translational+stem+cell+research+and+commercial+funding

... Ünal and Taner Demirer Chapter 14 Iron Overload and Hematopoetic Stem Cell Transplantation 305 Zeynep Arzu Yegin, Gülsan Türköz Sucak and Taner Demirer Chapter 15 Sickle Cell Disease (SCD) and Stem ... developments and innovations in cell- based therapies containing basic and clinical chapters from the respected authors involved in stem cell studies and research around the world It thereby complements and ... When a stem cell divides, each new cell has the potential to either remain a stem cell or be‐ come another type of cell with a more specialized function, such as a muscle cell, a red blood cell...

Ngày tải lên: 18/02/2014, 04:20

... respected authors involved with stem cell studies and research from around the world It complements and extends the basics of stem cell physiology, hematopoietic stem cells, issues related to clinical ... related to stem cells and Cell Transplantation, we feel it is important to take this opportunity to share these new developments and innovations describing stem cell research in the cell transplantation ... presentation and T -cell recognition, and appear to be important in innate immunity as ligands to NKG2D receptor expressed on most γ T cells, CD8  T cells, and NK cells (Tieng et al., 2002) 4.2 MICA and...

Ngày tải lên: 20/02/2014, 08:20

... CM and cell lysates (CM and L, respectively) were collected and TSP1 was detected by western blotting Note the low TSP1 secretion and higher intracellular levels in RCC cells (F) HNK and P769 cells ... Fig Calcium uptake and mediators in HNK and RCC cells (A) Ca2+ uptake in response to VEGF by HNK and RCC cells HNK and RCC cells were preloaded with fluo-4 acetoxymethyl ester and treated with 10 ... angiogenesis, and localization in renal cells and tissue (A) Sections of RCC tumors and adjacent normal tissue (HNK) were stained for TSP1 and counterstained with hematoxylin (B, C) CM from HNK and P769...

Ngày tải lên: 07/03/2014, 05:20

... against some human cell lines, such as human keratinocytes (HaCaT cells), human embryo lung fibroblast cells (HEL cells), human nasopharyngeal carcinoma cells (HEp-2 cells) and PMNs in vitro Results ... 48 Time (h) D 100 80 HEL cells 120 72 HEp-2 cells 120 Cell viability (% of control) 100 C Cell viability (% of control) B HaCaTcells 120 Cell viability (% of control) Cell viability (% of control) ... HaCaT cells were incubated with 100 lM each organic selenium compound Cell viability was measured at intervals of 24 h (B) Cell viability of HEL cells (C) Cell viability of HEp-2 cells (D) Cell...

Ngày tải lên: 23/03/2014, 07:20

... metformin, from DM, HS and CN for the care of melanoma cell lines and cell viability studies and from BC-A for the optimization and conduct of cell viability, cell cycle, apoptosis and phosphoflow studies: ... of μM vemurafenib and 10 mM metformin of all melanoma cell lines tested The green cell lines harbor BRAFV600E, red shows NRASQ61 mutant cell lines, and black the wild type cell line M257 Propidium ... all Cell lines Niehr et al Journal of Translational Medicine 2011, 9:76 http://www .translational- medicine.com/content/9/1/76 Table BRAFV600E and BRAFWT cell lines used for detailed analysis Cell...

Ngày tải lên: 18/06/2014, 19:20

... most hemapoietic cells; Dok-2 is expressed in T cells, mast cells and macrophages but not B cells; Dok-3 is expressed in B cells, mast cells and macrophages but not in T cells; Dok4 and Dok are expressed ... antigen is presented to and recognized by the antigen-specific receptors on T and B cells T and B cells upon activation will undergo cell priming, activation, proliferation and differentiation within ... helper cells) which can be subdivided to CD4+ Th1 cells that help in macrophages activation and CD4+ Th2 cells that help in B cells activation; whereas CD8+ T cells (also known as T cytotoxic cells)...

Ngày tải lên: 12/09/2015, 08:16

... of endogenous LPXN and Lyn in BJAB cells Cells were stimulated with 10 ␮g/ml cells (Fig 4A, lower panel) anti-human IgM F(abЈ)2 fragment for the indicated time points, and cell lysates were subjected ... production in T cells (49 –51) and in B cells (52, 53) Therefore, we speculate that LPXN regulates IL-2 production in B cells via regulating JNK, p38 MAPK, and Akt activities and that Tyr72 of ... endogenous interaction of LPXN and Lyn can occur in B cells upon BCR activation BJAB cells were treated with 10 ␮g/ml anti-human IgM F(abЈ)2 fragment for various time points, and cell lysates were immunoprecipitated...

Ngày tải lên: 12/09/2015, 08:16

... unique model for stem cell research Medaka is an excellent complementary system to human and mouse for stem cell biology Conditions for cell cultures from developing embryos and adult tissues ... hESCs or stem cell lines from other species Thus, a better understanding of stem cell biology requires comparative analysis of stem cells from different species In this regard, stem cells from ... function in tissues and organs Stem cells may also be bipotent or unipotent Examples are liver progenitor cells that can give rise to hepatocytes and bile ductal cells, and germ stem cells whose differentiation...

Ngày tải lên: 14/09/2015, 13:38

... cancer stem cells from different cancer tissues and cell lines [16,17] Qverexpressed MUC4 and control cells were stained with FITC-conjugated CD133 cells to analyze the percentage of the cancer stem ... CD44, CD24, ESA and ALDH1 in different cancers [1] Few of these markers were used for the confirmation of an MUC4 enriched cancer stem cell population Stem cells and cancer stem cells are known ... population of stem/ progenitor cells in the breast cancer (MCF7) cell line [11] The fact that the vast majority of MCF7 stem cell enriched SP cells express MUC1 suggests that epithelial cancer stem cells...

Ngày tải lên: 20/06/2014, 07:20

... Nursing Research and Translational Science, and currently is a Research Scientist, Outcomes Research Branch, NIH, National Cancer Institute MK, PP, NS, LW are involved in study coordination and data ... Intramural Research Transplant Teams; NIH Clinical Center staff; and research participants Funding source Funding for this study was provided by the NIH Clinical Center Intramural Research Program ... the study and are accountable for data acquisition and preparation of the manuscript MB is a Clinical Nurse Scientist with at the NIH Clinical Center, Department of Nursing Research and Translational...

Ngày tải lên: 20/06/2014, 15:20

... mesenchymal stem cell in vitro BMC cell biology 2006, 7:14 Hung SC, Chen NJ, Hsieh SL, Li H, Ma HL, Lo WH: Isolation and characterization of size-sieved stem cells from human bone marrow Stem cells ... converges toward embryonic stem cells Principal component analysis comparing the gene expression profiles of 3A6, embryonic stem cells (ESC), mesenchymal stem cells (MSC), and various tissues using ... embryonic stem cells Biochemical and biophysical research communications 2004, 323:86-90 Taylor SM, Jones PA: Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine Cell...

Ngày tải lên: 10/08/2014, 05:21

... allogeneic stem cell transplantation, severe disease is rare in patients after autologous stem cell transplantation Nevertheless, in patients with severe complications of infections after autologous stem ... PS interpreted the chest-CT and the MRI and added the figures, BM wrote the paper and all authors read and approved the final manuscript Authors' information G.J and B.M are attending physicians ... disease He had received four cycles of ABV and involved field radiation Seven months later the lymphoma relapsed and two cycles of DexaBEAM with stem cell harvest were applied We performed high-dose...

Ngày tải lên: 12/08/2014, 04:21

... allogeneic stem cell transplantation, severe disease is rare in patients after autologous stem cell transplantation Nevertheless, in patients with severe complications of infections after autologous stem ... PS interpreted the chest-CT and the MRI and added the figures, BM wrote the paper and all authors read and approved the final manuscript Authors' information G.J and B.M are attending physicians ... disease He had received four cycles of ABV and involved field radiation Seven months later the lymphoma relapsed and two cycles of DexaBEAM with stem cell harvest were applied We performed high-dose...

Ngày tải lên: 12/08/2014, 04:22

... endothelial cells and parenchymal cells after APAP overdose before cell injury [29] Both hydrogen peroxide and peroxynitrite decomposition products, OH and NO2 radicals can initiate LPO and lipid and ... Lai, W Wong, Y Y Dan, S K Lim and H K Ho, Mesenchymal stem cell- derived exosomes promote hepatic regeneration in drug-induced liver injury models, Stem Cell Research and Therapy, 5(3):76 (2014) ... cytotoxicity and cellular uptake of -TP, -T3, T3 and -T3 in TAMH hepatocytes 110 Figure 28 Concurrent effects of -TP, -T3, -T3 and -T3 in cell viability after APAP- and H2O2-induced...

Ngày tải lên: 09/09/2015, 11:21

... the altered dynamic and complex stem cell niche One way to distinguish between these alternatives would be to isolate and grow stem cells from healthy and diseased tissues and compare them under ... appeared in the cells from NP patients and controls 130 Figure 5.12 Basal or stem cells in differentiation of culture human NESPCs 131 Figure 5.13 mRNA expression of stem and cell proliferation ... survived and more than 90% of cells proved to have properties of epithelial stem or progenitor cells in a chemical-defined medium Meanwhile, these cells successfully differentiated into functional cells...

Ngày tải lên: 09/09/2015, 11:29

... Transcriptional control of stem cell pluripotency Embryonic stem cells (ESCs) are derived from the inner cell mass of blastocysts, and can be maintained undifferentiated in culture Pluripotency and self-renewal ... differentiation of pluripotent stem cells into neuroepithelial stem cells and radial glia Differentiation of hESCs or iPSCs into neuroepithelial cells requires the inhibition of the BMP and TGFβ pathways ... in the GIS Stem Cell groups for companionship, support and helpful discussions Most importantly, my family has given me incredible support and encouragement Their love and understanding helped...

Ngày tải lên: 09/09/2015, 17:54