... s, and indicate re-oxidation of the flavin and the formation of the hydride-Meisenheimer complex of TNT (C) As for panel B except the spectral changes are recorded over an extended time period and ... proximity of the N5 atom A putative flipping motion of the progesterone molecule along an axis parallel to the FMN plane aligns the C1-C2 with the 4666 plane of the isoalloxazine ring and in close ... confirming that the mutation of Tyr186 to Phe186 does not grossly perturb the overall framework of the enzyme or the active site The active sites of the enzymes are shown in stick format with the sigmaA...
Ngày tải lên: 20/02/2014, 02:21
... between the number of binding sites and the degree of repression [43,44] Together, the observations that both 3' UTR length and number of binding sites affect repression show that the strength of ... determined the number of targets a given miRNA targeted, and assigned the same number of random genes to that miRNA In the case that a miRNA belonged to a family of miRNAs, we assigned the same set of ... Watanabe, and Alex Adai for critical reading of the manuscript, and William Wood for interest and support throughout the project comment To determine the significance of the number of miRNAs...
Ngày tải lên: 14/08/2014, 08:20
INVESTIGATING THE HOST IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS THE ROLES OF ANNEXIN a1 PROTEIN AND CLEC9A+ DENDRITIC CELLS
... assistance regarding use of the flow cytometers, and Benson from the Kemeny Lab for accommodating my requests for animals To the members of the Alonso Lab, past and present (and honorary)— Aakanksha, ... SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF MICROBIOLOGY YONG LOO LIN SCHOOL OF MEDICINE NATIONAL UNIVERSITY OF SINGAPORE 2014 DECLARATION I hereby declare that the thesis is my ... Preparation and culture of BMMΦs 43 2.3.2 Preparation and culture of BMDCs 43 2.3.3 Isolation and culture of primary splenocytes 44 2.3.4 Infection of BMMΦs for quantification of...
Ngày tải lên: 09/09/2015, 08:20
The roles of histone deacetylases 1 and 2 in hepatocellular carcinoma
... HDAC1 and were silenced individually and together, in comparison to the use of HDAC inhibitor PXD101 Together, these results established the critical roles of HDAC1 and in the survival and proliferation ... treatment of cancer, we need to better understand the functions of the HDAC isoforms and their mechanism of actions Numerous studies tried to test the effect of knocking down each individual isoform of ... validate their roles in mediating the effects of HDAC1 and in cell survival and proliferation This study would shed light on the roles of the important members of the HDAC family in HCC, to help in the...
Ngày tải lên: 10/09/2015, 08:27
Tài liệu The Art of Computer Virus Research and Defense pptx
... STRATEGIES OF THE ATTACKER Chapter Introduction to the Games of Nature 1.1 Early Models of SelfReplicating Structures 1.2 Genesis of Computer Viruses 1.3 Automated Replicating Code: The Theory and Definition ... over the network, but did not "infect" objects on the disk Today, it is important to understand all of these major perspectives the file (storage), in-memory, and network views and correlate the ... strategies, anti much more Table of Contents • Index • Szor presents the state -of -the- art in bo full technical detail that professionals attacks Along the way, he provides ex and other emerging techniques,...
Ngày tải lên: 17/02/2014, 15:20
Civilian Workforce Planning in the Department of Defense - Different Levels, Different Roles pptx
... sponsored by the Office of the Secretary of Defense, the Joint Staff, the Unified Combatant Commands, the Department of the Navy, the Marine Corps, the defense agencies, and the defense Intelligence ... Prepared for the Office of the Secretary of Defense Approved for public release; distribution unlimited The research described in this report was prepared for the Office of the Secretary of Defense ... Karen Croom of the Office of the Secretary of Defense, Personnel and Readiness (Program Integration, Requirements Division) We appreciate their support in all aspects of the project, and their valuable...
Ngày tải lên: 06/03/2014, 20:20
Báo cáo khoa học: Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis pptx
... Schematic representation of the roles of the FadD proteins encoded by the DIM + PGL locus in the biosynthesis of DIMs and related compounds in Mycobacterium tuberculosis The role of the activation enzymes ... promote the transfer of the p-HB moiety onto PKS15 ⁄ [16,18] To examine the involvement of FadD29 in the biosynthesis of DIMs and PGLs, we took advantage of the existence in the laboratory of an ... the activation of the various intermediates in DIM and PGL biosynthesis has not been analyzed This study was undertaken to dissect the roles of FadD22, FadD26 and FadD29 in the biosynthesis of...
Ngày tải lên: 15/03/2014, 11:20
The Economics of Small Business Finance: The Roles of Private Equity and Debt Markets in the Financial Growth Cycle potx
... businesses and academics in the nature and behavior of the financial At the core of this issue are questions about the type of financing need and receive at various stages of their growth, the nature of ... implications among these alternative of small business finance is a growing of small business finance For example, the impact of the U.S of the early 1990s and the effect of the consolidation of the banking ... credit, and other sources of funds These data allow for tests of research regarding the cost and availability of different types of external finance and how the cost and availability vary with the...
Ngày tải lên: 15/03/2014, 21:20
Báo cáo khoa học: cGMP and glutathione-conjugate transport in human erythrocytes The roles of the multidrug resistance-associated proteins, MRP1, MRP4 and MRP5 pot
... Uptake of [3H]cGMP in the absence of ATP but in the presence of the nonhydrolysable ATP analogue, ATP-c-S, was less than 5% of the uptake in the presence of ATP The amount of [3H]cGMP taken up by these ... compared using an F-test on the ratio of the variance associated with the reduction in degrees of freedom to the variance of the fit with the smaller number of degrees of freedom [33], VR ¼ ðSSE2 ... to the protein concentration of the membrane vesicles, and all data were corrected for the amount of radiolabelled substrate bound to the filter in the absence of vesicle protein The substrate and...
Ngày tải lên: 23/03/2014, 21:20
ACCELERATING TECHNOLOGY TRANSITION Bridging the Valley of Death for Materials and Processes in Defense Systems potx
... by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of ... members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute acts under the responsibility given to the National Academy of Sciences ... by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the...
Ngày tải lên: 28/03/2014, 11:20
Báo cáo khoa học: Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake potx
... the roles of PrRP in the control of stress responses may depend upon the nature of stressful stimuli used Stressful stimuli affect food intake and increase energy expenditure On the other hand, ... in the brainstem and hypothalamus, and induce neuroendocrine and behavioral responses Food intake also activates the brainstem and hypothalamus, resulting in the termination of meals and the ... Y Takayanagi and T Onaka PrRP and RFRPs in metabolism and stress Table Summary of mammalian RFamide peptides and their receptors The effects of administration of RFamide peptides upon...
Ngày tải lên: 29/03/2014, 21:20
Financial Audit of the Department of Defense A Report to the Governor and the Legislature of the State of Hawaii_part1 pptx
... Organization The adjutant general is the head of the department and the director of civil defense for the State He is the commanding general of the Hawaii National Guard and responsible for Hawaii homeland ... Audit of the Department of Defense A Report to the Governor and the Legislature of the State of Hawaii Conducted by The Auditor State of Hawaii and PricewaterhouseCoopers LLP Submitted by THE AUDITOR ... Office of the Auditor The missions of the Office of the Auditor are assigned by the Hawaii State Constitution (Article VII, Section 10) The primary mission is to conduct post audits of the...
Ngày tải lên: 18/06/2014, 20:20
Financial Audit of the Department of Defense A Report to the Governor and the Legislature of the State of Hawaii_part2 ppt
... as of June 30, 2002, and is reflected as part of the $12 million restatement as of July 1, 2002, in the financial statements, and the recording of depreciation expense thereon of $373,000 in the ... in the salvage values of the assets, the state or local government is the party that uses the assets in its activities and makes the decisions regarding when and how the assets will be used and ... beginning of each fiscal year The screening committee, designated by the head of the purchasing agency, will then evaluate the statements of qualification and other pertinent information of those...
Ngày tải lên: 18/06/2014, 20:20
Financial Audit of the Department of Defense A Report to the Governor and the Legislature of the State of Hawaii_part3 ppt
... presents the results of the financial audit of the Department of Defense as of and for the fiscal year ended June 30, 2003 This chapter includes the independent auditors’ report and the report ... evaluation of all contractors Since the names of the employees on the screening committee and their qualifications and credentials in the area of services required were not properly documented, the ... major fund, and the aggregate remaining fund information of the State of Hawaii that are attributable to the transactions of the department They not purport to, and not, present fairly the financial...
Ngày tải lên: 18/06/2014, 20:20
Financial Audit of the Department of Defense A Report to the Governor and the Legislature of the State of Hawaii_part4 ppt
... department of the State of Hawaii and provides for the safety, welfare, and defense of the people of Hawaii by maintaining readiness to respond in the event of war or disaster Its divisions include the ... Army and Air National Guards, Civil Defense, and Office of Veterans Services The financial statements of the department present the financial position and the changes in financial position of only ... estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the financial statements, and the reported...
Ngày tải lên: 18/06/2014, 20:20
Financial Audit of the Department of Defense A Report to the Governor and the Legislature of the State of Hawaii_part5 doc
... be a “duplicate of benefits,” if the State is allowed to retain the insurance proceeds The insurance proceeds received by the State has been deposited and held in the accounts of the Risk Management ... www.adultpdf.com Response of the Affected Agency Comments on Agency Response We transmitted a draft of this report to the Department of Defense on March 9, 2004 A copy of the transmittal letter to the department ... required to record capital assets and the related accumulated depreciation as part of the implementation of GASB Statement No 34 as of June 30, 2002 The cumulative effect of applying this Statement...
Ngày tải lên: 18/06/2014, 20:20
Financial Audit of the Department of Defense A Report to the Governor and the Legislature of the State of Hawaii_part6 pot
Ngày tải lên: 18/06/2014, 20:20
Financial Audit of the Department of Defense A Report to the Governor and the Legislature of the State of Hawaii_part7 pdf
Ngày tải lên: 18/06/2014, 20:20
Financial Audit of the Department of Defense A Report to the Governor and the Legislature of the State of Hawaii Report No. 04-06 March 2004_part1 pptx
... Organization The adjutant general is the head of the department and the director of civil defense for the State He is the commanding general of the Hawaii National Guard and responsible for Hawaii homeland ... Audit of the Department of Defense A Report to the Governor and the Legislature of the State of Hawaii Conducted by The Auditor State of Hawaii and PricewaterhouseCoopers LLP Submitted by THE AUDITOR ... Office of the Auditor The missions of the Office of the Auditor are assigned by the Hawaii State Constitution (Article VII, Section 10) The primary mission is to conduct post audits of the...
Ngày tải lên: 20/06/2014, 02:20
Financial Audit of the Department of Defense A Report to the Governor and the Legislature of the State of Hawaii Report No. 04-06 March 2004_part2 doc
... as of June 30, 2002, and is reflected as part of the $12 million restatement as of July 1, 2002, in the financial statements, and the recording of depreciation expense thereon of $373,000 in the ... in the salvage values of the assets, the state or local government is the party that uses the assets in its activities and makes the decisions regarding when and how the assets will be used and ... beginning of each fiscal year The screening committee, designated by the head of the purchasing agency, will then evaluate the statements of qualification and other pertinent information of those...
Ngày tải lên: 20/06/2014, 02:20