proton magnetic resonance spectroscopy of the central nervous system
báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... angiitis of the central nervous system: serial MRI of brain and spinal cord Neuroradiology 2001, 43:599-607 14 Moore PM: Diagnosis and management of isolated angiitis of the central nervous system ... Angiitis of the Central Nervous System: a Case Report and Review CNS Spectrums 2008, 13:209-213 Page of 10 Ozawa T, Sasaki O, Sorimachi T, Tanaka R: Primary angiitis of the central nervous system: ... presentation of primary angiitis of the central nervous system Ann Rheum Dis 2008, 67:1732-1735 doi:10.1186/1477-7819-9-97 Cite this article as: You et al.: Isolated angiitis of the central nervous system...
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Region-specific effects on brain metabolites of hypoxia and hyperoxia overlaid on cerebral ischemia in young and old rats: a quantitative proton magnetic resonance spectroscopy stud pot
... agegroups of rats, young and senescent, in which selected metabolites were quantified by means of proton magnetic resonance spectroscopy The ultimate goal of the present study was the identification of ... subjected to the ischemic procedure consisting of surgical ligation of the right carotid artery One each of these subgroups was then hypoxia or hyperoxia-treated The animals of the remaining ... inserted into the MRS tube The ratio of peak area of each metabolite to signal area of TMSP-d4 was fitted to the linear concentration curve of Gly Finally, the absolute quantity of a metabolite...
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INVESTIGATION OF MEMBRANE PROPERTIES IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER STUDIED BY FLUORESCENCE CORRELATION SPECTROSCOPY
... onto the cover glass beside the sticky tape, with the help of a second blunt needle The embryo was not lifted above the surface of the dissecting medium, as this caused dispersion of the tissue The ... and is the excitation intensity of the laser at the centre of the laser π wo beam with laser power P wo and zo are the radial and axial distances of the laser focus, respectively, at which the fluorescence ... tissue interposed between the lens and the cell of interest (b) Enlarged schematic diagram showing the arrangement of aCC/RP2 motor neurons within the central nervous system of stage-16 embryo FCS...
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báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... that the lack of CCR5 does not protect from MS, but rather it may predispose to the chronic course of the disease [69] This would further imply that in view of the redundancy in the chemokine system, ... immunoneutralization of CCL3 [44], DNA vaccination [45], or genomic deletion of the CCR1 gene [22], reduces clinical disease Taken together, the results of the present study and from previous ones on the role of ... knock-out of CCR5 in humans per se confers no protection from MS, and the lack of effect of CCL3 deficiency in mice [67] illustrates redundancy in the chemokine system Although some of the data on the...
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Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx
... vulnerable, population of patients Chemotherapy-induced cognitive decline in the absence of radiation The best data on the cognitive effects of chemotherapy alone have come from studies of children with ... Abnormal CT scans of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemotherapy N Engl ... are planned that further reduce the dose of craniospinal radiation to 1,800 cGy, virtually no attention has been paid to the possible contribution of the chemotherapy to the cognitive decline...
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Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
... at the month time point, along with markedly decreased levels of MBP in the CC and in the white-matter tracts of the striatum of treated animals (Figure 10) In agreement with the majority of the ... nuclei; the distribution, morphology and size of these nuclei resembled those of the microvasculature endothelial cells of the CNS (Figure 11c-e) Double-labeling to visualize expression of Journal of ... contribute to the effects of chemotherapy on cognition The ability of irradiation to the CNS to suppress the generation of new neurons in the hippocampus has been suggested to be relevant to the understanding...
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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... Magnification A and B, ×66 C and D, ×132 Immunohistochmical study of nitric oxide synthase in the central nervous system of goat Enhanced expression of nNOS and iNOS in L monocytogenes-infected brain At ... is the first study of NOS expression in the goat brain with listeriosis The involvement of iNOS in bovine and caprine listeriosis has been reported previously, and the increased expression of ... disease of the central nervous system Proc Natl Acad Sci U.S.A 1995, 92, 5312-5316 Johnson, G.C., Fales, W.H., Maddox, C.W and RamosVara, J.A Evaluation of laboratory test for confirming the diagnosis...
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báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx
... known that the nanoparticles will interact with the proteins present in the biological system, i.e the material surrounding the nanoparticles are proteins present in the nervous system of the cockroach ... This correlation of activity and the effect of the nAuNPs on the CNS of the insect are due to how the brain of the cockroach controls its muscle response and locomotion [6] There is a significant ... in weather affect the activity of both groups The effects of these variables are diminished by presenting the activity ratio of the treated to the untreated group Although the treated/untreated...
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Báo cáo y học: "Use of T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure" pps
... could probably increase the precision of the measurement of ONSD Consequently, this test should not be used to predict the exact value of ICP but to estimate the probability of intracranial hypertension ... excluded because of lack of adequate view of both optic nerves In two other cases, ONSD and OND were only measured on one side The overall feasibility of measuring ONSD and OND was therefore calculated ... provided the best view of the ONSD was chosen and the slice was interpolated to 1,000 × 1,333 pixels using Image J 1.38 (National Institutes of Heath, Bethesda, MD, USA) The retrobulbar area was...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... common mechanisms of action of these drugs are the inhibition of the rate limiting steps of Aβ generation i.e β- and/or γ- secretases processing of APP (Citron, 2010) Although the reasoning behind ... 1.1 The trio of gasotransmitters In recent few decades, the scientific community has witnessed the rise of a whole new class of gaseous biological mediators in mammalian cells The size of this ... of H2S measurement, it’s almost impossible to determine the active form of H2S (H2S, HS- or S2-) present in the biological system Hence the all-encompassing term of H2S is now used to refer the...
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Genetic engineering and surface modification of baculovirus derived vectors for improved gene delivery to the central nervous system
... functions of the therapeutic genes 1.1.2 Non-viral and Viral Gene Delivery Systems Depending on the usage of vectors, there are two main types of gene delivery systems: non-viral and viral systems ... low efficiency of non-viral gene delivery remains a critical drawback of the system On the other hand, viral gene delivery systems are favoured because of the high efficiency of infective viral ... SURFACE MODIFICATION OF BACULOVIRUS DERIVED VECTORS FOR IMPROVED GENE DELIVERY TO THE CENTRAL NERVOUS SYSTEM YANG YI (B Eng.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY GRADUATE...
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Development of hybrid promoters and viral vectors for improved gene delivery to the central nervous system
... one of the key issues of gene therapy The expression level and specificity of the therapeutic gene is primarily determined by the activity of the promoter at the transcriptional level, and the ... in the nervous system, carrying out the fundamental tasks of receiving, conducting and transmitting signals Therapeutic protection of these cells is one of the main goals of gene therapy of neurological ... issue of gene therapy The tropism of the vector can essentially determine the cell type-specificity of the transgene expression at the transductional level, and the transduction efficiency of the...
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Fast registration of contrast enhanced magnetic resonance images of the breast
... FAST REGISTRATION OF CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGES OF THE BREAST SUN YIN (B.Eng (Hons.), NUS) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF ENGINEERING DEPARTMENT OF ELECTRICAL & ... (FEM), and the results confirmed the reliability of the method The calculation of MI and NMI is a highly computationally intensive task It requires the formation of the joint histogram of corresponding ... up the registration process by an order of magnitude with similar registration quality In the second part, we aimed to further speed up the registration process by offloading the bulk of the...
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The study of the mediation of ohanin, a king cobra (ophiophagus hannah) toxin through the central nervous system
... might be useful to the understanding of the control of locomotion and pain responses The identification of the receptor(s), and the identification of the specific regions of the receptor(s) and ... performed uѕing the two pаirѕ of oligonucleotideѕ Ligаtion of the frаgmentѕ viа XmаI reѕtriction ѕite yielded the full-length ѕynthetic gene of 369 bp The ѕynthetic gene wаѕ cloned into the pGEMT-eаѕy ... 5A) The effect of pro-ohanin on the locomotor activity of the mice was examined via i.p injection at the doses of 0.1 mg/kg, mg/kg and 10 mg/kg The total movement counts of pro-ohanin at the...
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Báo cáo khoa học: Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system pptx
... acquired the neuroendocrine vesicles equivalent to those seen in the present-day neurons of higher animals by the time of the emergence of the Plathelminthes in the evolutionary history The eye of the ... In the stalk region of the photoreceptor cells, neuropeptides may be synthesized and work to modulate the transmission of light stimulus To clarify the role of the amidated neuropeptides in the ... Binding of the peptidylglycine substrate caused the appearance of a second CO frequency at 2062 cm)1, assignable to CuH–CO As the binding of CO to the CuH center suggests the potential binding of...
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Section III - Drugs Acting on the Central Nervous System docx
... Norepinephrine There are relatively large amounts of norepinephrine within the hypothalamus and in certain zones of the limbic system, such as the central nucleus of the amygdala and the dentate gyrus of the ... in the Central Nervous System The capacity to integrate information from a variety of external and internal sources epitomizes the cardinal role of the CNS, namely to optimize the needs of the ... this term, because the components of the limbic system neither function consistently as a system nor are the boundaries of such a system precisely defined Parts of the limbic system also participate...
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Báo cáo sinh học: "How chemotherapy damages the central nervous system Christina A Meyers" ppsx
... injection They found a more persistent suppression of proliferation in regions of the brain where proliferation is essential to normal function (the subventricular zone, the dentate gyrus of the hippocampus ... also found that the agents caused increased cell death and decreased cell division in the subventricular zone, the dentate gyrus of the hippocampus and the corpus callosum in mice These effects ... whereas they found enhanced long-term potentiation in slices obtained and 53 weeks after treatment [11] Thus, some of the variability of the results in these studies may be related to the time...
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Characterization of MP2 cell division and pins function on spindle asymmetry of drosophila central nervous system
... CHARACTERIZATION OF MP2 CELL DIVISION AND PINS FUNCTION ON SPINDLE ASYMMETRY OF DROSOPHILA CENTRAL NERVOUS SYSTEM LIN SHUPING (M.Sc.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ... cell buds off from the larger ‘mother’ cell The mother cell can switch mating type but the daughter cannot This asymmetry exists because the mother, but not the daughter, can express the HO endonuclease ... translocates into the nucleus despite the high level of Mira at the cortex (Ikeshima, et al., 1997) Alternatively, the degradation of Mira might be the consequence of release of Pros from the cortex...
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Chemical drug assisted gene transfer a sensible approach to improve transgene expression in the central nervous system
... IN THE CENTRAL NERVOUS SYSTEM GUO HAIYAN (B.M., PRC) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF BIOLOGICAL SCIENCES NATIONAL UNIVERSITY OF SINGAPORE & INSTITUTE OF ... functional therapeutic effects to ameliorate the diseases The most ideal human gene therapy is the perfect combination of these three components to generate a safe and effective way for the delivery of ... are DNA sequences used for the control of the transgene expression and generally determine the specificity and expression level of the transgene(s) Therapeutic genes are the transgenes delivered...
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