tuneable anti cancer gene drug delivery systems

... reached about whether CNTs are the best carriers in anticancer drug delivery systems because there are many other anticancer drug delivery systems based on other nanomaterials, such as cationic ... system Drug delivery targeted to tumor To deliver anticancer drugs into cancer focus is the prerequisite for the drugs to develop their effects However, some drugs cannot arrive or enter cancer ... the molecular transporter in drug delivery Page 14 of 22 Drug delivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drug delivery systems targeted to the lymphatic...

Ngày tải lên: 20/06/2014, 22:20

... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... numerous types of protein drug [21–23] 15.6 Examples of Biodegradable Polymer Drug Delivery Systems Under Development 15.6.1 Polyketals Polyketal-based drug delivery systems are under development ... nanotechnology and biological mimicry to create drug delivery systems that penetrate into 15.6 Examples of Biodegradable Polymer Drug Delivery Systems Under Development articular cartilage tissue...

Ngày tải lên: 25/10/2013, 08:20

... stability Chemical Aspects of Drug Delivery Systems Table Routes of administration and general classification of drug delivery systems ROUTES OF ADMINISTRATION DRUG DELIVERY CLASS ORAL SOLIDS (e.g ... Aspects of Drug Delivery Systems Table Mechanisms and properties influencing drug release from particle carrier systems* MECHANISM OF DRUG RELEASE PROPERTIES INFLUENC~NG DRUG DIFFUSION DRUG RELEASE ... carrier materials incorporated into drug delivery systems 4 DRUG LEAKAGE+ +NON TARGET +METABOLISM /CLEARANCE IB ROUTE OF ADMINISTRATION IDRUG + CARRIER Ic IDRUG IDRUG + CARRIER P + CARRIER +NON...

Ngày tải lên: 28/03/2014, 10:20

... CONTENTS Generalities of drug delivery Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY ... Targeted drug delivery systems: deliver drug to a desired body location, organ, tissue, specific cells…  Controlled-release drug delivery systems: preprogramed drug release By the route of delivery: ...  Topical (local) drug delivery systems: drugs are delivered locally to the target organ/tissue without entering the systemic circulation  Systemic drug delivery systems: drugs are delivered...

Ngày tải lên: 18/04/2014, 15:37

... define drug- delivery systems of a certain size range Reflecting this trend of size definition, Nanoparticulate Drug Delivery Systems is a worthy attempt to bring together a wide range of drug- delivery ... and their delivery to where they are needed An ever increasing number of drug- and vaccinedelivery systems are being tested clinically, with many already marketed Recently, drug- delivery systems ... 0‑8493‑9073‑7 (alk paper) Drug delivery systems Nanoparticles I Thassu, Deepak II Deleers, Michel III Pathak, Yashwant IV Series [DNLM: Drug Delivery Systems ‑methods Nanostructures Drug Carriers W1 DR893B...

Ngày tải lên: 04/06/2014, 14:47

... soluble drugs [8,9], the targeting of drugs to a specific site, and drug bioavailability A schematic comparison of untargeted and targeted drug delivery systems is shown in Figure Several anti- cancer ... the widespread application of nanodelivery systems in medicine Design of nanotechnology – based drug delivery Systems Nanoparticles can be used in targeted drug delivery at the site of disease ... use in cancer therapy The effectiveness of drug delivery systems can be attributed to their small size, reduced drug toxicity, controlled time release of the drug and modification of drug pharmacokinetics...

Ngày tải lên: 20/06/2014, 00:20

... ophthalmic drug delivery systems, but the knowledge in this field is rapidly expanding Systems range from simple solutions to novel delivery systems such as biodegradable polymeric systems, corneal ... to provide maximal benefit, improvements in ocular drug delivery are essential Drug delivery is no less vital than drug discovery Although many drugs can be safely delivered by eye drops, effective ... Nash and Alfred H Wachter 130 Ophthalmic Drug Delivery Systems Second Edition, Revised and Expanded, edited by Ashim K Mitra 131 Pharmaceutical Gene Delivery Systems, edited by Alain Rolland and...

Ngày tải lên: 10/08/2014, 00:20

... of drugs (61) Concentrations in retina were lower than those in aqueous for drugs that easily penetrate into the Copyright © 2003 Marcel Dekker, Inc General Considerations in Ocular Drug Delivery ... local drug delivery to the eye generally provides direct access to the site of action and, in most cases, substantially reduces systemic exposure and toxicity, systemic administration of drugs ... (1990) Ocular drug delivery Pharmacokinetic considerations Clin Pharmacokinet., 18:255 Lang, J C., and Stiemke, M M Biological barriers to ocular delivery In: Ocular Therapeutics and Drug Delivery...

Ngày tải lên: 10/08/2014, 00:20

... increased as the drug diffusivity was reduced Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination halflife, decreased significantly as the drug diffusivity ... Kulkarni, P S., and Srinvasan, B D (1987) Nonsteroidal anti- inflammatory drugs in ocular inflammatory conditions In Nonsteroidal Anti- inflammatory Drugs, A J Lewis, D E Furst, eds., Marcel Dekker, New ... by changes to the drug diffusivity However, the time at which the peak concentration occurred increased as the drug diffusivity decreased because the average time required for a drug molecule to...

Ngày tải lên: 10/08/2014, 00:20

... Ophthalmic Drug Delivery Systems (A K Mitra, ed.), Marcel Dekker, Inc., New York, Chapter 12 17 Zheng, X., Marquart, M E., Mitra, A K., and Hill, J M (2002) Unique ocular drug delivery systems In: ... for rational design of drug delivery systems for therapeutic agents that are poorly absorbed across the cornea or require delivery to posterior segment of the eye Drug delivery across the conjunctiva ... ocular drug delivery J Pharm Sci 80:50–53, 1990 Harris, D., and Robinson, J R Bioadhesive polymers in peptide drug delivery Biomaterials 11:652–658, 1990 Grass, G M Mechanisms of Corneal Drug Penetration...

Ngày tải lên: 10/08/2014, 00:20

... protein drugs, Adv Drug Delivery Rev., 8:331–339 81 Chiou, G C Y (1994) Systemic delivery of polypeptide drugs through ocular route, J Ocul Pharmacol., 10:93–99 82 Morgan, R V (1995) Delivery ... (1998) Ophthalmic drug delivery systems recent advances, Prog Retinal Eye Res., 17:33–58 95 Robinson, J C (1993) Ocular anatomy and physiology relevant to ocular drug delivery Drugs Pharm Sci., ... J (1995) Review: Delivery systems for intraocular routes, Adv Drug Delivery Rev., 16:107–123 132 Velez, G., and Whitcup, S M (1999) New developments in sustained release drug delivery for the...

Ngày tải lên: 10/08/2014, 00:20

... future We hope that novel drug delivery systems will be developed to deliver potent polypeptide drugs through the ocular route REFERENCES Lee, V H L (1987) Ophthalmic delivery of peptides and ... insulin, Int J Pharm., 62:53 51 Su, K S E (1991) Nasal route delivery of peptide and protein drug delivery In: Peptide and Protein Drug Delivery V H L Lee (ed.) Marcel Dekker, New York, Chap 13 ... RETINAL DEGENERATION—GENETIC MODELS Retinal degeneration leads to impaired function of the photoreceptors and consequently gradual loss of vision., Many types of degeneration are based on genetic...

Ngày tải lên: 10/08/2014, 00:20

... polymer-based gene vectors to be the candidates of choice for pharmacological intervention in many diseases Gene Knockdown Therapy a Antisense Drugs Antisense technology is a novel gene delivery method ... to be very effective in gene therapy, there are a number of drawbacks associated with them Nonviral gene delivery systems consist of a therapeutic gene and a synthetic gene delivery system The main ... patients with metastatic breast cancer J Clin Oncol., 19(6):1716–1722 165 Schatzlein, A G (2001) Non-viral vectors in cancer gene therapy: principles and progress Anticancer Drugs, 12(4):275–304 166...

Ngày tải lên: 10/08/2014, 00:20

... therapeutics: drug delivery and targeting Adv Drug Delivery Rev., 18:115–131 167 J W Jaroszewski, and J S Cohen (1991) Cellular uptake of antisense oligodeoxynucleotides Adv Drug Delivery Rev., ... Rojanaskul (1996) Antisense oligonucleotide therapeutics: drug delivery and targeting Adv Drug Delivery Rev., 18:115–131 153 T M Woolf, D A Melton, and C G B Jennings (1992) Specificity of antisense oligonucleotides ... oncogene targeted cancer chemotherapy Anticancer Res., 10:1169–1182 Copyright © 2003 Marcel Dekker, Inc Gene, Oligonucleotide, and Ribozyme Therapy 655 164 C A Stein, and R Narayanan (1996) Antisense...

Ngày tải lên: 10/08/2014, 00:20

... increased as the drug diffusivity was reduced Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination halflife, decreased significantly as the drug diffusivity ... Kulkarni, P S., and Srinvasan, B D (1987) Nonsteroidal anti- inflammatory drugs in ocular inflammatory conditions In Nonsteroidal Anti- inflammatory Drugs, A J Lewis, D E Furst, eds., Marcel Dekker, New ... by changes to the drug diffusivity However, the time at which the peak concentration occurred increased as the drug diffusivity decreased because the average time required for a drug molecule to...

Ngày tải lên: 10/08/2014, 03:20

... pharmaceutical drug delivery system Copyright © 2003 Marcel Dekker, Inc Microparticles and Nanoparticles in Ocular Drug Delivery II PARTICULATE SYSTEMS IN OCULAR DRUG DELIVERY A 441 Topical Systems ... Ocular drug delivery Mechanism(s) of corneal drug transport and mucoadhesive delivery systems, S.T.P Pharma, 5:839 11 Mikos, A G., and Peppas, N A (1986) Systems for controlled release of drug ... in Ocular Drug Delivery 439 discomfort excludes inserts from the list of potentially popular drug delivery systems Although adding soluble polymers to ophthalmic solutions can increase drug retention...

Ngày tải lên: 10/08/2014, 03:20