... some ofthe great names inthe development of our understanding ofthe changes inthe breast The ANDI concept provides a framework to enable clinicians to explain to patients the nature of their ... still the most insistent Benign disorders anddiseasesofthe breast single group to maintain the use ofthe term, despite this stinging remark from eminent members of their own discipline Greater ... years since the first edition of this book and since the second edition The intervening years have seen advances in imaging technology, understanding ofthe molecular events leading to disease and...
... knowledge and practice training of maritime medicine for deck officers 11 Table 3.11 Training result of practice skill of maritime medicine knowledge for deck officers before and after training (n=104) ... conducted the intervention applying one inthe main proposed measures namely "strengthening maritime medicine training programs for companies’ deck officers under the provisions ofthe STCW Convention/2010 ... practice (intensive training for weeks at the Center for Marine Medicine Training subordinate Vietnam National Institute of Maritime Medicine) The students were evaluated in terms of knowledge...
... begins inthe gut ofthe sandfly, but the organism completes its life cycle inthe host following the fly bite The sandfly inoculates the host with the organisms inthe promastigote stage Once the ... mass at the angle ofthe jaw The masses gradually increase in size and number and form sinuses that open onto the face and neck Although infection is often seen inthe jaw area, Actinomyces infections ... weapon There are major forms of infection with the organism: cutaneous, inhalation, and gastrointestinal.93 The details of these forms of anthrax will not be discussed with the exception of gastrointestinal...
... obligations In January of 2005, the OIE combined the lists into a single entity, containing 130 diseasesof interest A list of these diseases can be found in Table and also at the OIE website (www.oie.int) ... generous in allowing us to borrow Dr Jason Baldwin, who served as an infallible and incredibly diligent copy and content editor PDS also supplied the funding for the final formatting ofthe book, including ... factors inherent inthe assay andthe host response In order to understand the diagnostic reliability of an assay or series of assays, it is important to understand the intended use ofthe assay,...
... tropical diseases due to increased traffic across the continents and migration ofthepopulation Physicians need to be aware ofthe symptoms and imaging findings of these diseases mainly in travelers ... Aberrant regulation ofthe activity or action of EGFR and other members ofthe RTK family have been involved in multiple cancers, including of brain, lung, breast and ovary Furthermore, in many tumors ... cause in- frame deletions inthe extracellular domain ofthe receptor, the most frequent is the EGFRvIII variant Somatic mutations inthe tyrosinekinase domain of EGFR were also identified in NSCLC...
... disorders anddiseasesofthe brain, the advances in brain research provide hope inthe form of their own understanding of what is going wrong andinthe form of advances in novel therapies which ... 89] These findings suggest an important role of inhibition inthe PFC: controlling the timing of neuronal activities during cognitive operations and thereby shaping the temporal flow of information ... systems, including noradrenaline (NA)-containing neurons inthe pontine locus coeruleus, dopamine (DA)-containing neurons inthe ventral tegmental area, serotonin (5-HT) neurons inthe raphe nuclei and...
... dihydrotestosterone intheglandThe periurethral portion ofthegland increases in size during puberty and after the age of 55 due to the growth of nonmalignant cells inthe transition zone ofthe prostate ... composed of branching tubuloalveolar glands arranged in lobules and surrounded by a stroma The acinal unit includes an epithelial compartment made up of epithelial, basal, and neuroendocrine cells and ... (SRD5A2) gene have also been implicated inthe variations in incidence The incidence of autopsy-detected cancers is similar around the world, while the incidence of clinical disease varies Thus, environmental...
... control, in which the tempo ofthe illness is altered and symptoms controlled until the patient dies of other causes These can be equivalent therapeutically from a patient standpoint if the patient ... based on the tempo ofthe illness as it unfolds inthe individual, relative to the riskto-benefit ratio ofthe therapy being considered No Cancer Diagnosis Prevention Several agents are under investigation ... double-blind, randomized multicenter trial The prostate cancer detection rate was 18.4% (803 of 4364) inthe finasteride group and 24.4% (1147 of 4692) inthe placebo group Early concerns that the...
... during the patient's lifetime The side effects of treatment, including impotence, incontinence, and bowel dysfunction, are unacceptable for these patients Formal clinical trials to assess the ... palpable, andof these, 70% are pathologically organ-confined The downside of widespread PSA screening is the detection and treatment of cancers with such a low malignant potential that they would ... for the presence of cancer, andthe amount of cancer is quantified based on the length ofthe tumor within the core andthe percentage ofthe core involved ...
... to the extent ofthe disease within the gland, the presence or absence of capsular invasion, involvement of seminal vesicles, and extension of disease to lymph nodes Because ofthe inadequacy of ... on the basis of an abnormal PSA (T1c), those that are palpable but clinically confined to thegland (T2), and those that have extended outside thegland (T3 and T4) (Table 91-1) DRE alone is inaccurate ... staging, the staging system was modified to include the results of imaging studies Unfortunately, no single test has proven to indicate accurately the stage or the presence of organ-confined...
... assess The more advanced the disease, the lower the probability of local control andthe higher the probability of systemic relapse More important is that within the categories of T1, T2, and T3 ... rates range from 25 to 89% Part ofthe variability relates to how the complication is defined and whether the patient or physician is reporting the event The time ofthe assessment is also important ... undetectable inthe blood within weeks, based on the PSA half-life inthe blood of days If PSA remains detectable, the patient is considered to have persistent disease After radiation therapy, in contrast,...
... maximize the dose to the prostate and to minimize the exposure ofthe surrounding normal structures The addition of IMRT has permitted further shaping ofthe dose, allowing the delivery of still ... disruption ofthe vascular supply and not the nerve fibers Neoadjuvant hormone therapy has also been studied in combination with radiation therapy The aim is to decrease the size ofthe prostate and, ... probability of cure Prostatectomy techniques continue to improve as the ability to determine whether the tumor is localized to thegland improves based on different biopsy algorithms and with imaging The...
... waiting, or deferred therapy, is a policy of monitoring the illness at fixed intervals with DREs, PSA measurements, and repeat biopsies ofthe prostate as indicated, but with no therapeutic intervention(s) ... evidence of disease on scan For these patients the central issue is whether the rise in PSA results from persistent disease inthe primary site, systemic disease, or both In theory, disease inthe ... undergone radiation therapy The decision to recommend radiation therapy after prostatectomy is often made on the basis ofthe pathologic findings at surgery, as imaging studies such as CT and bone scan...
... results of randomized comparisons involving thousands of patients showed no advantage for combining an antiandrogen with surgical orchiectomy, while separate analyses of trials combining an antiandrogen ... differentiation pathway In this way, the surviving cells that are allowed to proliferate inthe presence of androgen will retain sensitivity to subsequent androgen depletion Applied inthe clinic, androgen ... first 2–4 weeks of treatment to protect against the flare Intermittent Hormone Therapy Another way to reduce the side effects of androgen depletion is to administer hormones on an intermittent basis...
... terazosin (1–10 mg PO at bedtime) act by relaxing the smooth muscle ofthe bladder neck and increasing peak urinary flow rates No data show that these agents influence the progression ofthe disease ... you finished urinating? Over the 5 how often past month, have you had to urinate again less than h after you finished urinating? Over the past month, how often have you found you stopped and started ... Diagnostic Procedures and Treatment Asymptomatic patients not require treatment regardless ofthe size ofthe gland, while those with an inability to urinate, gross hematuria, recurrent infection, or...
... medication for PsA in Finland inthe years 1990 and 1995 A total of 65 incident cases of PsA were identified inthe 1990 study, resulting in an annual incidence of per 100,000 ofthe adult population ... rheumatic diseasesand highlight the key role of epidemiological research in understanding these intriguing conditions Competing interests 13 14 15 16 The authors declare that they have no competing interests ... increasing inthe USA, Finland, New Zealand, and Taiwan [81-84] The most recent study ofthe incidence of gout was a longitudinal cohort study of 1,337 eligible medical students who received a standardized...
... factors inthe control of sphincter of Oddi • Prostaglandin Prostaglandin E1 inhibits sphincter of Oddi activity by suppressing its membrane activity In addition, prostaglandin E2 has an inhibitory ... prostaglandins [93] Another study suggested that the inhibitory effect of indomethacin is related to the inhibition of prostaglandin synthesis [94], and it was effective in relieving pain in patients with ... individuals, the body and tail ofthe pancreas drain via the duct of Santorini (pancreas divisum) to the minor papilla In this instance, only the ventral aspect ofthe pancreas drains through the duct of...
... gallbladder carcinoma is indirect and based on relative ages of patients with these lesions andthe presence of dysplasia and intramucosal carcinoma in gallbladders with invasive carcinoma Another study ... diffuse or inthe form of small polyps In autopsy studies, the prevalence of cholesterolosis is to 20% The disorder is more common with increasing age andin women The cause ofthe accumulation of cholesterol ... define the extent of local invasion, thus affecting surgical treatment Common findings include diffuse nodular thickening ofthe gallbladder wall, a mass inthe gallbladder fossa, and invasion of the...
... multifocal disease Involvement ofthe main trunk ofthe portal vein Involvement of both branches ofthe portal vein or bilateral involvement ofthe hepatic artery and portal vein Vascular involvement ... dilatation ofthe bile duct without clear pathology Release of bile into the duodenum is not continuous but regulated by the activity ofthe sphincter of Oddi, a ring of smooth muscle at the level ofthe ... position The role of this mutation inthe genesis of cholangiocarcinoma is uncertain Other mutations that have been described in pancreatic and biliary cancers include the p53 mutation and loss of integrity...