... Commission onHuman Rights andthe Commission onthe Status of Women The Commission onHuman Rights, in turn, established the Sub-Commission on Prevention of Discrimination andthe Protection of Minorities ... Discrimination Convention onthe Elimination of All Forms of Discrimination Against Women Convention Against Torture and Other Cruel, Inhuman, or Degrading Treatment or Punishment Convention onthe ... the law of armed conflict They are the Convention Relative tothe Protection of Civilian Persons in Time of War; the Convention for the Amelioration ofthe Condition ofthe Wounded and Sick in Armed...
... expression of these genes could not be distinguished from the response ofthe skin fibroblasts, indicating that the wound healing expression signature is not specific tothe response of dermal ... the activation ofthe phosphoinositide pathway is the physiological activator of protein kinase C (PKC) as well as other protein kinase C conserved region (C1)-domain proteins, such as protein ... inthe response of fibroblasts but, interestingly, only the MAPK pathway activation and c-Myc induction are believed to be indispensable during the early to hour period of fibroblast response...
... having no personal history of autoimmune conditions Appropriate informed consent was obtained For the first SNP map (Section 3.1), subjects consisted of 93 males and 105 females B-lymphoblastoid ... used to construct a standard curve DNA samples were subsequently stained with PicoGreen using the same protocol and concentrations determined by comparing fluorescence readings against the standard ... manufacturer’s instructions, each reaction was performed in a total volume of 10µl, comprising of: 2µl of BigDye v3.1 reaction mix, 1µl of 5x sequencing buffer, 1µl of 5µM sequencing primer and 50ng of PCR...
... black border onthe heatmap The positions ofthe SNPs inthe blocks are highlighted in blue These blocks lie within the high LD peak described earlier and overlap with zinc finger and histone clusters ... indicator ofthe absence of recombination inthe history ofthe studied population samples, whereas a high r2 value has an additional requirement of correlation between allele frequencies ( Devlin ... obtained from the first maps guided sample selection for the third map, allowing the detailed analysis ofthe common and conserved MHC haplotypes present inthe Singapore Chinese population 50...
... High-Resolution SNP Variation Map ofthe MHC For constructing a fine-scale variation map ofthe MHC, 2360 SNPs were genotyped in 284 Singaporean Chinese individuals The bulk of these samples consisted of ... other SNP, but only serve to ‘tag’ themselves A large number of singleton tags lie in regions of low LD and outside of haplotype blocks, 27.8% (108 out of 388) of singleton tags lie outside of ... Chinese genotypes in release 22 ofthe HapMap consist of 9479 SNPs across the MHC, including the 1877 informative SNPs genotyped in this study To test the efficacy of these 1877 in representing...
... SNPs also capture the DR haplotypes in these cell lines, confirming the validity ofthe tags and indicating that these tags not only apply tothe local Chinese population The DR52 and DR53 haplotype ... clustered together inthe same location To see if these segments of clustered EHH decay are consistent with the location of established recombination hotspots, the locations ofthe latter are mapped onto ... none of other common HLA-C alleles show strong homozygosity into the HLA-B locus Onthe other hand, if the plots are anchored on HLA-B instead, high EHH in all HLA-B alleles (with the exception...
... providing a wealth of variation data ofthe MHC inthe Caucasian population The high-resolution SNP map ofthe Chinese CEHs in this study contributes to this objective and enables comparisons to ... with the HLA locus are major contributing factors, possibly transmitted along within the conserved haplotype A lack of detailed knowledge ofthe variation and allelic content ofthe CEHs beyond the ... within these haplotypes 3.4.2 Haplotypes of HLA Homozygous Samples The inclusion of HLA homozygous individuals inthe genotyped samples provides robustness tothe description ofthe CEHs in the...
... re-sequencing The grey tracks at the top ofthe figure mark the locations of repeat elements inthe region The large grey shadow indicates the location of a 3kb SVA insertion seen inthe PGF haplotype ... each ofthe Cullen hotspot segments, the location ofthe crossover was refined by identifying intervals onthe SNP map using the following factors: 1) Spikes inthe population recombination rate, ... of these were resequenced in this study, with the corresponding crossover locations fine-mapped to windows of less than 2kb wide The locations ofthe narrowed crossover locations in each of the...
... as a reason for the presence of some of these CEHs inthe population A recent introduction of these CEHs into the Chinese gene pool could have resulted in an increase in frequency of these haplotypes ... population, and a key to identifying the genetic aetiology of these diseases lies inthe understanding ofthe LD structure ofthe MHC LD describes the non-independence of alleles at different loci, and ... available To this end, SNP maps of increasing marker density were constructed and these sets of data provide a comprehensive guide tothe patterns of variation and LD ofthe MHC inthe Singaporean Chinese...
... segment ofthe MHC from HLA-A to TAPBP using sets of SNPs at each ofthe 25 loci These haplotypes were then linked together to construct “surrogate inter-gene haplotypes” The LD of each of these ... (PSMB8/9) and peptide chaperone TAPBP could benefit from clustering together for the coordination of expression profiles (Horton et al 2004) Other gene families such as the RNA and histone genes ... ofthe CEHs inthe Chinese population will also add tothe currently available data that is limited tothe Caucasian population, and allow comparisons to be drawn between thetwoOf special interest...
... Studies conducted on challenges and prospects of Wonchi creator lake showed that there is question of sustainable ecotourism development because of conflict of interest onthe ownership ofthe lake, ... monitoring the changes inthe water quality of a given source as a function of time and other influencing factors Time ofthe sampling also significantly influences water quality parameters and ... longitude The altitude ofthe area ranged from 2000 to3 400 m a.s.l from the Crater rim inthe North tothe highly dissected landscape along the southern slope ofthe Mt Wonchi andthe undulating foot...
... increase inthe Q-8 content, andthe denitrification rate was independent of Q-10 with the second highest ubiquinone content As for menaquinones, MK-7 had the strongest correlation with DNR In ... environment DISCUSSION Correlation between denitrification rate and quinone compositions Table lists the correlation coefficients for DNRs andthe contents of quinones The correlations for the ... denitrification inthe paddy Quinone composition provides information for the evaluation ofthe biological potential for denitrification in paddies The arrangement of environmental factors of paddy,...
... that one ofthe reasons for the poor health Mother’s education, according totheof Indian women is the discriminatory treatment girls and women NFHS, is highly correlated with the level of malnutrition ... improving the overall healthof Indian women Increasing the use of contraceptives is one way to reduce fertility While the knowledge of family planning is nearly universal in India, only 36 percent of ... presented at the Association of Women in Development International Conference, Washington, DC Kelkar, Govind, 1992, Violence Against Women: Perspectives and Strategies in India, Indian Institute of Advanced...
... against France, the object ofthe combination being to exclude Louis from the Netherlands and West Indies, andto prevent the union ofthe crowns of France andSpain upon the same head King William ... As soon as the captain and naval men had gained the quarterdeck they threw off the lashings ofthe guns, and had all in readiness for running them inand taking them aft tothe edge ofthe quarterdeck ... Austria and Holland in opposition to France, the subject of dispute being the succession tothe crown of Spain, England's feelings inthe matter being further imbittered by the recognition by Louis...
... for maintaining a steady Cys availability as it is continuously exported out of cells into plasma and converted to circulating cysteine by the action of c-GT and dipeptidase (Fig 9) Among the various ... decreased the flux of cysteine towards the hematic compartment by 25% and 30%, respectively Concomitant use of these inhibitors enhanced the inhibitory effect onthe Cys increase in blood This ... onthe thiol ⁄ disulfide balance of tissues other than blood, and did not induce evident decreases in cysteine and GSH levels inthe organs analyzed Together, these findings prompted us to further...
... results ofthe mannose titration to be reasonable We then considered the relative contributions of diet, salvaging and glucose interconversion to glycoprotein synthesis (Fig 6) The mannose titration ... determined the variation of amount of glycoprotein in cells As shown in Fig 5E, although the total amount of protein in cells decreased to 87% after 48 h of incubation, the amount of glycoprotein ... mannose titration curves (Fig 3B) This distinction may be due to differences inthe mechanism of action of swainsonine and bafilomycin A1 Swainsonine inhibits both lysosomal and nonlysosomal mannosidases,...
... regulation, technology and demography Planning for reducing imbalances inthe supply ofhealth professionals inSpainInSpain there is an intense debate within the medical profession andin society ... salaries and income ofthe professionals) and quantity control (barriers to entry into the profession and international mobility) InSpainthe deficit of physicians, which varies substantially among ... it is ontheright track The challenge of dynamically adjusting the supply and demand of doctors involves making theright decisions at theright time about the number of slots for training, about...
... participated inthe statistical analysis QL and RH conceived ofthe study, and participated in its design and coordination DX contributed effort in designing, performing, and analyzing the results and conclusion ... via the Page 13 of 15 intrinsic apoptosis pathway involving down-regulation of Bcl-2 protein, loss of MMP and activation of caspase-3, followed by PARP degradation Furthermore, suppression of ... leads to permeabilization ofthe mitochondrial membrane [39] We therefore investigated the effects of curcumin on MMP using JC-1 fluorescent dye and flow cytometry Exposure ofthe three cell lines...