the role of the immune response in pathogenesis
Báo cáo y học: "Application of in vivo microscopy: evaluating the immune response in living animals" pps
... mobility in lymph nodes of living animals breathing either room air or 95% O2/5% CO2 In contrast, manipulations involved in the intravital approach including the trauma associated with anesthesia ... allow the tracking of specific cell types such as endogenous DCs in the steady state [18] The ideal goal, of course, is to image single immune cells within their undisturbed environment in an intact ... resident DCs are labeled in the skin by injecting CSFE together with antigen and adjuvant CSFE+ DCs are then detected after migration in the draining lymph nodes and the interaction with antigenspecific...
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Báo cáo y học: " The role of the humoral immune response in the molecular evolution of the envelope C2, V3 and C3 regions in chronically HIV-2 infected patients" pdf
... below), in the envelope complex of HIV-2 differs substantially from that of HIV-1 Glycans on HIV-1 envelope protein play an important role in the folding of the glycoproteins, in infection and in ... common in HIV-2 than in HIV-1 infection Still, little is known about the role of humoral immunity in the evolution of the HIV-2 env gene In the present study we analyze, for the first time, the ... Overall, these results provide support for a crucial role of neutralizing antibody response in the effective containment of viral replication in HIV-2 infection in vivo [36] Surprisingly, in some...
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study on the immune response of orange spotted grouper (epinephelus coioides hamilton, 1822) cultured in khanh hoa province to bacteria vibrio parahaemolyticus
... characteristics of V parahaemolyticus causing the ulcerative disease in grouper Study on the effect of oral administration β-glucan on the native immune response of orange-spotted grouper Study on the ... monitoring environment and disease in the North Vietnam; Strain V2 was kindly supplied by The center of monitoring environment and disease in the South Vietnam; Strain A was reference strain V ... antibodies in fish sera were analyzed by ELISA following Jakobsen et al (1999) The antibody response of orange-spotted grouper to the bacterin containing FIA and the protective efficacy testing: The...
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Báo cáo khoa học: "Efficiency of Matricaria chamomilla CH12 and number of doses of rabies vaccine on the humoral immune response in cattle" potx
... rabies, indicating that these animals had no prior contact with rabies virus or the vaccine Thus, all the antibody titers found here were induced by the rabies vaccination during the study In the ... after the second dose of rabies vaccine inactivated The results found in the present study lead to the conclusion that the use of Matricaria chamomilla CH12 added to mineral salt did not affect the ... between the first and the second weighing divided by the number of animals that fed at the feeder was considered the average salt consumption per calf in 24 h From these calculations, the amount of...
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Báo cáo y học: " Characterisation of the immune response to type I collagen in scleroderma" pps
... Arthritis Research & Therapy Vol No Warrington et al Cell line cytokine profile We were interested in comparing the Th1 and Th2 cytokine secretion profile of CI-specific cell lines Cell lines generated ... T-cell lines was determined by intracellular (IC) staining of lines PMA (phorbol 12-myristate 13-acetate)/ionomycin activated T cells (a) We detected interferon (IFN)-γ staining but no interleukin ... matrix proteins in SSc Laminin and, less often, type IV collagen can induce proliferation of SSc lymphocytes [16] Autoantibodies to fibrillin-1, the major component of microfibrils in the extracellular...
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Báo cáo khoa học: "The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques" ppt
... participate on the final outcome The association of acute GU toxicity with the percentage of the urinary bladder receiving 50 Gy found in our study was in accordance with the results of Fiorino et al.[32] ... dose of 10-18 Gy in 5-9 fractions Patients from the WP group received a dose of 45 Gy in 25 fractions to the PTV1, then a dose of 20 Gy in 10 fractions to the PTV2 Finally the PTV3 received the ... normalized to the ICRU reference point, located in the central part of the PTV or near the central axis of the beam intersection, according to ICRU 50 Dose homogeneity was between 95% and 107% of the ICRU...
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Báo cáo y học: "α The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis" pot
... anti-α-actinin antibodies in lupus patients was associated with a 2.5-fold increase in the prevalence of LN [14] Finally, levels of anti-α-actinin antibodies correlated with those of anti-DNA ... to several of the studies cited in this editorial Studies in the laboratory of CP are funded by the National Institute of Arthritis and Musculoskeletal Disease, the National Institute of Diabetes ... considering that only of the 16 patients had pure proliferative disease (in which the association with pathogenic antibodies is the strongest) The low frequency of αactinin antibodies in this...
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Báo cáo sinh học: " Enhancement of the expression of HCV core gene does not enhance core-specific immune response in DNA immunization: advantages of the heterologous DNA prime, protein boost immunization regimen" ppsx
... patients including non-responders to the standard therapy [13,14] Another therapeutic vaccine employed peptides chosen individually for their ability to induce the strongest in vitro cellular response ... acquisition of anti-HCV core immunity affect the immune status and functionality of the immune system in gene recipients Competing interests The authors declare that they have no competing interests ... and the development of immune response [30-33] Extermination of core expressing cells and inhibition of the activity of extracellular core (non-enveloped particles containing HCV RNA [34]) could...
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Mechanisms and functions of lymphangiogenesis in regulating the immune response and inflammation resolution 2
... VEGF-A expression was mainly confined to the subcapsular region of the LN The heparin-binding carboxyl-domain of the predominant VEGF-A isoform, VEGF164 may bound the molecule to the extracellular ... to further confirm and extend the role of neutrophils in driving lymphangiogenesis in a disease model of inflammation We choose to examine this in a chronic skin inflammation, in a model of cutaneous ... important role in driving lymphangiogenesis in a disease model of chronic skin inflammation In order to ascertain whether neutrophils are required for lymphangiogenesis in chronic skin inflammation,...
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Mechanisms and functions of lymphangiogenesis in regulating the immune response and inflammation resolution 1
... underscores the roles that FRCs play in maintaining the immune response 25 1.6 Lymph node remodeling during inflammation Organization of the stromal elements or ontogeny of LNs is initiated during ... 2009) There is a wealth of evidence indicating that differences in the expression of the NRPs and heparin-binding domains give rise to the diverse biochemical and functional properties of the VEGF-A ... lymphangiogenesis in the draining LNs 58 Figure 3.3 Immunization induced expansion of the BEC and FRC populations in DLNs 59 Figure 3.4 Lymphangiogenesis in inflamed LNs is initiated and maintained by continued...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 1
... unique Therefore, the study of the cross-talk between cancer cells and the immune system must be analyzed in the context of the organ in which the tumor exists and the type of cells that the tumor ... by the histologically defined layers of the skin However, this can be inaccurate as the thickness of the different layers of the skin can vary between individuals The Breslow’s thickness is the ... investigate the interactions between tumor cells and immune cells In Chapter 1, I investigate the tumor immune infiltrates in RETAAD mice I find that the immune infiltrates are all different in three...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 2
... is the number of melanoma cells at the end of the experiment, N is the number of melanoma cells at the onset of the experiment, k is the fraction of proliferating cells, t is the duration of the ... is the number of melanoma cells at the end of the experiment, N is the number of melanoma cells at the onset of the experiment, k is the fraction of proliferating cells, t is the duration of the ... is the ratio of Dct expression in the lungs of control vs PMNMDSC-depleted mice, k c is the fraction of proliferating cells in the lungs of control mice and k d is the fraction of proliferating...
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THE ROLE OF ANNEXIN 1 IN THE REGULATION OF INFLAMMATORY STRESS RESPONSE IN MACROPHAGES
... determine the role of ANXA1 in the regulation of the inflammatory response upon induction with heat and with heat and LPS 2) To determine the signaling pathways, involved in the regulation of the inflammatory ... effectiveness in the treatment of certain cancers induced the de novo protein 36 synthesis of ANXA1 that resulted in the induction of a HS like response in human neutrophils (Binet et al., 2008) The induction ... a key role in the inhibition of autophagy by preventing the formation of the complex of autophagy genes to 13 (Kamada et al., 2000; Pattingre et al., 2008) The induction of autophagy in response...
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Tài liệu Role of diffusion-weighted imaging in the diagnosis of gynecological diseases pdf
... satisfactory in the evaluation of nodal status in this patient group Since the highly cellular tissue in reactive lymph nodes may also show increased intensity, the role of DWI and ADC in distinguishing ... tissue in the uterine cervix and endometrium In the uterine myometrium, the ADC value may play a limited role due to the large overlap between sarcomas and benign leiomyomas The role of DWI for the ... enhancing cervical cancer (arrow) The tumor invades the cervical stroma (arrowhead) c DWI with b = 1,000 s/mm2 shows a well-defined hyperintensity mass in the cervical area The shape of the uterine...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... Protein targeting to the microsomes requires the cotranslational insertion of the newly synthesized protein into the microsomal membrane, where the N-terminal hydrophobic signal sequence of the ... mitochondria-targeting signal in the yeast system Mitochondrial localization of intact CYP2E1 in yeast cells Because of the existing ambiguity in the literature on the nature and extent of CYP2E1 import into ... consistent with the model suggesting a transmembrane topology of CYPs with a single N-terminal membrane anchor and most of the remaining protein exposed to the cytosolic side [15,17,30,31] The intramitochondrial...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... lysine reduces the probability of forming the fully closed form of the protein The results obtained with the K22V/R120K double mutant protein point toward a central role of arginine 120 in the ... enthalpies of binding and stoichiometries were determined from the binding isotherm by fitting a : binding model to the data using the software provided by the manufacturer Results Reaction of fosfomycin ... chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin binding to the K22V and K22E mutant proteins However, two other positively charged amino...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... iron-peroxo intermediate [11] The sum of these ndings points at the involvement of more than one active oxidant in the diverse types of P450-catalyzed substrate processing [1215] The goal of the present ... reect ring opening of an epoxide intermediate at either of its two C-O bonds [219,220] The sum of these ndings strongly invokes the notion of oxygen activation during redox cycling of the diverse ... alterations in the environment can cause drastic changes in the reactivity of the active species [76] Further support in favour of the idea of the involvement of a high-valent iron-oxene in P450...
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Tài liệu The Role of Public Regional Universities in Community and Economic Development doc
... Regional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... $28,000 in average annual salary) Preserving Value Continuing education is important to preserving the market value of specialized education – particularly in professional fields Continuing education ... Shippensburg University Small Business Initiative in the Frehn Center for Management; offering information and assistance to individuals and groups planning to start a new business Best Practice Highlights...
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Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf
... Amino–aromatic interactions in proteins FEBS Lett 203, 139–143 19 Chakrabarti, P & Samanta, U (1995) CH/, p interaction in the packing of the adenine ring in protein structures Advan Protein ... determined as part of the investigation into the shielding from solvent of the electrostatic interaction between Asp113 and His210 With increasing NaCl, the maximum activity decreased, while the ... deviation, the solvent ASA of the side-chain of His210 increased with the decrease in size of the side-chain at residue 169 (Table and Fig 3A) However, the ASAs of Asp113 and His57 remained constant...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... Ala219 of the catalytic site and His135 of the Mg2+ binding site The most striking result was the loss of the psychrophilic character of mutant W260K/A219N (as reflected by a threefold increase of the ... value in this temperature range is considerably lowered On the basis of the model, the behavior of the G261A variant can be interpreted in terms of constraints introduced by the Ala side chain The ... our incomplete understanding of the relation between enzyme properties and conformational flexibility limits the exploitation of the full potential of protein engineering in the redesign of psychrophilic...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25