... afterincubation of cells with TUDCA. In contrast, DCA and TDCAinduced apoptosis but did not significantly change cyclin D1 and E-cadherin proteins, or cyclin D1 transcriptional activation. Inconclusion, ... the media; but because that is the way science can ensurea balanced public debate where the public have access to accu-rate, good, evidence-based science and the scienti c approach tonew developments. ... Genentech Inc.,South San Francisco, CA, USA,3Department of Bioinformatics,Genentech Inc., South San Francisco, CA, USA,4Department ofMolecular Biology, Genentech Inc., South San Francisco, CA,USA,5Department...
... Education,Culture, Sports, Science and Technology; the JapanSociety for the Promotion of Science; and the JapanScience and Technology Agency.References1 Pawson T & Nash P (2000) Proteinprotein ... FEBSInteraction between very-KIND Ras guanine exchangefactor and microtubule-associated protein 2, and its rolein dendrite growth – structureandfunction of the secondkinase noncatalytic C- lobe ... GSTCD2-1CD2-2CD2-3CD2PD250150Input GSTCD2-1-6-1CD2-1-6-2CD2-1-6-3CD2-1PDIB: -v-KIND250150InputGSTCD2-1-5CD2-1-6CD2-1-7CD2-1-8CD2-1PD250Input GSTCD2-1-1CD2-1-2CD2-1-3CD2-1-4CD2-1PD250150MAP2MBDRIICD1CD2CD31–147148–599600–10991100–15181519–1829767934CD2-1CD2-2CD2-3600CD21099Inter-action600...
... the final 48 calculated structures.Twenty-four structures of the closed protein conformer are shown in red, and 24structures of the open conformer areshown in cyan. The N-termini and C- terminiare ... pelletedwith ice-cold 5% trichloroacetic acid, supplemented with0.75% casamino acids, and centrifuged at 4 C and 14 000 g. The amount of released [35S]Met-containing tetra-peptide, which indicated ... HN and the Ca signals, correlating the amide HN and the Ca signalof the preceding amino acid, correlating the amide NH withthe Ca and Cb signals, correlating the amide NH with theCa and Cb...
... (E .C. 3.5.2). Other cyclicamidohydrolases include hydantoinase, allantoinase and dihydrooratase [32]. Cyclic amidohydrolases sharea number of physicochemical characteristics. Thesecharacteristics ... tetrameric structure. Acta Biochim Pol 44, 505–517.36 Sunde M, Richardson SJ, Chang L, Pettersson TM,Schreiber G & Blake CC (1996) The crystal structure oftransthyretin from chicken. Eur J Biochem ... remark-able conservation of the prealbumin-like fold (asdescribed by SCOP, http://scop.mrc-lmb.cam.ac.uk),which consists of an eight-stranded b-sandwich (strandsA-H) with each sheet adopting...
... percentages.Figure 2. C- reactiveprotein (CRP) and procalcitonin (PCT) concentration according to the pneumonia severity index in bacterialcommunity-acquired pneumonia. Patients in risk classes ... significantpositive correlation was detected between the CRP and PCT concentrations (r=0.648, p=0.01).Diagnostic accuracy for discriminating TB frombacterial CAPIn the ROC curve analysis, the CRP ... CRP concentration had aKang YA, et al. C- reactiveproteinand procalcitonin for the diagnosis of tuberculosis 339Table 1. Clinical and laboratory characteristics of the participantsBacterial...
... E, DeMaat MP. C- reactiveprotein in atherosclerosis: A causal factor? Cardiovasc Res. 2006; 71: 30-39. 24. Yip HK, Sun CK, Chang LT, Chen MC, Liou CW. Time course and prognostic value of plasma ... 12. Among ischemic strokes 6 were cardioembolic, 7 were lacunar, and the remainder (16) were ischemic non-cardioembolic (11 atherosclerotic and 5 of undetermined cause). The location of stroke ... ischemic stroke. J Neurol Sci. 2005; 236: 65-71. 19. Masotti L, Ceccarelli E, Forconi S, Cappelli R. Prognostic role of C- reactiveprotein in very old patients with acute ischemic stroke. J Intern...
... the bacterium. C- reactiveprotein (CRP) is an acute-phase reac-tant that originates from the liver. CRP has many clinical and biological effects and can be used for the diagnosis and follow-up ... inflammatory and immune responses with release of various bacterial and host-dependent cytotoxic substances [2], resulting in chronic gastritis, peptic ulcer, and gastric cancer [3]. Epidemiological ... inflammation can have sys-temic effects; (ii) H. pylori gastric infection is a chronic process that lasts for decades; and (iii) persistent in-fection induces chronic inflammatory and immune...
... i.dransfield@ed.ac.uk* Corresponding author AbstractBackground: It has been reported that C- reactiveprotein (CRP) binds both leukocyte FcγRIIA(CD32) and the plasma membrane of apoptotic cells. Since FcγRIIA ... Hirschfield GM: C- reactive protein: a critical update.J Clin Invest 2003, 111:1805-1812.9. Gershov D, Kim S, Brot N, Elkon KB: C- Reactiveprotein binds toapoptotic cells, protects the cells ... for providing the FcγRIIA-transfected Jurkat cells, and to Linda Wilson for operating the confocal microscope. This work was funded by a Medical Research Council Clinician Scientist Fel-lowship...
... against C- reactiveproteinand other acute phase proteins.Clin Chim Acta 2007, 378:13-23.13. Marnell L, Mold C, Du Clos TW: C- reactive protein: ligands,receptors and role in inflammation. Clin ... inflammation, CRP dissoci-ates to mCRP, which may enhance binding of circulatingsoluble immune complexes to phagocytic Fcγ receptors[12,43] and constitute a vicious circle.ConclusionsWe have ... microscopy, immunofluorescence and elec-tron microscopy. The biopsies were graded according to astandardized semiquantitative histological scoring protocol foractivity and chronicity indices...