... penicillin binding Arginines 306 and 307 Fig Proposed binding mode for penicillin N to the iron(II)-2-oxoglutarate complex of DAOCS, showing possible involvement of selected residues The specific ... clavaminic acid synthase [20,21]) have suggested that prime substrate binding activates the enzyme–iron(II)-2-oxoglutarate ternary complex to oxygen binding, thereby initiating catalysis and ensuring ... to the proposed mode of penicillin binding by DAOCS [1,12] a key feature of which is that arginines 160 and 162 bind to the carbonyl and/ or carboxylate of the bicyclic b-lactam nucleus, with the...
... game theories New findings out of the thesis This thesis presents the following new findings (1) New findings related to theory (a) A new economic equation to relate two levels of sustainable ... producers and consumers inthe world Therefore, its decisions could influence Vietnam andthe world trade of tropical forests if they are properly introduced ITTO also holds the best information inthe ... of poverty and environmental degradation in developing countries One of the most important turning point was the WTO Ministerial Meeting held in November 1999 in Seattle, USA The meeting was prohibited...
... tax-loss selling (Griffiths & White, 1993; Jones et al., 1991) inthatthe marginal investor is selling at the end of December and buying inthe first few trading days of January That is, the majority ... With the assumption again that there is only one purchaser inthe market in 1993, only $8.2 million can be invested inthe small-capitalization portfolio on the last trading day of the year and ... findings The analyses commence by ensuring thatthe TOYE continues to appear to exist in Canada Two daily indices from the TSE-Western Business School Database were obtained The first is an index...
... rights Sometimes, the cost and time that are needed to win the cases are more than the benefit thatthe defendants of the case can obtain Inthe case of international society, the transaction cost ... remains to be seen Further, it would be very useful to introduce some leading present economic theories and analyze the international agreements in accordance with these theories By adopting theoretical ... reform and intellectual property rights, are also discussed inthe Chapter of the Thesis (2) Limitation of the Study However, there are a few limitations in writing the proposed thesis Functions...
... cells and eosinophils also synthesize interleukin-5, indicating that autocrine production of interleukin-5 may contribute to the chronicity of inflammation [41,42] The interleukin-5 receptor is in ... autophosphorylation Like interleukin-3 and GM-CSF, interleukin-5 induces rapid tyrosine phosphorylation of several proteins, further indicating that tyrosine kinases are involved inthe cellular activation ... [78] Whereas interleukin-4 and interleukin-13 are redundant with regard to these inflammatory parameters, interleukin-5 plays a distinct rolein both Furthermore, interleukin-5 and eotaxin synergistically...
... explored and consideration will be given as to therole each theory may have played in raising the profile of women in management or leadership roles Early leadership theories Inthe 18th and 19th ... out focussing on the individual traits of a person as well as the situation the individual found themselves in (Hollander and Julian, 1970) These theories are also known as contingency theories ... domain These two factors could account for the lack of women or feminine characteristics being included inthe leadership theories between 1940s and 1980s Not surprisingly, all the researchers and...
... financial institutions ( IFIs ) The IFIs have played an active rolein financial restructuring in China by introducing international standards and good practice and providing policy advice and personnel ... rendered the dominance of the banking sector inthe financial system At the same time, opening of markets and reforms have contributed to the strengthening of intermediation function of financial markets, ... developing economies Using this ratio, Professor Ronald Mckinnon analyzed the gap in financial deepening between the developed and developing countries andthe process of financial deepening in the...
... Control and Prevention Therole of BCG vaccine inthe prevention and control of tuberculosis inthe United States: a joint statement by the Advisory Council for the Elimination of Tuberculosis andthe ... heterogeneity inthe efficacy of the BCG vaccine reported inthe individual studies Using a model that included the geographic latitude of the study site andthe data validity score as covariates, they ... adults These studies also were not useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered Vol 45 / No RR-4 MMWR andthe vaccinee’s...
... important roleinthe banking industry, even as technology and market conditions change The paper concludes thatthe Federal Reserve therefore has a strong interest in understanding issues facing community ... Among the large banking organizations falling inthe latter group are two kinds—those that conduct most of their business within a single state (for example, Commerce and UMB in Missouri), and ... important roleinthe banking system But can they continue to so as technology and market conditions change? This section begins by pointing out that banking industry observers expect the number...
... Fig 4) onto the axis z, and (b) to conserve the minimal distance ˚ between protein and membrane at 3.5 A The EIE, i.e., the electrostatic contribution to the binding energy (DGbindingR ⁄ M) of ... with the negative end of the dipoles toward the bottom, andthe positive one toward the top of the figure Figure S4 shows instead the N-terminal surfaces colored by charge As expected, inthe orientation ... membrane-attractive region, and (b) their cytotoxic action This finding strongly suggests thatthe electrostatic surface potential of a defined 3D district of these proteins has a rolein determining their cytotoxic...
... side-chains are important for the GABA transport activity 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into therole of the terminal structures of the N-glycans ... a misfolding of this protein, resulting in its partial retention inthe ER and its rapid digestion thereafter [16,19] Accordingly, our results indicate thatthe intracellular trafficking of N-glycosylation ... reported that, inthe endoplasmic reticulum (ER) andinthe early secretory pathway, the N-glycans play a pivotal rolein protein folding, oligomerization, quality control, sorting, and transport...
... resting state, that is modified over time depending on the input, interconnections to other information, and an automatic a c t i v i t y decay scheme In addition, the decay scheme is based on the ... affected by other information inthe system Similar control philosophies have been employed in l e t t e r perception by McClelland and Rumelhart (1981), andinthe connectionist theories applied ... is thein interaction of the results of these asynchronous processes thatthe process of comprehension is defined 4.1 The processes are independent of the knowledge representations defined and...
... financial constraints The descriptive, statistical analysis in Table indeed confirms thatthe lower the decline in production (or the higher its increase, inthe best cases), the higher the probability ... constraints deriving mostly from the real good markets - demand-side constraints for most of them and access-to-input for the worst in this sub-pool Conversely, the overbearing influence of the financial ... probability of increasing debt raises with the fact thatthe enterprise was indebted inthe past (in all the groups) Nodebt thus appears as a strong inertial component inthe credit-demand equation...
... clients The lessons from various experiences demonstrate that removing the regulatory obstacles and allowing these institutions to expand their mission and diversify into lending and other banking functions ... expertise in disbursing credits and securely collecting and managing deposits A number of them have efficient management information’s systems and some are already involved in payments and international ... of part of their profits for increasing social and financial inclusion, WSBI member banks generally go further than other financial institutions in their educational role to stimulate the mobilization...
... by the level of ambiguity inherent inthe visual scene Specifically, the more ambiguous the meaning of the visual image, the more influence is exerted by the musical score inthe process of interpreting ... communicate information to the listener, enhancing the filmic experience Though the title for this paper includes the phrase “ music communication,” the present authors maintain that “music,” in a cinematic ... by the performers involved in recording the score cannot be separated from therole of the sound editor who is eventually responsible for the manner in which the sound and image are combined and...
... relevant The fact thatthe wildtype and mutant curves merge at higher pH inthe pHkcat plot would then be in accordance with the prediction that substrate-binding raises the pKa of Glu144 Tyr10 and ... indicate thatthe pKa of Glu144 is further, and somewhat drastically, increased upon substrate-binding The D142N mutant is interesting because it retains significant activity (suggesting that a ... Table shows that substrate-binding has drastic effects on the pKa of Glu144, raising it by 3.8 to 5.4 units, depending on the position of Asp142 andthe calculation used Interestingly, the calculations...
... of the document containing the sentence and properties of the sentence itself Regarding the former type, two features come into play: the relevance score of the document (from the IR engine) and ... Israel and India show an increase in cooperation? If so, what are the driving factors behind this increase? Evidence for a relationship includes both the means to in uence some entity andthe motivation ... of information needs formally introduced as a subtask inthe NIST-sponsored TREC QA evaluations in 2005 (Voorhees, 2005) Previously, they were the focus of a small pilot study within the AQUAINT...
... not the same as finding that school quality differences not exist Second, the findings not say that spending and resources never matter Indeed, there is some indication, particularly in developing ... censuses and other surveys, which find it easy to collect information on earnings, school attainment, age, and other demographic information On the other hand, it is difficult to obtain data on ... with employers relying on readily available information on school attainment when they not have other information and switching to observations of skills and performance as that information becomes...
... and increasing investments in rainfed areas WATER HARVESTING Water harvesting involves concentrating and collecting the rainwater from a larger catchment area onto a smaller cultivated area The ... rainfed areas; and improving the coordination among farmers, NGOs, and public institutions CONCLUSIONS Rainfed agriculture will maintain an important roleinthe growth of food production inthe ... system in India (Ojasvi et al 1999) These linings served to harvest water and mulch jujube trees The largest plant height was obtained using linings of stone and marble During the first year of the...
... as Points of Access into the Financial System TheRole of African Post Offices in Payments TheRole of Post Offices in International Remittances TheRole of Post Offices in Savings TheRole of ... On the other hand, inthe course of the desk research in 2004, other countries that were not included inthe list of 24 countries were found to have postal networks with an active rolein financial ... infrastructure as the main points for collecting, processing, sorting, and distributing mail items Increasingly, Asian postal operators are re-engineering their postal business processes By creating large,...