báo cáo khoa học: " LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett’s Esophagus?" ppsx

... expression and cancer stem cell hypothesis: clue to define th e true origin of esophageal adenocarcinomas with and without Barrett’sEsophagus?Journal of Experimental & Clinical Cancer Research ... by a cancer stem cell compartment [8]. The existence of cancer stem cells would explain why only a small minority of cancer cells is capab...

Ngày tải lên: 10/08/2014, 10:21

... reflect the govern- ment context would render the tool more applicable in this sector. The breadth of focus groups across sectors, and the number of them, lend to the credibility of findings. Fur- thermore ... participated in the design and analysis of the study, and led the development of the manuscript. NE partici- pated in the design and analysis of...

Ngày tải lên: 11/08/2014, 16:20

... flashbacks and perturbance of memory) patients had a rather positive view of cannabis and stated to use it to reduce te nsion, to attenuate symp- toms of depression, to blunt the disturbing effects of acoustic ... use and their illness alto- gether. This may be motivated by the fact that they clearly distinguish between the causation of their illness and an exa...

Ngày tải lên: 11/08/2014, 18:20

... aim to end the sale of single cigarettes and small packs, and ban the distribution of free samples of tobacco products” (p. 697). The purpose of the present article is to examine the validity of ... “autonomy theory.” According to autonomy theory, the onset of dependence can be defined as the moment when an individual loses full autonomy over the use of...

Ngày tải lên: 11/08/2014, 18:20

... in the development of the epithelial cell phenotype [13]. Its expression is controlled by andro- gens in LNCaP cells [9]. The major circulating andro- gen, testosterone, interacts with the androgen ... tumor cells to evade apoptosis is the upregulation of anti-apopto- tic proteins or the downregulation of pro-apoptotic proteins. Human D53L1, another member of the...

Ngày tải lên: 30/03/2014, 02:20

... Time-dependent somatostatin and Octreoti de-induced expression of XAF1 mRNA and protein in LNCaP cell line. Cells were stimulated with 1 nM somatostatin (a and b) and 1 nM Octreotide (c and d) for the time ... dependency and invasive- ness in the development of prostate cancer. The antiproliferati ve effect of somatostatin may result from incr eased apoptosis. I...

Ngày tải lên: 10/08/2014, 10:20

... stabilized and is translocated to the nucleus. There, it binds to the subunit HIF-1β and the co-activator p300 and activates the transcription of target genes that are involved in several cellular ... inhibi- tors using high-throughput screens. A better under stand- ing of the HIF activation pathway could inform the choice of therapy, the individualization of...

Ngày tải lên: 11/08/2014, 12:21

... the control of the tac-promotor The E. coli ⁄ C. glutamicum shuttle vector, pXMJ19 [21], was used for subcloning of the nrdF gene under the control of the hybrid tac promotor. The resulting expression ... after 5 h of incubation in the presence of 0.6 mm IPTG. This amounted to 5% of the total cellular protein as assessed by SDS ⁄ PAGE and immunodetection (s...

Ngày tải lên: 15/02/2014, 01:20

... verify incorporation of the desired modification and to ensure the absence of random mutations. The mutagenized plasmids were transformed into P. pastoris GS115 competent cells and expression was performed ... influenced by the presence of up to 10 000-fold molar excess of ACMSD II and the same result was obtained when detection of ACMSD II was performed in the...

Ngày tải lên: 19/02/2014, 02:20

... levels; at the level of the hepatic cell itself and at the level of the relationship with neighboring cells. At the level of the hepatocyte, CD1d redistribution may influence quanti- tatively and qualitatively ... loading of the liver epithelial cell line HepG2 influenced the expression of immune regulatory molecules known to function as ligands of sele...

Ngày tải lên: 19/02/2014, 16:20