design of controlled release drug delivery systems

... sustained release of the large protein model drug of bovine serum albumin (BSA) on SBA-15 Chapter covers the factors affecting stability of the released BSA in fabrication of drug delivery systems, ... surface of the polymer, resulting in a release rate that is proportional to the surface area of the drug delivery system (See Figure 2.5b) a Drug Drug Drug- loaded biodegradable particles b Drug Drug ... application of SBA-15 in the delivery of the small molecule model drug of ibuprofen (IBU), with emphasis on the influence of the different functional methods on the adsorption and release of IBU Chapter...

Ngày tải lên: 13/09/2015, 19:46

... matrix, control of the rate of polymer degradation can be achieved thereby changing rate of release of the drug Our study focuses on developing controlled releases implants in the form of discs for ... reported release profile suggested a form of delayed release where little or no drug was released for 30 days before a gradual controlled release was observable thereafter The objective of this ... 85:15 Foams release ~ 40% wt of Paclitaxel within the first weeks of implantation and releases ~ 0.35 % of the encapsulated drug per day a over the range of 14 to 28 days • Sustained released from...

Ngày tải lên: 05/10/2015, 21:33

... to advanced drug delivery systems Chemical Aspects of Drug Delivery Systems Table Mechanisms and properties influencing drug release from particle carrier systems* MECHANISM OF DRUG RELEASE PROPERTIES ... stability Chemical Aspects of Drug Delivery Systems Table Routes of administration and general classification of drug delivery systems ROUTES OF ADMINISTRATION DRUG DELIVERY CLASS ORAL SOLIDS ... DELIVERY eg gastric floating systems eg microbiologically controlled delivery PULSATILE DRUG DELIVERY - PHYSICAL - BIOLOGICAL eg swelling of hydrogel 'plug' to release pulse of drug eg drug release...

Ngày tải lên: 28/03/2014, 10:20

... Targeted drug delivery systems: deliver drug to a desired body location, organ, tissue, specific cells…  Controlled- release drug delivery systems: preprogramed drug release By the route of delivery: ... A4: series of multiple doses of a conventional drug delivery system B: ideal drug concentration profile PRODRUG What is a prodrug?  Prodrug is an inactive precursor of a drug  Prodrug reconversion ... Society of Chemistry, American Chemical Society, Wiley InterScience journals… CONTENTS Generalities of drug delivery Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery...

Ngày tải lên: 18/04/2014, 15:37

... construction of drug delivery systems in not too long a time The functionalization of CNTs used in the construction of drug delivery systems will be discussed in later sections In vivo behavior of functionalized ... application of CNTs as the molecular transporter in drug delivery Page 14 of 22 Drug delivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drug delivery systems ... schematic illustration of the strategy for the preparation of the CNT-based drug delivery systems Figure The modification of CNTs Schematic illustration of modification of CNTs with various molecules...

Ngày tải lên: 20/06/2014, 22:20

... Chapter Review of Microfabricated Microneedles 2.1 Microneedles in Transdermal Drug Delivery Transdermal drug delivery is an alternative method for delivery of DNA/protein based drugs These drugs which ... used for local delivery of other drugs, for example, drugs in anti-restenosis and anti-tumor therapies In transdermal drug delivery, microneedles are designed to painlessly deliver drugs into subcutaneous ... the implementation of time varying delivery of different therapeutics, which is essential for a more effective drug delivery system The direct delivery of DNA/portent based drugs into the metabolic...

Ngày tải lên: 14/09/2015, 11:17

... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... terms of duration of clinical use and Table 15.1 Use of a drug delivery system for kinetic control Dissolution of drug is too slow Drug and/or formulation is physically removed from the site of ... loading of up to 20% w/w of protein in the polymer with full retention of the protein enzymatic activity The addition of PEG to the formulation eliminated the burst release of drug and drug release...

Ngày tải lên: 25/10/2013, 08:20

... define drug- delivery systems of a certain size range Reflecting this trend of size definition, Nanoparticulate Drug Delivery Systems is a worthy attempt to bring together a wide range of drug- delivery ... nanoparticulate drug- delivery systems The first chapter covers a complete overview of the nanoparticulate drugdelivery system, covering wide applications and evaluation of the nanoparticulate drug- delivery ... polymer therapeutics for drug and gene delivery J Control Release 2002; 82:189 58 Torchilin VP Structure and design of polymeric surfactant-based drug delivery systems J Control Release 2001; 23:137...

Ngày tải lên: 04/06/2014, 14:47

... application of nanodelivery systems in medicine Design of nanotechnology – based drug delivery Systems Nanoparticles can be used in targeted drug delivery at the site of disease to improve the uptake of ... therapy The effectiveness of drug delivery systems can be attributed to their small size, reduced drug toxicity, controlled time release of the drug and modification of drug pharmacokinetics and ... uptake of poorly soluble drugs [8,9], the targeting of drugs to a specific site, and drug bioavailability A schematic comparison of untargeted and targeted drug delivery systems is shown in Figure...

Ngày tải lên: 20/06/2014, 00:20

... Morinville, Drug delivery to the nervous system Trend Biotechnol 15, 410–418 (1997) doi:10.1016/S01677799(97)01095-0 M Danckwerts, A Fassihi, Implantable controlled release drug delivery systems: ... acquire most of the characteristic properties of sympathetic neurons Other salient responses to NGF include cessation of proliferation, generation of long neurites, acquisition of electrical ... CNT-based interfaces, as demonstrated, could be used for controlled drug delivery: any bioactive factor could be released in a spatially and temporally controlled manner The proposed approach represents...

Ngày tải lên: 22/06/2014, 00:20

... Preface A major goal of pharmacotherapeutics is the attainment of an effective drug concentration at the intended site of action for a desired length of time Efficient delivery of a drug while minimizing ... edited by James W Munson 12 Techniques of Solubilization of Drugs, edited by Samuel H Yalkowsky 13 Orphan Drugs, edited by Fred E Karch 14 Novel Drug Delivery Systems: Fundamentals, Developmental ... Nixon Drug Metabolism: Chemical and Biochemical Aspects, Bernard Testa and Peter Jenner New Drugs: Discovery and Development, edited by Alan A Rubm Sustained and Controlled Release Drug Delivery Systems, ...

Ngày tải lên: 10/08/2014, 00:20

... loss of efficacy, the development of prodrugs takes advantage of the increased corneal permeability of the prodrug and the subsequent hydrolysis of the prodrug to active compound (16, 99,100) Prodrugs ... advantages of direct topical drug administration include targeted drug delivery to the anterior segment of the eye and avoidance of systemic drug toxicity Many of the disadvantages of eyedrops, ... P., and Camber, O (1987) Design and evaluation of controlled release systems for the eye J Controlled Release, 6:367 20 Ahmed, I., and Patton, T F (1985) Importance of the noncorneal absorption...

Ngày tải lên: 10/08/2014, 00:20

... increased utility of the microdialysis approach in the study of ocular drug delivery and disposition Unique applications of the microdialysis approach in the examination of drug ocular disposition ... pathophysiology of the posterior eye segment affects the distribution and elimination of drug from the vitreous (29) In particular, the effect of three conditions were examined: changes in the diffusivity of drugs ... weight of the diffusing species, and CP represents the concentration of polymer (collagen and hyaluronic acid) in the hydrogel in units of grams of polymer per gram of hydrogel Using the sum of the...

Ngày tải lên: 10/08/2014, 00:20

... framework for rational design of drug delivery systems for therapeutic agents that are poorly absorbed across the cornea or require delivery to posterior segment of the eye Drug delivery across the ... to promote site-specific delivery of drugs to intraocular tissues in the back of the eye (23) The increasing interest in intraocular delivery of peptide and protein drugs, drug therapy targeting ... STUDIES A variety of studies have described the pharmacokinetics of ocular delivery of dyes and drugs by collagen shields as well as the use of the shields in the chemotherapy of various disorders...

Ngày tải lên: 10/08/2014, 00:20

... fundamental basis of drug penetration via the noncorneal pathway The challenge for the future is to creatively apply the available knowledge to the practical design of drugs and drug delivery systems for ... surfactants, Drug Dev Res., 27:177–183 80 Harris, D., Liaw, J H., and Robinson, J R (1992) Routes of delivery: case studies (7) Ocular delivery of peptide and protein drugs, Adv Drug Delivery Rev., ... increasing the time of application of a constant low current), more of the drug enters the tissue C Design of Iontophoresis Devices Iontophoretic devices vary in complexity, but the basic design is a...

Ngày tải lên: 10/08/2014, 00:20

... OCULAR DELIVERY OF PEPTIDE AND PROTEIN DRUGS Peptides and proteins may be instilled into the eye for local/topical use Instillation of a topical dose of a drug to the eye leads to absorption of a drug ... route delivery of peptide and protein drug delivery In: Peptide and Protein Drug Delivery V H L Lee (ed.) Marcel Dekker, New York, Chap 13 52 Harris, A S (1986) Biopharmaceutical aspects of the ... (94) demonstrated the feasibility of effective systemic delivery of topically instilled peptides in the eye Their findings suggest that systemic delivery of peptide drugs is superior to the parenteral...

Ngày tải lên: 10/08/2014, 00:20

... advantageous properties of several delivery systems will enhance the use of gene therapy and provide flexibility in the treatment of many diseases Non Viral Vectors One of the greatest concerns ... therapeutically active drugs This is a fascinating technology that has the potential of being a tailor-made delivery system that will improve the therapeutic index of a number of drugs Another modification ... refers to a number of related inherited retinal diseases with an incidence of in 3000 An understanding of the genetic causes of retinitis pigmentosa could lead to delivery of specific genes in...

Ngày tải lên: 10/08/2014, 00:20

... reviewed as a new drug product by the FDA’s Drug Center (CDER) V CLINICAL TESTING OF NEW OPHTHALMIC DRUG DELIVERY SYSTEMS A Human Versus Animal Testing Human drug products are often tested during ... orphan drug for the same rare disease, and more than one applicant can obtain designation for the same drug and rare disease The drug must be designated as an orphan drug prior to submission of the ... regulation of food, drugs, devices, and cosmetics One of the major provisions of the Act was the reauthorization of PDUFA for years as described above A number of the reforms affecting drug products...

Ngày tải lên: 10/08/2014, 00:20