the cancer stem cell hypothesis
báo cáo khoa học: " LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett’s Esophagus?" ppsx
... According to our hypothesis, that the intestinal stem cell marker LgR5 might also be suited to identify cancer stem cells, these might be the actively cycling Barrett (cancer) stem cells Our findings ... by a cancer stem cell compartment [8] The existence of cancer stem cells would explain why only a small minority of cancer cells is capable of extensive proliferation within the tumor Furthermore, ... 1b), as they stained the well-described putative colon mucosa stem cells, located at the basis of the crypts, or the transit amplifying zone, which are regarded to resemble the stem cell niche...
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báo cáo hóa học:" MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells" ppt
... overexpressed ovarian cancer cells induce the aggressiveness of the cancer cells and enrich the cancer stem cell population It also showed that MUC4 is expressed in the ovarian cancer stem cell population ... in different cancers [1] Few of these markers were used for the confirmation of an MUC4 enriched cancer stem cell population Stem cells and cancer stem cells are known to possess the phenomenal ... (MCF7) cell line [11] The fact that the vast majority of MCF7 stem cell enriched SP cells express MUC1 suggests that epithelial cancer stem cells would also be the targets of various immunotherapy...
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báo cáo hóa học:" Targeting the osteosarcoma cancer stem cell" pot
... and therefore, there is a great need for developing new osteosarcoma treatments The Cancer Stem Cell Hypothesis The cancer stem cell hypothesis proposes that within a heterogeneous tumor there ... stem cell nature [13] Cells of Origin for Osteosarcoma Cancer Stem Cells CSCs have been proposed to arise either from the transformation of normal stem cells to cancerous stem cells or from the ... of cells called cancer stem cells (CSCs)” that are responsible for forming the bulk of the tumor [14-16] They are similar to stem cells and may arise from the transformation of stem cells or the...
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báo cáo hóa học:" Targeting the osteosarcoma cancer stem cell" ppt
... and therefore, there is a great need for developing new osteosarcoma treatments The Cancer Stem Cell Hypothesis The cancer stem cell hypothesis proposes that within a heterogeneous tumor there ... stem cell nature [13] Cells of Origin for Osteosarcoma Cancer Stem Cells CSCs have been proposed to arise either from the transformation of normal stem cells to cancerous stem cells or from the ... of cells called cancer stem cells (CSCs)” that are responsible for forming the bulk of the tumor [14-16] They are similar to stem cells and may arise from the transformation of stem cells or the...
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Báo cáo sinh học: "Cancer stem cell subsets and their relationship" pot
... reported the isolation of a type of precancerous stem cells from dendritic cell- like leukemic mice and the establishment of this precancerous stem cell line The precancerous stem cells had stem cell- like ... distinguish precancerous stem cells from primary cancer stem cells First is the location Precancerous stem cells mainly exist in precancerous lesions, but primary cancer stem cells exist in primary cancer ... primary cancer stem cells initiate from; whether primary cancer stem cells are same in the same type of cancer among different patients; and how to distinguish cancer stem cells from normal stem cells...
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báo cáo hóa học:" Cancer stem cell subsets and their relationships" pot
... reported the isolation of a type of precancerous stem cells from dendritic cell- like leukemic mice and the establishment of this precancerous stem cell line The precancerous stem cells had stem cell- like ... distinguish precancerous stem cells from primary cancer stem cells First is the location Precancerous stem cells mainly exist in precancerous lesions, but primary cancer stem cells exist in primary cancer ... primary cancer stem cells initiate from; whether primary cancer stem cells are same in the same type of cancer among different patients; and how to distinguish cancer stem cells from normal stem cells...
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Báo cáo y học: "Liposarcoma cells with aldefluor and CD133 activity have a cancer stem cell potential" pot
... ALDH and other stem cell markers The extracted xenograft cells were therefore maintained for 10-14 days in either standard RPMI medium containing fetal bovine serum (RPMI) or stem cell medium ... G, Medema JP: Cancer stem cells - old concepts, new insights Cell Death Differ 2008, 15:947-958 Bomken S, Fiser K, Heidenreich O, Vormoor J: Understanding the cancer stem cell Br J Cancer 103:439-445 ... cancer stem cell- defining molecules Mol Cancer Ther 9:2450-2457 43 Todaro M, Alea MP, Di Stefano AB, Cammareri P, Vermeulen L, et al: Colon cancer stem cells dictate tumor growth and resist cell...
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Clinical significance of cancer stem cell markers and other related proteins in colorectal carcinomas biological and methodological considerations
... asymmetric division in stem cells The mutated cancer stem cells then differentiate into other committed cancer daughter cells This cancer daughter cell harbours a combination of other mutations ... examine the prognostic and predictive effects of these cancer stem- cell markers in colorectal cancers Currently, there are limited data to support the clinical relevance of cancer stem cells Taking ... our hypothesis in determining clinical significance of cancer stem- cell marks in colorectal cancer Our main objective is to understand the clinical value of cancer stem- cell markers and their...
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Báo cáo y học: "Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study" pptx
... expression of the cancer stem cell markers in LCNEC over SCLC suggests that the mechanism of increasing the extent of malignancy in LCNEC differs from that in SCLC Previous studies suggested that these ... Abbreviations NSCLC: non-small cell lung carcinoma; LCNEC: large cell neuroendocrine carcinoma; LCC: large cell carcinoma; SCLC: small cell lung carcinoma; CSC: cancer stem cell; LC: liquid chromatography; ... expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells Mol Cancer 2007, 6:75 19 Pfeiffer MJ, Smit FP, Sedelaar JP, Schalken JA: Steroidogenic enzymes and stem cell markers are...
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Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot
... the recruitment of CD26 and CD45 to these rafts [80] and induces T -cell activation DPIV family in cancer and cell biology Fig Features of the effects of DP upon T -cell activation ⁄ function Cell- surface ... endothelial cells, pancreas, liver astrocytes Acts on activated T cells Acts on lymphocytes, dendritic cells, haematopoetic cells LD78b (CCL3 ⁄ L1) Eotaxin (CCL11) Expressed by T cells, B cells ... of testis, and in Purkinje cells and in the granular layer of cerebellum The results of other studies are in agreement with these findings [63–66] The significance of the three DP8 splice variants...
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Commercializing the stem cell sciences pot
... 1.2 Emerging stem cell therapies and the commercialization of biotechnology On the one hand, the stem cell sciences are clearly part of the biotech industry Most obviously, stem cells are biological ... viable products There are a number of similarities in how stem cell science and biotechnology progress On the other hand though, the unique properties of stem cells and the way stem cell products ... influencing the future shape of the stem cell market 1.4.2 The relationship between risk and return The other major factor limiting the potential success of emerging stem cell companies is the relationship...
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university of california press fundamentals of the stem cell debate the scientific religious ethical and political issues dec 2007
... differentiate embryonic stem cells from adult stem cells and point out that many tissues undergo continual replacement from stem cells They note the tremendous therapeutic potential of stem cells in replacing ... structure known as the stem cell niche At least in the hematopoietic (blood cell forming) system, the niche develops independently and the stem cells migrate to and colonize the niche (Schofield ... adult stem cells, although they are sometimes designated more conservatively as progenitor cells They are referred to as adult stem cells to distinguish them from embryonic stem cells, even if they...
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Báo cáo hóa học: " Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke" ppt
... of the class I MHC, mediated by NSC-derived neurotrophins in the lesioned micro-environment of the CNS Materials and methods Culture of Neural stem cells Neural stem cells were harvested from the ... parenchyma near the third ventricle (Figure 4) Migration of the BrdU+ cells along the corpus callosum and the ventricular wall was noted Small clusters of BrdU + cells and BrdU + cells with glial ... for 15 s Quantification of the gene of interest was accomplished by measuring the threshold cycles and comparing them to the standard curve to determine the copy number The process of calculating...
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Báo cáo sinh học: " Risk factors in the development of stem cell therapy" pdf
... in the aetiology of cancer where these cells may become tumourigenic [43] According to this cancer stem cell theory, only small Page of 14 fraction of cells within a tumour, the so-called cancer ... [81-85] Most likely the observed effect depends on the nature of the cancer cells, the Page of 14 characteristics of the used MSC, on the integrity of the immune system and on the timing and site ... accompanied by cell sorting to minimise the number of pluri/ multipotent stem cells in the cell preparation [86], or to separate tumourigenic stem cells from non-tumourigenic stem cells (by e.g cell sorting...
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Báo cáo sinh học: "The ‘stem cell’ concept: is it holding us back" pptx
... definition is the ability to generate cells of other types, but there are two problems with this First, there are clearly cells in the body that generate cell types other than themselves but ... probability that stem and progenitor cell progeny remain at the stem or progenitor cell stage (that is, they increase the probability of differentiation) Thus, the machinery for achieving stem cell- driven ... Polyak K: Cancer stem cells: a model in the making Curr Opin Genet Dev 2009, 19:44-50 Enver T, Pera M, Peterson C, Andrews PW: Stem cell states, fates, and the rules of attraction Cell Stem Cell 2009,...
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Báo cáo y học: "Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model" pps
... formation by the transformed P63+ basal /stem cells in the metastatic loci The data evidently demonstrated both cancer cell and stem cell characteristics of the transformed P63+ basal /stem cells, supporting ... in the P63+ basal/ stem cells Patch1 and Smo were found highly expressed in the P63+ basal /stem cells of the pCX-shh-IG-injected prostates, being located in the cell membrane of P63+ basal cells ... candidate therapeutic agents [23,24] In this study, we used the Hh overexpression mouse model to elucidate whether the PCSCs arise from P63+ basal /stem cells and to examine whether these cancer cells...
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báo cáo khoa học: "The research on the immuno-modulatory defect of Mesenchymal Stem Cell from Chronic Myeloid Leukemia patients" pdf
... injury Besides HSCs, there also existed another kind of stem cells called MSCs (Mesenchymal Stem Cells), they could differentiated into stroma cells and acted as the “niche” in the micro-environment[24] ... tumor cells consists of three major steps: the receptormediated adhesion of tumor cells to the extracellular matrix, the degradation of the extracellular matrix by the proteinase secreted by the ... defined endothelial cells at the single -cell level, suggesting these cells have the properties of hemangioblasts Page of 10 The main purpose of our article was to examine the immune characteristics...
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báo cáo khoa học: "Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/b-catenin pathway" potx
... determine the effects on suppressing the tumorigenicity of SP cells In addition, further studies are warranted to confirm the effects of CKI on cancer stem- like cells of other cancer cell lines ... that the activation of the Wnt pathway promotes the proliferation and selfrenewal of SP cells, and the DDP only inhibits non-SP cells (differentiated cells) leading to the survival of cancerstem ... M: Cancer stem cells in human gastrointestinal cancers Hum Cell 2006, 19:24-29 Kondo T, Setoguchi T, Taga T: Persistence of a small subpopulation of cancer stem- like cells in the C6 glioma cell...
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