báo cáo khoa học: " LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett’s Esophagus?" ppsx

... expression and cancer stem cell hypothesis: clue to define th e true origin of esophageal adenocarcinomas with and without Barrett’sEsophagus?Journal of Experimental & Clinical Cancer Research ... by a cancer stem cell compartment[8]. The existence of cancer stem cells would explainwhy only a small minority of cancer cells is capable of extensive proliferation within the tumor. Furthermore,these ... line with the clonal selection theo ry. If LgR5 marks stem cells, there are m any of LgR5 negative non -stem cells, which are nevertheless cycling. Therefore a combi-nation of clonal selection and...

báo cáo khoa học: " Is research working for you? validating a tool to examine the capacity of health organizations to use research" pdf

... reflect the govern-ment context would render the tool more applicable inthis sector. The breadth of focus groups across sectors, and the number of them, lend to the credibility of findings. Fur-thermore ... participated in the design and analysis of the study, and led the development of the manuscript. NE partici-pated in the design and analysis of the study, and contrib-uted to the manuscript. ... from the focus groups was that the more useful aspect of the exer-cise was the discussion that took place as a result of the item on the tool, rather than the actual score assigned. The tool...

báo cáo khoa học: " Do patients think cannabis causes schizophrenia? A qualitative study on the causal beliefs of cannabis using patients with schizophrenia" pps

... flashbacks and perturbance of memory) patients had a rather positive view of cannabis and stated to use it to reduce te nsion, to attenuate symp-toms of depression, to blunt the disturbing effects of acoustic ... use and their illness alto-gether. This may be motivated by the fact that theyclearly distinguish between the causation of their illness and an exacerbation of individual symptoms. As the fol-lowing ... anattorney, my older brother is a doctor, and the otheris a philologist. During m y first years of attendingschool, I was successful as well. But then I started to feel a lot of pressure and...

báo cáo khoa học: " Can one puff really make an adolescent addicted to nicotine? A critical review of the literature" potx

... aim to end the sale of singlecigarettes and small packs, and ban the distribution of free samples of tobacco products” (p. 697). The purpose of the present article is to examine the validity of ... “autonomy theory.”According to autonomy theory, the onset of dependencecan be defined as the moment when an individual losesfull autonomy over the use of tobacco. In philosophicalterms, the ... physical and mental “symptoms”In addition to the problems inherited in using a singleitem to assess “loss of autonomy,” there are problems with the validity of the HONC items themselves. The principal...

Báo cáo khoa học: Altered expression of tumor protein D52 regulates apoptosis and migration of prostate cancer cells potx

... in the development of the epithelial cell phenotype [13]. Its expression is controlled by andro-gens in LNCaP cells [9]. The major circulating andro-gen, testosterone, interacts with the androgen ... tumor cells to evade apoptosis is the upregulation of anti-apopto-tic proteins or the downregulation of pro-apoptoticproteins. Human D53L1, another member of the TPD52 family, interacts with ... and -9), and by the loss of mitochondrial membrane potential, cell death occurs due to apopto-sis. The disruption of the mitochondrial membrane potential indicates thatTPD52 acts upstream of...

báo cáo khoa học: " XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate cancer cells" docx

... Time-dependent somatostatin and Octreoti de-induced expression of XAF1 mRNA and protein in LNCaP cell line. Cells werestimulated with 1 nM somatostatin (a and b) and 1 nM Octreotide (c and d) for the time ... dependency and invasive-ness in the development of prostate cancer. The antiproliferati ve effect of somatostatin may resultfrom incr eased apoptosis. In breast cancer cells MCF-7, the cytotoxic ... regulatory effects of somatostatin on XAF1 expression during the development of prostate cancer cells.Methods: XAF1 mRNA and protein expression in human prostate epithelial cells RWPE-1, androgen...

báo cáo khoa học: " Gene expression and hypoxia in breast cancer" doc

... stabilized and is translocated to the nucleus. There, it binds to the subunit HIF-1β and the co-activator p300 and activates the transcription of target genes that are involved in several cellular ... inhibi-tors using high-throughput screens. A better under stand-ing of the HIF activation pathway could inform the choice of therapy, the individualization of treatments and the development of ... xenografts and also that this therapy augments the eﬃcacy of the antiangiogenic agent angiostatin [58]. Nevertheless, the great variability in the level of hypoxia, and hence HIF-1α expression, within...

Tài liệu Báo cáo khoa học: Homologous expression of the nrdF gene of Corynebacterium ammoniagenes strain ATCC 6872 generates a manganese-metallocofactor (R2F) and a stable tyrosyl radical (Y•) involved in ribonucleotide reduction ppt

... the control of the tac-promotor The E. coli ⁄ C. glutamicum shuttle vector, pXMJ19[21], was used for subcloning of the nrdF gene under the control of the hybrid tac promotor. The resulting expression ... after 5 h of incubationin the presence of 0.6 mm IPTG. This amounted to 5% of the total cellular protein as assessed bySDS ⁄ PAGE and immunodetection (see above). The high expression of the nrdF ... this RNR and that of other class 1RNRs or, instead, is a result of the interaction of the R2F with the inactivated (oxidized) form of the R1E.We consider the ﬁrst option unlikely. Under these...

Tài liệu Báo cáo khoa học: Tissue expression and biochemical characterization of human 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, a key enzyme in tryptophan catabolism pptx

... verifyincorporation of the desired modiﬁcation and to ensure the absence of random mutations. The mutagenized plasmidswere transformed into P. pastoris GS115 competent cells and expression was performed ... inﬂuenced by the presence of up to 10 000-fold molar excess of ACMSD II and the sameresult was obtained when detection of ACMSD II wasperformed in the presence of ACMSD I. The expression levels of ACMSD ... and ACMSD II extracellular expression. TricineSDS ⁄ PAGE of the culture ﬁltrates of the best expressing clonesobtained by transformation of P. pastoris GS115 cells with pPIC9-ACMSD I (A) and...

Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx

... levels; at the level of the hepatic cell itself and at the level of the relationship with neighboring cells. At the level of the hepatocyte, CD1d redistribution may inﬂuence quanti-tatively and qualitatively ... loading of the liver epithelial cell line HepG2 inﬂuenced the expression of immune regulatory molecules known to function as ligands of selected subsets of T cells, suchas MHC class I and II, ... FACSCalibur and analyzed using the CELLQUEST software. (A) Histograms show cell surface expression of the transferrin receptor (thick lines) innonpermeabilized cells cultured without and with iron. Thin linesrepresent...

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