies a variety of functions, including a possible regulatory role in the secretion of cytokines and antibodies ... Especially, inflammation related genes were up-regulated upon the P aeruginosa infection in both WT and CF mice, including 27 interferon-stimulated genes Interestin...

Ngày tải lên: 12/08/2014, 14:20

... only after 72 h of culture (not shown) Effects of IL-1β on neurotrophin mRNA and protein expression We next investigated the ability of the proinflammatory cytokine IL-1β to induce neurotrophin ... may provide a framework for differential functional effects of neurotrophins in airway inflammation and asthma, controlled by HBSMC and regulated by inflammatory cytokines Methods...

Ngày tải lên: 12/08/2014, 16:20

... supported by studies demonstrating the involvement of CD8 T cells in the generation of protective CD4 Th1 responses during retroviral infection (Peterson et al., 2002) Importantly, CD8 T cells ... depletion of CD8 T cells abrogated the protective Th1 response induced by DNA vaccination (Gurunathan et al., 2000), suggesting that CD8 T cells were vita...

Ngày tải lên: 09/09/2015, 18:58

... junction barrier integrity (7) Conversely, activation of atypical PKC isoforms using bryostatin instead increased the expression of claudin-1 in the tight junction complex, and increased tight ... cell motility We have previously shown that increasing the levels of CLDN-1 increases the invasion of melanoma cells (4) To determine if the increase in claudin-1 needs...

Ngày tải lên: 03/11/2012, 11:17

... and 3) Translational regulation of iPLA2c in myocardium Owing to the obvious complexity of the regulation of iPLA2c resulting from the combined presence of transcriptional and translational regulation, ... start sites initiating biosynthesis of the 88, 77, 74 and 63 kDa iPLA2c isoforms Instead, based on current information about iPLA2c and its splici...

Ngày tải lên: 19/02/2014, 16:20