wilson s disease in brain magnetic resonance spectroscopy

... hemispheres In both age-groups, these increases, albeit significant, were somewhat smaller than those found in the corresponding brain areas during ischemia-hypoxia, but the decline in Lac increase in ... this issue by measuring the concentrations of selected metabolites, using proton magnetic resonance spectroscopy (1H-MRS), in two contrastingly different age-groups of animals: young - months ... vivo studies [12,13] Nevertheless, the increase in Lac is an interesting finding in that the Lac level in the hippocampus might be considered a useful marker of aging Indeed, increased Lac levels...

Ngày tải lên: 10/08/2014, 05:21

... American Association for the Study of Liver Diseases (AASLD) patients in whom Wilson s disease is suspected should undergo screening with serum ceruloplasmin, 24-hour basal urinary copper, and slit-lamp ... immunologic disease were excluded, the diagnosis of Wilson s disease underlying leptospirosis appeared more likely The three most relevant features that characterize Wilson s disease include age ... encephalopathy in a person with no history of liver disease [5] Conclusions The clinician should suspect an underlying disease in an unexplained liver failure associated with leptospirosis The unexplained...

Ngày tải lên: 11/08/2014, 03:21

... American Association for the Study of Liver Diseases (AASLD) patients in whom Wilson s disease is suspected should undergo screening with serum ceruloplasmin, 24-hour basal urinary copper, and slit-lamp ... immunologic disease were excluded, the diagnosis of Wilson s disease underlying leptospirosis appeared more likely The three most relevant features that characterize Wilson s disease include age ... encephalopathy in a person with no history of liver disease [5] Conclusions The clinician should suspect an underlying disease in an unexplained liver failure associated with leptospirosis The unexplained...

Ngày tải lên: 11/08/2014, 07:20

... metabolites responsible for PGinduced toxicosis using proton nuclear magnetic resonance (NMR) spectroscopy Since it remains unknown which metabolites are responsible for a PG-induced toxicosis, a non-selective ... metabolites inducing the response by use of 1H NMR spectroscopy Competing interests The authors declare that they have no competing interests Authors' contributions HCB carried out the NMR measurements, ... profiling of biofluids, among other to identify biochemical changes in response to disease in mammals [5] In the present study proton NMR spectroscopy was applied on ruminal and blood plasma samples...

Ngày tải lên: 12/08/2014, 18:22

... Figure 2.2 shows the Matlab program 26 f=text; SWs=SWs; % start point in ppm SWe=SWe; % end point in ppm SI=32768; %total points n=1:1:SI; x=SWs-(SWs-SWe)/SI*(n-1); m1=floor((SWs+0.2)*SI/(SWs-SWe)+1); ... concentrations in human brain were observed to increase in brain tumors, ischemia, and in vivo in brain abscesses (Martin, 1994) Acetate is a simple molecule containing a single CH3 group that provides ... between certain brain tumors, based on changes in metabolite ratios across the lesion and the surrounding tissue The changes of lactate/AA ratio from varies type of brain abscesses make it possible...

Ngày tải lên: 10/11/2015, 11:35

... quantied by AQSES and AQSES Lineshape In vivo AQSES AQSES Lineshape In vivo AQSES AQSES Lineshape Residual AQSES Residual AQSES Residual AQSES Lineshape 4.5 3.5 Residual AQSES Lineshape 2.5 ppm ... AQSES Lineshape Simulated AQSES AQSES Lineshape Residual AQSES Residual AQSES Residual AQSES Lineshape Residual AQSES Lineshape 4.5 3.5 2.5 1.5 0.5 4.5 3.5 2.5 ppm 1.5 Simulated AQSES AQSES Lineshape ... in vivo signals) The bottom plots represent the amplitude estimates for the corresponding simulated signals using AQSES and AQSES Lineshape In vivo signals An in vivo signal was acquired using...

Ngày tải lên: 17/03/2014, 02:20

... Cushing s disease Two of our patients presented with such problems as initial symptoms Thus a high index of suspicion of Cushing s syndrome is essential for its diagnosis in children with obesity, ... two and a half years’ follow-up Discussion Cushing s disease is rare in children, and its clinical presentations differ from those in adults In children with Cushing s disease, growth retardation ... Cushing s disease The diagnosis of Cushing s disease is based on the clinical suspicion and biochemical confirmation of hypercortisolism Lack of a diurnal rhythm in serum cortisol levels is the...

Ngày tải lên: 22/03/2014, 10:20

... mechanisms of many disease processes and will continue to impact our understanding of disease pathogenesis This minireview will examine the previous studies of genes for ROCO or LRRK2 homologs in slime ... enhanced sensitivity to endoplasmic reticulum stress induced by tunicamycin, a specific inhibitor for N-linked glycosylation Interestingly, this enhanced sensitivity is suppressed in mutant worms with ... Petersen RB, WilsonDelfosse AL & Chen SG (2007) The Parkinson s disease- associated protein, leucine-rich repeat kinase (LRRK2), is an authentic GTPase that stimulates kinase activity Exp Cell Res 313,...

Ngày tải lên: 23/03/2014, 04:20

... as noninfectious diseases such as small vessel vasculitides, systemic lupus erythematosus or even malignancies The initial diagnosis of leptospirosis remains a clinical one, a presumed analysis ... diagnosis of leptospirosis requires a high degree of clinical suspicion because the disease s numerous manifestations can mimic other tropical infections or other nonspecific febrile illnesses, as ... and did manuscript revisions EE was involved in direct patient care as the hospitalist NM was involved in direct patient care as the infectious disease specialist SE was involved in Page of direct...

Ngày tải lên: 11/08/2014, 02:22

... mutation in our cohorts Discussion As recently shown, mutations in the PINK1 gene rarely cause autosomal-recessively transmitted PD [3] Besides an early age of onset, the observed clinical symptoms in ... a serine-threonine kinase domain with homology to kinases of the Ca2+/calmodulin family[3] It appears to exert protective effects against cellular stress within mitochondria[3] These findings ... variant was not associated with late-onset PD in our study These findings correspond to previously published data of no leading association of other coding SNPs within the PINK1 gene and PD [13] In...

Ngày tải lên: 11/08/2014, 08:20

... biosynthesis Rate limiting enzyme in the synthesis of serotonin APS II 21-Hydroxylase (21-OH) Steroid hormone synthesis Description of important autoantigens in Addison 's disease, Addison 's disease ... melanin catalyser in the inner ear [22] Some inner ear diseases are known to be caused by water and ion regulating problems, which is the case with Addison 's disease The aim of this study was to investigate ... history was attained, focusing on autoimmune diseases, previous and current ear diseases, ear operations and hearing problems A clinical investigation of the EarNose and Throat area was also...

Ngày tải lên: 11/08/2014, 08:21

... problems caused by limb-length discrepancy, as lesions frequently involve the femur or tibia [2] Malignant changes in Ollier s disease may occur in adult patients [2] As dysplasia progresses, there ... calcifies, it is detected as irregular opacities It has been emphasized that Ollier s disease usually stops spontaneously with skeletal maturity; therefore, any lesion showing activity or increased ... diagnosis of benign lesions was reliable Retrospective assessment of our patient revealed that the etiology of increased uptake in the lower limb lesions was due to previous insufficiency fractures...

Ngày tải lên: 11/08/2014, 14:20

... Hematoxylin and Eosin Competing interests The authors declare that they have no competing interests simultaneous occurrence of Hodgkin 's disease, Langerhans cell histiocytosis and multiple myeloma in ... frequent initial symptom In 5– 10% of patients, general symptoms such as fever, malaise and peripheral eosinophilia may be present Microscopic findings of Langerhans cell histiocytosis include eosinophils ... Giardini R: Langerhans cell histiocytosis arising after Hodgkin 's disease Pediatr Hematol Oncol 1997, 14:585-8 Shin MS, Buchalter SE, Ho KJ: Langerhans' cell histiocytosis associated with Hodgkin's...

Ngày tải lên: 11/08/2014, 19:21

... reach the subcutaneous tissues through imperceptible abrasions on the upper layers of the skin Since this pathogen is a slow growing fungus in its parasitic stage, L loboi should possess a yet ... staining showed spherical to oval yeast-like cells mostly uniform in size and arranged singly or in small chains of cells linked by small tube-like structures (Figures Figure Hematoxylin-eosin stained ... Lobo 's disease proven cases in humans or dolphins, or researchers working with purified yeast-like cells of L loboi, should be carefully considered during clinical investigation of nodular skin disease...

Ngày tải lên: 11/08/2014, 20:20

... lấy dung thiết bị kiểm soát với núm xoay tiếp xúc với thiết bị CW hay gắn với máy tính máy FT sau phổ chỉnh s a in Các khái niệm NMR 2.1 Tần s máy Nếu lượng trạng thái spin thấp, trạng thái m ... để xác định cấu trúc protein hay phân tử sinh học Tài liệu tham khảo PGS-TS Nguyễn Kim Phi Phụng (2005), Phổ NMR s dụng phân tích hữu cơ,NXB Đại học quốc gia TPHCM TS Lê Thanh Phước Các Phương ... kiện tần s Bohr, ∆E = hv = 2µzBo = γhBo Hoặc tầng s vô tuyến: υ = γBo/2π ví dụ với cường độ từ trường Bo = 11.7 Tesla ứng với máy NMR 500MHz thường s dụng; với proton γH = 2.675 x 108 T- 1S- 1 Ta...

Ngày tải lên: 16/04/2015, 08:57

... either polyglutamine or polyalanine expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies [27] Taken ... Foundation, SADF (Insamlingsstiftelsen for ¨ Alzheimer- och Demensforskning), Socialstyrelsens Stiftelser, Stiftelsen for Alderssjukdomar, and Svenska ¨ ˚ Lakaresallskapet ¨ ¨ FEBS Journal 272 ... eEF2 in its N-terminus (Thr56) that subsequently blocks eEF2 binding to ribosomes, resulting in decreased rates of protein synthesis Dephosphorylation of eEF2 relieves its translational restriction...

Ngày tải lên: 16/03/2014, 22:20

... cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington s disease J Neurochem 95, 553–562 42 Jenkins BG, Klivenyi P, Kustermann E, Andreassen OA, Ferrante ... Huntington s and Parkinson s diseases Neurology 50, 1033–1040 Ma Y & Eidelberg D (2007) Functional imaging of cerebral blood flow and glucose metabolism in Parkinson s disease and Huntington s disease ... RJ, Rosen BR & Beal MF (2000) Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington s disease...

Ngày tải lên: 23/03/2014, 10:20

... for six months after diagnosis Based on these findings, a diagnosis of Ewing s sarcoma of the calcaneus was made Discussion Ewing s sarcoma is a rare malignant neoplasm, predominantly affecting ... patient s foot shows a hypointense tumor mass on T1-weighted spin-echo sequences compared to surrounding musculature The skip lesion of the talus displays a hyposignal on T1-weighted sequences less ... pulmonary involvement, bone or bone marrow spreading, skip metastases, or combined metastatic disease [7,9] The imaging features of local spread of Ewing s sarcoma, involving small bones to adjacent...

Ngày tải lên: 10/08/2014, 23:20

... accurately Magnetic resonance spectroscopy This sequence is a noninvasive technique for assessing brain metabolism in vivo Proton -magnetic resonance spectroscopy (MRS) is most commonly used Four main ... assessing fibre tract degeneration, thus predicting chances of recovery Figure Ascending reticular activating system and prognosis of brain injuries Several brain areas involved in the prognosis ... phase (>21 days) Characteristics Brain swelling Brain swelling Absence of brain swelling Diffuse atrophy and dilatation of the ventricles DWI Hypersignals in the cortex, in the thalamus and in...

Ngày tải lên: 13/08/2014, 08:20