The roles of histone deacetylases 1 and 2 in hepatocellular carcinoma

... 17 1. 9 Cooperative and distinct functions of HDAC1 and 18 1. 9 .1 Redundancy of HDAC1 and HDAC2 functions 18 1. 9 .2 Distinct functions of HDAC1 and HDAC2 19 1. 10 Inhibition of ... 20 1. 11 Biological effects and mechanisms of action of HDAC inhibitors 20 1. 11. 1 Apoptosis 20 1. 11. 2 Growth arrest 22 1. 11. 3 Mitotic disruption and autophagy .....

Ngày tải lên: 10/09/2015, 08:27

... study Ann Oncol 2 010 , 21 : 1877 -18 83 Page of doi :10 .11 86 /17 56 -99 66-30 -16 Cite this article as: Pisani et al.: FCR (Fludarabine, Cyclophosphamide, Rituximab) regimen followed by 90 yttrium ibritumomab ... ibritumomab tiuxetan consolidation for the treatment of relapsed grades and follicular lymphoma: a report of cases Journal...

Ngày tải lên: 10/08/2014, 10:21

... ,D( reyal mrofixelp retuo ni deniatsonummi ylesuffid saw 2-niloevaC )worra ,C( noitacol dna ygolohprom ni sllec relluM lacitnedi ,sllec lailg fo ssecorp eht ni dnuof saw gniniatsonummi-2-niloevaC ... dna ,02 -neewT %1.0 gniniatnoc SBT ni semit eerht dehsaw erew stolb ehT 2-niloevac ro ,1-niloevac rehtie tsniaga ydobitna esuom htiw h rof detabucni neht erew senarbmeM h rof )lCaN Mm 051 dna ,4....

Ngày tải lên: 07/08/2014, 18:21

... histidine residues in PETN reductase inferred to be involved in ligand binding and counterpart residues in related enzymes and also the location of the tyrosine residue implicated as proton donor in ... unusual in having two histidine residues (rather than the His-Asn pair seen in OYE, MR and some of the other member proteins; Fig 1B) in the active...

Ngày tải lên: 20/02/2014, 02:21

... ERK signaling pathway by Ó FEBS 20 04 28 29 30 31 32 33 34 35 36 37 38 39 40 41 Role of ERK1 /2 in neuronal survival (Eur J Biochem 2 71) 20 55 fructose -1, 6-bisphosphate during hypoxia involves intracellular ... neuronal survival (Eur J Biochem 2 71) 20 53 Rsk-mediated phosphorylation of Bad Ser 1 12 [29 ] Moreover, in murine brain, TGFb1 protected against isc...

Ngày tải lên: 30/03/2014, 14:20

... overlapping sites Given the large number of potential binding sites in a localized region of 3' UTR, the increased repression of multiple pairs of binding sites can be explained by having more binding ... binding sites available to bind to, which in turn means a greater probability of binding and thus repression In contrast, the reduced repression of a sing...

Ngày tải lên: 14/08/2014, 08:20

... INVESTIGATING THE HOST IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS: THE ROLES OF ANNEXIN A1 PROTEIN AND CLEC9A+ DENDRITIC CELLS KOH HUI QI VANESSA (B Sc (Life Sciences, Hons.), NUS) A THESIS ... variety of immune cells, and the role of CLEC9A+ dendritic cells (DCs), which includes CD103+ migratory DCs in the lung and CD8+ DCs in the...

Ngày tải lên: 09/09/2015, 08:20

... (19 88) The cellbinding domains of plasminogen and their function in plasma J Biol Chem 263, 11 928 11 9 34 24 Thewes T, Constantine K, Byeon IJ & Llinas M (19 90) Ligand interactions with the kringle ... rate of plasmin formation in the absence of mAbs Plasmin-induced cell detachment and apoptosis are impaired by selectively blocking the LBS of plasminogen K1 o...

Ngày tải lên: 20/02/2014, 01:20

... single band on these gels, as the ODN hybridizes to the center of the input target RNA The asterisk indicates the input target RNA; the arrow indicates the digested product bands The amount of ... detected in the cytoplasm 15PC3 cells are the only cells that have RNase H2 protein both in the cytoplasm and the nucleus, as opposed to a strict nuclear...

Ngày tải lên: 08/03/2014, 10:20

... irradiation Afterwards, the reactor reached steady state and the concentration of 4-CBA remained constant At steady state, the effluent concentration of 4-CBA was approximately 64% of the initial ... beneficial This is because the concentration of organic contaminants decreases but that of hydrogen peroxide remains the same, resulting in continually increasing...

Ngày tải lên: 16/03/2014, 00:07

... ACCELERATING TECHNOLOGY TRANSITION Bridging the Valley of Death for Materials and Processes in Defense Systems ————————————————————— Committee on Accelerating Technology Transition National Materials ... CREATING A CULTURE FOR INNOVATION AND RAPID TECHNOLOGY TRANSITION What Is Technology Transition and Why Is It Difficult?, The Culture of...

Ngày tải lên: 28/03/2014, 11:20

... presented They reveal an interesting feature In the last part of the day BST time, from about the closing time of the European exchanges and until the closing time of the New York exchange, volatility ... dummies, is the return in activity after the Tokyo lunch-break and around Interaction between quotations, spread, and volatility in FOREX 383 Fig...

Ngày tải lên: 23/04/2014, 15:52

... Journal of the International AIDS Society 2004, 6:56 http://www.jiasociety.org/content/6/3/56 sharing, and education that must attend expanding global HIV/AIDS care initiatives Authors and ... grants for clinical research and/ or honoraria for educational and/ or advisory activities from Bristol-Myers Squibb, Boehringer Ingelheim, Gilead Sciences, GlaxoSmithKline, Idenix, Merck,...

Ngày tải lên: 20/06/2014, 08:20

... deployment, they were collected in different ways The PDHRA data was collected cross-sectionally in 20056 and enquiry was made about both exposure and PTSD symptoms at the same time The UK data ... statistical power than envisaged as the final response rate was 76% Analysis All statistical analyses were undertaken using the statistical software package STATA (versi...

Ngày tải lên: 11/08/2014, 17:20