who is protected by the right against self incrimination
Tài liệu Báo cáo khoa học: Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1 pptx
... of the observed interaction Further studies are necessary to shed light on the function of this interaction in the in vivo situation By influencing the duration of the Ca2+ signal of ORs in the ... of the channel [12,29,30] On the other hand, in contrast to the findings of the present study, MUPP1 was shown to prolong the duration of GABAB receptor signaling and increase the stability of the ... within the cell We found this translocation to be dependent on the final amino acids of the receptor protein Similar to the other PDZ domain interactions that have been shown to be abolished by mutating...
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Tài liệu Báo cáo Y học: Thermostability of manganese- and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a glutamine residue pdf
... identified to distinguish between FeSOD and MnSOD [7] The position of the glutamine residue, which is structurally equivalent in the enzymes, is contributed by the N domain of FeSODs (Q69) and the C domain ... metal at the active site The presence of iron is therefore a prerequisite for its effect and suggests that the absence of reactivity with the MnSOD mutants is due to the lack of activity in these ... causing a shift in the position of Y34 and a twist in the ring of the metalbinding H81 Thermostability is not a new phenomenon amongst SODs; those isolated from hyperthermophilic organisms, for example,...
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Báo cáo khoa học: Androgen receptor function is modulated by the tissue-specific AR45 variant ppt
... to the absence of the NTD This might be overcome by the overexpression of cofactors To test this hypothesis, we analyzed the effects of two AR cofactors known to interact with the AR LBD TIF2 and ... observed The important role of the NTD, which is absent in AR45, has been documented by several studies [40–42] The hormone-dependent interaction between this region and the LBD of the AR is essential ... (not shown) Finally we tested the effects of androstenedione on AR45 function This hormone is synthesized primarily by the adrenal glands and is not suppressed by chemical castration used to...
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Báo cáo khoa học: Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90 potx
... because they indicate that the formation of the ternary complex is correlated with the level of calpastatin present in the cytosol By quantification analysis of the immunoblots, it has been established ... calpastatin If the active calpain species increases over the binding capacity of HSP90, the complex and obviously the isolated proteins are degraded by the protease On the basis of these observations, ... quantified as described in the Experimental procedures The areas of the peaks were normalized on the basis of the amount of protein loaded on the column The values reported are the arithmetical mean...
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Báo cáo khoa học: The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p ppt
... formation by Psd1p This process includes synthesis of PtdSer in the endoplasmic reticulum by the PtdSer synthase Pss1p and translocation of PtdSer to the site of Psd1p-catalyzed decarboxylation in the ... mitochondria caused by psd1D might be harmful in the phb1 ⁄ 2D background, which by itself causes an increase in mitochondrial PtdEtn In view of the results of this study, this hypothesis appears to ... When functional Oxa1p is missing the membrane subunits of these complexes cannot be assembled and are cleaved by the intermembrane space (i)-AAA protease Yme1p and ⁄ or by the matrix (m)AAA protease...
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Báo cáo khoa học: In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS–HSP90 heterocomplex pot
... The particulate material was discarded by centrifugation (100 000 g for 10 min) Thoracic aorta was rapidly excised from the same animals After the removal of the adhering connective tissue, the ... from proteolysis, even under conditions of prolonged protease activation This conclusion is further supported by the finding reported here that, in brain, the nNOS–HSP90 complex is in equilibrium ... been established that the protective effect is caused by HSP90-specific recruitment by active calpain molecules In this associated form, HSP90 becomes resistant to digestion, although the protease...
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– THE GRE ANALYTICAL WRITING SECTION – The argument, as given, is weakened by the fact that it docx
... the premise or conclusion may be unstated ■ If the premise is missing, ask yourself if there are any assumptions that must be true for the argument to be valid Find the missing link between the ... about together Think about why this issue is significant and address its significance in your conclusion Think about the questions this issue raises, and address the implications of the issue in ... whether you agree or disagree with the argument, or even whether the report the author gives is accurate You should the following: ■ ■ ■ ■ Talk about the argument the author makes Examine whether...
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báo cáo hóa học: " Astrocyte production of the chemokine macrophage inflammatory protein-2 is inhibited by the spice principle curcumin at the level of gene transcription" pptx
... CNS inflammation by mechanisms distinct from its antioxidant and known anti-inflammatory activities, we examined the effect of this spice principle on the synthesis of MIP-2 by astrocytes Our ... to the CNS is followed by a breeching of the blood-brain barrier that is especially severe after administration of MIP-2[21] and may further contribute to inflammation by causing indiscriminate ... NFκB and NF-IL-6 cis-acting elements demonstrate that inhibition of MIP-2 by curcumin occurs at the level of gene transcription The importance of either of these elements in the regulation of...
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Báo cáo hóa học: " Glycerol conversion to 1, 3-Propanediol is enhanced by the expression of a heterologous alcohol dehydrogenase gene in Lactobacillus reuteri" ppt
... has the potential to further improve 1, 3-PD productivity In this work, expression of yqhD has increased the molar yield of 1, 3-PD from glycerol by 13% in L reuteri HR2 This is in contrast to the ... reuteri Further engineering of the strain to improve the redox balance and minimize the formation of byproducts like lactate and ethanol could pave the way for maximizing 1, 3-PD biosynthesis Acknowledgements ... coupled with the diversion of NADPH away from biosynthesis by YqhD, could have contributed to the decreased growth rate of the recombinant culture (Jarboe et al 2010; Zhu et al 2009) The decreased...
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Báo cáo y học: "Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis" pdf
... tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis Arthritis ... measurements, dissections, and radiological analyses, analyzed the data, and wrote the paper CZ assisted with surgeries and dissections, performed histological studies, and revised the paper BV ... BV reverse-engineered the static weight bearing apparatus and assisted with data analysis PS contributed the BKB1 antagonist R-954 FM conceived the study and supervised the research group GNK...
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What is meant by the case
... Here the noun Peter is used for addressing a person or thing A noun used to address a person or thing is said to be in the vocative case Be first to know when ... Be first to know when grammar rules change! Sign up to our newsletter here: englishgrammar.org (It's free) Powered by TCPDF (www.tcpdf.org) ...
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Báo cáo hóa học: " The synergistic effect of IFN-α and IFN-γ against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin" pptx
... this network of cytokines, which is tightly regulated [19] This in vivo situation led us to query whether the administration of meliacine to HSV-2 infected mice could altered the homoestasis ... state is induced [26] However, nearly all the animal viruses evolved mechanisms to antagonize the effect to IFN-induced antiviral state [27] In the case of HSV-1 it was reported that the resistance ... Thus, the results reported here indicated that the presence of CDM did not alter the biological activity of IFN-α or IFN-γ or their combination As a result we can envision that the administration...
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Báo cáo sinh học: "Respiratory syncytial virus infection in Fischer 344 rats is attenuated by short interfering RNA against the RSV-NS1 gene" doc
... shifts the T lymphocyte population from Th2 to Th1 The ratio of IL-4 to IFN-γ is an indicator of the allergic phenotype in the lung the higher the ratio, the more T helper 2-like (Th2) is the response ... bases long These short interfering RNAs (siRNAs) then activate the cell's RNA cleavage machinery (the RNA interference silencing complex, or RISC) to destroy the viral RNA The RSV genome is a single-stranded, ... Vaccines and Therapy 2007, 5:4 predisposing factor for the development of asthma later in life [2] There is no effective vaccine commercially available against RSV and the relative weakness of the immune...
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Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
... 6B–D) Akt-1 Discussion The function of PPARc in adipogenesis is well established [19] However, in many other types of cell, the activation of PPARc is linked to the induction of apoptosis It has ... apoptosis is also induced by troglitazone through a PPARc-dependent Akt-1 signaling pathway (Fig 3A,B) However, the mechanism by which PPARc agonists reduce Akt-1 levels is not fully understood It is ... adipocytes, apoptosis may be induced by PPARc agonists These effects may change the balance of adipocyte populations in adipose tissue The insensitive FEBS Journal 277 (2010) 687–696 ª 2009 The Authors...
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Tài liệu Báo cáo khoa học: The PA-TM-RING protein RING finger protein 13 is an endosomal integral membrane E3 ubiquitin ligase whose RING finger domain is released to the cytoplasm by proteolysis ppt
... suggesting that the N-terminal portion of the protein containing the HA epitope was lost from these proteins by proteolysis To determine which of the RNF13 bands is the initial biosynthetic product, ... brain The solubilization of the ICD of RNF13 and the presence of the putative NLS on the C-terminal side of the TM domain are consistent with the possibility that the ICD, released from the membrane ... dimethylsulfoxide alone, establishes the specificity of the anti-FLAG serum A Genome sequencing suggests that RNF13 is ubiquitously expressed This is supported by expression data from the Stanford Microarray...
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Tài liệu Báo cáo khoa học: Reversible tetramerization of human TK1 to the high catalytic efficient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration ppt
... values is exclusively displayed by the tetramer forms, and lowefficiency kinetics with high Km values is displayed by the dimer forms These observations strengthen the previous hypothesis that the ... In the present work, the part of the phosphate donor that is necessary for the dimer–tetramer transition of native hTK1 purified from human lymphocytes was identified Further, the effect of the ... Therefore, it can be concluded that the nature of the base is insignificant for the tetramerization effect The next goal was to determine the role played by the sugar and phosphate groups As seen...
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Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx
... multidrug efflux pumps is assumed to correspond to the outward-facing conformation The energy produced by the hydrolysis of ATP is harnessed for the resetting of the transporter to the initial high-affinity, ... Originally, the impetus for the switch in binding site affinity and orientation was thought to be the energy produced by nucleotide hydrolysis In the case of ABCB1, this was revised through the observations ... conformation for the transporter, which is supported by the restoration of high-affinity binding in the ADPbound conformation That this step of the catalytic cycle is associated with the greatest...
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Tài liệu Báo cáo khoa học: Aggregative organization enhances the DNA end-joining process that is mediated by DNA-dependent protein kinase pdf
... linear DNA in the absence of Ku and predominantly forms a large complex without any mobility shift in the well of the gel [31] The stability of the complex against salt is also enhanced by the presence ... helices, allowing the efficient catenation of the circular duplexes by Escherichia coli topoisomerases, the free exchange of DNA between neighboring aggregates by the enzyme [18], and the activation ... hallmark of the initial response to DSBs is the rapid activation of ATM (product of the ataxia telangiectasia mutated gene), the protein kinase that is mutated in the human hereditary disease ataxia...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008