Homoeostatic regulation of cytokines to retard liver fibrosis 1

... endothelia……… .12 1. 2 FIBROSIS ……………………………………………………………… .13 1. 2 .1 Etiology…………………………………………………………… 15 1. 2.2 Homeostatic Regulation Of Cytokines During Liver Repair/Wound Healing……………………………………………… .16 1. 2.2 .1 ... LIST OF TABLES………………………………………………………………xii LIST OF FIGURES…………………………………………………………….xiii INTRODUCTION 1. 1 LIVER STRUCTURE AND FUNCTION……………………………… .1 1 .1....

Ngày tải lên: 09/09/2015, 10:07

... 2 NOVEL REGULATORY ROLE OF HGF ON TGF-β1 ACTIVATION DURING LIVER FIBROSIS 2. 1 AIMS & OBJECTIVES Liver fibrosis is characterized by crucial changes to important cell types in the liver such ... of fibrous tissue, and disruption of the liver vasculature hindering liver repair High TGF-β1 also causes further apoptosis of hepatocytes, reducing the regeneration potentia...

Ngày tải lên: 09/09/2015, 10:07

... 149.67 ± 247 .33 ± 167.75 ± AST (U/L)   46.67 ± 3. 67 1 23. 5 ± 182 ± 5. 93 14.85 LDH VALH 53. 5 ± 4.09 44 .33 ± 1 .33 VALD 19 .36 4.48 148 ± 1. 63 1 43 ± 8.96 291.5 ± 136 .75 ± 14. 43* ,# 131 .33 ± 82   (kU/L) ... particles demonstrated the ability to control the levels of fibrotic factors in vitro 3. 3 .3 Establishment Of DMN-Induced Liver Fibrosis 0In order to induce liv...

Ngày tải lên: 09/09/2015, 10:07

... and Chandel, N S (2006) Proc Natl Acad Sci U S A 103, 46 04- 4609 111   138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 1 54 155 156 157 158 159 160 161 162   van't Veer, M B., ... 11 34- 1 144 Lim, Y S., and Kim, W R (2008) Clin Liver Dis 12, 733- 746 , vii Kisseleva, T., and Brenner, D A (2007) J Gastroenterol Hepatol 22 Suppl 1, S73-78 107   34 35 36 37 38 39 40 41...

Ngày tải lên: 09/09/2015, 10:07

... inside (Fig 5B) Human hepatocyte specific delivery of EGFP by infection The preS1 peptide displayed on the surface of L particles recognizes the specific receptor present on human hepatocytes and is ... transmembrane region by replacing it with one of the transmembrane-type receptors to limit the topology of the particle to type I Our BNC has the same tis...

Ngày tải lên: 23/03/2014, 15:20

... expression by small RNAs - possible roles of miRNAs in psoriasis An extensive and important group of non-coding RNAs (ncRNAs) appeared with the discovery of miRNAs More than 700 different miRNAs have ... Cite this article as: Bak and Mikkelsen, Regulation of cytokines by small RNAs during skin inflammation Journal of Biomedical Science 2010, 17:53 Page 19 of...

Ngày tải lên: 10/08/2014, 05:21

... I.5 Na+- H+ Exchanger (NHE) The Na+- H+ exchangers (NHEs) are a family of membrane glycoproteins which transport H+ out of the cell in exchange for Na+ with a stoichiometry of 1: 1 In mammalian cells, ... increased 11 2 susceptibility to cell death IV .12 Regulation of intracellular pH as one of the mechanisms of 11 3 NHE- 1 -mediated cell...

Ngày tải lên: 16/09/2015, 08:31

... values TGF-b1 signalling was affected similarly, with no effect by inhibiting PLC-b (Fig 5A), strong down -regulation of collagen I levels after inhibition of PC-PLC (Fig 5B), and similar collagen I ... subunit of Gai [45] was inhibited specifically by U73122 [46] Inhibiting PLC-b by U73122 did not alter ET-1- induced collagen I synthesis, nor did it influence b...

Ngày tải lên: 23/03/2014, 11:20

... in down-regulation of CXCR4 from the cell surface CXCR4 down-regulation may be due in part to intracellular sequestering of HIV glycoprotein/ CXCR4 complexes Methods Cells and virus Cells of ... between a lack of Env expression and expression of CXCR4 in cells of the induced cultures The distribution of CXCR4 on the minor population of induced Jurkat cells (

Ngày tải lên: 20/06/2014, 01:20

... MOLECULAR FUNCTION AND REGULATION OF THE BAX- ASSOCIATING PROTEIN MOAP- 1 Fu Nai Yang INSTITUTE OF MOLECULAR AND CELL BIOLOGY NATIONAL UNIVERSITY OF SINGAPORE 2007 MOLECULAR FUNCTION AND REGULATION ... pore 35 1. 3.3.3 Channel formation 38 ii 1. 4 THE MULTIDOMAIN PRO-APOPTOTIC PROTEIN BAX AND BAK 41 1.4 .1 Bax plays dominant role over Bak 41...

Ngày tải lên: 14/09/2015, 12:54

... deaminase, dTTP regulation occurs by binding of the inhibitor to an allosteric site in competition with the activator dCTP [7] For dCTP deaminase, the mechanism of dTTP regulation is not understood ... in a slow transformation from an inactive to an active enzyme dTTP inhibition may then be achieved by stabilizing the inactive form of pr...

Ngày tải lên: 18/02/2014, 16:20

... preponderant role of p38 in the regulation of gene expression at the level of mRNA stability The p38 MAP kinase is now known to stabilize a wide range of mRNAs including those encoding TNF-a, interferon ... organization of the actin cytoskeleton and the superinduction of the CTGF/ CCN2 gene Rho-like GTPases play a pivotal role in orchestrating changes...

Ngày tải lên: 19/02/2014, 16:20

... raise the possibility that GSK3 may help to coordinate increases in glucose uptake and glycogen synthesis allowing for more effective ÔchannellingÕ of glucose into glycogen in response to insulin ... Effects of insulin, Li and SB-415286 on signalling elements implicated in the regulation of GSK3 and GS To further understand the effects of Li and...

Ngày tải lên: 08/03/2014, 08:20

... Relocalization of RAS from the cytoplasmic to the cytoskeleton fraction could suggest an involvement of RAS during cytoskeleton rearrangement of platelets Our study shows that in platelets RAS is not sufficient ... activation of PKC, does not stimulate activation of ERK in platelets This result indicates that activation of RAS is not suffic...

Ngày tải lên: 08/03/2014, 16:20

... characteristics of the genetically modified food to those of comparable food; • A discussion of “available data” on the allergenic and toxic potential of the modified food; • A description of any applications ... and its products could be the subject of regulatory review This report is intended to provide a general descriptive guide to the current set of...

Ngày tải lên: 13/03/2014, 21:59