crystal design structure and function

... Netherlands Jon A. Zubieta, Department of Chemistry, Syracuse University, Syracuse, NY 13244, USA viii Contributors Crystal Design: Structure and Function Crystal Design: Structure and Function. ... Cross-linking of tapes via C±H Á Á Á O and C±H Á Á Á F hydrogen bonds not shown. Oxygen, nitrogen and key hydrogen atoms are shaded. 22 Crystal Design: Structure and F...

Ngày tải lên: 03/07/2014, 16:06

... cooperative binding, and creates an accessi- ble environment that also enables Sp1 and Runx1 binding [85,86,233]. Both NFAT and AP-1 have the potential to recruit the HATs CBP and p300 which may ... required for function in either T cells or mast cells. Shown below are the positions that nucleo- somes and GATA-2 occupy in unstimulated T cells and mast cells [85]. Active chromati...

Ngày tải lên: 14/02/2014, 18:20

... clarified the structural and functional importance of the v-KIND and MAP2 interaction core modules in the regulation of dendrite growth and branching in hippocampal neu- rons and cerebellar granule ... MAP2 cDNA and its derivatives generated by PCR were cloned into pGEX-4T-2. The KIND domains of Spir-2 and PTPN13 were generated by RT-PCR and inserted into pEGFP-C1 and pGEX-4T-2...

Ngày tải lên: 14/02/2014, 19:20

... from Koehl, 1995). BODY SIZE AND SUSPENSION FEEDING 21 Body Size The Structure and Function of Aquatic Ecosystems Edited by ALAN G. HILDREW School of Biological and Chemical Sciences, Queen Mary, ... SIZE AND SUSPENSION FEEDING 19 Body Size: The Structure and Function of Aquatic Ecosystems Ecologists have long struggled to predict features of ecological systems, such as the...

Ngày tải lên: 17/02/2014, 19:20

... Tecnologia). References 1. Davies, D.R. (1990) The structure and function of the aspartic proteinases. Annu. Rev. Biophys. Biophys. Chem. 19, 189–215. 2. Dunn, B.M. (2002) Structure and mechanism of the pepsin-like family ... Science 282, 121–125. 41. Anderson, D.H., Sawaya, M.R., Cascio, D., Ernst, W., Modlin, R., Krensky, A. & Eisenberg, D. (2003) Granulysin crystal structu...

Ngày tải lên: 19/02/2014, 12:20

... investigation and understanding of their structure- activity relationships, may start to provide a rational way to develop additional pharmacological tools for the elucidation of nAChR structure and function. Ó ... perisynaptically, and a less abundant population of a3* nAChRs which contain a5andb4 subunits and in some cases b2 subunits, and is localized at postsynaptic densiti...

Ngày tải lên: 19/02/2014, 12:20

... to express CD2 was Fig. 2. Ribbon diagram of crystal structure o f CD2–CD58 complex and crystal structure of rat CD2. (A) Ribbon diagram of crystal structure of CD2–CD58 (LFA-3) complex. Starting ... located at the N- and C-termini. A comparison of the b-turn structure of cER with the similar region in the crystal structure of rat and human CD2 was carried out. In the...

Ngày tải lên: 19/02/2014, 13:20

... and TmAFPwitheachotherandwithproteinsthathavea similar fold. Structure of sbwAFP and TmAFP The structure of sbwAFP has been determined by X-ray crystallography to 2.5 A ˚ and by NMR at both 30 °Cand 5 °C ... (1999) Structure, function and evolution of an tifreeze proteins. Cell Mol. Life Sci. 55 , 271 – 283. 11. Yeh, Y. & Feeney, R.E. (1996) Antifreeze proteins: Structures...

Ngày tải lên: 19/02/2014, 16:20

... three antiparallel strands (1, 2 and 7) and strand 6, which is parallel to strand 2. b-Strands are located between the four a-helices (a1, 278–294; a2, 305–313; a4, 374–381; and a5, 397–405), with ... b-strands (b3, 329–335; b4, 339–344; and b5, 367–372) and a distorted a-helix (a3, 348–356) (Fig. 3B,C). The three b-strands of the minidomain are all antiparallel, and form a single...

Ngày tải lên: 06/03/2014, 11:20

... multiple amyloidogenic forms and with various ligands bound). The crystal structures of transthyretin from rat [35], chicken [36] and sea bream [37,38] have also been solved. All of these structures demonstrate ... between the loops joining stands G and H with the loops joining strands A and B, mak- ing the transthyretin tetramer a ‘dimer of dimers.’ Recently, the first crystal str...

Ngày tải lên: 07/03/2014, 00:20