Characterization of the molecular mechanisms involved in ethionamide activation in mycobacteria

... implicated in INHR clinical Mtb isolates as well, although their roles in INH resistance remains unascertained in a large proportion of these genes (119) Approximately 10-25% of INHR strains not contain ... isolate Regardless, the numerous handling and in vitro passages of these individual strains in various labs could translate into the acquirement of stable mutations...

Ngày tải lên: 09/09/2015, 08:14

... seen in the putative T-box DNA-binding domain of t-bet, the STAT protein interaction domain, STAT protein all-alpha domain, STAT protein DNA-binding domain and SH2 domain of stat6, and the zinc-finger ... implicated in other protein–protein interactions, a STAT protein DNA-binding domain and an SH2 domain, which binds phosphorylated tyrosine residues in the context...

Ngày tải lên: 16/02/2014, 09:20

... (Dsh) The amino-terminal extracellular Wnt binding domain and the 18 19 carboxy-terminal PDZ-binding domain of the Fz protein are known to be essential for Fz function Deletion of the PDZ-binding ... In this thesis, we use the zebrafish as a model to study the molecular mechanisms behind the specification of embryonic ectoderm Specifically, we attempt to isol...

Ngày tải lên: 16/09/2015, 17:12

... accumulation of citrulline in wild watermelon As a first step to understand the mechanism of citrulline and arginine accumulation in wild watermelon, we focused on the fifth step of citrulline biosynthesis, ... thermotolerance and insensitivity to inhibition by downstream products, citrulline and arginine Results The enzyme involved in catalysis of the fi...

Ngày tải lên: 20/02/2014, 03:20

... structure / w 16 1 ± )4 8 ± )2 0 16 0 )4 8 14 )4 0 ± 11 )9 0 ± 21 )6 4 )4 3 )6 0 13 12 8 ± 12 )6 3 ± 30 )7 0 13 0 )6 0 17 48 ± 68 )1 2 8 ± 93 )1 2 0 45 18 0 51 )4 ± 13 90 58 )2 2 ± 46 )6 2 ± 10 5 )6 3 )4 0 )6 0 10 4 )1 3 5 ... )1 3 5 ± 73 )8 7 )1 7 0 44 )2 3 ± 16 )6 3 )3 5 23 13 5 ± )1 1 0 ± 17 )7 5 1...

Ngày tải lên: 07/03/2014, 05:20

... step and to elute the recombinant enzyme in the elution step were determined in preliminary experiments Fractions were analysed for epoxide hydrolase activity and protein content based on the ... probably corresponding to the histidine and tyrosine residues, respectively [6–8] Several compounds were tested for potential inhibitory effects on the hydrolysis of TSO...

Ngày tải lên: 31/03/2014, 08:20

... This is the first study to examine the binding of DBA, SBA, Isolectin B4, WGA, PNA, and UEA-I in the vomeronasal organ of the horse We found unique characteristics of lectin binding depending cell ... binding; ++, >66% binding Lectin Isolectin B4 WGA ＋ ＋＋ － ＋＋ － － － － － ＋＋ PNA ＋ － － － － UEA-Ⅰ ＋＋ － － － ＋ Histochemical Characterization of the Lec...

Ngày tải lên: 07/08/2014, 17:22

... 15.69% in the alkalinity induced library The relatively lower percentage of 24 nt reads indicates that more kinds of miRNAs are involved in the response of G max to alkalinity compared with other stress ... complete profile of miRNAs in Glycine max Keyword: deep sequencing, Glycine max, microRNAs, stresses associated, miRNA Background Terrestrial plants face...

Ngày tải lên: 11/08/2014, 11:21

... be involved in the induction of apoptosis, including the 7a and 7b proteins [18,46,47] To analyze whether the deletion in ORF 7b had any influence on its Amino acid variability in ORF 7b and ... overexpression of ORF 7a, ORF interferon induction the Influence on apoptosis and type I 7b, and ORF 7b with by Influence on apoptosis and type I interferon indu...

Ngày tải lên: 12/08/2014, 04:20

... apoptosis, including the 7a and 7b proteins [18,46,47] To analyze whether the deletion in ORF 7b had any influence on its Amino acid variability in ORF 7b and RT-PCR analysis of ORF 7b in clinical ... sequences in GenBank (except in an independent sequence of the Frankfurt strain) , and in none of SARSlike bat-CoV sequenced in the ORF 7b region...

Ngày tải lên: 12/08/2014, 04:20

... Northeastern (NE) offshore Song Hong basin Therefore, the topic "Characterization of the Cenozoic petroleum system in the Northeastern offshore Song Hong Basin" was chosen with the objectives and research ... STRUCTURE IN THE NORTHEAST AREA OFFSHORE SONG HONG BASIN 1.1 Overview the geology of study area 1.1.1 Location Study location is par...

Ngày tải lên: 31/12/2014, 08:55

... Biochemical characterization of the bi- lobe complex in Trypanosoma brucei LADAN GHEIRATMAND A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF BIOLOGICAL SCIENCES ... Structural complexity of the bi- lobe 106 4.4 Characterization of bi- lobe associated proteins reveals extensive connection of bi- lobe to other cellular struct...

Ngày tải lên: 10/09/2015, 09:09

... to the 9th cycle from the N-terminus including the initiating Met: MHKTHSTMS for Sno1p and MTGEDFKIKS for Snz1p Properties of the complex of Sno1p and Snz1p When Sno1p with a His-tag and Snz1p ... SNO3, SNZ2 and SNZ3 complement the defect The relationship of all of these genes remains to be clarified Expression and purification of Sno1p and Snz1p In light...

Ngày tải lên: 19/02/2014, 12:20

... this minireview is to summarize what is currently known about the molecular mechanisms of osmotic stress resistance, osmosensing and signal transduction in C elegans Osmosensing and signaling in ... process of interest, allows genes to be ordered into pathways, and can provide important and novel mechanistic insights into the molecular structure and functio...

Ngày tải lên: 30/03/2014, 03:20

... as: Qin and Tian: Exploring the molecular mechanisms underlying the potentiation of exogenous growth hormone on alcoholinduced fatty liver diseases in mice Journal of Translational Medicine 2010 ... mRNA expression HMW adiponectin is the major bioactive isoform of adiponectin, and is responsible for the insulin-sensitizing effects of adiponectin, whil...

Ngày tải lên: 18/06/2014, 16:20